Project name: water
Status: done
submitted: 2018-08-06 15:17:01, status changed: 2018-08-06 15:29:28
Settings
Chain sequence(s)
|
A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.5144
-
Maximal score value
-
1.8392
-
Average score
-
-0.6603
-
Total score value
-
-287.2349
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
Q |
A |
-0.8417 |
|
2 |
I |
A |
0.1204 |
|
3 |
V |
A |
1.2330 |
|
4 |
L |
A |
0.0000 |
|
5 |
S |
A |
-0.5797 |
|
6 |
Q |
A |
-0.8491 |
|
7 |
S |
A |
-0.2573 |
|
8 |
P |
A |
0.3498 |
|
9 |
A |
A |
0.6664 |
|
10 |
I |
A |
1.7980 |
|
11 |
L |
A |
0.8476 |
|
12 |
S |
A |
-0.0787 |
|
13 |
A |
A |
0.0000 |
|
14 |
S |
A |
-1.9905 |
|
15 |
P |
A |
-2.4657 |
|
16 |
G |
A |
-2.1981 |
|
17 |
E |
A |
-2.9272 |
|
18 |
K |
A |
-3.0728 |
|
19 |
V |
A |
0.0000 |
|
20 |
T |
A |
-0.6215 |
|
21 |
M |
A |
0.0000 |
|
22 |
T |
A |
-0.5622 |
|
23 |
C |
A |
0.0000 |
|
24 |
R |
A |
-1.7050 |
|
25 |
A |
A |
-0.5808 |
|
26 |
S |
A |
-0.2898 |
|
27 |
S |
A |
-0.3838 |
|
28 |
S |
A |
-0.5790 |
|
29 |
V |
A |
0.0000 |
|
30 |
S |
A |
-0.1228 |
|
31 |
Y |
A |
0.4308 |
|
32 |
I |
A |
0.0000 |
|
33 |
H |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
F |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
-0.4474 |
|
38 |
K |
A |
0.0000 |
|
39 |
P |
A |
-0.7032 |
|
40 |
G |
A |
-0.7425 |
|
41 |
S |
A |
-0.5557 |
|
42 |
S |
A |
-0.3727 |
|
43 |
P |
A |
0.0000 |
|
44 |
K |
A |
-0.6283 |
|
45 |
P |
A |
0.0000 |
|
46 |
W |
A |
-0.0101 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
0.2035 |
|
49 |
A |
A |
0.1401 |
|
50 |
T |
A |
-0.0651 |
|
51 |
S |
A |
-0.3692 |
|
52 |
N |
A |
-0.4608 |
|
53 |
L |
A |
0.3140 |
|
54 |
A |
A |
0.0000 |
|
55 |
S |
A |
-0.6936 |
|
56 |
G |
A |
-0.5046 |
|
57 |
V |
A |
0.0000 |
|
58 |
P |
A |
0.5452 |
|
59 |
V |
A |
1.5116 |
|
60 |
R |
A |
-0.3472 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-0.0621 |
|
63 |
G |
A |
-0.3362 |
|
64 |
S |
A |
-0.4192 |
|
65 |
G |
A |
-0.6937 |
|
66 |
S |
A |
-0.6328 |
|
67 |
G |
A |
-0.6779 |
|
68 |
T |
A |
-0.9388 |
|
69 |
S |
A |
-1.1195 |
|
70 |
Y |
A |
0.0000 |
|
71 |
S |
A |
-0.5498 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-0.8282 |
|
74 |
I |
A |
0.0000 |
|
75 |
S |
A |
-1.8982 |
|
76 |
R |
A |
-3.5144 |
|
77 |
V |
A |
0.0000 |
|
78 |
E |
A |
-3.0301 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-3.0528 |
|
81 |
D |
A |
0.0000 |
|
82 |
A |
A |
0.0000 |
|
83 |
A |
A |
0.0000 |
|
84 |
T |
A |
-0.0765 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
-0.0459 |
|
87 |
C |
A |
0.0000 |
|
88 |
Q |
A |
0.0000 |
|
89 |
Q |
A |
0.0000 |
|
90 |
W |
A |
0.0000 |
|
91 |
T |
A |
-0.5298 |
|
92 |
S |
A |
-1.1455 |
|
93 |
N |
A |
-1.7427 |
|
94 |
P |
A |
-1.4099 |
|
95 |
P |
A |
0.0000 |
|
96 |
T |
A |
0.0952 |
|
97 |
F |
A |
0.3479 |
|
98 |
G |
A |
-0.1672 |
|
99 |
G |
A |
-0.8965 |
|
100 |
G |
A |
-0.2064 |
|
101 |
T |
A |
0.0000 |
|
102 |
K |
A |
0.1200 |
|
103 |
L |
A |
0.0000 |
|
104 |
E |
A |
0.0000 |
|
105 |
I |
A |
0.0000 |
|
106 |
K |
A |
-1.9868 |
|
107 |
R |
A |
-1.3601 |
|
108 |
T |
A |
-0.3622 |
|
109 |
V |
A |
-0.0328 |
|
110 |
A |
A |
-0.2108 |
|
111 |
A |
A |
-0.2467 |
|
112 |
P |
A |
-0.3149 |
|
113 |
S |
A |
-0.3927 |
|
114 |
V |
A |
0.0000 |
|
115 |
F |
A |
0.1824 |
|
116 |
I |
A |
0.2124 |
|
117 |
F |
A |
0.0000 |
|
118 |
P |
A |
-0.6516 |
|
119 |
P |
A |
-0.6079 |
|
120 |
S |
A |
-1.1865 |
|
121 |
D |
A |
-2.3753 |
|
122 |
E |
A |
-1.9982 |
|
123 |
Q |
A |
0.0000 |
|
124 |
L |
A |
-1.5656 |
|
125 |
K |
A |
-1.9257 |
|
126 |
S |
A |
-1.4362 |
|
127 |
G |
A |
-1.1510 |
|
128 |
T |
A |
-1.3124 |
|
129 |
A |
A |
0.0000 |
|
130 |
S |
A |
0.0000 |
|
131 |
V |
A |
0.0000 |
|
132 |
V |
A |
0.0000 |
|
133 |
C |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
L |
A |
0.0000 |
|
136 |
N |
A |
-0.5691 |
|
137 |
N |
A |
-1.2303 |
|
138 |
F |
A |
0.0000 |
|
139 |
Y |
A |
0.0000 |
|
140 |
P |
A |
-1.7011 |
|
141 |
R |
A |
-2.4813 |
|
142 |
E |
A |
-3.0190 |
|
143 |
A |
A |
0.0000 |
|
144 |
K |
A |
-2.8127 |
|
145 |
V |
A |
-1.7185 |
|
146 |
Q |
A |
-1.6330 |
|
147 |
W |
A |
0.0000 |
|
148 |
K |
A |
-0.9162 |
|
149 |
V |
A |
0.0000 |
|
150 |
D |
A |
-1.8457 |
|
151 |
N |
A |
-1.6207 |
|
152 |
A |
A |
-0.4564 |
|
153 |
L |
A |
0.0747 |
|
154 |
Q |
A |
-0.6831 |
|
155 |
S |
A |
-0.8894 |
|
156 |
G |
A |
-1.1587 |
|
157 |
N |
A |
-1.3767 |
|
158 |
S |
A |
-1.2681 |
|
159 |
Q |
A |
-1.3728 |
|
160 |
E |
A |
-1.6891 |
|
161 |
S |
A |
-0.4642 |
|
162 |
V |
A |
0.1810 |
|
163 |
T |
A |
-0.3650 |
|
164 |
E |
A |
-1.0997 |
|
165 |
Q |
A |
0.0000 |
|
166 |
D |
A |
-2.3675 |
|
167 |
S |
A |
-2.7060 |
|
168 |
K |
A |
-3.1247 |
|
169 |
D |
A |
-2.1812 |
|
170 |
S |
A |
0.0000 |
|
171 |
T |
A |
0.0000 |
|
172 |
Y |
A |
0.0000 |
|
173 |
S |
A |
0.0000 |
|
174 |
L |
A |
0.0000 |
|
175 |
S |
A |
0.0000 |
|
176 |
S |
A |
0.0000 |
|
177 |
T |
A |
-0.2995 |
|
178 |
L |
A |
0.0531 |
|
179 |
T |
A |
-0.1140 |
|
180 |
L |
A |
-0.5524 |
|
181 |
S |
A |
-1.2055 |
|
182 |
K |
A |
-2.0523 |
|
183 |
A |
A |
-1.7526 |
|
184 |
D |
A |
-2.4172 |
|
185 |
Y |
A |
0.0000 |
|
186 |
E |
A |
-2.8624 |
|
187 |
K |
A |
-3.1501 |
|
188 |
H |
A |
-2.8948 |
|
189 |
K |
A |
-3.4555 |
|
190 |
V |
A |
0.0000 |
|
191 |
Y |
A |
0.0000 |
|
192 |
A |
A |
0.0000 |
|
193 |
C |
A |
0.0000 |
|
194 |
E |
A |
-1.1901 |
|
195 |
V |
A |
0.0000 |
|
196 |
T |
A |
-1.3916 |
|
197 |
H |
A |
0.0000 |
|
198 |
Q |
A |
-1.7462 |
|
199 |
G |
A |
-0.5046 |
|
200 |
L |
A |
-0.2960 |
|
201 |
S |
A |
-0.4576 |
|
202 |
S |
A |
-0.4437 |
|
203 |
P |
A |
-0.6231 |
|
204 |
V |
A |
-0.1495 |
|
205 |
T |
A |
-0.6170 |
|
206 |
K |
A |
-0.6874 |
|
207 |
S |
A |
-0.6980 |
|
208 |
F |
A |
-1.3302 |
|
209 |
N |
A |
-2.7301 |
|
210 |
R |
A |
-2.7309 |
|
211 |
G |
A |
-2.4818 |
|
212 |
E |
A |
-2.9701 |
|
1 |
Q |
A |
-0.9394 |
|
2 |
V |
A |
0.1490 |
|
3 |
Q |
A |
-1.1452 |
|
4 |
L |
A |
0.0000 |
|
5 |
Q |
A |
-1.5352 |
|
6 |
Q |
A |
-1.0662 |
|
7 |
P |
A |
-0.9732 |
|
8 |
G |
A |
-1.1650 |
|
9 |
A |
A |
-0.8590 |
|
10 |
E |
A |
-0.8628 |
|
11 |
L |
A |
-0.4319 |
|
12 |
V |
A |
0.0000 |
|
13 |
K |
A |
-1.9387 |
|
14 |
P |
A |
-1.3823 |
|
15 |
G |
A |
-1.1856 |
|
16 |
A |
A |
-0.9707 |
|
17 |
S |
A |
-1.2793 |
|
18 |
V |
A |
0.0000 |
|
19 |
K |
A |
-2.0756 |
|
20 |
M |
A |
0.0000 |
|
21 |
S |
A |
-0.7695 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.4248 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.6036 |
|
26 |
G |
A |
-0.3082 |
|
27 |
Y |
A |
0.0619 |
|
28 |
T |
A |
-0.2160 |
|
29 |
F |
A |
0.0000 |
|
30 |
T |
A |
-0.6614 |
|
31 |
S |
A |
0.2767 |
|
32 |
Y |
A |
0.8350 |
|
33 |
N |
A |
0.6942 |
|
34 |
M |
A |
0.0000 |
|
35 |
H |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
K |
A |
0.0000 |
|
39 |
Q |
A |
-0.5905 |
|
40 |
T |
A |
-1.2368 |
|
41 |
P |
A |
-1.3341 |
|
42 |
G |
A |
-1.5517 |
|
43 |
R |
A |
-2.3574 |
|
44 |
G |
A |
-1.3510 |
|
45 |
L |
A |
-0.5280 |
|
46 |
E |
A |
-0.7071 |
|
47 |
W |
A |
0.0000 |
|
48 |
I |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
A |
A |
0.0000 |
|
51 |
I |
A |
0.0000 |
|
52 |
Y |
A |
-0.3270 |
|
53 |
P |
A |
0.0000 |
|
54 |
G |
A |
-1.3284 |
|
55 |
N |
A |
-1.9710 |
|
56 |
G |
A |
-2.1468 |
|
57 |
D |
A |
-2.3236 |
|
58 |
T |
A |
-1.1080 |
|
59 |
S |
A |
-0.7935 |
|
60 |
Y |
A |
-1.1782 |
|
61 |
N |
A |
0.0000 |
|
62 |
Q |
A |
-2.7034 |
|
63 |
K |
A |
-2.8618 |
|
64 |
F |
A |
-2.1812 |
|
65 |
K |
A |
-2.9575 |
|
66 |
G |
A |
-2.1822 |
|
67 |
K |
A |
-2.0055 |
|
68 |
A |
A |
0.0000 |
|
69 |
T |
A |
-0.9501 |
|
70 |
L |
A |
0.0000 |
|
71 |
T |
A |
-0.5220 |
|
72 |
A |
A |
-1.2335 |
|
73 |
D |
A |
-1.9317 |
|
74 |
K |
A |
-2.3552 |
|
75 |
S |
A |
-1.3829 |
|
76 |
S |
A |
-1.1149 |
|
77 |
S |
A |
-1.2901 |
|
78 |
T |
A |
0.0000 |
|
79 |
A |
A |
0.0000 |
|
80 |
Y |
A |
-0.4919 |
|
81 |
M |
A |
0.0000 |
|
82 |
Q |
A |
-1.4875 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-1.0513 |
|
85 |
S |
A |
-0.8825 |
|
86 |
L |
A |
0.0000 |
|
87 |
T |
A |
-1.2027 |
|
88 |
S |
A |
-1.3291 |
|
89 |
E |
A |
-1.7130 |
|
90 |
D |
A |
-1.0366 |
|
91 |
S |
A |
-0.7500 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
0.1182 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
0.0000 |
|
99 |
S |
A |
0.0000 |
|
100 |
T |
A |
0.8782 |
|
101 |
Y |
A |
1.8305 |
|
102 |
Y |
A |
1.8392 |
|
103 |
G |
A |
0.2936 |
|
104 |
G |
A |
-0.3735 |
|
105 |
D |
A |
0.0059 |
|
106 |
W |
A |
0.0000 |
|
107 |
Y |
A |
0.4515 |
|
108 |
F |
A |
0.0000 |
|
109 |
N |
A |
-0.1739 |
|
110 |
V |
A |
0.0000 |
|
111 |
W |
A |
0.0000 |
|
112 |
G |
A |
0.0000 |
|
113 |
A |
A |
-0.6337 |
|
114 |
G |
A |
-0.3585 |
|
115 |
T |
A |
0.0000 |
|
116 |
T |
A |
-0.2858 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.6484 |
|
119 |
V |
A |
0.0000 |
|
120 |
S |
A |
-0.7696 |
|
121 |
A |
A |
-0.7164 |
|
122 |
A |
A |
-0.4350 |
|
123 |
S |
A |
-0.5476 |
|
124 |
T |
A |
-0.6611 |
|
125 |
K |
A |
-1.1992 |
|
126 |
G |
A |
-1.6272 |
|
127 |
P |
A |
0.0000 |
|
128 |
S |
A |
-0.6011 |
|
129 |
V |
A |
0.0000 |
|
130 |
F |
A |
-0.4536 |
|
131 |
P |
A |
-0.9881 |
|
132 |
L |
A |
0.0000 |
|
133 |
A |
A |
-0.7990 |
|
134 |
P |
A |
-1.0725 |
|
135 |
S |
A |
-1.9226 |
|
136 |
S |
A |
-1.6519 |
|
137 |
K |
A |
-2.3633 |
|
138 |
S |
A |
-1.5064 |
|
139 |
T |
A |
-1.1911 |
|
140 |
S |
A |
-1.0093 |
|
141 |
G |
A |
-0.8950 |
|
142 |
G |
A |
-0.8966 |
|
143 |
T |
A |
-0.6587 |
|
144 |
A |
A |
0.0000 |
|
145 |
A |
A |
0.0000 |
|
146 |
L |
A |
0.0000 |
|
147 |
G |
A |
0.0000 |
|
148 |
C |
A |
0.0000 |
|
149 |
L |
A |
0.0000 |
|
150 |
V |
A |
0.0000 |
|
151 |
K |
A |
-0.2899 |
|
152 |
D |
A |
-0.8297 |
|
153 |
Y |
A |
0.0000 |
|
154 |
F |
A |
-0.3104 |
|
155 |
P |
A |
0.0000 |
|
156 |
E |
A |
-0.3858 |
|
157 |
P |
A |
-0.6791 |
|
158 |
V |
A |
-0.6054 |
|
159 |
T |
A |
-0.5734 |
|
160 |
V |
A |
-0.2647 |
|
161 |
S |
A |
-0.3388 |
|
162 |
W |
A |
0.0000 |
|
163 |
N |
A |
-0.7335 |
|
164 |
S |
A |
-0.6276 |
|
165 |
G |
A |
-0.4773 |
|
166 |
A |
A |
-0.1775 |
|
167 |
L |
A |
0.0357 |
|
168 |
T |
A |
-0.1998 |
|
169 |
S |
A |
-0.2452 |
|
170 |
G |
A |
-0.3246 |
|
171 |
V |
A |
-0.0224 |
|
172 |
H |
A |
-0.2624 |
|
173 |
T |
A |
-0.0576 |
|
174 |
F |
A |
0.0000 |
|
175 |
P |
A |
-0.2243 |
|
176 |
A |
A |
0.0163 |
|
177 |
V |
A |
0.2131 |
|
178 |
L |
A |
0.6919 |
|
179 |
Q |
A |
-0.1017 |
|
180 |
S |
A |
-0.4045 |
|
181 |
S |
A |
-0.4026 |
|
182 |
G |
A |
-0.2067 |
|
183 |
L |
A |
-0.0900 |
|
184 |
Y |
A |
0.2235 |
|
185 |
S |
A |
0.0000 |
|
186 |
L |
A |
0.0000 |
|
187 |
S |
A |
-0.0823 |
|
188 |
S |
A |
0.0000 |
|
189 |
V |
A |
0.0000 |
|
190 |
V |
A |
0.0000 |
|
191 |
T |
A |
-0.1673 |
|
192 |
V |
A |
0.0000 |
|
193 |
P |
A |
-0.6858 |
|
194 |
S |
A |
-0.6835 |
|
195 |
S |
A |
-0.7356 |
|
196 |
S |
A |
-0.7455 |
|
197 |
L |
A |
0.0000 |
|
198 |
G |
A |
-1.3641 |
|
199 |
T |
A |
-0.8208 |
|
200 |
Q |
A |
-1.4293 |
|
201 |
T |
A |
-1.1105 |
|
202 |
Y |
A |
0.0000 |
|
203 |
I |
A |
-1.2277 |
|
204 |
C |
A |
0.0000 |
|
205 |
N |
A |
-1.3410 |
|
206 |
V |
A |
0.0000 |
|
207 |
N |
A |
-1.9451 |
|
208 |
H |
A |
0.0000 |
|
209 |
K |
A |
-2.8308 |
|
210 |
P |
A |
-1.8395 |
|
211 |
S |
A |
-1.9187 |
|
212 |
N |
A |
-2.6452 |
|
213 |
T |
A |
-2.1615 |
|
214 |
K |
A |
-2.5744 |
|
215 |
V |
A |
-1.3169 |
|
216 |
D |
A |
-2.0802 |
|
217 |
K |
A |
-1.8246 |
|
218 |
K |
A |
-2.4105 |
|
219 |
V |
A |
0.0000 |
|
220 |
E |
A |
-2.7048 |
|
221 |
P |
A |
-1.9905 |
|
222 |
K |
A |
-2.2543 |
|
223 |
S |
A |
-1.2167 |
|