Project name: ef6a4e5712c569f

Status: done

submitted: 2017-09-14 12:43:57, status changed: 2017-09-14 12:57:49
Settings
Chain sequence(s) A: NLYFQGGTMYDFEYLNGLSYTELTNLIKNIKWNQINGLFNYSTGSQKFFGDKNRVQAIINALQESGRTYTANDMKGIETFTEVLRAGFYLGYYNDGLSYLNDRNFQDKCIPAMIAIQKNPNFKLGTAVQDEVITSLGKLIGNASANAEVVNNCVPVLKQFRENLNQYAPDYVKGTAVNELIKGIEFDFSGAAYEKDVKTMPWYGKIDPFINELKALGLYGNITSATEWASDVGIYYLSKFGLYSTNRNDIVQSLEKAVDMYKYGKIAFVAMERITWDYDGIGSNGKKVDHDKFLDDAEKHYLPKTYTFDNGTFIIRAGDKVSEEKIKRLYWASREVKSQFHRVVGNDKALEVGNADDVLTMKIFNSPEEYKFNTNINGVSTDNGGLYIEPRGTFYTYERTPQQSIFSLEELFRHEYTHYLQARYLVDGLWGQGPFYEKNRLTWFDEGTAEFFAGSTRTSGVLPRKLILGYLAKDKVDHRYSLKKTLNSDDSDWMFYNYGFAVAHYLYEKDMPTFIKMNKAILNTDVKSYDEIIKKLSDDANKNTEYQNHIQELVDKYQGAGIPLVSDDYLKDHGYKKASEVYSEISKAASLTNTSVTAEKSQYFNTFTLRGTYTGETSKGEFKDWDEMSKKLDGTLESLAKNSWSGYKTLTAYFTNYRVTSDNKVQYDVVFHGVLTDNG
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-4.1638
Maximal score value
1.9533
Average score
-0.8781
Total score value
-596.2357

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
110 N A -1.0900
111 L A 0.6657
112 Y A 1.9533
113 F A 1.7734
114 Q A -0.2405
115 G A -0.7235
116 G A -0.6677
117 T A -0.3088
118 M A -0.2360
119 Y A 0.0000
120 D A -1.5310
121 F A 0.0000
122 E A -1.5839
123 Y A -0.1581
124 L A 0.0000
125 N A -0.9886
126 G A -0.1214
127 L A -0.2537
128 S A -0.4820
129 Y A -0.5502
130 T A -0.9884
131 E A -2.0137
132 L A 0.0000
133 T A -1.3137
134 N A -2.1606
135 L A -1.4682
136 I A 0.0000
137 K A -1.9987
138 N A -2.1615
139 I A 0.0000
140 K A -2.3645
141 W A -1.5480
142 N A -1.5788
143 Q A -1.2437
144 I A 0.0000
145 N A -1.8344
146 G A -1.2999
147 L A 0.0000
148 F A 0.1151
149 N A -0.7900
150 Y A 0.2748
151 S A -0.5199
152 T A -0.8116
153 G A 0.0000
154 S A 0.0000
155 Q A -1.5537
156 K A -2.3891
157 F A 0.0000
158 F A 0.0000
159 G A -1.8347
160 D A -2.3491
161 K A -2.7311
162 N A -2.4662
163 R A 0.0000
164 V A 0.0000
165 Q A -2.0293
166 A A -1.1993
167 I A 0.0000
168 I A 0.0000
169 N A -1.7526
170 A A -1.7313
171 L A 0.0000
172 Q A -1.9538
173 E A -2.9016
174 S A 0.0000
175 G A 0.0000
176 R A -2.9713
177 T A -1.7575
178 Y A 0.0000
179 T A -1.2163
180 A A -1.1411
181 N A -1.8143
182 D A -1.8614
183 M A -1.4963
184 K A -2.1673
185 G A -1.7179
186 I A 0.0000
187 E A -1.3412
188 T A 0.0000
189 F A 0.0000
190 T A 0.0000
191 E A -0.7268
192 V A 0.0000
193 L A 0.0000
194 R A -0.3403
195 A A 0.0000
196 G A 0.0000
197 F A 0.0000
198 Y A 1.1162
199 L A 0.0000
200 G A 0.0000
201 Y A 1.1660
202 Y A 1.4360
203 N A -0.2517
204 D A -1.8237
205 G A -1.5382
206 L A 0.0000
207 S A -1.0717
208 Y A -1.3826
209 L A 0.0000
210 N A -1.9591
211 D A -2.9301
212 R A -3.6055
213 N A -3.0830
214 F A -2.4343
215 Q A 0.0000
216 D A -2.5816
217 K A -2.2006
218 C A 0.0000
219 I A 0.0000
220 P A -0.8154
221 A A 0.0000
222 M A 0.0000
223 I A -0.7653
224 A A 0.0000
225 I A 0.0000
226 Q A 0.0000
227 K A -2.0994
228 N A 0.0000
229 P A -1.3302
230 N A -1.3425
231 F A 0.0000
232 K A -1.7670
233 L A 0.0000
234 G A -0.7586
235 T A -0.5595
236 A A -0.2331
237 V A -0.8747
238 Q A -1.1392
239 D A 0.0000
240 E A -0.9702
241 V A 0.0000
242 I A 0.0000
243 T A -0.7228
244 S A 0.0000
245 L A 0.0000
246 G A 0.0000
247 K A -1.1361
248 L A 0.0000
249 I A 0.0000
250 G A -0.6075
251 N A -0.6735
252 A A 0.0000
253 S A 0.0000
254 A A 0.0000
255 N A -1.4524
256 A A 0.0000
257 E A -2.3624
258 V A 0.0000
259 V A 0.0000
260 N A -1.6896
261 N A -1.2995
262 C A 0.0000
263 V A -0.6340
264 P A -0.9757
265 V A 0.0000
266 L A 0.0000
267 K A -1.7300
268 Q A -1.7278
269 F A 0.0000
270 R A 0.0000
271 E A -2.6735
272 N A -2.1785
273 L A 0.0000
274 N A -2.4737
275 Q A -2.3449
276 Y A -1.2763
277 A A 0.0000
278 P A -0.8006
279 D A -0.5485
280 Y A 1.2114
281 V A 0.9879
282 K A -0.0036
283 G A 0.0000
284 T A 0.1346
285 A A 0.0000
286 V A 0.0000
287 N A -0.7013
288 E A -1.0715
289 L A 0.0000
290 I A 0.0000
291 K A -0.8231
292 G A 0.0000
293 I A 0.0000
294 E A 0.0000
295 F A 1.1714
296 D A -0.0639
297 F A 0.0000
298 S A 0.4829
299 G A 0.0419
300 A A -0.3588
301 A A 0.0000
302 Y A -0.4254
303 E A -2.4235
304 K A -3.2262
305 D A -3.1808
306 V A -1.6594
307 K A -2.2416
308 T A -1.5342
309 M A -1.0785
310 P A -0.8799
311 W A 0.0000
312 Y A -0.9684
313 G A -1.7616
314 K A -2.5998
315 I A 0.0000
316 D A -2.6899
317 P A -1.7541
318 F A 0.0000
319 I A 0.0000
320 N A -1.5782
321 E A -1.2380
322 L A 0.0000
323 K A -0.4541
324 A A -0.2955
325 L A 0.0000
326 G A 0.0000
327 L A 0.0986
328 Y A 0.2114
329 G A -0.3535
330 N A -1.1415
331 I A -0.4453
332 T A -0.5400
333 S A -0.2465
334 A A -0.6169
335 T A 0.0000
336 E A -0.7254
337 W A -0.1380
338 A A 0.0000
339 S A 0.0000
340 D A -0.0760
341 V A 0.0000
342 G A 0.0000
343 I A 0.0000
344 Y A 0.2080
345 Y A 0.0000
346 L A 0.0000
347 S A 0.0000
348 K A -0.0924
349 F A 0.0000
350 G A 0.0000
351 L A 0.0182
352 Y A 0.0000
353 S A -1.6356
354 T A -1.7171
355 N A -2.2351
356 R A -2.1275
357 N A -2.8127
358 D A -2.6662
359 I A 0.0000
360 V A 0.0000
361 Q A -2.4479
362 S A 0.0000
363 L A 0.0000
364 E A -1.8318
365 K A -2.2706
366 A A 0.0000
367 V A -1.5081
368 D A -2.3103
369 M A -1.1609
370 Y A 0.0000
371 K A -1.6132
372 Y A -0.9343
373 G A -0.5697
374 K A -1.0302
375 I A 0.0000
376 A A 0.0000
377 F A 0.0000
378 V A -0.2298
379 A A 0.0000
380 M A 0.0000
381 E A -0.4495
382 R A 0.0000
383 I A 0.0000
384 T A -0.7289
385 W A 0.3431
386 D A -0.2103
387 Y A 0.0000
388 D A -1.6292
389 G A 0.0000
390 I A -1.9813
391 G A 0.0000
392 S A -2.3166
393 N A -2.4631
394 G A -2.3067
395 K A -3.1330
396 K A -3.2321
397 V A -2.6025
398 D A -3.3541
399 H A -2.9304
400 D A -3.6847
401 K A -3.9289
402 F A 0.0000
403 L A -2.5867
404 D A -3.6520
405 D A -3.1108
406 A A 0.0000
407 E A 0.0000
408 K A -2.7420
409 H A -2.3887
410 Y A 0.0000
411 L A 0.0000
412 P A -2.0508
413 K A -2.0160
414 T A -1.0036
415 Y A 0.0000
416 T A -0.6551
417 F A 0.0000
418 D A -1.4180
419 N A -2.0548
420 G A -1.1188
421 T A -0.5959
422 F A 0.0000
423 I A 0.1406
424 I A 0.0000
425 R A -1.1058
426 A A 0.0000
427 G A 0.0000
428 D A -3.2207
429 K A -2.9717
430 V A 0.0000
431 S A -2.3845
432 E A -3.0855
433 E A -3.0825
434 K A -2.0336
435 I A 0.0000
436 K A -1.5373
437 R A -1.4847
438 L A 0.0000
439 Y A 0.0000
440 W A 0.0000
441 A A 0.0000
442 S A 0.0000
443 R A -0.3800
444 E A 0.0000
445 V A 0.0000
446 K A -0.3209
447 S A 0.0000
448 Q A 0.0000
449 F A 0.0000
450 H A 0.0000
451 R A 0.0000
452 V A 0.0000
453 V A 0.0000
454 G A -0.6676
455 N A -1.0182
456 D A -1.3301
457 K A -1.7530
458 A A -1.2588
459 L A -0.7042
460 E A -1.0048
461 V A 0.4415
462 G A -0.4757
463 N A -1.2104
464 A A -1.0704
465 D A 0.0000
466 D A -1.8047
467 V A -0.6526
468 L A 0.0000
469 T A -0.1675
470 M A 0.0000
471 K A -0.4582
472 I A 0.0000
473 F A 0.0000
474 N A -1.5374
475 S A -1.4363
476 P A -1.8122
477 E A -2.3574
478 E A -1.6282
479 Y A 0.0000
480 K A -2.3735
481 F A -1.2166
482 N A 0.0000
483 T A -1.1297
484 N A -1.0326
485 I A 0.0000
486 N A -0.7585
487 G A -0.7719
488 V A 0.0000
489 S A -1.1658
490 T A -1.5933
491 D A -2.2785
492 N A -1.5122
493 G A -0.5485
494 G A -0.4560
495 L A -0.0208
496 Y A 0.0000
497 I A -0.0466
498 E A -0.4283
499 P A -0.7072
500 R A -1.3714
501 G A 0.0000
502 T A 0.0000
503 F A 0.0000
504 Y A 0.0000
505 T A 0.0000
506 Y A 0.0000
507 E A -0.7774
508 R A 0.0000
509 T A -0.5971
510 P A -0.5103
511 Q A -1.2801
512 Q A -1.0463
513 S A 0.2091
514 I A 1.7501
515 F A 1.1150
516 S A 0.2828
517 L A 0.0000
518 E A 0.0000
519 E A 0.0000
520 L A 0.3504
521 F A 0.0000
522 R A 0.0000
523 H A -0.2805
524 E A -0.2628
525 Y A 0.0000
526 T A 0.0000
527 H A 0.0000
528 Y A 0.0000
529 L A 0.0000
530 Q A 0.0000
531 A A 0.0000
532 R A -0.9134
533 Y A 0.0000
534 L A 0.0000
535 V A 0.0000
536 D A -1.5744
537 G A -0.8257
538 L A -0.1017
539 W A -0.0840
540 G A -0.7057
541 Q A -1.3761
542 G A -1.2981
543 P A -1.4061
544 F A 0.0000
545 Y A -2.0105
546 E A -3.1300
547 K A -3.1739
548 N A -2.9912
549 R A -1.8588
550 L A 0.0000
551 T A -0.7403
552 W A 0.0000
553 F A 0.0000
554 D A 0.0000
555 E A -0.2723
556 G A 0.0000
557 T A 0.0000
558 A A 0.0000
559 E A -0.2213
560 F A 0.0000
561 F A 0.0000
562 A A 0.0000
563 G A 0.0000
564 S A 0.0000
565 T A 0.1054
566 R A -0.5322
567 T A -0.8955
568 S A -0.5883
569 G A 0.0000
570 V A 0.0000
571 L A 0.5811
572 P A 0.1492
573 R A 0.0000
574 K A -0.4406
575 L A 0.6008
576 I A 0.0000
577 L A 0.0000
578 G A -0.3941
579 Y A 0.0841
580 L A 0.0000
581 A A -1.2007
582 K A -2.2866
583 D A -3.3387
584 K A -2.9542
585 V A -0.9675
586 D A -2.4808
587 H A -2.8986
588 R A -2.5515
589 Y A 0.0000
590 S A -1.8899
591 L A 0.0000
592 K A -3.6397
593 K A -2.9788
594 T A 0.0000
595 L A 0.0000
596 N A -2.9755
597 S A -2.4786
600 D A -3.0061
601 D A -2.9646
602 S A -1.8177
603 D A -1.5083
604 W A 0.3816
605 M A 0.0000
606 F A 0.0000
607 Y A 0.8201
608 N A 0.0000
609 Y A 0.0000
610 G A 0.0000
611 F A 0.0000
612 A A 0.0000
613 V A 0.0000
614 A A 0.0000
615 H A 0.0000
616 Y A 0.0000
617 L A 0.0000
618 Y A -1.2297
619 E A -2.5868
620 K A -2.7860
621 D A -1.5866
622 M A 0.0000
623 P A -0.9134
624 T A 0.0000
625 F A 0.0000
626 I A -0.7430
627 K A -1.3857
628 M A 0.0000
629 N A 0.0000
630 K A -1.4614
631 A A 0.0000
632 I A 0.0000
633 L A -1.1297
634 N A -1.8360
635 T A -1.6431
636 D A -2.0224
637 V A -1.8061
638 K A -2.5541
639 S A -2.4691
640 Y A 0.0000
641 D A -2.6944
642 E A -3.3116
643 I A 0.0000
644 I A 0.0000
645 K A -4.1638
646 K A -3.8746
647 L A 0.0000
648 S A -3.7181
649 D A -3.7108
650 D A -3.1287
651 A A -2.1866
652 N A -2.3915
653 K A -2.4697
654 N A -2.3017
655 T A -1.9071
656 E A -2.6797
657 Y A 0.0000
658 Q A -2.1072
659 N A -2.4186
660 H A 0.0000
661 I A 0.0000
662 Q A -2.5227
663 E A -2.7564
664 L A 0.0000
665 V A -1.8584
666 D A -2.9521
667 K A -2.5901
668 Y A -1.4998
669 Q A -1.9786
670 G A -1.5645
671 A A -0.9653
672 G A -0.2719
673 I A 0.6351
674 P A 0.5813
675 L A 0.5889
676 V A 0.0000
677 S A -1.2233
678 D A -2.5164
679 D A -2.2187
680 Y A 0.0000
681 L A -1.9723
682 K A -3.0293
683 D A -2.5475
684 H A -1.5113
685 G A -0.5803
686 Y A 0.1151
687 K A -1.2519
688 K A -2.2275
689 A A -1.7168
690 S A -1.7202
691 E A -2.6872
692 V A 0.0000
693 Y A -1.1422
694 S A -1.6569
695 E A -1.9873
696 I A 0.0000
697 S A -1.6347
698 K A -2.0302
699 A A -1.1355
700 A A 0.0000
701 S A -0.7970
702 L A -0.9038
703 T A -1.1066
704 N A -1.5410
705 T A -1.0851
706 S A -0.6365
707 V A 0.2217
708 T A 0.0261
709 A A -0.7101
710 E A -1.5421
711 K A -2.4468
712 S A 0.0000
713 Q A -1.0107
714 Y A -0.3203
715 F A -0.3680
716 N A -1.3578
717 T A 0.0000
718 F A 0.0000
719 T A -0.1688
720 L A 0.0000
721 R A -1.5837
722 G A 0.0000
723 T A -0.8200
724 Y A -0.3321
725 T A -0.6044
726 G A -1.2027
727 E A -2.6214
728 T A -2.2401
729 S A -2.5356
730 K A -3.1119
731 G A -2.1084
732 E A -2.2194
733 F A -1.8670
734 K A -2.7942
735 D A 0.0000
736 W A -1.9240
737 D A -2.6682
738 E A -3.5031
739 M A 0.0000
740 S A -2.2014
741 K A -3.1288
742 K A -2.5729
743 L A 0.0000
744 D A -1.7871
745 G A -1.6110
746 T A 0.0000
747 L A 0.0000
748 E A -2.0820
749 S A -1.5747
750 L A 0.0000
751 A A -1.7622
752 K A -2.4614
753 N A -1.7781
754 S A -0.9306
755 W A 0.0000
756 S A -1.3196
757 G A 0.0000
758 Y A 0.0000
759 K A -1.6668
760 T A 0.0000
761 L A 0.0000
762 T A 0.0000
763 A A 0.0000
764 Y A 0.0000
765 F A 0.0000
766 T A 0.0000
767 N A -1.1286
768 Y A -0.6025
769 R A -0.9441
770 V A -1.0259
771 T A -1.2306
772 S A -1.4809
773 D A -2.7361
774 N A -2.8524
775 K A -2.4806
776 V A -1.5940
777 Q A -0.7940
778 Y A 0.0000
779 D A -1.0498
780 V A 0.0000
781 V A 0.0000
782 F A 0.0000
783 H A 0.0000
784 G A 0.0000
785 V A 0.0000
786 L A 0.0000
787 T A -0.7752
788 D A -1.3546
789 N A -1.7609
790 G A -1.3174

 

Laboratory of Theory of Biopolymers 2015