Project name: PRO_5p_2osl
Status: done
submitted: 2018-08-12 12:48:13, status changed: 2018-08-12 12:58:43
Settings
Chain sequence(s)
|
A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.7736
-
Maximal score value
-
1.7756
-
Average score
-
-0.6424
-
Total score value
-
-279.4509
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
Q |
A |
-1.0599 |
|
2 |
I |
A |
0.1164 |
|
3 |
V |
A |
1.0680 |
|
4 |
L |
A |
0.0000 |
|
5 |
S |
A |
-0.6034 |
|
6 |
Q |
A |
-0.5487 |
|
7 |
S |
A |
-0.3898 |
|
8 |
P |
A |
0.3541 |
|
9 |
A |
A |
0.6180 |
|
10 |
I |
A |
1.7249 |
|
11 |
L |
A |
0.8034 |
|
12 |
S |
A |
-0.3554 |
|
13 |
A |
A |
0.0000 |
|
14 |
S |
A |
-1.9819 |
|
15 |
P |
A |
-2.1368 |
|
16 |
G |
A |
-2.4107 |
|
17 |
E |
A |
-2.9161 |
|
18 |
K |
A |
-2.8366 |
|
19 |
V |
A |
-1.2295 |
|
20 |
T |
A |
-0.4672 |
|
21 |
M |
A |
0.0000 |
|
22 |
T |
A |
-0.7464 |
|
23 |
C |
A |
0.0000 |
|
24 |
R |
A |
-1.9589 |
|
25 |
A |
A |
0.0000 |
|
26 |
S |
A |
-0.3029 |
|
27 |
S |
A |
-0.5284 |
|
28 |
S |
A |
-0.6743 |
|
29 |
V |
A |
0.0000 |
|
30 |
S |
A |
-0.2663 |
|
31 |
Y |
A |
0.1153 |
|
32 |
I |
A |
0.0000 |
|
33 |
H |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
F |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
-0.7466 |
|
38 |
K |
A |
-1.1379 |
|
39 |
P |
A |
-0.9627 |
|
40 |
G |
A |
-0.6560 |
|
41 |
S |
A |
-0.7052 |
|
42 |
S |
A |
-0.4867 |
|
43 |
P |
A |
0.0000 |
|
44 |
K |
A |
-1.1517 |
|
45 |
P |
A |
0.0000 |
|
46 |
W |
A |
-0.3736 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
-0.1002 |
|
49 |
A |
A |
-0.2600 |
|
50 |
T |
A |
0.0000 |
|
51 |
S |
A |
-0.7755 |
|
52 |
N |
A |
-1.1586 |
|
53 |
L |
A |
-0.0533 |
|
54 |
A |
A |
0.0000 |
|
55 |
S |
A |
-0.4432 |
|
56 |
G |
A |
-0.1584 |
|
57 |
V |
A |
0.0000 |
|
58 |
P |
A |
0.6286 |
|
59 |
V |
A |
1.3561 |
|
60 |
R |
A |
-0.4310 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-0.1631 |
|
63 |
G |
A |
-0.5615 |
|
64 |
S |
A |
-0.7121 |
|
65 |
G |
A |
-0.9381 |
|
66 |
S |
A |
-0.7877 |
|
67 |
G |
A |
-0.7698 |
|
68 |
T |
A |
-1.0829 |
|
69 |
S |
A |
-1.1487 |
|
70 |
Y |
A |
0.0000 |
|
71 |
S |
A |
-0.6661 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-0.7342 |
|
74 |
I |
A |
0.0000 |
|
75 |
S |
A |
-1.9463 |
|
76 |
R |
A |
-3.1069 |
|
77 |
V |
A |
0.0000 |
|
78 |
E |
A |
-2.9090 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.4711 |
|
81 |
D |
A |
0.0000 |
|
82 |
A |
A |
-1.5314 |
|
83 |
A |
A |
0.0000 |
|
84 |
T |
A |
-0.1685 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
-0.1428 |
|
87 |
C |
A |
0.0000 |
|
88 |
Q |
A |
0.0000 |
|
89 |
Q |
A |
0.0000 |
|
90 |
W |
A |
0.0000 |
|
91 |
T |
A |
-0.3225 |
|
92 |
S |
A |
-0.9764 |
|
93 |
N |
A |
-1.6569 |
|
94 |
P |
A |
-1.4779 |
|
95 |
P |
A |
0.0000 |
|
96 |
T |
A |
-0.1730 |
|
97 |
F |
A |
0.0000 |
|
98 |
G |
A |
0.0000 |
|
99 |
G |
A |
-0.6897 |
|
100 |
G |
A |
-0.2402 |
|
101 |
T |
A |
0.0000 |
|
102 |
K |
A |
0.0130 |
|
103 |
L |
A |
0.0000 |
|
104 |
E |
A |
-1.0126 |
|
105 |
I |
A |
0.0000 |
|
106 |
K |
A |
-1.7842 |
|
107 |
R |
A |
-1.1549 |
|
108 |
T |
A |
0.1155 |
|
109 |
V |
A |
0.9631 |
|
110 |
A |
A |
0.0595 |
|
111 |
A |
A |
-0.0807 |
|
112 |
P |
A |
0.0000 |
|
113 |
S |
A |
-0.2142 |
|
114 |
V |
A |
0.0000 |
|
115 |
F |
A |
0.0083 |
|
116 |
I |
A |
0.0000 |
|
117 |
F |
A |
0.0000 |
|
118 |
P |
A |
-0.4296 |
|
119 |
P |
A |
-0.7789 |
|
120 |
S |
A |
-1.7070 |
|
121 |
D |
A |
-2.7728 |
|
122 |
E |
A |
-2.6994 |
|
123 |
Q |
A |
0.0000 |
|
124 |
L |
A |
-1.7306 |
|
125 |
K |
A |
-2.0794 |
|
126 |
S |
A |
-1.3882 |
|
127 |
G |
A |
-1.0332 |
|
128 |
T |
A |
-0.9480 |
|
129 |
A |
A |
0.0000 |
|
130 |
S |
A |
0.0000 |
|
131 |
V |
A |
0.0000 |
|
132 |
V |
A |
0.0000 |
|
133 |
C |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
L |
A |
0.0000 |
|
136 |
N |
A |
0.0000 |
|
137 |
N |
A |
-0.9804 |
|
138 |
F |
A |
0.0000 |
|
139 |
Y |
A |
0.0000 |
|
140 |
P |
A |
-1.7422 |
|
141 |
R |
A |
-3.0588 |
|
142 |
E |
A |
-3.4036 |
|
143 |
A |
A |
-2.5358 |
|
144 |
K |
A |
-2.6944 |
|
145 |
V |
A |
0.0000 |
|
146 |
Q |
A |
-0.6786 |
|
147 |
W |
A |
0.0000 |
|
148 |
K |
A |
-0.5724 |
|
149 |
V |
A |
0.0000 |
|
150 |
D |
A |
-2.1991 |
|
151 |
N |
A |
-1.6679 |
|
152 |
A |
A |
-0.3013 |
|
153 |
L |
A |
0.6693 |
|
154 |
Q |
A |
-0.2049 |
|
155 |
S |
A |
-0.7352 |
|
156 |
G |
A |
-1.3204 |
|
157 |
N |
A |
-1.4881 |
|
158 |
S |
A |
-1.1087 |
|
159 |
Q |
A |
-1.8427 |
|
160 |
E |
A |
-1.5886 |
|
161 |
S |
A |
-0.8124 |
|
162 |
V |
A |
-0.7815 |
|
163 |
T |
A |
-1.0215 |
|
164 |
E |
A |
-2.0555 |
|
165 |
Q |
A |
0.0000 |
|
166 |
D |
A |
-2.3204 |
|
167 |
S |
A |
-2.4638 |
|
168 |
K |
A |
-2.9306 |
|
169 |
D |
A |
-2.2256 |
|
170 |
S |
A |
0.0000 |
|
171 |
T |
A |
0.0000 |
|
172 |
Y |
A |
0.0000 |
|
173 |
S |
A |
0.0000 |
|
174 |
L |
A |
0.0000 |
|
175 |
S |
A |
0.0000 |
|
176 |
S |
A |
0.0000 |
|
177 |
T |
A |
-0.1964 |
|
178 |
L |
A |
0.4970 |
|
179 |
T |
A |
0.0638 |
|
180 |
L |
A |
-0.5044 |
|
181 |
S |
A |
-1.1838 |
|
182 |
K |
A |
-2.1057 |
|
183 |
A |
A |
-1.8234 |
|
184 |
D |
A |
-2.6498 |
|
185 |
Y |
A |
0.0000 |
|
186 |
E |
A |
-3.7736 |
|
187 |
K |
A |
-3.7728 |
|
188 |
H |
A |
-3.1829 |
|
189 |
K |
A |
-3.4899 |
|
190 |
V |
A |
0.0000 |
|
191 |
Y |
A |
0.0000 |
|
192 |
A |
A |
0.0000 |
|
193 |
C |
A |
0.0000 |
|
194 |
E |
A |
-0.6929 |
|
195 |
V |
A |
0.0000 |
|
196 |
T |
A |
-1.3051 |
|
197 |
H |
A |
0.0000 |
|
198 |
Q |
A |
-1.7336 |
|
199 |
G |
A |
-0.3753 |
|
200 |
L |
A |
-0.1224 |
|
201 |
S |
A |
-0.4101 |
|
202 |
S |
A |
-0.4238 |
|
203 |
P |
A |
-0.5719 |
|
204 |
V |
A |
-0.0284 |
|
205 |
T |
A |
-0.3451 |
|
206 |
K |
A |
-0.5139 |
|
207 |
S |
A |
-0.4404 |
|
208 |
F |
A |
-0.9621 |
|
209 |
N |
A |
-1.8881 |
|
210 |
R |
A |
-2.5908 |
|
211 |
G |
A |
-2.3089 |
|
212 |
E |
A |
-2.4798 |
|
1 |
Q |
A |
-0.8450 |
|
2 |
V |
A |
0.3546 |
|
3 |
Q |
A |
-0.6705 |
|
4 |
L |
A |
0.0000 |
|
5 |
Q |
A |
-1.7630 |
|
6 |
Q |
A |
-1.0611 |
|
7 |
P |
A |
-0.8728 |
|
8 |
G |
A |
-1.0560 |
|
9 |
A |
A |
-0.8248 |
|
10 |
E |
A |
-1.0306 |
|
11 |
L |
A |
-0.3366 |
|
12 |
V |
A |
0.0000 |
|
13 |
K |
A |
-1.7886 |
|
14 |
P |
A |
-1.1597 |
|
15 |
G |
A |
-1.1075 |
|
16 |
A |
A |
-0.9656 |
|
17 |
S |
A |
-1.1381 |
|
18 |
V |
A |
0.0000 |
|
19 |
K |
A |
-1.7510 |
|
20 |
M |
A |
0.0000 |
|
21 |
S |
A |
-0.9296 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.5336 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.7430 |
|
26 |
G |
A |
-0.4120 |
|
27 |
Y |
A |
-0.0040 |
|
28 |
T |
A |
0.0054 |
|
29 |
F |
A |
0.0000 |
|
30 |
T |
A |
-0.5622 |
|
31 |
S |
A |
-0.2401 |
|
32 |
Y |
A |
0.3359 |
|
33 |
N |
A |
-0.2446 |
|
34 |
M |
A |
0.0000 |
|
35 |
H |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
K |
A |
-0.5051 |
|
39 |
Q |
A |
-0.6215 |
|
40 |
T |
A |
-1.1241 |
|
41 |
P |
A |
-0.9625 |
|
42 |
G |
A |
-1.5726 |
|
43 |
R |
A |
-2.3817 |
|
44 |
G |
A |
-1.4748 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-1.1391 |
|
47 |
W |
A |
0.0000 |
|
48 |
I |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
A |
A |
0.0000 |
|
51 |
I |
A |
0.0000 |
|
52 |
Y |
A |
-0.7907 |
|
53 |
P |
A |
0.0000 |
|
54 |
G |
A |
-1.3588 |
|
55 |
N |
A |
-2.0502 |
|
56 |
G |
A |
-1.9869 |
|
57 |
D |
A |
-2.3452 |
|
58 |
T |
A |
-1.1020 |
|
59 |
S |
A |
-0.8887 |
|
60 |
Y |
A |
-1.0873 |
|
61 |
N |
A |
0.0000 |
|
62 |
Q |
A |
-2.8302 |
|
63 |
K |
A |
-2.8981 |
|
64 |
F |
A |
0.0000 |
|
65 |
K |
A |
-2.8780 |
|
66 |
G |
A |
-1.9774 |
|
67 |
K |
A |
-1.6978 |
|
68 |
A |
A |
0.0000 |
|
69 |
T |
A |
-0.9358 |
|
70 |
L |
A |
0.0000 |
|
71 |
T |
A |
-0.6600 |
|
72 |
A |
A |
-1.2130 |
|
73 |
D |
A |
-1.6812 |
|
74 |
K |
A |
-1.8708 |
|
75 |
S |
A |
-1.1179 |
|
76 |
S |
A |
-1.0528 |
|
77 |
S |
A |
-1.1861 |
|
78 |
T |
A |
0.0000 |
|
79 |
A |
A |
0.0000 |
|
80 |
Y |
A |
-0.5863 |
|
81 |
M |
A |
0.0000 |
|
82 |
Q |
A |
-1.4587 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-0.9268 |
|
85 |
S |
A |
-0.9369 |
|
86 |
L |
A |
0.0000 |
|
87 |
T |
A |
-1.1725 |
|
88 |
S |
A |
-1.1051 |
|
89 |
E |
A |
-1.9356 |
|
90 |
D |
A |
0.0000 |
|
91 |
S |
A |
-0.5738 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
0.4237 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
0.0000 |
|
99 |
S |
A |
0.0000 |
|
100 |
T |
A |
0.0000 |
|
101 |
Y |
A |
1.7756 |
|
102 |
Y |
A |
1.6265 |
|
103 |
G |
A |
0.3490 |
|
104 |
G |
A |
0.0617 |
|
105 |
D |
A |
0.4685 |
|
106 |
W |
A |
0.9641 |
|
107 |
Y |
A |
0.7035 |
|
108 |
F |
A |
0.0000 |
|
109 |
N |
A |
-0.1262 |
|
110 |
V |
A |
0.0739 |
|
111 |
W |
A |
-0.1738 |
|
112 |
G |
A |
0.0000 |
|
113 |
A |
A |
-0.5913 |
|
114 |
G |
A |
-0.3334 |
|
115 |
T |
A |
0.0000 |
|
116 |
T |
A |
-0.2037 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.4653 |
|
119 |
V |
A |
-0.7376 |
|
120 |
S |
A |
-0.5284 |
|
121 |
A |
A |
-0.5809 |
|
122 |
A |
A |
-0.4351 |
|
123 |
S |
A |
-0.5870 |
|
124 |
T |
A |
-0.7098 |
|
125 |
K |
A |
-1.2530 |
|
126 |
G |
A |
-1.3069 |
|
127 |
P |
A |
-0.5826 |
|
128 |
S |
A |
-0.2788 |
|
129 |
V |
A |
0.0000 |
|
130 |
F |
A |
-0.6636 |
|
131 |
P |
A |
-1.1438 |
|
132 |
L |
A |
0.0000 |
|
133 |
A |
A |
-1.1401 |
|
134 |
P |
A |
0.0000 |
|
135 |
S |
A |
-1.1915 |
|
136 |
S |
A |
-1.1422 |
|
137 |
K |
A |
-1.2416 |
|
138 |
S |
A |
-0.7770 |
|
139 |
T |
A |
-0.7337 |
|
140 |
S |
A |
-0.7700 |
|
141 |
G |
A |
-0.8559 |
|
142 |
G |
A |
-0.7860 |
|
143 |
T |
A |
-0.5918 |
|
144 |
A |
A |
-0.4056 |
|
145 |
A |
A |
0.0000 |
|
146 |
L |
A |
0.0000 |
|
147 |
G |
A |
0.0000 |
|
148 |
C |
A |
0.0000 |
|
149 |
L |
A |
0.0000 |
|
150 |
V |
A |
0.0000 |
|
151 |
K |
A |
0.0000 |
|
152 |
D |
A |
-0.4975 |
|
153 |
Y |
A |
0.0000 |
|
154 |
F |
A |
-0.2272 |
|
155 |
P |
A |
0.0000 |
|
156 |
E |
A |
-0.5531 |
|
157 |
P |
A |
-0.7564 |
|
158 |
V |
A |
-0.3787 |
|
159 |
T |
A |
-0.5169 |
|
160 |
V |
A |
-0.1460 |
|
161 |
S |
A |
-0.3086 |
|
162 |
W |
A |
0.0000 |
|
163 |
N |
A |
-0.8314 |
|
164 |
S |
A |
-0.6160 |
|
165 |
G |
A |
-0.6023 |
|
166 |
A |
A |
-0.2646 |
|
167 |
L |
A |
-0.0057 |
|
168 |
T |
A |
-0.2006 |
|
169 |
S |
A |
-0.2155 |
|
170 |
G |
A |
-0.3032 |
|
171 |
V |
A |
0.0879 |
|
172 |
H |
A |
-0.1773 |
|
173 |
T |
A |
-0.0542 |
|
174 |
F |
A |
0.0000 |
|
175 |
P |
A |
-0.2992 |
|
176 |
A |
A |
0.4083 |
|
177 |
V |
A |
0.7008 |
|
178 |
L |
A |
1.4385 |
|
179 |
Q |
A |
0.1938 |
|
180 |
S |
A |
-0.0864 |
|
181 |
S |
A |
-0.2689 |
|
182 |
G |
A |
-0.0329 |
|
183 |
L |
A |
0.2338 |
|
184 |
Y |
A |
0.5217 |
|
185 |
S |
A |
0.3738 |
|
186 |
L |
A |
0.0000 |
|
187 |
S |
A |
0.0000 |
|
188 |
S |
A |
0.0000 |
|
189 |
V |
A |
0.0000 |
|
190 |
V |
A |
0.0000 |
|
191 |
T |
A |
-0.1402 |
|
192 |
V |
A |
0.0000 |
|
193 |
P |
A |
-0.5122 |
|
194 |
S |
A |
-0.5816 |
|
195 |
S |
A |
-0.6322 |
|
196 |
S |
A |
-0.6147 |
|
197 |
L |
A |
-0.7281 |
|
198 |
G |
A |
-0.7701 |
|
199 |
T |
A |
-0.8103 |
|
200 |
Q |
A |
-1.2275 |
|
201 |
T |
A |
-1.2198 |
|
202 |
Y |
A |
0.0000 |
|
203 |
I |
A |
-1.0098 |
|
204 |
C |
A |
0.0000 |
|
205 |
N |
A |
-1.2974 |
|
206 |
V |
A |
0.0000 |
|
207 |
N |
A |
-1.6998 |
|
208 |
H |
A |
0.0000 |
|
209 |
K |
A |
-2.7661 |
|
210 |
P |
A |
-1.5718 |
|
211 |
S |
A |
-1.7865 |
|
212 |
N |
A |
-2.5266 |
|
213 |
T |
A |
-2.0330 |
|
214 |
K |
A |
-2.5428 |
|
215 |
V |
A |
-1.2610 |
|
216 |
D |
A |
-1.9684 |
|
217 |
K |
A |
-1.9177 |
|
218 |
K |
A |
-2.4351 |
|
219 |
V |
A |
0.0000 |
|
220 |
E |
A |
-2.6624 |
|
221 |
P |
A |
-2.0275 |
|
222 |
K |
A |
-2.0899 |
|
223 |
S |
A |
-1.2745 |
|