| Chain sequence(s) |
A: AERRPTLPIPDLLLTTTDDARNRIQQLTIGAGQQSTFGGKTTATTWGYNGNLLGPAVKLQRGKAVTVDIYNQLTEEETTLHWHGLLEVPGEEVDGGPQGIIPPGGKRSSVTLNVDQPAATCWFHPHQHGKTGRQVAMGLAGLLVVIEDDDEILKLMMLPKQWGIDDVVPVIVQDKKFSSADGQIDYQLDVVMTAAVGWFGDTLLTNGAIYYPQHAAPRGWLRLRLLNGCNARSLNFATSDNNRPLYVIASDGGLLPEPVKVSSELPVLMGERFEVLVEVNNDNKPFDDLVTLPVSQMGMAIIAPFDKPHPVMMRRIQQQPIAISSASGALPDDTLSSSLPALPSLEGLTVRKKLQLSMDPMMLDMMMGMQMLMEKYGDQAMAGMDHSQMMGHMGHHGNMMNHMNHGGKFDFHHHANKKINGQAFDMNKPMFAAAKGQYERRWVISGVGDMMMLHPFHIHGTQFRILSENGKPPAAHRAGWKDTVKVEGNVSEEVLVVKKFNHDAPKEHAYMAHCHLLEHEDTGMMLGFTV |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
| Mutated residues | MA355A |
| Energy difference between WT (input) and mutated protein (by FoldX) | 1.84066 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 29 | A | A | -1.0218 | |
| 30 | E | A | -2.2305 | |
| 31 | R | A | -1.6307 | |
| 32 | P | A | -0.8752 | |
| 33 | T | A | -0.4904 | |
| 34 | L | A | 0.0000 | |
| 35 | P | A | -0.0788 | |
| 36 | I | A | 0.3866 | |
| 37 | P | A | -0.3945 | |
| 38 | D | A | -1.3813 | |
| 39 | L | A | -0.1370 | |
| 40 | L | A | -0.3034 | |
| 41 | T | A | -0.8089 | |
| 42 | T | A | -1.5349 | |
| 43 | D | A | -2.0850 | |
| 44 | A | A | -1.6129 | |
| 45 | R | A | -2.6592 | |
| 46 | N | A | -2.1524 | |
| 47 | R | A | -2.6475 | |
| 48 | I | A | 0.0000 | |
| 49 | Q | A | -1.7250 | |
| 50 | L | A | 0.0000 | |
| 51 | T | A | -0.9353 | |
| 52 | I | A | 0.0000 | |
| 53 | G | A | -0.9554 | |
| 54 | A | A | -0.8441 | |
| 55 | G | A | -1.1924 | |
| 56 | Q | A | -1.6864 | |
| 57 | S | A | -1.2641 | |
| 58 | T | A | -1.2025 | |
| 59 | F | A | 0.0000 | |
| 60 | G | A | -1.0270 | |
| 61 | G | A | -1.5014 | |
| 62 | K | A | -2.3482 | |
| 63 | T | A | -1.6766 | |
| 64 | A | A | 0.0000 | |
| 65 | T | A | -0.7571 | |
| 66 | T | A | 0.0000 | |
| 67 | W | A | 0.0000 | |
| 68 | G | A | 0.0000 | |
| 69 | Y | A | 0.0000 | |
| 70 | N | A | -1.5051 | |
| 71 | G | A | -1.4794 | |
| 72 | N | A | -1.7804 | |
| 73 | L | A | -0.8248 | |
| 74 | L | A | 0.0000 | |
| 75 | G | A | -0.6393 | |
| 76 | P | A | 0.0000 | |
| 77 | A | A | 0.0000 | |
| 78 | V | A | 0.0000 | |
| 79 | K | A | -0.7922 | |
| 80 | L | A | 0.0000 | |
| 81 | Q | A | -3.2071 | |
| 82 | R | A | -3.7395 | |
| 83 | G | A | -2.9971 | |
| 84 | K | A | -2.5922 | |
| 85 | A | A | -1.9328 | |
| 86 | V | A | 0.0000 | |
| 87 | T | A | -1.3007 | |
| 88 | V | A | 0.0000 | |
| 89 | D | A | -1.4737 | |
| 90 | I | A | 0.0000 | |
| 91 | Y | A | -1.2275 | |
| 92 | N | A | 0.0000 | |
| 93 | Q | A | -1.6655 | |
| 94 | L | A | 0.0000 | |
| 95 | T | A | -0.9119 | |
| 96 | E | A | -1.1930 | |
| 97 | E | A | -1.3803 | |
| 98 | T | A | 0.0000 | |
| 99 | T | A | 0.0000 | |
| 100 | L | A | 0.0000 | |
| 101 | H | A | 0.0000 | |
| 102 | W | A | 0.0000 | |
| 103 | H | A | 0.0000 | |
| 104 | G | A | 0.0000 | |
| 105 | L | A | 0.0000 | |
| 106 | E | A | -0.9348 | |
| 107 | V | A | 0.0000 | |
| 108 | P | A | -1.4519 | |
| 109 | G | A | 0.0000 | |
| 110 | E | A | -2.3870 | |
| 111 | V | A | -0.9073 | |
| 112 | D | A | 0.0000 | |
| 113 | G | A | 0.0000 | |
| 114 | G | A | 0.0000 | |
| 115 | P | A | 0.0000 | |
| 116 | Q | A | -0.9331 | |
| 117 | G | A | -0.5645 | |
| 118 | I | A | 0.2277 | |
| 119 | I | A | 0.0000 | |
| 120 | P | A | -1.0093 | |
| 121 | P | A | -1.2125 | |
| 122 | G | A | -1.3539 | |
| 123 | G | A | -1.3249 | |
| 124 | K | A | -1.8344 | |
| 125 | R | A | -1.8014 | |
| 126 | S | A | -1.2712 | |
| 127 | V | A | -0.7079 | |
| 128 | T | A | -0.6384 | |
| 129 | L | A | 0.0000 | |
| 130 | N | A | -2.4457 | |
| 131 | V | A | 0.0000 | |
| 132 | D | A | -3.2318 | |
| 133 | Q | A | 0.0000 | |
| 134 | P | A | -1.5956 | |
| 135 | A | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | T | A | 0.0000 | |
| 138 | C | A | 0.0000 | |
| 139 | W | A | 0.0000 | |
| 140 | F | A | 0.0000 | |
| 141 | H | A | 0.0000 | |
| 142 | P | A | 0.0000 | |
| 143 | H | A | 0.0000 | |
| 144 | Q | A | 0.0000 | |
| 145 | H | A | -0.7773 | |
| 146 | G | A | -1.1228 | |
| 147 | K | A | -1.4333 | |
| 148 | T | A | 0.0000 | |
| 149 | G | A | 0.0000 | |
| 150 | R | A | -1.0505 | |
| 151 | Q | A | 0.0000 | |
| 152 | V | A | 0.0000 | |
| 153 | A | A | 0.0000 | |
| 154 | M | A | -0.2165 | |
| 155 | G | A | 0.0000 | |
| 156 | L | A | 0.0000 | |
| 157 | A | A | 0.0000 | |
| 158 | G | A | 0.0000 | |
| 159 | L | A | 0.0000 | |
| 160 | V | A | 0.0000 | |
| 161 | V | A | 0.0000 | |
| 162 | I | A | 0.0000 | |
| 163 | E | A | -1.9554 | |
| 164 | D | A | -3.0945 | |
| 165 | D | A | -3.4628 | |
| 166 | E | A | -3.1087 | |
| 167 | I | A | 0.0000 | |
| 168 | L | A | -1.0670 | |
| 169 | K | A | -1.8492 | |
| 170 | L | A | -0.4307 | |
| 171 | M | A | 0.4974 | |
| 172 | L | A | 0.0000 | |
| 173 | P | A | 0.0000 | |
| 174 | K | A | -1.6483 | |
| 175 | Q | A | -1.2947 | |
| 176 | W | A | -0.4406 | |
| 177 | G | A | 0.1381 | |
| 178 | I | A | 0.6991 | |
| 179 | D | A | 0.0000 | |
| 180 | D | A | 0.0000 | |
| 181 | V | A | 0.0000 | |
| 182 | P | A | 0.0000 | |
| 183 | V | A | 0.0000 | |
| 184 | I | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | Q | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | K | A | 0.0000 | |
| 189 | K | A | -0.7727 | |
| 190 | F | A | -0.7561 | |
| 191 | S | A | -0.7529 | |
| 192 | A | A | -1.1055 | |
| 193 | D | A | -2.1778 | |
| 194 | G | A | 0.0000 | |
| 195 | Q | A | -1.3301 | |
| 196 | I | A | -0.4971 | |
| 197 | D | A | -0.7739 | |
| 198 | Y | A | -0.4169 | |
| 199 | Q | A | -0.5007 | |
| 200 | L | A | -0.4206 | |
| 201 | D | A | -0.4674 | |
| 202 | V | A | 0.0068 | |
| 203 | M | A | 0.0000 | |
| 204 | T | A | 0.0000 | |
| 205 | A | A | 0.0000 | |
| 206 | A | A | 0.0000 | |
| 207 | V | A | 0.0000 | |
| 208 | G | A | 0.0000 | |
| 209 | W | A | 0.0000 | |
| 210 | F | A | 0.0000 | |
| 211 | G | A | 0.0000 | |
| 212 | D | A | -1.7790 | |
| 213 | T | A | -0.7629 | |
| 214 | L | A | 0.0000 | |
| 215 | L | A | 0.0000 | |
| 216 | T | A | 0.0000 | |
| 217 | N | A | 0.0000 | |
| 218 | G | A | 0.0883 | |
| 219 | A | A | 0.2881 | |
| 220 | I | A | 0.8345 | |
| 221 | Y | A | 0.3392 | |
| 222 | P | A | 0.0000 | |
| 223 | Q | A | -0.8577 | |
| 224 | H | A | 0.0000 | |
| 225 | A | A | 0.0127 | |
| 226 | A | A | 0.0000 | |
| 227 | P | A | 0.0000 | |
| 228 | R | A | -1.6160 | |
| 229 | G | A | -1.0082 | |
| 230 | W | A | -0.5424 | |
| 231 | L | A | 0.0000 | |
| 232 | R | A | 0.0000 | |
| 233 | L | A | 0.0000 | |
| 234 | R | A | 0.0000 | |
| 235 | L | A | 0.0000 | |
| 236 | L | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | G | A | 0.0000 | |
| 239 | C | A | 0.0000 | |
| 240 | N | A | 0.0000 | |
| 241 | A | A | 0.0000 | |
| 242 | R | A | 0.0000 | |
| 243 | S | A | 0.0000 | |
| 244 | L | A | 0.0000 | |
| 245 | N | A | -0.4387 | |
| 246 | F | A | 0.0000 | |
| 247 | A | A | 0.0000 | |
| 248 | T | A | 0.0000 | |
| 249 | S | A | -1.0934 | |
| 250 | D | A | -1.6638 | |
| 251 | N | A | -1.9507 | |
| 252 | R | A | 0.0000 | |
| 253 | P | A | -1.1608 | |
| 254 | L | A | 0.0000 | |
| 255 | Y | A | -0.6005 | |
| 256 | V | A | 0.0000 | |
| 257 | I | A | 0.0000 | |
| 258 | A | A | 0.0000 | |
| 259 | S | A | 0.0000 | |
| 260 | D | A | 0.0000 | |
| 261 | G | A | 0.0000 | |
| 262 | G | A | 0.0000 | |
| 263 | L | A | -0.1324 | |
| 264 | L | A | 0.0000 | |
| 265 | P | A | -1.0156 | |
| 266 | E | A | -2.1698 | |
| 267 | P | A | -1.3851 | |
| 268 | V | A | -0.8874 | |
| 269 | K | A | -1.8061 | |
| 270 | V | A | -1.0844 | |
| 271 | S | A | -1.4090 | |
| 272 | E | A | -1.7900 | |
| 273 | L | A | 0.0000 | |
| 274 | P | A | -0.4419 | |
| 275 | V | A | 0.0000 | |
| 276 | L | A | 0.0000 | |
| 277 | M | A | 0.0000 | |
| 278 | G | A | 0.0000 | |
| 279 | E | A | 0.0000 | |
| 280 | R | A | 0.0000 | |
| 281 | F | A | 0.0000 | |
| 282 | E | A | 0.0000 | |
| 283 | V | A | 0.0000 | |
| 284 | L | A | 0.0000 | |
| 285 | V | A | 0.0000 | |
| 286 | E | A | -1.0463 | |
| 287 | V | A | 0.0000 | |
| 288 | N | A | -2.7441 | |
| 289 | D | A | -2.0646 | |
| 290 | N | A | -2.5748 | |
| 291 | K | A | -2.6593 | |
| 292 | P | A | -1.7528 | |
| 293 | F | A | 0.0000 | |
| 294 | D | A | -0.8228 | |
| 295 | L | A | 0.0000 | |
| 296 | V | A | 0.0000 | |
| 297 | T | A | 0.0000 | |
| 298 | L | A | -0.7400 | |
| 299 | P | A | -0.9921 | |
| 300 | V | A | -0.4281 | |
| 301 | S | A | -0.4930 | |
| 302 | Q | A | 0.0000 | |
| 303 | M | A | 0.0000 | |
| 304 | G | A | 0.0000 | |
| 305 | M | A | 0.0000 | |
| 306 | A | A | 0.0000 | |
| 307 | I | A | -0.9302 | |
| 308 | A | A | -1.1601 | |
| 309 | P | A | -1.3572 | |
| 310 | F | A | 0.0000 | |
| 311 | D | A | -2.3935 | |
| 312 | K | A | -2.4723 | |
| 313 | P | A | -1.3254 | |
| 314 | H | A | -0.9164 | |
| 315 | P | A | -0.3080 | |
| 316 | V | A | 0.0000 | |
| 317 | M | A | 0.0000 | |
| 318 | R | A | -0.8515 | |
| 319 | I | A | 0.0000 | |
| 320 | Q | A | -1.2517 | |
| 321 | P | A | -1.1586 | |
| 322 | I | A | 0.2462 | |
| 323 | A | A | 0.3723 | |
| 324 | I | A | 1.6484 | |
| 325 | S | A | 0.1098 | |
| 326 | A | A | -0.2647 | |
| 327 | S | A | -0.4524 | |
| 328 | G | A | -0.4062 | |
| 329 | A | A | 0.0523 | |
| 330 | L | A | -0.0769 | |
| 331 | P | A | -0.8562 | |
| 332 | D | A | -2.1886 | |
| 333 | T | A | -1.5715 | |
| 334 | L | A | 0.0000 | |
| 335 | S | A | -0.9130 | |
| 336 | S | A | -0.3572 | |
| 337 | L | A | 0.0568 | |
| 338 | P | A | 0.0517 | |
| 339 | A | A | 0.2898 | |
| 340 | L | A | 0.7031 | |
| 341 | P | A | 0.0763 | |
| 342 | S | A | -0.4284 | |
| 343 | L | A | -0.4452 | |
| 344 | E | A | -1.8724 | |
| 345 | G | A | -0.9970 | |
| 346 | L | A | -0.3368 | |
| 347 | T | A | 0.0696 | |
| 348 | V | A | 0.4637 | |
| 349 | R | A | -0.6373 | |
| 350 | K | A | -1.7951 | |
| 351 | L | A | 0.0000 | |
| 352 | Q | A | -1.1131 | |
| 353 | L | A | 0.0000 | |
| 354 | S | A | -0.7251 | |
| 355 | A | A | -0.6932 | mutated: MA355A |
| 356 | D | A | -0.5921 | |
| 357 | P | A | -0.3601 | |
| 358 | M | A | 0.5216 | |
| 359 | L | A | 0.0000 | |
| 360 | D | A | 0.0645 | |
| 361 | M | A | 0.6556 | |
| 362 | M | A | 0.3704 | |
| 363 | G | A | 0.0000 | |
| 364 | M | A | 0.0998 | |
| 365 | Q | A | 0.0000 | |
| 366 | M | A | -0.5229 | |
| 367 | L | A | 0.0000 | |
| 368 | M | A | -1.7521 | |
| 369 | E | A | -2.7807 | |
| 370 | K | A | -2.4608 | |
| 371 | Y | A | -1.2524 | |
| 372 | G | A | -1.8649 | |
| 373 | D | A | -2.3487 | |
| 374 | Q | A | -1.4906 | |
| 375 | A | A | 0.0000 | |
| 376 | M | A | 0.0000 | |
| 377 | A | A | -1.2690 | |
| 378 | G | A | -1.2142 | |
| 379 | M | A | -1.2326 | |
| 380 | D | A | -2.3454 | |
| 381 | H | A | -1.8044 | |
| 382 | S | A | -1.1389 | |
| 383 | Q | A | -0.9769 | |
| 384 | M | A | -1.0330 | |
| 385 | M | A | -0.2447 | |
| 386 | G | A | -1.1535 | |
| 387 | H | A | -0.8842 | |
| 388 | M | A | 0.0673 | |
| 389 | G | A | -0.9980 | |
| 390 | H | A | -1.8740 | |
| 391 | G | A | -1.5988 | |
| 392 | N | A | -2.0029 | |
| 393 | M | A | -0.9666 | |
| 394 | N | A | -1.6828 | |
| 395 | H | A | -1.4718 | |
| 396 | M | A | -0.5910 | |
| 397 | N | A | -1.5600 | |
| 398 | H | A | -1.7733 | |
| 399 | G | A | -1.4332 | |
| 400 | G | A | -1.6441 | |
| 401 | K | A | -1.6360 | |
| 402 | F | A | -0.1906 | |
| 403 | D | A | -1.1740 | |
| 404 | F | A | -0.5967 | |
| 405 | H | A | -1.0354 | |
| 406 | H | A | -1.8611 | |
| 407 | A | A | -1.0836 | |
| 408 | N | A | 0.0000 | |
| 409 | K | A | -1.5055 | |
| 410 | I | A | 0.0000 | |
| 411 | N | A | -1.5960 | |
| 412 | G | A | -1.4705 | |
| 413 | Q | A | -1.8737 | |
| 414 | A | A | -1.5417 | |
| 415 | F | A | 0.0000 | |
| 416 | D | A | -2.3343 | |
| 417 | M | A | -1.9896 | |
| 418 | N | A | -2.9046 | |
| 419 | K | A | -2.9855 | |
| 420 | P | A | -1.7187 | |
| 421 | M | A | -0.5640 | |
| 422 | F | A | 0.0758 | |
| 423 | A | A | -0.0276 | |
| 424 | A | A | 0.0000 | |
| 425 | A | A | -1.3698 | |
| 426 | K | A | -2.7230 | |
| 427 | G | A | -2.1940 | |
| 428 | Q | A | -1.9503 | |
| 429 | Y | A | -0.6951 | |
| 430 | E | A | 0.0000 | |
| 431 | R | A | -0.3277 | |
| 432 | W | A | 0.0000 | |
| 433 | V | A | -0.3707 | |
| 434 | I | A | 0.0000 | |
| 435 | S | A | -0.3567 | |
| 436 | G | A | 0.0000 | |
| 437 | V | A | 0.9948 | |
| 438 | G | A | -0.0875 | |
| 439 | D | A | -0.2320 | |
| 440 | M | A | -0.1681 | |
| 441 | M | A | 0.0000 | |
| 442 | L | A | 0.0000 | |
| 443 | H | A | 0.0000 | |
| 444 | P | A | 0.0000 | |
| 445 | F | A | 0.0000 | |
| 446 | H | A | 0.0000 | |
| 447 | I | A | 0.0000 | |
| 448 | H | A | 0.0000 | |
| 449 | G | A | 0.0000 | |
| 450 | T | A | 0.0000 | |
| 451 | Q | A | 0.0000 | |
| 452 | F | A | 0.0000 | |
| 453 | R | A | 0.0000 | |
| 454 | I | A | 0.0000 | |
| 455 | L | A | -0.1957 | |
| 456 | S | A | -0.8732 | |
| 457 | E | A | 0.0000 | |
| 458 | N | A | -1.2756 | |
| 459 | G | A | -1.7019 | |
| 460 | K | A | -2.1530 | |
| 461 | P | A | -1.2115 | |
| 462 | P | A | -0.7137 | |
| 463 | A | A | -0.2799 | |
| 464 | A | A | -0.3213 | |
| 465 | H | A | -0.3535 | |
| 466 | R | A | 0.0000 | |
| 467 | A | A | 0.0628 | |
| 468 | G | A | 0.0000 | |
| 469 | W | A | 0.2418 | |
| 470 | K | A | 0.0000 | |
| 471 | D | A | 0.0000 | |
| 472 | T | A | 0.0000 | |
| 473 | V | A | 0.0000 | |
| 474 | K | A | -0.9852 | |
| 475 | V | A | 0.0000 | |
| 476 | E | A | -0.8481 | |
| 477 | G | A | -0.4094 | |
| 478 | N | A | -0.7642 | |
| 479 | V | A | -0.2344 | |
| 480 | S | A | 0.0000 | |
| 481 | E | A | -0.5654 | |
| 482 | V | A | 0.0000 | |
| 483 | L | A | 0.0000 | |
| 484 | V | A | 0.0000 | |
| 485 | K | A | -1.6141 | |
| 486 | F | A | 0.0000 | |
| 487 | N | A | -2.4896 | |
| 488 | H | A | -2.0286 | |
| 489 | D | A | -2.2482 | |
| 490 | A | A | 0.0000 | |
| 491 | P | A | -1.9626 | |
| 492 | K | A | -2.9536 | |
| 493 | E | A | -3.2912 | |
| 494 | H | A | -2.2917 | |
| 495 | A | A | 0.0000 | |
| 496 | Y | A | 0.0000 | |
| 497 | M | A | 0.0000 | |
| 498 | A | A | 0.0000 | |
| 499 | H | A | 0.0000 | |
| 500 | C | A | 0.0000 | |
| 501 | H | A | 0.0000 | |
| 502 | L | A | 0.0000 | |
| 503 | L | A | 0.0000 | |
| 504 | E | A | 0.0000 | |
| 505 | H | A | 0.0000 | |
| 506 | E | A | 0.0000 | |
| 507 | D | A | -0.8698 | |
| 508 | T | A | 0.0000 | |
| 509 | G | A | 0.0000 | |
| 510 | M | A | 0.0000 | |
| 511 | M | A | 0.0000 | |
| 512 | L | A | 0.0000 | |
| 513 | G | A | 0.0000 | |
| 514 | F | A | 0.0000 | |
| 515 | T | A | -0.8615 | |
| 516 | V | A | -0.9904 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine