Project name: 2IV1 [mutate: KA24Y, KA25Y, DA26Y, KB24Y, KB25Y, DB26Y, KC24Y, KC25Y, DC26Y, KD24Y, KD25Y, DD26Y, KE24Y, KE25Y, DE26Y, KF24Y, KF25Y, DF26Y, KG24Y, KG25Y, DG26Y, KH24Y, KH25Y, DH26Y, KI24Y, KI25Y, DI26Y, KJ24Y, KJ25Y, DJ26Y]

Status: done

submitted: 2017-09-12 23:53:08, status changed: 2017-09-13 00:37:43
Settings
Chain sequence(s) A: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
C: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
B: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
E: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
D: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
G: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
F: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
I: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
H: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
J: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues KA24Y, KA25Y, DA26Y, KB24Y, KB25Y, DB26Y, KC24Y, KC25Y, DC26Y, KD24Y, KD25Y, DD26Y, KE24Y, KE25Y, DE26Y, KF24Y, KF25Y, DF26Y, KG24Y, KG25Y, DG26Y, KH24Y, KH25Y, DH26Y, KI24Y, KI25Y, DI26Y, KJ24Y, KJ25Y, DJ26Y
Energy difference between WD and mutated (by FoldX) 10.5098 kcal/mol
Show buried residues

Minimal score value
-3.7846
Maximal score value
2.7067
Average score
-0.5467
Total score value
-852.9041

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 1.8080
2 I A 1.0857
3 Q A 0.0000
4 S A 0.0000
5 Q A 0.0000
6 I A -0.2329
7 N A -1.0466
8 R A -1.1825
9 N A -1.6475
10 I A -0.7101
11 R A 0.0000
12 L A -1.0990
13 D A -2.0182
14 L A 0.0000
15 A A 0.0000
16 D A -0.7556
17 A A -0.3520
18 I A 0.0000
19 L A 0.0000
20 L A 0.5840
21 S A 0.6426
22 K A 0.0000
23 A A 0.0000
24 Y A 1.7929 mutated: KA24Y
25 Y A 2.0747 mutated: KA25Y
26 Y A 2.6741 mutated: DA26Y
27 L A 1.2737
28 S A 0.0000
29 F A 0.0000
30 A A -1.6497
31 E A -2.4224
32 I A 0.0000
33 A A 0.0000
34 D A -2.7842
35 G A -1.6055
36 T A -1.6258
37 G A -0.9621
38 L A -0.5695
39 A A -1.0968
40 E A -1.9239
41 A A 0.0000
42 F A 0.0000
43 V A 0.0000
44 T A 0.0000
45 A A 0.0000
46 A A 0.0000
47 L A 0.0000
48 L A 0.0000
49 G A 0.0000
50 Q A 0.0000
51 Q A 0.0000
52 A A -0.3641
53 L A 0.0000
54 P A -0.9278
55 A A -1.2612
56 D A -2.2415
57 A A 0.0000
58 A A 0.0000
59 R A -2.3768
60 L A -1.2606
61 V A 0.0000
62 G A 0.0000
63 A A -1.2108
64 K A -1.0802
65 L A 0.0000
66 D A -2.4212
67 L A -2.4543
68 D A -3.4433
69 E A -3.6199
70 D A -2.7577
71 S A -2.1524
72 I A -1.9928
73 L A -1.0353
74 L A -0.2915
75 L A 0.0000
76 Q A -0.4821
77 M A 0.0000
78 I A 0.0000
79 P A 0.0000
80 L A -0.0512
81 R A 0.0000
82 G A 0.0000
83 C A 0.0000
84 I A 0.0000
85 D A -2.8229
86 D A -3.2898
87 R A -1.9416
88 I A 0.0000
89 P A 0.0000
90 T A -0.8282
91 D A 0.0000
92 P A 0.0000
93 T A 0.0000
94 M A 0.0000
95 Y A 0.0000
96 Q A 0.0000
97 F A 0.0000
98 Y A 0.0000
99 E A 0.0000
100 M A 0.0000
101 L A 0.0000
102 Q A 0.0000
103 V A 0.0000
104 Y A 0.0000
105 G A 0.0000
106 T A 0.0000
107 T A 0.0000
108 L A 0.0000
109 K A 0.0000
110 A A 0.0000
111 L A 0.0000
112 V A 0.0000
113 H A 0.0000
114 E A -0.1551
115 K A -1.0954
116 F A -0.6833
117 G A -0.2623
118 D A -0.5417
119 G A 0.0000
120 I A 0.0000
121 I A 0.0000
122 S A 0.0000
123 A A 0.0000
124 I A -0.6921
125 N A -1.3585
126 F A 0.0000
127 K A -1.9338
128 L A 0.0000
129 D A -2.5679
130 V A 0.0000
131 K A -2.7193
132 K A -2.3077
133 V A -0.9326
134 A A -0.8917
135 D A 0.0000
136 P A -1.3693
137 E A -2.2886
138 G A -1.6939
139 G A -1.3640
140 E A -1.5079
141 R A 0.0000
142 A A 0.0000
143 V A -1.1246
144 I A 0.0000
145 T A -1.1644
146 L A 0.0000
147 D A -1.2530
148 G A 0.0000
149 K A -1.0518
150 Y A -0.6226
151 L A -0.5506
152 P A -0.8941
153 T A -1.0336
154 K A -1.9235
155 P A -0.8358
156 F A -0.3216
1 M B 1.8003
2 I B 1.0553
3 Q B 0.0000
4 S B 0.0000
5 Q B 0.0000
6 I B -0.3004
7 N B -1.1421
8 R B -1.2729
9 N B -1.7707
10 I B -0.9463
11 R B 0.0000
12 L B -1.1369
13 D B -2.0310
14 L B 0.0000
15 A B 0.0000
16 D B 0.0000
17 A B -0.2625
18 I B 0.0000
19 L B 0.0000
20 L B 0.6332
21 S B 0.6604
22 K B 0.0000
23 A B 0.0000
24 Y B 1.7963 mutated: KB24Y
25 Y B 2.0647 mutated: KB25Y
26 Y B 2.7067 mutated: DB26Y
27 L B 1.3891
28 S B 0.0000
29 F B 0.0000
30 A B -1.3789
31 E B -2.0201
32 I B 0.0000
33 A B 0.0000
34 D B -2.6224
35 G B -1.5443
36 T B -1.6118
37 G B -0.9162
38 L B -0.4967
39 A B -1.0067
40 E B -1.7495
41 A B 0.0000
42 F B 0.0000
43 V B 0.0000
44 T B 0.0000
45 A B 0.0000
46 A B 0.0000
47 L B 0.0000
48 L B 0.0000
49 G B 0.0000
50 Q B 0.0000
51 Q B 0.0000
52 A B -0.3750
53 L B 0.0000
54 P B -1.1248
55 A B -1.3314
56 D B -2.3291
57 A B 0.0000
58 A B 0.0000
59 R B -2.6205
60 L B -1.4007
61 V B 0.0000
62 G B 0.0000
63 A B -1.2951
64 K B -1.0425
65 L B 0.0000
66 D B -2.4421
67 L B -2.4721
68 D B -3.4549
69 E B -3.6698
70 D B -2.7847
71 S B -2.1686
72 I B -2.0839
73 L B -1.0795
74 L B -0.3268
75 L B 0.0000
76 Q B -0.5323
77 M B 0.0000
78 I B 0.0000
79 P B 0.0000
80 L B -0.0765
81 R B 0.0000
82 G B 0.0000
83 C B 0.0000
84 I B 0.0000
85 D B -2.3041
86 D B -3.1167
87 R B -1.9948
88 I B 0.0000
89 P B 0.0000
90 T B 0.0000
91 D B 0.0000
92 P B 0.0000
93 T B 0.0000
94 M B 0.0000
95 Y B 0.0000
96 Q B 0.0000
97 F B 0.0000
98 Y B 0.0000
99 E B 0.0000
100 M B 0.0000
101 L B 0.0000
102 Q B 0.0000
103 V B 0.0000
104 Y B 0.0000
105 G B 0.0000
106 T B 0.0000
107 T B 0.0000
108 L B 0.0000
109 K B 0.0000
110 A B 0.0000
111 L B 0.0000
112 V B 0.0000
113 H B 0.0000
114 E B -0.2690
115 K B -1.2873
116 F B -0.8435
117 G B -0.3376
118 D B -0.5784
119 G B 0.0000
120 I B 0.0000
121 I B 0.0000
122 S B 0.0000
123 A B 0.0000
124 I B -0.6519
125 N B -1.2776
126 F B 0.0000
127 K B -1.7929
128 L B 0.0000
129 D B -2.5546
130 V B 0.0000
131 K B -2.6174
132 K B -2.1137
133 V B -0.8608
134 A B -0.9228
135 D B 0.0000
136 P B -1.3913
137 E B -2.3157
138 G B -1.7857
139 G B -1.4408
140 E B -1.5717
141 R B -1.3344
142 A B 0.0000
143 V B -1.1279
144 I B 0.0000
145 T B -0.9203
146 L B 0.0000
147 D B 0.0000
148 G B 0.0000
149 K B -1.0098
150 Y B 0.0000
151 L B -0.5999
152 P B -0.9202
153 T B -1.0474
154 K B -1.9119
155 P B -0.8026
156 F B -0.2443
1 M C 1.8357
2 I C 1.1881
3 Q C 0.0000
4 S C 0.0000
5 Q C 0.0000
6 I C 0.0000
7 N C -1.2304
8 R C -1.3060
9 N C -1.7860
10 I C -0.9667
11 R C 0.0000
12 L C -1.1280
13 D C -2.0201
14 L C 0.0000
15 A C 0.0000
16 D C 0.0000
17 A C -0.2589
18 I C 0.0000
19 L C 0.0000
20 L C 0.6296
21 S C 0.6597
22 K C 0.0000
23 A C 0.0000
24 Y C 1.7855 mutated: KC24Y
25 Y C 2.0846 mutated: KC25Y
26 Y C 2.6820 mutated: DC26Y
27 L C 1.3721
28 S C 0.0000
29 F C 0.0000
30 A C -1.3855
31 E C -1.9888
32 I C 0.0000
33 A C 0.0000
34 D C -2.6254
35 G C -1.5481
36 T C -1.6557
37 G C -0.9481
38 L C -0.5000
39 A C -1.0240
40 E C -1.8312
41 A C 0.0000
42 F C 0.0000
43 V C 0.0000
44 T C 0.0000
45 A C 0.0000
46 A C 0.0000
47 L C 0.0000
48 L C 0.0000
49 G C 0.0000
50 Q C 0.0000
51 Q C 0.0000
52 A C -0.3740
53 L C 0.0000
54 P C -1.0926
55 A C -1.3376
56 D C -2.3288
57 A C 0.0000
58 A C 0.0000
59 R C -2.8598
60 L C -1.4729
61 V C 0.0000
62 G C 0.0000
63 A C -1.3337
64 K C -1.0658
65 L C 0.0000
66 D C -2.4938
67 L C -2.5544
68 D C -3.6960
69 E C -3.7490
70 D C -2.8313
71 S C -2.2645
72 I C 0.0000
73 L C -1.1603
74 L C -0.3820
75 L C 0.0000
76 Q C -0.5462
77 M C 0.0000
78 I C 0.0000
79 P C 0.0000
80 L C -0.1423
81 R C 0.0000
82 G C 0.0000
83 C C 0.0000
84 I C 0.0000
85 D C -1.6064
86 D C -2.2268
87 R C -1.3017
88 I C 0.0000
89 P C 0.0000
90 T C -0.5815
91 D C 0.0000
92 P C 0.0000
93 T C 0.0000
94 M C 0.0000
95 Y C 0.0000
96 Q C 0.0000
97 F C 0.0000
98 Y C 0.0000
99 E C 0.0000
100 M C 0.0000
101 L C 0.0000
102 Q C 0.0000
103 V C 0.0000
104 Y C 0.0000
105 G C 0.0000
106 T C 0.0000
107 T C 0.0000
108 L C 0.0000
109 K C 0.0000
110 A C 0.0000
111 L C 0.0000
112 V C 0.0000
113 H C 0.0000
114 E C -0.1591
115 K C -1.0714
116 F C -0.7234
117 G C -0.2945
118 D C -0.5887
119 G C 0.0000
120 I C 0.0000
121 I C 0.0000
122 S C 0.0000
123 A C 0.0000
124 I C -0.6623
125 N C -1.2198
126 F C 0.0000
127 K C -1.7621
128 L C 0.0000
129 D C -2.5932
130 V C 0.0000
131 K C -2.6038
132 K C -2.0311
133 V C -0.8326
134 A C -0.8600
135 D C 0.0000
136 P C -1.3855
137 E C -2.2849
138 G C -1.7100
139 G C -1.3687
140 E C -1.4628
141 R C -1.1809
142 A C 0.0000
143 V C -1.0970
144 I C 0.0000
145 T C -1.0822
146 L C 0.0000
147 D C 0.0000
148 G C 0.0000
149 K C -0.9967
150 Y C 0.0000
151 L C -0.5720
152 P C -0.9058
153 T C -1.0353
154 K C -1.7955
155 P C -0.9028
156 F C -0.4014
1 M D 1.7690
2 I D 1.0936
3 Q D 0.0000
4 S D 0.0000
5 Q D 0.0000
6 I D 0.0000
7 N D -1.2404
8 R D -1.3167
9 N D -1.8413
10 I D -1.1996
11 R D 0.0000
12 L D -1.2095
13 D D -2.0971
14 L D 0.0000
15 A D 0.0000
16 D D -0.6479
17 A D -0.3405
18 I D 0.0000
19 L D 0.0000
20 L D 0.5789
21 S D 0.5372
22 K D 0.0000
23 A D 0.0000
24 Y D 1.6285 mutated: KD24Y
25 Y D 1.6345 mutated: KD25Y
26 Y D 2.4382 mutated: DD26Y
27 L D 1.0936
28 S D 0.0647
29 F D 0.0000
30 A D -1.4671
31 E D -2.1108
32 I D 0.0000
33 A D 0.0000
34 D D -2.6516
35 G D -1.5631
36 T D -1.6185
37 G D -1.1051
38 L D -0.4912
39 A D -1.0539
40 E D -1.7803
41 A D 0.0000
42 F D 0.0000
43 V D 0.0000
44 T D 0.0000
45 A D 0.0000
46 A D 0.0000
47 L D 0.0000
48 L D 0.0000
49 G D 0.0000
50 Q D 0.0000
51 Q D 0.0000
52 A D -0.3979
53 L D 0.0000
54 P D -1.1231
55 A D -1.3465
56 D D -2.3939
57 A D 0.0000
58 A D 0.0000
59 R D -2.9169
60 L D -1.4881
61 V D 0.0000
62 G D 0.0000
63 A D -1.3738
64 K D -1.2528
65 L D 0.0000
66 D D -2.5814
67 L D -2.5472
68 D D -3.7222
69 E D -3.7846
70 D D -2.8429
71 S D -2.3821
72 I D 0.0000
73 L D -1.2307
74 L D 0.0000
75 L D 0.0000
76 Q D -0.6364
77 M D 0.0000
78 I D 0.0000
79 P D 0.0000
80 L D 0.0000
81 R D 0.0000
82 G D 0.0000
83 C D 0.0000
84 I D 0.0000
85 D D -1.8657
86 D D -2.8069
87 R D -1.5705
88 I D 0.0000
89 P D 0.0000
90 T D 0.0000
91 D D 0.0000
92 P D 0.0000
93 T D 0.0000
94 M D 0.0000
95 Y D 0.0000
96 Q D 0.0000
97 F D 0.0000
98 Y D 0.0000
99 E D 0.0000
100 M D 0.0000
101 L D 0.0000
102 Q D 0.0000
103 V D 0.0000
104 Y D 0.0000
105 G D 0.0000
106 T D 0.0000
107 T D 0.0000
108 L D 0.0000
109 K D 0.0000
110 A D 0.0000
111 L D 0.0000
112 V D 0.0000
113 H D 0.0000
114 E D -0.2491
115 K D -1.2675
116 F D -0.7911
117 G D -0.4387
118 D D -0.5836
119 G D 0.0000
120 I D 0.0000
121 I D 0.0000
122 S D 0.0000
123 A D 0.0000
124 I D -0.6250
125 N D -1.1874
126 F D 0.0000
127 K D -1.7049
128 L D 0.0000
129 D D -2.5652
130 V D 0.0000
131 K D -2.6709
132 K D -2.2907
133 V D -0.9962
134 A D -0.9903
135 D D 0.0000
136 P D -1.3982
137 E D -2.3035
138 G D -1.7340
139 G D -1.4195
140 E D -1.6670
141 R D -1.3636
142 A D 0.0000
143 V D -1.2801
144 I D 0.0000
145 T D -1.1209
146 L D 0.0000
147 D D 0.0000
148 G D 0.0000
149 K D -0.8912
150 Y D 0.0000
151 L D -0.5765
152 P D -0.8799
153 T D -1.0574
154 K D -1.9252
155 P D -0.8222
156 F D -0.2642
1 M E 1.9201
2 I E 1.3225
3 Q E 0.0000
4 S E 0.0000
5 Q E 0.0000
6 I E -0.2692
7 N E -1.0927
8 R E -1.2169
9 N E -1.6856
10 I E -0.7372
11 R E 0.0000
12 L E -1.0716
13 D E -1.9362
14 L E 0.0000
15 A E 0.0000
16 D E 0.0000
17 A E -0.2420
18 I E 0.0000
19 L E 0.0000
20 L E 0.7104
21 S E 0.6043
22 K E 0.0000
23 A E 0.0000
24 Y E 1.7416 mutated: KE24Y
25 Y E 1.8905 mutated: KE25Y
26 Y E 2.5998 mutated: DE26Y
27 L E 1.2334
28 S E 0.0000
29 F E 0.0000
30 A E -1.5359
31 E E -2.1508
32 I E 0.0000
33 A E 0.0000
34 D E -2.6756
35 G E -1.5576
36 T E -1.6319
37 G E -0.9662
38 L E -0.5495
39 A E -1.1119
40 E E -1.8518
41 A E 0.0000
42 F E 0.0000
43 V E 0.0000
44 T E 0.0000
45 A E 0.0000
46 A E 0.0000
47 L E 0.0000
48 L E 0.0000
49 G E 0.0000
50 Q E 0.0000
51 Q E 0.0000
52 A E -0.3412
53 L E 0.0000
54 P E -1.0871
55 A E -1.2638
56 D E -2.2616
57 A E 0.0000
58 A E 0.0000
59 R E -2.6646
60 L E -1.3197
61 V E 0.0000
62 G E 0.0000
63 A E -1.2520
64 K E -1.1023
65 L E 0.0000
66 D E -2.4678
67 L E -2.4336
68 D E -3.6274
69 E E -3.6389
70 D E -2.7611
71 S E -2.1807
72 I E -2.0098
73 L E -0.9925
74 L E -0.2445
75 L E 0.0000
76 Q E -0.3655
77 M E 0.0000
78 I E 0.0000
79 P E 0.0000
80 L E 0.0000
81 R E 0.0000
82 G E 0.0000
83 C E 0.0000
84 I E 0.0000
85 D E -2.6894
86 D E -3.0023
87 R E -1.6388
88 I E -0.8457
89 P E 0.0000
90 T E -0.6269
91 D E 0.0000
92 P E 0.0000
93 T E 0.0000
94 M E 0.0000
95 Y E 0.0000
96 Q E 0.0000
97 F E 0.0000
98 Y E 0.0000
99 E E 0.0000
100 M E 0.0000
101 L E 0.0000
102 Q E 0.0000
103 V E 0.0000
104 Y E 0.0000
105 G E 0.0000
106 T E 0.0000
107 T E 0.0000
108 L E 0.0000
109 K E 0.0000
110 A E 0.0000
111 L E 0.0000
112 V E 0.0000
113 H E 0.0000
114 E E -0.2602
115 K E -1.2778
116 F E -0.8243
117 G E -0.4673
118 D E -0.6129
119 G E 0.0000
120 I E 0.0000
121 I E 0.0000
122 S E 0.0000
123 A E -0.4079
124 I E -0.6722
125 N E -1.3078
126 F E 0.0000
127 K E -2.1925
128 L E 0.0000
129 D E -2.6660
130 V E 0.0000
131 K E -2.4734
132 K E -1.8127
133 V E -0.6708
134 A E -0.8157
135 D E 0.0000
136 P E -1.3815
137 E E -2.3005
138 G E -1.7403
139 G E -1.3765
140 E E -1.4028
141 R E -1.0890
142 A E 0.0000
143 V E -1.0622
144 I E 0.0000
145 T E -1.0814
146 L E 0.0000
147 D E -1.4980
148 G E 0.0000
149 K E -1.1101
150 Y E 0.0000
151 L E -0.5908
152 P E -0.9205
153 T E -1.0133
154 K E -1.8685
155 P E -0.7887
156 F E -0.1517
1 M F 1.8074
2 I F 1.1890
3 Q F 0.0000
4 S F 0.0000
5 Q F 0.0000
6 I F 0.0000
7 N F -1.1696
8 R F -1.2692
9 N F -1.7156
10 I F -0.8110
11 R F 0.0000
12 L F -1.1693
13 D F -2.0272
14 L F 0.0000
15 A F 0.0000
16 D F -0.8115
17 A F -0.3045
18 I F 0.0000
19 L F 0.0000
20 L F 0.6926
21 S F 0.4307
22 K F 0.0000
23 A F 0.0000
24 Y F 1.6629 mutated: KF24Y
25 Y F 1.7547 mutated: KF25Y
26 Y F 2.5350 mutated: DF26Y
27 L F 1.2231
28 S F 0.0000
29 F F 0.0000
30 A F -1.5494
31 E F -2.1409
32 I F 0.0000
33 A F 0.0000
34 D F -2.7034
35 G F -1.5669
36 T F -1.6130
37 G F -0.9306
38 L F -0.5196
39 A F -1.0943
40 E F -1.9199
41 A F 0.0000
42 F F 0.0000
43 V F 0.0000
44 T F 0.0000
45 A F 0.0000
46 A F 0.0000
47 L F 0.0000
48 L F 0.0000
49 G F 0.0000
50 Q F 0.0000
51 Q F 0.0000
52 A F -0.3382
53 L F 0.0000
54 P F -1.0964
55 A F -1.3598
56 D F -2.3331
57 A F 0.0000
58 A F 0.0000
59 R F -2.9051
60 L F -1.4282
61 V F 0.0000
62 G F 0.0000
63 A F -1.3622
64 K F -1.1923
65 L F 0.0000
66 D F -2.5238
67 L F -2.4358
68 D F -3.5602
69 E F -3.5413
70 D F -2.3588
71 S F -2.0513
72 I F 0.0000
73 L F 0.0000
74 L F -0.2809
75 L F 0.0000
76 Q F -0.5164
77 M F 0.0000
78 I F 0.0000
79 P F 0.0000
80 L F -0.1224
81 R F 0.0000
82 G F 0.0000
83 C F 0.0000
84 I F 0.0000
85 D F -2.1646
86 D F -3.0306
87 R F -2.0201
88 I F 0.0000
89 P F 0.0000
90 T F 0.0000
91 D F 0.0000
92 P F 0.0000
93 T F 0.0000
94 M F 0.0000
95 Y F 0.0000
96 Q F 0.0000
97 F F 0.0000
98 Y F 0.0000
99 E F 0.0000
100 M F 0.0000
101 L F 0.0000
102 Q F 0.0000
103 V F 0.0000
104 Y F 0.0000
105 G F 0.0000
106 T F 0.0000
107 T F 0.0000
108 L F 0.0000
109 K F 0.0000
110 A F 0.0000
111 L F 0.0000
112 V F 0.0000
113 H F 0.0000
114 E F -0.2151
115 K F -1.2418
116 F F -0.7838
117 G F -0.4510
118 D F -0.6058
119 G F 0.0000
120 I F 0.0000
121 I F 0.0000
122 S F 0.0000
123 A F 0.0000
124 I F -0.5944
125 N F -1.1666
126 F F 0.0000
127 K F -1.8684
128 L F 0.0000
129 D F -2.6253
130 V F 0.0000
131 K F -2.7431
132 K F -2.3422
133 V F -1.0010
134 A F -0.9374
135 D F 0.0000
136 P F -1.3830
137 E F -2.2744
138 G F -1.6813
139 G F -1.3626
140 E F -1.5992
141 R F -1.3382
142 A F 0.0000
143 V F -1.1756
144 I F 0.0000
145 T F -0.9590
146 L F 0.0000
147 D F -1.1997
148 G F 0.0000
149 K F -1.1973
150 Y F 0.0000
151 L F 0.0000
152 P F -1.0247
153 T F -1.0954
154 K F -1.9942
155 P F -0.9149
156 F F -0.4788
1 M G 1.8286
2 I G 1.1083
3 Q G 0.0000
4 S G 0.0000
5 Q G 0.0000
6 I G -0.2230
7 N G -1.0214
8 R G -1.1790
9 N G -1.7030
10 I G -0.7908
11 R G 0.0000
12 L G -1.1482
13 D G -2.0140
14 L G 0.0000
15 A G 0.0000
16 D G -0.7565
17 A G -0.3459
18 I G 0.0000
19 L G 0.0000
20 L G 0.6104
21 S G 0.5675
22 K G 0.0000
23 A G 0.0000
24 Y G 1.7155 mutated: KG24Y
25 Y G 1.9141 mutated: KG25Y
26 Y G 2.5892 mutated: DG26Y
27 L G 1.2940
28 S G 0.1333
29 F G 0.0000
30 A G -1.5053
31 E G -2.1019
32 I G 0.0000
33 A G 0.0000
34 D G -2.6724
35 G G -1.5573
36 T G -1.5934
37 G G -0.9598
38 L G -0.5386
39 A G -1.0779
40 E G -1.8748
41 A G 0.0000
42 F G 0.0000
43 V G 0.0000
44 T G 0.0000
45 A G 0.0000
46 A G 0.0000
47 L G 0.0000
48 L G 0.0000
49 G G 0.0000
50 Q G 0.0000
51 Q G 0.0000
52 A G -0.3552
53 L G 0.0000
54 P G -0.8899
55 A G -1.1849
56 D G -2.1670
57 A G 0.0000
58 A G 0.0000
59 R G -2.1935
60 L G -1.1655
61 V G 0.0000
62 G G 0.0000
63 A G -1.1844
64 K G -1.0409
65 L G 0.0000
66 D G -2.4084
67 L G -2.4193
68 D G -3.4346
69 E G -3.5906
70 D G -2.7466
71 S G -2.1479
72 I G -1.9283
73 L G -0.9633
74 L G -0.2590
75 L G 0.0000
76 Q G -0.3962
77 M G 0.0000
78 I G 0.0000
79 P G 0.0000
80 L G 0.0000
81 R G 0.0000
82 G G 0.0000
83 C G 0.0000
84 I G 0.0000
85 D G -2.8236
86 D G -3.2679
87 R G -1.7878
88 I G 0.0000
89 P G 0.0000
90 T G -0.8319
91 D G 0.0000
92 P G 0.0000
93 T G 0.0000
94 M G 0.0000
95 Y G 0.0000
96 Q G 0.0000
97 F G 0.0000
98 Y G 0.0000
99 E G 0.0000
100 M G 0.0000
101 L G 0.0000
102 Q G 0.0000
103 V G 0.0000
104 Y G 0.0000
105 G G 0.0000
106 T G 0.0000
107 T G 0.0000
108 L G 0.0000
109 K G 0.0000
110 A G 0.0000
111 L G 0.0000
112 V G 0.0000
113 H G 0.0000
114 E G -0.2158
115 K G -1.1998
116 F G -0.5094
117 G G -0.3626
118 D G -0.5066
119 G G 0.0000
120 I G 0.0000
121 I G 0.0000
122 S G 0.0000
123 A G 0.0000
124 I G -0.5628
125 N G -1.1222
126 F G 0.0000
127 K G -1.8834
128 L G 0.0000
129 D G -2.6369
130 V G 0.0000
131 K G -2.7364
132 K G -2.2378
133 V G -1.0117
134 A G -0.9868
135 D G -1.5444
136 P G -1.4701
137 E G -2.3529
138 G G -1.7902
139 G G -1.4858
140 E G -1.6132
141 R G -1.3958
142 A G 0.0000
143 V G -1.3568
144 I G 0.0000
145 T G -1.1939
146 L G 0.0000
147 D G 0.0000
148 G G 0.0000
149 K G -0.8521
150 Y G -0.4044
151 L G -0.4268
152 P G -0.6200
153 T G -0.9797
154 K G -1.9042
155 P G -0.8385
156 F G -0.1794
1 M H 1.9055
2 I H 1.2921
3 Q H 0.0000
4 S H 0.0000
5 Q H 0.0000
6 I H -0.2302
7 N H -1.0356
8 R H -1.1924
9 N H -1.6731
10 I H -0.7894
11 R H 0.0000
12 L H -1.0877
13 D H -1.9795
14 L H 0.0000
15 A H 0.0000
16 D H 0.0000
17 A H -0.2549
18 I H 0.0000
19 L H 0.0000
20 L H 0.6257
21 S H 0.6352
22 K H 0.0000
23 A H 0.0000
24 Y H 1.7765 mutated: KH24Y
25 Y H 1.9977 mutated: KH25Y
26 Y H 2.6682 mutated: DH26Y
27 L H 1.1874
28 S H 0.0000
29 F H 0.0000
30 A H -1.6141
31 E H -2.6011
32 I H 0.0000
33 A H 0.0000
34 D H -2.7711
35 G H -1.6383
36 T H -1.6393
37 G H -0.8953
38 L H -0.3920
39 A H -0.7901
40 E H -1.4343
41 A H 0.0000
42 F H 0.0000
43 V H 0.0000
44 T H 0.0000
45 A H 0.0000
46 A H 0.0000
47 L H 0.0000
48 L H 0.0000
49 G H 0.0000
50 Q H 0.0000
51 Q H 0.0000
52 A H -0.3795
53 L H 0.0000
54 P H -1.1263
55 A H -1.3351
56 D H -2.3310
57 A H 0.0000
58 A H 0.0000
59 R H -2.6868
60 L H -1.4602
61 V H 0.0000
62 G H 0.0000
63 A H -1.3953
64 K H -1.2770
65 L H 0.0000
66 D H -2.5270
67 L H -2.4766
68 D H -3.3074
69 E H -3.4232
70 D H -2.1707
71 S H -1.9824
72 I H 0.0000
73 L H -0.9573
74 L H -0.2118
75 L H 0.0000
76 Q H -0.5330
77 M H 0.0000
78 I H 0.0000
79 P H 0.0000
80 L H -0.0482
81 R H 0.0000
82 G H 0.0000
83 C H 0.0000
84 I H 0.0000
85 D H -2.3413
86 D H -2.2558
87 R H -1.5103
88 I H 0.0000
89 P H 0.0000
90 T H -0.5843
91 D H 0.0000
92 P H 0.0000
93 T H 0.0000
94 M H 0.0000
95 Y H 0.0000
96 Q H 0.0000
97 F H 0.0000
98 Y H 0.0000
99 E H 0.0000
100 M H 0.0000
101 L H 0.0000
102 Q H 0.0000
103 V H 0.0000
104 Y H 0.0000
105 G H 0.0000
106 T H 0.0000
107 T H 0.0000
108 L H 0.0000
109 K H 0.0000
110 A H 0.0000
111 L H 0.0000
112 V H 0.0000
113 H H 0.0000
114 E H -0.2775
115 K H -1.2484
116 F H -0.7190
117 G H -0.3814
118 D H -0.5087
119 G H 0.0000
120 I H 0.0000
121 I H 0.0000
122 S H 0.0000
123 A H -0.3208
124 I H -0.6246
125 N H -1.1976
126 F H 0.0000
127 K H -1.7289
128 L H 0.0000
129 D H -2.3521
130 V H 0.0000
131 K H -2.6076
132 K H -2.1750
133 V H -0.9520
134 A H -0.9648
135 D H -1.4994
136 P H -1.4509
137 E H -2.3141
138 G H -1.7118
139 G H -1.4126
140 E H -1.6181
141 R H -1.3151
142 A H 0.0000
143 V H -1.1215
144 I H 0.0000
145 T H -1.0421
146 L H 0.0000
147 D H 0.0000
148 G H 0.0000
149 K H -0.8723
150 Y H -0.4520
151 L H -0.4008
152 P H -0.7052
153 T H -0.9397
154 K H -1.8844
155 P H -0.8730
156 F H -0.2623
1 M I 1.8722
2 I I 1.2652
3 Q I 0.0000
4 S I 0.0000
5 Q I 0.0000
6 I I -0.2550
7 N I -1.0762
8 R I -1.1848
9 N I -1.6469
10 I I -0.7193
11 R I 0.0000
12 L I -1.0522
13 D I -1.9462
14 L I 0.0000
15 A I 0.0000
16 D I 0.0000
17 A I -0.2684
18 I I 0.0000
19 L I 0.0000
20 L I 0.6567
21 S I 0.6325
22 K I 0.0000
23 A I 0.0000
24 Y I 1.7568 mutated: KI24Y
25 Y I 2.0290 mutated: KI25Y
26 Y I 2.6491 mutated: DI26Y
27 L I 1.3452
28 S I 0.0000
29 F I 0.0000
30 A I -1.4949
31 E I -2.0547
32 I I 0.0000
33 A I 0.0000
34 D I -2.7269
35 G I -1.5688
36 T I -1.6037
37 G I -0.9915
38 L I -0.5983
39 A I -1.0848
40 E I -1.8329
41 A I 0.0000
42 F I 0.0000
43 V I 0.0000
44 T I 0.0000
45 A I 0.0000
46 A I 0.0000
47 L I 0.0000
48 L I 0.0000
49 G I 0.0000
50 Q I 0.0000
51 Q I 0.0000
52 A I -0.3566
53 L I 0.0000
54 P I -1.0718
55 A I -1.3163
56 D I -2.3191
57 A I 0.0000
58 A I 0.0000
59 R I -2.8415
60 L I -1.1922
61 V I 0.0000
62 G I 0.0000
63 A I -1.3193
64 K I -1.0626
65 L I 0.0000
66 D I -2.4841
67 L I -2.5472
68 D I -3.6955
69 E I -3.7413
70 D I -2.8067
71 S I -2.2449
72 I I 0.0000
73 L I -1.1187
74 L I -0.3295
75 L I 0.0000
76 Q I -0.4822
77 M I 0.0000
78 I I 0.0000
79 P I 0.0000
80 L I -0.0563
81 R I 0.0000
82 G I 0.0000
83 C I 0.0000
84 I I 0.0000
85 D I -2.4586
86 D I -2.4938
87 R I -1.4262
88 I I 0.0000
89 P I 0.0000
90 T I -0.7009
91 D I 0.0000
92 P I 0.0000
93 T I 0.0000
94 M I 0.0000
95 Y I 0.0000
96 Q I 0.0000
97 F I 0.0000
98 Y I 0.0000
99 E I 0.0000
100 M I 0.0000
101 L I 0.0000
102 Q I 0.0000
103 V I 0.0000
104 Y I 0.0000
105 G I 0.0000
106 T I 0.0000
107 T I 0.0000
108 L I 0.0000
109 K I 0.0000
110 A I 0.0000
111 L I 0.0000
112 V I 0.0000
113 H I 0.0000
114 E I -0.2396
115 K I -1.2366
116 F I -0.7668
117 G I -0.4626
118 D I -0.6361
119 G I 0.0000
120 I I 0.0000
121 I I 0.0000
122 S I 0.0000
123 A I -0.3779
124 I I -0.5807
125 N I -1.2040
126 F I 0.0000
127 K I -1.7910
128 L I 0.0000
129 D I -1.8904
130 V I 0.0000
131 K I -1.9888
132 K I -2.1541
133 V I -0.7290
134 A I -0.8760
135 D I 0.0000
136 P I -1.3605
137 E I -2.2871
138 G I -1.7051
139 G I -1.3385
140 E I -1.5598
141 R I -1.2030
142 A I 0.0000
143 V I -0.8942
144 I I 0.0000
145 T I -0.9436
146 L I 0.0000
147 D I -1.3956
148 G I 0.0000
149 K I -1.2322
150 Y I -0.7603
151 L I 0.0000
152 P I -1.0109
153 T I -1.0851
154 K I -1.9282
155 P I -0.8080
156 F I -0.2177
1 M J 1.7438
2 I J 1.1219
3 Q J 0.0000
4 S J 0.0000
5 Q J 0.0000
6 I J -0.2948
7 N J -1.1293
8 R J -1.2685
9 N J -1.8078
10 I J -1.0029
11 R J 0.0000
12 L J -1.2405
13 D J -2.0852
14 L J 0.0000
15 A J 0.0000
16 D J -0.8016
17 A J -0.3524
18 I J 0.0000
19 L J 0.0000
20 L J 0.5261
21 S J 0.5317
22 K J 0.0000
23 A J 0.0000
24 Y J 1.6267 mutated: KJ24Y
25 Y J 1.7059 mutated: KJ25Y
26 Y J 2.5317 mutated: DJ26Y
27 L J 1.1783
28 S J 0.0000
29 F J 0.0000
30 A J -1.5979
31 E J -2.3984
32 I J 0.0000
33 A J 0.0000
34 D J -2.7437
35 G J -1.6058
36 T J -1.6419
37 G J -0.9272
38 L J -0.4833
39 A J -0.9993
40 E J -1.7212
41 A J 0.0000
42 F J 0.0000
43 V J 0.0000
44 T J 0.0000
45 A J 0.0000
46 A J 0.0000
47 L J 0.0000
48 L J 0.0000
49 G J 0.0000
50 Q J 0.0000
51 Q J 0.0000
52 A J -0.3448
53 L J 0.0000
54 P J -1.0688
55 A J -1.2168
56 D J -2.2312
57 A J 0.0000
58 A J 0.0000
59 R J -2.3723
60 L J -1.3386
61 V J 0.0000
62 G J 0.0000
63 A J -1.2509
64 K J -1.2172
65 L J 0.0000
66 D J -2.4919
67 L J -2.4623
68 D J -3.4414
69 E J -3.6102
70 D J -2.7551
71 S J -2.1433
72 I J -1.9201
73 L J -0.9299
74 L J -0.2720
75 L J 0.0000
76 Q J -0.3908
77 M J 0.0000
78 I J 0.0000
79 P J 0.0000
80 L J 0.0000
81 R J 0.0000
82 G J 0.0000
83 C J 0.0000
84 I J 0.0000
85 D J -2.8115
86 D J -3.2081
87 R J -1.8404
88 I J 0.0000
89 P J 0.0000
90 T J -0.6993
91 D J 0.0000
92 P J 0.0000
93 T J 0.0000
94 M J 0.0000
95 Y J 0.0000
96 Q J 0.0000
97 F J 0.0000
98 Y J 0.0000
99 E J 0.0000
100 M J 0.0000
101 L J 0.0000
102 Q J 0.0000
103 V J 0.0000
104 Y J 0.0000
105 G J 0.0000
106 T J 0.0000
107 T J 0.0000
108 L J 0.0000
109 K J 0.0000
110 A J 0.0000
111 L J 0.0000
112 V J 0.0000
113 H J 0.0000
114 E J -0.2832
115 K J -1.2352
116 F J -0.8182
117 G J -0.4573
118 D J -0.6072
119 G J 0.0000
120 I J 0.0000
121 I J 0.0000
122 S J 0.0000
123 A J -0.3222
124 I J -0.5906
125 N J -1.2129
126 F J 0.0000
127 K J -1.8508
128 L J 0.0000
129 D J -2.5990
130 V J 0.0000
131 K J -2.6690
132 K J -2.1731
133 V J -0.9251
134 A J -0.9579
135 D J 0.0000
136 P J -1.4149
137 E J -2.3335
138 G J -1.8239
139 G J -1.4529
140 E J -1.6494
141 R J -1.4237
142 A J 0.0000
143 V J -1.3253
144 I J 0.0000
145 T J -1.1447
146 L J 0.0000
147 D J -1.1415
148 G J 0.0000
149 K J -0.9993
150 Y J 0.0000
151 L J -0.6081
152 P J -0.9526
153 T J -1.0904
154 K J -1.9486
155 P J -0.8755
156 F J -0.3420

 

Laboratory of Theory of Biopolymers 2015