Project name: 3N75 [mutate: KA437Y, KA440Y, EA445Y, KB437Y, KB440Y, EB445Y, KC437Y, KC440Y, TC444Y, KD437Y, KD440Y, ED445Y, KE437Y, KE440Y, EE445Y]

Status: done

submitted: 2017-09-13 11:51:37, status changed: 2017-09-13 15:41:13
Settings
Chain sequence(s) A: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
C: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
B: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
E: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
D: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues KA437Y, KA440Y, EA445Y, KB437Y, KB440Y, EB445Y, KC437Y, KC440Y, TC444Y, KD437Y, KD440Y, ED445Y, KE437Y, KE440Y, EE445Y
Energy difference between WD and mutated (by FoldX) -8.34955 kcal/mol
Show buried residues

Minimal score value
-4.078
Maximal score value
2.8324
Average score
-0.7192
Total score value
-2553.2239

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.3219
2 N A -1.1220
3 V A 0.0000
4 I A 0.0000
5 A A 0.0000
6 I A 0.0000
7 L A 0.0000
8 N A -1.3066
9 H A -1.4140
10 M A -0.6006
11 G A -0.6337
12 V A -0.6902
13 Y A -0.5278
14 F A 0.0000
15 K A 0.0000
16 E A -0.6554
17 E A -0.5920
18 P A 0.0000
19 I A -0.6954
20 R A -1.4210
21 E A -1.6176
22 L A 0.0000
23 H A -1.9910
24 R A -3.1509
25 A A 0.0000
26 L A 0.0000
27 E A -3.7431
28 R A -3.6233
29 L A -2.6501
30 N A -2.8253
31 F A 0.0000
32 Q A -1.4388
33 I A -0.7193
34 V A 0.0000
35 Y A 0.0835
36 P A 0.0000
37 N A -2.1346
38 D A -2.4019
39 R A -2.4279
40 D A -2.5580
41 D A 0.0000
42 L A 0.0000
43 L A -1.5511
44 K A -1.7422
45 L A 0.0000
46 I A 0.0000
47 E A -1.7945
48 N A -1.5649
49 N A 0.0000
50 A A -0.6863
51 R A -0.8911
52 L A 0.0000
53 C A 0.0000
54 G A 0.0000
55 V A 0.0000
56 I A 0.0000
57 F A 0.0000
58 D A 0.0000
59 W A 0.0000
60 D A -1.0630
61 K A -1.5101
62 Y A 0.0000
63 N A 0.0000
64 L A -0.4483
65 E A -1.9570
66 L A 0.0000
67 C A 0.0000
68 E A -2.2121
69 E A -2.0884
70 I A 0.0000
71 S A -2.1786
72 K A -2.7847
73 M A 0.0000
74 N A -1.7206
75 E A -1.7157
76 N A -0.8177
77 L A 0.0000
78 P A 0.0000
79 L A 0.0000
80 Y A 0.0000
81 A A 0.0000
82 F A 0.0000
83 A A 0.0000
84 N A -0.1933
85 T A 0.2066
86 Y A 0.9603
87 S A 0.0000
88 T A -0.0704
89 L A 0.0000
90 D A -0.4187
91 V A -0.4104
92 S A -0.4981
93 L A 0.0000
94 N A -1.8087
95 D A -2.5367
96 L A -2.4014
97 R A -2.9068
98 L A 0.0000
99 Q A -0.7661
100 I A -0.1440
101 S A -0.3496
102 F A 0.0000
103 F A 0.0000
104 E A -0.8202
105 Y A 0.0000
106 A A -0.7379
107 L A 0.0000
108 G A -1.2992
109 A A -1.4058
110 A A 0.0000
111 E A -3.7226
112 D A -3.6844
113 I A 0.0000
114 A A 0.0000
115 N A -3.7607
116 K A -3.8454
117 I A 0.0000
118 K A -3.5853
119 Q A -3.5829
120 T A -2.7097
121 T A 0.0000
122 D A -3.2236
123 E A -2.8616
124 Y A 0.0000
125 I A -0.5637
126 N A -0.8673
127 T A -0.3092
128 I A 0.6821
129 L A 0.7373
130 P A 0.0000
131 P A -0.7151
132 L A 0.0000
133 T A 0.0000
134 K A -0.0835
135 A A -0.5327
136 L A 0.0000
137 F A -0.4648
138 K A -1.3148
139 Y A -1.6550
140 V A 0.0000
141 R A -3.1488
142 E A -3.1326
143 G A -2.0622
144 K A -1.9195
145 Y A 0.5541
146 T A 0.9812
147 F A 2.1301
148 C A 1.3721
149 T A 0.4736
150 P A -0.2352
151 G A -0.1089
152 H A -0.3678
153 M A 0.3995
154 G A -0.7604
155 G A 0.0000
156 T A -0.6512
157 A A -0.6477
158 F A -0.0511
159 Q A -1.2456
160 K A -1.9004
161 S A -0.2891
162 P A 0.5360
163 V A 1.9647
164 G A 0.0000
165 S A 0.7672
166 L A 2.6177
167 F A 2.6713
168 Y A 1.3449
169 D A 0.5236
170 F A 2.4346
171 F A 1.8087
172 G A 0.2705
173 P A -0.9238
174 N A -1.6993
175 T A -0.5686
176 M A 0.0000
177 K A -1.5223
178 S A -1.1520
179 D A -1.0549
180 I A 0.0000
181 S A 0.5894
182 I A 1.6041
183 S A 0.8983
184 V A 0.0000
185 S A -0.5355
186 E A -1.5268
187 L A 0.0000
188 G A -1.1529
189 S A -0.7277
190 L A 0.0000
191 L A -0.7762
192 D A -2.0300
193 H A -1.9317
194 S A -2.0389
195 G A -2.0040
196 P A -1.9511
197 H A 0.0000
198 K A -3.2812
199 E A -3.0647
200 A A 0.0000
201 E A 0.0000
202 Q A -3.0464
203 Y A -2.0082
204 I A 0.0000
205 A A 0.0000
206 R A -2.6883
207 V A 0.0000
208 F A 0.0000
209 N A -1.6115
210 A A -1.9686
211 D A -2.4320
212 R A -2.9869
213 S A 0.0000
214 Y A 0.0000
215 M A 0.0000
216 V A 0.0000
217 T A 0.0000
218 N A -1.7047
219 G A -1.1951
220 T A 0.0000
221 S A -0.8404
222 T A 0.0000
223 A A 0.0000
224 N A 0.0000
225 K A 0.0184
226 I A 0.0000
227 V A 0.0000
228 G A 0.0000
229 M A 0.2523
230 Y A -0.1209
231 S A 0.0109
232 A A 0.0000
233 P A -0.4167
234 A A -0.6812
235 G A -0.9969
236 S A 0.0000
237 T A 0.0000
238 I A 0.0000
239 L A 0.0000
240 I A 0.0000
241 D A 0.0000
242 R A 0.0000
243 N A -0.6863
244 C A 0.0000
245 H A -1.4207
246 K A -1.2781
247 S A 0.0000
248 L A 0.0000
249 T A 0.0000
250 H A -0.4201
251 L A 0.0000
252 M A 0.0000
253 M A 0.2781
254 M A 0.4499
255 S A -0.2377
256 D A -0.9601
257 V A 0.0000
258 T A 0.0000
259 P A 0.0000
260 I A 0.0000
261 Y A 0.0000
262 F A 0.0000
263 R A -1.5842
264 P A 0.0000
265 T A -0.6403
266 R A 0.0000
267 N A 0.0000
268 A A -0.8921
269 Y A -0.0620
270 G A -0.1276
271 I A 0.0000
272 L A 0.0000
273 G A 0.0000
274 G A 0.0000
275 I A 0.0000
276 P A -0.9938
277 Q A -0.7198
278 S A -0.9636
279 E A -1.0025
280 F A 0.0000
281 Q A -1.6149
282 H A -1.7288
283 A A -1.0858
284 T A -1.1537
285 I A 0.0000
286 A A -1.7829
287 K A -2.9383
288 R A -2.1913
289 V A -2.0217
290 K A -3.3465
291 E A -3.3217
292 T A -2.0650
293 P A -1.4618
294 N A -1.8892
295 A A -1.3256
296 T A -0.5052
297 W A 0.0594
298 P A 0.0000
299 V A -0.2932
300 H A 0.0000
301 A A 0.0000
302 V A 0.0000
303 I A 0.0000
304 T A -0.1102
305 N A 0.0000
306 S A 0.0000
307 T A 0.0000
308 Y A 0.2737
309 D A 0.0000
310 G A 0.0000
311 L A 0.0000
312 L A 0.0000
313 Y A 0.0000
314 N A -1.5057
315 T A 0.0000
316 D A -2.4672
317 F A -1.4711
318 I A 0.0000
319 K A 0.0000
320 K A -2.4779
321 T A -1.6877
322 L A 0.0000
323 D A -2.1104
324 V A 0.0000
325 K A -2.2667
326 S A 0.0000
327 I A 0.0000
328 H A 0.0000
329 F A 0.0000
330 D A 0.0000
331 S A 0.0000
332 A A -0.0039
333 W A 0.3626
334 V A 0.0000
335 P A 0.0000
336 Y A 0.0000
337 T A 0.0000
338 N A -1.0707
339 F A 0.0000
340 S A 0.0000
341 P A -1.2005
342 I A -0.8885
343 Y A 0.0000
344 E A -2.3508
345 G A -1.7367
346 K A -1.3014
347 C A 0.0000
348 G A 0.0000
349 M A 0.0000
350 S A -1.6553
351 G A -1.7333
352 G A -1.7706
353 R A -2.6914
354 V A -2.4592
355 E A -3.0382
356 G A -2.3995
357 K A -2.2830
358 V A -1.4294
359 I A 0.0000
360 Y A 0.0000
361 E A 0.0000
362 T A 0.0000
363 Q A 0.0000
364 S A -0.2974
365 T A 0.0000
366 H A -0.3092
368 L A 0.0508
369 L A 0.0000
370 A A 0.2498
371 A A 0.5434
372 F A 1.4622
373 S A -0.0392
374 Q A -1.0638
375 A A 0.0000
376 S A 0.0000
377 M A 0.0000
378 I A 0.0000
379 H A 0.0000
380 V A 0.0000
381 K A 0.0000
382 G A 0.0000
383 D A -2.9724
384 V A -2.3343
385 N A -3.0400
386 E A -4.0780
387 E A -3.6374
388 T A -2.4609
389 F A 0.0000
390 N A -2.2662
391 E A -2.1001
392 A A 0.0000
393 Y A 0.0000
394 M A 0.1037
395 M A 0.6763
396 H A 0.0360
397 T A -0.0679
398 T A -0.1545
399 T A 0.1942
400 S A -0.0600
401 P A 0.0000
402 H A -0.9183
403 Y A 0.0000
404 G A 0.0936
405 I A 0.1188
406 V A 0.0000
407 A A 0.0000
408 S A 0.0000
409 T A 0.0000
410 E A 0.0000
411 T A 0.1007
412 A A 0.0000
413 A A 0.0000
414 A A 0.0969
415 M A 0.0581
416 M A 0.0000
417 K A -1.5490
418 G A -1.4992
419 N A -2.1355
420 A A -1.6145
421 G A 0.0000
422 K A -2.6465
423 R A -2.5771
424 L A -1.1189
425 I A 0.0000
426 N A -2.0208
427 G A -1.5527
428 S A 0.0000
429 I A 0.0000
430 E A -2.1741
431 R A -1.1532
432 A A 0.0000
433 I A -0.4767
434 K A -0.1809
435 F A 0.0000
436 R A 0.0000
437 Y A 0.8749 mutated: KA437Y
438 E A 0.0000
439 I A 0.0000
440 Y A 0.1819 mutated: KA440Y
441 R A 0.2064
442 L A 0.0000
443 R A -0.7477
444 T A -0.1502
445 Y A 0.5212 mutated: EA445Y
446 S A -0.7767
447 D A -1.8153
448 G A -1.3915
449 W A -0.7643
450 F A 0.0000
451 F A 0.0000
452 D A -0.4654
453 V A 0.0000
454 W A 0.0000
455 Q A 0.0000
456 P A -1.5482
457 D A -2.3925
458 H A -2.1772
459 I A -1.4620
460 D A -2.1526
461 T A -1.2570
462 T A -1.1228
463 E A -0.9922
464 C A 0.0000
465 W A 0.0000
466 P A -1.3510
467 L A 0.0000
468 R A -3.3695
469 S A -3.2233
470 D A -2.7592
471 S A -1.9936
472 T A -1.8398
473 W A -1.0778
474 H A 0.0000
475 G A -1.5430
476 F A 0.0000
477 K A -2.4975
478 N A -2.8666
479 I A -2.5142
480 D A -2.4961
481 N A -3.4062
482 E A -2.8975
483 H A 0.0000
484 M A 0.0000
485 Y A 0.0000
486 L A 0.0000
487 D A 0.0000
488 P A 0.0000
489 I A 0.0000
490 K A 0.0000
491 V A 0.0000
492 T A 0.0000
493 L A 0.0000
494 L A 0.0402
495 T A 0.0000
496 P A -0.2434
497 G A 0.0000
498 M A -1.4340
499 E A -3.2797
500 K A -3.4590
501 D A -3.3172
502 G A -2.3929
503 T A -1.9129
504 M A -1.1420
505 S A -1.1933
506 D A -1.6877
507 F A -0.2926
508 G A 0.0000
509 I A 0.0000
510 P A 0.0000
511 A A 0.0000
512 S A -0.1059
513 I A 0.0000
514 V A 0.0000
515 A A -0.5689
516 K A -1.0389
517 Y A 0.0000
518 L A 0.0000
519 D A -2.0023
520 E A -1.8391
521 H A -1.7855
522 G A -1.1784
523 I A -0.3696
524 V A 0.8526
525 V A 0.2041
526 E A -0.5099
527 K A -0.3845
528 T A -0.2978
529 G A -0.0063
530 P A 0.0000
531 Y A 0.0000
532 N A 0.0000
533 L A 0.0000
534 L A 0.0000
535 F A 0.0000
536 L A 0.1550
537 F A 0.0000
538 S A 0.2091
539 I A 0.2374
540 G A -0.2144
541 I A -0.2264
542 D A -1.0005
543 K A -0.9020
544 T A -0.9980
545 K A -1.3484
546 A A 0.0000
547 L A 0.0000
548 S A -0.5962
549 L A 0.0000
550 L A 0.0000
551 R A 0.0000
552 A A 0.0000
553 L A 0.0000
554 T A 0.0000
555 D A -0.9676
556 F A 0.0000
557 K A 0.0000
558 R A -1.2659
559 A A 0.0000
560 F A 0.0000
561 D A -0.9460
562 L A 0.3975
563 N A -0.5463
564 L A -0.6792
565 R A -2.0855
566 V A 0.0000
567 K A -2.4157
568 N A -2.0058
569 M A 0.0000
570 L A 0.0000
571 P A -1.7332
572 S A -1.9808
573 L A 0.0000
574 Y A -2.6032
575 R A -3.3528
576 E A -3.1958
577 D A -2.5510
578 P A -2.6124
579 E A -2.5073
580 F A -1.0719
581 Y A 0.0000
582 E A -2.4687
583 N A -2.1795
584 M A -1.8076
585 R A -2.1573
586 I A 0.0000
587 Q A -1.8156
588 E A -2.2988
589 L A 0.0000
590 A A 0.0000
591 Q A -2.1682
592 N A -1.6535
593 I A -0.8315
594 H A 0.0000
595 K A -1.2589
596 L A -0.8687
597 I A 0.0000
598 V A -0.7777
599 H A -1.0853
600 H A -1.2926
601 N A -1.5064
602 L A 0.0000
603 P A 0.0000
604 D A -2.2330
605 L A -1.5751
606 M A 0.0000
607 Y A -1.0107
608 R A -2.2340
609 A A 0.0000
610 F A -0.4044
611 E A -0.8186
612 V A -0.3786
613 L A 0.3022
614 P A 0.0000
615 T A 0.3582
616 M A 0.7980
617 V A 1.1535
618 M A 0.8168
619 T A 0.2795
620 P A 0.0000
621 Y A 0.0355
622 A A 0.0697
623 A A 0.0000
624 F A 0.1954
625 Q A -0.3517
626 K A -1.1408
627 E A -0.9618
628 L A 0.3774
629 H A -0.8893
630 G A -1.0019
631 M A -1.2631
632 T A -1.7759
633 E A -2.3685
634 E A -2.1949
635 V A -1.5175
636 Y A -1.6097
637 L A 0.0000
638 D A -2.7579
639 E A -2.4714
640 M A 0.0000
641 V A -1.0274
642 G A -0.6782
643 R A -0.7705
644 I A -0.0934
645 N A 0.0000
646 A A 0.0000
647 N A -0.4990
648 M A 0.0000
649 I A 0.0000
650 L A -0.4267
651 P A 0.0000
652 Y A -0.0399
653 P A 0.0576
654 P A 0.0000
655 G A -0.1129
656 V A 0.0000
657 P A 0.0000
658 L A 0.0000
659 V A 0.0000
660 M A 0.0000
661 P A 0.0000
662 G A 0.0000
663 E A 0.0000
664 M A 0.5741
665 I A 0.0000
666 T A -1.5613
667 E A -2.9020
668 E A -2.7149
669 S A 0.0000
670 R A -2.0574
671 P A -1.6143
672 V A 0.0000
673 L A 0.0000
674 E A -1.7454
675 F A 0.0000
676 L A 0.0000
677 Q A -1.5777
678 M A 0.0000
679 L A 0.0000
680 C A -1.9402
681 E A -2.2178
682 I A -1.0607
683 G A -1.4524
684 A A -1.2667
685 H A -0.9933
686 Y A -0.3978
687 P A -1.0536
688 G A -1.2489
689 F A -0.9016
690 E A -2.2547
691 T A -2.0551
692 D A -2.2500
693 I A 0.0000
694 H A -1.1932
695 G A -0.7029
696 A A -1.0907
697 Y A -1.1632
698 R A -2.7034
699 Q A -2.4073
700 A A -1.8333
701 D A -2.8548
702 G A -2.7461
703 R A -3.0534
704 Y A 0.0000
705 T A 0.0000
706 V A 0.0000
707 K A -1.4932
708 V A 0.0000
709 L A 0.0000
710 K A -3.0916
711 E A -2.6402
1 M B -0.1482
2 N B -1.0343
3 V B 0.0000
4 I B 0.0000
5 A B 0.0000
6 I B 0.0000
7 L B 0.0000
8 N B -1.2728
9 H B -1.3813
10 M B -0.5433
11 G B -0.5834
12 V B -0.6447
13 Y B -0.4692
14 F B 0.0000
15 K B 0.0000
16 E B -0.6116
17 E B -0.5735
18 P B 0.0000
19 I B -0.7207
20 R B -1.4732
21 E B -1.6706
22 L B 0.0000
23 H B -2.1114
24 R B -3.3785
25 A B 0.0000
26 L B 0.0000
27 E B -3.7702
28 R B -3.5769
29 L B -2.4112
30 N B -2.7561
31 F B 0.0000
32 Q B -1.4120
33 I B 0.0000
34 V B 0.0000
35 Y B -0.0165
36 P B 0.0000
37 N B -2.2359
38 D B -2.5887
39 R B -2.5292
40 D B -2.7189
41 D B 0.0000
42 L B 0.0000
43 L B -1.7704
44 K B -2.0533
45 L B 0.0000
46 I B 0.0000
47 E B -2.3765
48 N B -1.8072
49 N B 0.0000
50 A B -0.8258
51 R B -0.8453
52 L B 0.0000
53 C B 0.0000
54 G B 0.0000
55 V B 0.0000
56 I B 0.0000
57 F B 0.0000
58 D B 0.0000
59 W B 0.0000
60 D B -1.1619
61 K B -1.4082
62 Y B 0.0000
63 N B 0.0000
64 L B 0.0170
65 E B -1.6184
66 L B 0.0000
67 C B 0.0000
68 E B -2.6197
69 E B -2.1863
70 I B 0.0000
71 S B 0.0000
72 K B -2.7191
73 M B 0.0000
74 N B -1.6561
75 E B -1.7782
76 N B -1.0198
77 L B 0.0000
78 P B 0.0000
79 L B 0.0000
80 Y B 0.0000
81 A B 0.0000
82 F B 0.0000
83 A B 0.0000
84 N B -0.1347
85 T B 0.2203
86 Y B 0.9281
87 S B 0.0000
88 T B -0.0790
89 L B 0.0000
90 D B -0.2103
91 V B -0.1119
92 S B -0.3197
93 L B 0.0000
94 N B -1.5014
95 D B -2.4477
96 L B -2.3740
97 R B -2.6988
98 L B 0.0000
99 Q B -0.9399
100 I B -0.2218
101 S B -0.3401
102 F B 0.0000
103 F B 0.0000
104 E B -0.7981
105 Y B 0.0000
106 A B -0.6538
107 L B 0.0000
108 G B -1.2141
109 A B -1.3742
110 A B 0.0000
111 E B -3.5755
112 D B -3.4621
113 I B 0.0000
114 A B 0.0000
115 N B -3.1615
116 K B -3.4229
117 I B 0.0000
118 K B -3.3154
119 Q B -3.4144
120 T B -2.6435
121 T B 0.0000
122 D B -3.2267
123 E B -2.9995
124 Y B 0.0000
125 I B -0.6427
126 N B -0.9615
127 T B -0.4235
128 I B 0.5213
129 L B 0.6769
130 P B 0.0000
131 P B -0.6866
132 L B 0.0000
133 T B 0.0000
134 K B -0.0948
135 A B -0.5559
136 L B 0.0000
137 F B -0.4855
138 K B -1.3798
139 Y B -1.7151
140 V B -2.0158
141 R B -3.1406
142 E B -3.1489
143 G B -2.2122
144 K B -2.0764
145 Y B 0.2585
146 T B 0.8517
147 F B 2.0879
148 C B 1.3067
149 T B 0.4322
150 P B -0.2805
151 G B -0.0994
152 H B -0.3755
153 M B 0.3490
154 G B -0.8034
155 G B 0.0000
156 T B -0.6653
157 A B -0.6611
158 F B -0.0817
159 Q B -1.2928
160 K B -1.9311
161 S B -0.3040
162 P B 0.5502
163 V B 1.9698
164 G B 1.1711
165 S B 0.7665
166 L B 2.6643
167 F B 2.7696
168 Y B 1.3651
169 D B 0.5163
170 F B 2.4437
171 F B 1.7826
172 G B 0.2187
173 P B -0.9825
174 N B -1.7155
175 T B -0.5777
176 M B 0.0000
177 K B -1.6078
178 S B -1.1503
179 D B -1.0053
180 I B 0.0000
181 S B 0.0000
182 I B 1.2427
183 S B 0.6636
184 V B 0.0000
185 S B -0.7416
186 E B -1.7530
187 L B 0.0000
188 G B -1.2761
189 S B -0.8238
190 L B 0.0000
191 L B -0.6486
192 D B -2.0248
193 H B -1.8982
194 S B -2.0121
195 G B -2.0046
196 P B -1.9127
197 H B 0.0000
198 K B -3.2628
199 E B -2.9927
200 A B 0.0000
201 E B 0.0000
202 Q B -3.0343
203 Y B -1.9791
204 I B 0.0000
205 A B 0.0000
206 R B -2.7577
207 V B 0.0000
208 F B 0.0000
209 N B -1.8982
210 A B -2.1171
211 D B -2.5048
212 R B -3.0251
213 S B 0.0000
214 Y B 0.0000
215 M B 0.0000
216 V B 0.0000
217 T B 0.0000
218 N B -1.6967
219 G B 0.0000
220 T B 0.0000
221 S B -0.7834
222 T B 0.0000
223 A B 0.0000
224 N B 0.0000
225 K B 0.0271
226 I B 0.0000
227 V B 0.0000
228 G B 0.0000
229 M B 0.2541
230 Y B -0.1321
231 S B -0.0125
232 A B 0.0000
233 P B -0.4540
234 A B -0.7844
235 G B -1.0897
236 S B 0.0000
237 T B 0.0000
238 I B 0.0000
239 L B 0.0000
240 I B 0.0000
241 D B 0.0000
242 R B 0.0000
243 N B -0.4813
244 C B 0.0000
245 H B -1.0804
246 K B -1.1642
247 S B 0.0000
248 L B 0.0000
249 T B 0.0000
250 H B -0.3641
251 L B 0.0000
252 M B 0.0000
253 M B 0.3037
254 M B 0.5005
255 S B 0.0000
256 D B -1.2057
257 V B 0.0000
258 T B 0.0000
259 P B 0.0000
260 I B 0.0000
261 Y B 0.0000
262 F B 0.0000
263 R B -0.9895
264 P B -0.6913
265 T B -0.6712
266 R B 0.0000
267 N B 0.0000
268 A B -0.7799
269 Y B 0.0169
270 G B -0.0968
271 I B 0.0000
272 L B 0.0000
273 G B 0.0000
274 G B 0.0000
275 I B 0.0000
276 P B -0.8834
277 Q B -0.9249
278 S B -0.8840
279 E B -0.8650
280 F B 0.0000
281 Q B -1.4468
282 H B -1.7496
283 A B -1.0999
284 T B -1.1760
285 I B 0.0000
286 A B -1.8453
287 K B -2.9962
288 R B -2.2883
289 V B 0.0000
290 K B -3.4390
291 E B -3.3847
292 T B -2.1373
293 P B -1.4973
294 N B -1.9189
295 A B -1.3765
296 T B -0.5495
297 W B 0.0078
298 P B 0.0000
299 V B -0.2717
300 H B 0.0000
301 A B 0.0000
302 V B 0.0000
303 I B 0.0000
304 T B 0.0000
305 N B 0.0000
306 S B 0.0000
307 T B 0.0000
308 Y B 0.2552
309 D B 0.0000
310 G B 0.0000
311 L B 0.0000
312 L B 0.0000
313 Y B 0.0000
314 N B -1.4708
315 T B 0.0000
316 D B -2.4661
317 F B -1.5188
318 I B 0.0000
319 K B 0.0000
320 K B -2.4463
321 T B -1.7288
322 L B 0.0000
323 D B -2.2241
324 V B 0.0000
325 K B -2.3283
326 S B 0.0000
327 I B 0.0000
328 H B 0.0000
329 F B 0.0000
330 D B 0.0000
331 S B 0.0000
332 A B 0.0118
333 W B 0.2812
334 V B 0.0000
335 P B 0.0000
336 Y B 0.0000
337 T B 0.0000
338 N B -1.1810
339 F B 0.0000
340 S B 0.0000
341 P B -1.3926
342 I B 0.0000
343 Y B 0.0000
344 E B -2.3697
345 G B -1.6940
346 K B 0.0000
347 C B 0.0000
348 G B 0.0000
349 M B 0.0000
350 S B -1.6949
351 G B -1.7822
352 G B -1.8775
353 R B -2.8691
354 V B -2.5609
355 E B -3.1027
356 G B -2.4652
357 K B -2.4075
358 V B 0.0000
359 I B 0.0000
360 Y B 0.0000
361 E B 0.0000
362 T B 0.0000
363 Q B 0.0000
364 S B -0.3083
365 T B 0.0000
366 H B -0.1212
368 L B 0.1276
369 L B 0.0000
370 A B 0.3223
371 A B 0.6169
372 F B 1.5148
373 S B 0.0052
374 Q B -1.0461
375 A B 0.0000
376 S B 0.0000
377 M B 0.0000
378 I B 0.0000
379 H B 0.0000
380 V B 0.0000
381 K B 0.0000
382 G B 0.0000
383 D B -3.0561
384 V B -2.3927
385 N B -3.0570
386 E B -4.0664
387 E B -3.6217
388 T B -2.4807
389 F B 0.0000
390 N B -2.3213
391 E B -2.1412
392 A B 0.0000
393 Y B 0.0000
394 M B 0.0129
395 M B 0.6351
396 H B 0.0093
397 T B -0.1189
398 T B -0.1550
399 T B 0.1481
400 S B -0.1137
401 P B 0.0000
402 H B -0.9196
403 Y B 0.0000
404 G B 0.1052
405 I B 0.1387
406 V B 0.0000
407 A B 0.0000
408 S B 0.0000
409 T B 0.0000
410 E B 0.0000
411 T B 0.1268
412 A B 0.0000
413 A B 0.0000
414 A B 0.1588
415 M B 0.2031
416 M B 0.0000
417 K B -1.2048
418 G B -1.1835
419 N B -1.5441
420 A B -1.2974
421 G B 0.0000
422 K B -2.1170
423 R B -1.9839
424 L B -0.7481
425 I B 0.0000
426 N B -1.8683
427 G B -1.4091
428 S B 0.0000
429 I B 0.0000
430 E B -2.2140
431 R B -1.2400
432 A B 0.0000
433 I B -0.5025
434 K B -0.2479
435 F B 0.0000
436 R B 0.0000
437 Y B 0.8411 mutated: KB437Y
438 E B 0.0000
439 I B 0.0000
440 Y B -0.0128 mutated: KB440Y
441 R B 0.1365
442 L B 0.0000
443 R B -0.8672
444 T B -0.2250
445 Y B 0.4889 mutated: EB445Y
446 S B -0.8062
447 D B -1.8089
448 G B -1.4173
449 W B -0.7862
450 F B 0.0000
451 F B 0.0000
452 D B -0.4959
453 V B 0.0000
454 W B 0.0000
455 Q B 0.0000
456 P B -1.5616
457 D B -2.3990
458 H B -2.1372
459 I B -1.5682
460 D B -2.2250
461 T B -1.4460
462 T B -1.5154
463 E B -1.8018
464 C B 0.0000
465 W B 0.0000
466 P B -1.5247
467 L B 0.0000
468 R B -3.4595
469 S B -3.2671
470 D B -2.7988
471 S B -1.9782
472 T B -1.7518
473 W B -0.9942
474 H B 0.0000
475 G B -1.2337
476 F B 0.0000
477 K B -2.4171
478 N B -2.8548
479 I B -2.5311
480 D B -2.5297
481 N B -3.4475
482 E B -2.9521
483 H B 0.0000
484 M B 0.0000
485 Y B 0.0000
486 L B 0.0000
487 D B 0.0000
488 P B 0.0000
489 I B 0.0000
490 K B 0.0000
491 V B 0.0000
492 T B 0.0000
493 L B 0.0000
494 L B 0.0409
495 T B 0.0000
496 P B -0.2260
497 G B 0.0000
498 M B -1.4371
499 E B -3.2361
500 K B -3.3755
501 D B -3.2519
502 G B -2.1968
503 T B -1.7802
504 M B -1.3679
505 S B -1.4945
506 D B -1.8646
507 F B -0.3968
508 G B 0.0000
509 I B 0.0000
510 P B 0.0000
511 A B 0.0000
512 S B -0.1902
513 I B 0.0000
514 V B 0.0000
515 A B -0.5069
516 K B -1.0840
517 Y B 0.0000
518 L B 0.0000
519 D B -2.0305
520 E B -1.8323
521 H B -1.7780
522 G B -1.1721
523 I B -0.3354
524 V B 0.8218
525 V B 0.1354
526 E B -0.5806
527 K B -0.4002
528 T B -0.2856
529 G B 0.0158
530 P B 0.0701
531 Y B 0.0000
532 N B 0.0000
533 L B 0.0000
534 L B 0.0000
535 F B 0.0000
536 L B 0.1948
537 F B 0.0000
538 S B 0.2345
539 I B 0.2519
540 G B -0.1951
541 I B -0.2139
542 D B -1.0712
543 K B -0.9185
544 T B -0.9633
545 K B -1.2400
546 A B 0.0000
547 L B 0.0000
548 S B -0.5397
549 L B 0.0000
550 L B 0.0000
551 R B 0.0000
552 A B 0.0000
553 L B 0.0000
554 T B 0.0000
555 D B -1.3161
556 F B 0.0000
557 K B 0.0000
558 R B -1.5547
559 A B 0.0000
560 F B 0.0000
561 D B -1.3646
562 L B -0.2168
563 N B -0.7629
564 L B -0.7380
565 R B -1.8291
566 V B 0.0000
567 K B -2.2134
568 N B -1.8691
569 M B 0.0000
570 L B 0.0000
571 P B -1.6375
572 S B -1.9496
573 L B 0.0000
574 Y B -2.3435
575 R B -3.2630
576 E B -3.1567
577 D B -2.4461
578 P B -2.4970
579 E B -2.4310
580 F B -0.9959
581 Y B 0.0000
582 E B -2.2631
583 N B -2.0418
584 M B -1.6018
585 R B -1.9537
586 I B 0.0000
587 Q B -1.7356
588 E B -2.0576
589 L B 0.0000
590 A B 0.0000
591 Q B -2.3785
592 N B -1.9005
593 I B 0.0000
594 H B 0.0000
595 K B -2.5477
596 L B -1.6070
597 I B 0.0000
598 V B -1.5581
599 H B -1.7059
600 H B -1.6591
601 N B -2.0097
602 L B 0.0000
603 P B 0.0000
604 D B -1.8206
605 L B -1.2943
606 M B 0.0000
607 Y B -0.9478
608 R B -1.9950
609 A B 0.0000
610 F B 0.0000
611 E B -1.5279
612 V B -0.6212
613 L B 0.1085
614 P B 0.0000
615 T B 0.3535
616 M B 0.8078
617 V B 1.1079
618 M B 0.8320
619 T B 0.2411
620 P B 0.0000
621 Y B 0.0539
622 A B 0.0992
623 A B 0.0000
624 F B 0.3332
625 Q B -0.1742
626 K B -0.9659
627 E B -0.6864
628 L B 0.5167
629 H B -0.7585
630 G B -0.7851
631 M B -1.0004
632 T B -1.5528
633 E B -2.2545
634 E B -2.2368
635 V B -1.5503
636 Y B -1.2201
637 L B 0.0000
638 D B -2.0109
639 E B -2.1314
640 M B 0.0000
641 V B -0.9547
642 G B -0.6296
643 R B -0.7358
644 I B -0.0512
645 N B 0.0000
646 A B 0.0000
647 N B -0.5220
648 M B 0.0000
649 I B 0.0000
650 L B -0.4243
651 P B 0.0000
652 Y B 0.0575
653 P B 0.1178
654 P B 0.0000
655 G B -0.0731
656 V B 0.0000
657 P B 0.0000
658 L B 0.0000
659 V B 0.0000
660 M B 0.0000
661 P B 0.0000
662 G B 0.0000
663 E B 0.0000
664 M B 0.5437
665 I B 0.0000
666 T B -1.6257
667 E B -2.9738
668 E B -2.7588
669 S B 0.0000
670 R B -2.1495
671 P B -1.6737
672 V B 0.0000
673 L B 0.0000
674 E B -1.5985
675 F B 0.0000
676 L B 0.0000
677 Q B -1.3787
678 M B 0.0000
679 L B 0.0000
680 C B -1.9378
681 E B -2.1342
682 I B -1.0367
683 G B -1.3387
684 A B -1.1504
685 H B -0.9327
686 Y B -0.3357
687 P B -0.7757
688 G B -1.1458
689 F B -0.7812
690 E B -1.9194
691 T B -1.8971
692 D B -2.1778
693 I B 0.0000
694 H B -1.1934
695 G B -0.9060
696 A B -1.0563
697 Y B -1.0860
698 R B -2.5550
699 Q B -2.1829
700 A B -1.7245
701 D B -2.7314
702 G B -2.5362
703 R B -2.4881
704 Y B 0.0000
705 T B 0.0000
706 V B 0.0000
707 K B -1.5139
708 V B 0.0000
709 L B 0.0000
710 K B -2.6339
711 E B -2.4301
1 M C -0.5055
2 N C -1.2147
3 V C 0.0000
4 I C 0.0000
5 A C 0.0000
6 I C 0.0000
7 L C 0.0000
8 N C -1.2607
9 H C -1.3880
10 M C -0.5757
11 G C -0.5705
12 V C -0.6384
13 Y C -0.4900
14 F C 0.0000
15 K C 0.0000
16 E C -0.6432
17 E C -0.6422
18 P C 0.0000
19 I C -0.7893
20 R C -1.5875
21 E C -1.7354
22 L C 0.0000
23 H C -2.2944
24 R C -3.3322
25 A C 0.0000
26 L C 0.0000
27 E C -3.6435
28 R C -3.5149
29 L C -2.3353
30 N C -2.6841
31 F C 0.0000
32 Q C -1.4358
33 I C 0.0000
34 V C 0.0000
35 Y C 0.0238
36 P C 0.0000
37 N C -2.1640
38 D C -2.4818
39 R C -2.4357
40 D C -2.5970
41 D C 0.0000
42 L C 0.0000
43 L C -1.5746
44 K C -1.8681
45 L C 0.0000
46 I C 0.0000
47 E C -1.8977
48 N C -1.6778
49 N C 0.0000
50 A C -1.0549
51 R C -1.5380
52 L C 0.0000
53 C C 0.0000
54 G C 0.0000
55 V C 0.0000
56 I C 0.0000
57 F C 0.0000
58 D C 0.0000
59 W C 0.0000
60 D C -1.8084
61 K C -1.9110
62 Y C -1.2406
63 N C 0.0000
64 L C -0.3182
65 E C -2.0530
66 L C 0.0000
67 C C 0.0000
68 E C -2.9658
69 E C -2.2865
70 I C 0.0000
71 S C -2.2629
72 K C -2.8207
73 M C -1.9943
74 N C -1.5273
75 E C -1.5943
76 N C -0.6740
77 L C 0.0000
78 P C 0.0000
79 L C 0.0000
80 Y C 0.0000
81 A C 0.0000
82 F C 0.0000
83 A C 0.0000
84 N C -0.5065
85 T C 0.1953
86 Y C 0.8692
87 S C 0.0000
88 T C -0.1753
89 L C 0.0000
90 D C -0.2891
91 V C -0.2410
92 S C -0.4347
93 L C 0.0000
94 N C -1.5071
95 D C -2.3621
96 L C -2.3600
97 R C -2.6625
98 L C -1.5200
99 Q C -0.6009
100 I C -0.0683
101 S C -0.3294
102 F C 0.0000
103 F C 0.0000
104 E C -0.8450
105 Y C 0.0000
106 A C -0.6101
107 L C 0.0000
108 G C -1.2676
109 A C -1.3934
110 A C 0.0000
111 E C -3.6711
112 D C -3.5459
113 I C 0.0000
114 A C 0.0000
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