Project name: 10%_ag_2osl
Status: done
submitted: 2018-08-15 12:24:04, status changed: 2018-08-15 12:35:18
Settings
Chain sequence(s)
|
A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.9308
-
Maximal score value
-
1.7844
-
Average score
-
-0.6937
-
Total score value
-
-301.7525
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
Q |
A |
-0.9640 |
|
2 |
I |
A |
0.2098 |
|
3 |
V |
A |
1.2122 |
|
4 |
L |
A |
0.0000 |
|
5 |
S |
A |
-0.6790 |
|
6 |
Q |
A |
-0.8692 |
|
7 |
S |
A |
-0.3001 |
|
8 |
P |
A |
0.3045 |
|
9 |
A |
A |
0.7034 |
|
10 |
I |
A |
1.7844 |
|
11 |
L |
A |
0.7886 |
|
12 |
S |
A |
-0.3609 |
|
13 |
A |
A |
0.0000 |
|
14 |
S |
A |
-2.0143 |
|
15 |
P |
A |
-2.0142 |
|
16 |
G |
A |
-2.2607 |
|
17 |
E |
A |
-3.0735 |
|
18 |
K |
A |
-3.0237 |
|
19 |
V |
A |
-1.3932 |
|
20 |
T |
A |
-0.4017 |
|
21 |
M |
A |
0.0000 |
|
22 |
T |
A |
-0.6543 |
|
23 |
C |
A |
0.0000 |
|
24 |
R |
A |
-1.7681 |
|
25 |
A |
A |
-0.5784 |
|
26 |
S |
A |
-0.2071 |
|
27 |
S |
A |
-0.4444 |
|
28 |
S |
A |
-0.5408 |
|
29 |
V |
A |
-0.1358 |
|
30 |
S |
A |
0.1579 |
|
31 |
Y |
A |
0.8315 |
|
32 |
I |
A |
0.0000 |
|
33 |
H |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
F |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
-0.6942 |
|
38 |
K |
A |
0.0000 |
|
39 |
P |
A |
-0.7783 |
|
40 |
G |
A |
-0.8154 |
|
41 |
S |
A |
-0.7019 |
|
42 |
S |
A |
-0.6061 |
|
43 |
P |
A |
0.0000 |
|
44 |
K |
A |
-1.1032 |
|
45 |
P |
A |
0.0000 |
|
46 |
W |
A |
-0.1902 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
0.3076 |
|
49 |
A |
A |
0.1969 |
|
50 |
T |
A |
0.0652 |
|
51 |
S |
A |
-0.4056 |
|
52 |
N |
A |
-0.4549 |
|
53 |
L |
A |
0.1857 |
|
54 |
A |
A |
-0.2488 |
|
55 |
S |
A |
-0.3693 |
|
56 |
G |
A |
-0.1050 |
|
57 |
V |
A |
0.0000 |
|
58 |
P |
A |
0.6364 |
|
59 |
V |
A |
1.4718 |
|
60 |
R |
A |
-0.2510 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-0.0985 |
|
63 |
G |
A |
-0.5385 |
|
64 |
S |
A |
-0.4722 |
|
65 |
G |
A |
-0.7459 |
|
66 |
S |
A |
-0.6835 |
|
67 |
G |
A |
-0.7153 |
|
68 |
T |
A |
-1.0487 |
|
69 |
S |
A |
-1.1353 |
|
70 |
Y |
A |
0.0000 |
|
71 |
S |
A |
-0.6650 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-0.7831 |
|
74 |
I |
A |
0.0000 |
|
75 |
S |
A |
-1.9377 |
|
76 |
R |
A |
-3.3517 |
|
77 |
V |
A |
0.0000 |
|
78 |
E |
A |
-2.6655 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.8430 |
|
81 |
D |
A |
-1.4466 |
|
82 |
A |
A |
-1.2603 |
|
83 |
A |
A |
0.0000 |
|
84 |
T |
A |
-0.1044 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
-0.1440 |
|
87 |
C |
A |
0.0000 |
|
88 |
Q |
A |
0.0000 |
|
89 |
Q |
A |
0.0000 |
|
90 |
W |
A |
0.0000 |
|
91 |
T |
A |
-0.3127 |
|
92 |
S |
A |
-0.9376 |
|
93 |
N |
A |
-1.5694 |
|
94 |
P |
A |
-1.3393 |
|
95 |
P |
A |
0.0000 |
|
96 |
T |
A |
0.0000 |
|
97 |
F |
A |
0.0455 |
|
98 |
G |
A |
0.0000 |
|
99 |
G |
A |
-0.9684 |
|
100 |
G |
A |
-0.1850 |
|
101 |
T |
A |
0.0000 |
|
102 |
K |
A |
0.1779 |
|
103 |
L |
A |
0.0000 |
|
104 |
E |
A |
-0.7036 |
|
105 |
I |
A |
0.0000 |
|
106 |
K |
A |
-1.8654 |
|
107 |
R |
A |
-1.1329 |
|
108 |
T |
A |
-0.0204 |
|
109 |
V |
A |
0.7517 |
|
110 |
A |
A |
0.3888 |
|
111 |
A |
A |
0.0470 |
|
112 |
P |
A |
-0.2735 |
|
113 |
S |
A |
-0.1761 |
|
114 |
V |
A |
0.0000 |
|
115 |
F |
A |
0.1496 |
|
116 |
I |
A |
0.0763 |
|
117 |
F |
A |
0.0000 |
|
118 |
P |
A |
-0.5593 |
|
119 |
P |
A |
-0.8371 |
|
120 |
S |
A |
-1.6252 |
|
121 |
D |
A |
-3.0301 |
|
122 |
E |
A |
-3.1147 |
|
123 |
Q |
A |
0.0000 |
|
124 |
L |
A |
0.0000 |
|
125 |
K |
A |
-2.3853 |
|
126 |
S |
A |
-1.5638 |
|
127 |
G |
A |
-1.4045 |
|
128 |
T |
A |
-1.3853 |
|
129 |
A |
A |
0.0000 |
|
130 |
S |
A |
0.0000 |
|
131 |
V |
A |
0.0000 |
|
132 |
V |
A |
0.0000 |
|
133 |
C |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
L |
A |
0.0000 |
|
136 |
N |
A |
0.0000 |
|
137 |
N |
A |
-0.7319 |
|
138 |
F |
A |
0.0000 |
|
139 |
Y |
A |
-0.8035 |
|
140 |
P |
A |
-1.4578 |
|
141 |
R |
A |
-2.6085 |
|
142 |
E |
A |
-3.1193 |
|
143 |
A |
A |
-2.3045 |
|
144 |
K |
A |
-2.4722 |
|
145 |
V |
A |
-1.2179 |
|
146 |
Q |
A |
-0.8471 |
|
147 |
W |
A |
0.0000 |
|
148 |
K |
A |
-0.6884 |
|
149 |
V |
A |
0.0000 |
|
150 |
D |
A |
-2.1412 |
|
151 |
N |
A |
-1.6867 |
|
152 |
A |
A |
-0.3513 |
|
153 |
L |
A |
0.5684 |
|
154 |
Q |
A |
-0.5156 |
|
155 |
S |
A |
-0.8221 |
|
156 |
G |
A |
-1.5081 |
|
157 |
N |
A |
-1.6989 |
|
158 |
S |
A |
-1.4480 |
|
159 |
Q |
A |
-1.7904 |
|
160 |
E |
A |
-1.6802 |
|
161 |
S |
A |
-0.7545 |
|
162 |
V |
A |
-0.4707 |
|
163 |
T |
A |
-0.7093 |
|
164 |
E |
A |
-1.2712 |
|
165 |
Q |
A |
-1.7416 |
|
166 |
D |
A |
-2.0892 |
|
167 |
S |
A |
-2.4941 |
|
168 |
K |
A |
-2.9615 |
|
169 |
D |
A |
-2.3870 |
|
170 |
S |
A |
0.0000 |
|
171 |
T |
A |
0.0000 |
|
172 |
Y |
A |
0.0000 |
|
173 |
S |
A |
0.0000 |
|
174 |
L |
A |
0.0000 |
|
175 |
S |
A |
0.0000 |
|
176 |
S |
A |
0.0000 |
|
177 |
T |
A |
-0.2815 |
|
178 |
L |
A |
0.4239 |
|
179 |
T |
A |
0.1039 |
|
180 |
L |
A |
-0.4098 |
|
181 |
S |
A |
-1.4372 |
|
182 |
K |
A |
-2.4648 |
|
183 |
A |
A |
-2.0761 |
|
184 |
D |
A |
-3.0005 |
|
185 |
Y |
A |
0.0000 |
|
186 |
E |
A |
-3.9308 |
|
187 |
K |
A |
-3.8686 |
|
188 |
H |
A |
-3.2997 |
|
189 |
K |
A |
-3.5278 |
|
190 |
V |
A |
0.0000 |
|
191 |
Y |
A |
0.0000 |
|
192 |
A |
A |
0.0000 |
|
193 |
C |
A |
0.0000 |
|
194 |
E |
A |
-0.6226 |
|
195 |
V |
A |
0.0000 |
|
196 |
T |
A |
-1.0221 |
|
197 |
H |
A |
0.0000 |
|
198 |
Q |
A |
-1.5892 |
|
199 |
G |
A |
-0.3726 |
|
200 |
L |
A |
-0.1965 |
|
201 |
S |
A |
-0.3621 |
|
202 |
S |
A |
-0.2961 |
|
203 |
P |
A |
-0.1756 |
|
204 |
V |
A |
0.3821 |
|
205 |
T |
A |
-0.3127 |
|
206 |
K |
A |
-0.6817 |
|
207 |
S |
A |
-0.6524 |
|
208 |
F |
A |
-1.1969 |
|
209 |
N |
A |
-2.0108 |
|
210 |
R |
A |
-2.5434 |
|
211 |
G |
A |
-2.3234 |
|
212 |
E |
A |
-2.6807 |
|
1 |
Q |
A |
-1.3037 |
|
2 |
V |
A |
-0.4741 |
|
3 |
Q |
A |
-1.6366 |
|
4 |
L |
A |
0.0000 |
|
5 |
Q |
A |
-1.8757 |
|
6 |
Q |
A |
-1.0866 |
|
7 |
P |
A |
-1.0333 |
|
8 |
G |
A |
-1.2942 |
|
9 |
A |
A |
-1.4340 |
|
10 |
E |
A |
-2.0924 |
|
11 |
L |
A |
-0.8727 |
|
12 |
V |
A |
-0.9725 |
|
13 |
K |
A |
-1.7248 |
|
14 |
P |
A |
-1.2374 |
|
15 |
G |
A |
-1.1535 |
|
16 |
A |
A |
-0.9197 |
|
17 |
S |
A |
-0.9176 |
|
18 |
V |
A |
-1.0622 |
|
19 |
K |
A |
-1.6499 |
|
20 |
M |
A |
0.0000 |
|
21 |
S |
A |
-0.7555 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.5004 |
|
24 |
A |
A |
-1.0190 |
|
25 |
S |
A |
-1.1238 |
|
26 |
G |
A |
-0.8629 |
|
27 |
Y |
A |
-0.2628 |
|
28 |
T |
A |
-0.2190 |
|
29 |
F |
A |
0.0000 |
|
30 |
T |
A |
-0.7083 |
|
31 |
S |
A |
-0.1867 |
|
32 |
Y |
A |
0.5669 |
|
33 |
N |
A |
-0.0561 |
|
34 |
M |
A |
0.0000 |
|
35 |
H |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
K |
A |
0.0000 |
|
39 |
Q |
A |
-1.0110 |
|
40 |
T |
A |
-1.4314 |
|
41 |
P |
A |
-1.3022 |
|
42 |
G |
A |
-1.8036 |
|
43 |
R |
A |
-2.4398 |
|
44 |
G |
A |
-1.5143 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-1.3266 |
|
47 |
W |
A |
0.0000 |
|
48 |
I |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
A |
A |
0.0000 |
|
51 |
I |
A |
0.0000 |
|
52 |
Y |
A |
-0.7276 |
|
53 |
P |
A |
0.0000 |
|
54 |
G |
A |
-1.4464 |
|
55 |
N |
A |
-2.2434 |
|
56 |
G |
A |
-1.9748 |
|
57 |
D |
A |
-2.2909 |
|
58 |
T |
A |
-1.0982 |
|
59 |
S |
A |
-0.7476 |
|
60 |
Y |
A |
-1.0057 |
|
61 |
N |
A |
-1.7459 |
|
62 |
Q |
A |
-2.4700 |
|
63 |
K |
A |
-2.7761 |
|
64 |
F |
A |
-1.9741 |
|
65 |
K |
A |
-2.3997 |
|
66 |
G |
A |
-1.6932 |
|
67 |
K |
A |
-1.3477 |
|
68 |
A |
A |
0.0000 |
|
69 |
T |
A |
-0.6878 |
|
70 |
L |
A |
0.0000 |
|
71 |
T |
A |
-0.5010 |
|
72 |
A |
A |
-1.1433 |
|
73 |
D |
A |
-1.7596 |
|
74 |
K |
A |
-2.3740 |
|
75 |
S |
A |
-1.2985 |
|
76 |
S |
A |
-1.0772 |
|
77 |
S |
A |
-1.1913 |
|
78 |
T |
A |
0.0000 |
|
79 |
A |
A |
0.0000 |
|
80 |
Y |
A |
-0.3336 |
|
81 |
M |
A |
0.0000 |
|
82 |
Q |
A |
-1.1184 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-0.7797 |
|
85 |
S |
A |
-0.7941 |
|
86 |
L |
A |
0.0000 |
|
87 |
T |
A |
-1.1875 |
|
88 |
S |
A |
-1.1643 |
|
89 |
E |
A |
-2.0532 |
|
90 |
D |
A |
0.0000 |
|
91 |
S |
A |
-0.8555 |
|
92 |
A |
A |
-0.3449 |
|
93 |
V |
A |
0.2734 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
0.0000 |
|
99 |
S |
A |
0.0000 |
|
100 |
T |
A |
0.0000 |
|
101 |
Y |
A |
1.6629 |
|
102 |
Y |
A |
1.5805 |
|
103 |
G |
A |
0.3341 |
|
104 |
G |
A |
0.1751 |
|
105 |
D |
A |
0.2089 |
|
106 |
W |
A |
0.6101 |
|
107 |
Y |
A |
0.0000 |
|
108 |
F |
A |
0.0000 |
|
109 |
N |
A |
-0.1180 |
|
110 |
V |
A |
-0.2093 |
|
111 |
W |
A |
0.0000 |
|
112 |
G |
A |
0.0000 |
|
113 |
A |
A |
-0.6451 |
|
114 |
G |
A |
0.0000 |
|
115 |
T |
A |
0.0000 |
|
116 |
T |
A |
-0.5091 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.8447 |
|
119 |
V |
A |
-0.9127 |
|
120 |
S |
A |
-0.5004 |
|
121 |
A |
A |
-0.3857 |
|
122 |
A |
A |
-0.2878 |
|
123 |
S |
A |
-0.3427 |
|
124 |
T |
A |
-0.6117 |
|
125 |
K |
A |
-1.1336 |
|
126 |
G |
A |
-1.2468 |
|
127 |
P |
A |
-0.6069 |
|
128 |
S |
A |
-0.6400 |
|
129 |
V |
A |
0.0000 |
|
130 |
F |
A |
0.0000 |
|
131 |
P |
A |
-1.1954 |
|
132 |
L |
A |
0.0000 |
|
133 |
A |
A |
-1.1480 |
|
134 |
P |
A |
-1.0595 |
|
135 |
S |
A |
-1.6382 |
|
136 |
S |
A |
-1.7099 |
|
137 |
K |
A |
-2.2797 |
|
138 |
S |
A |
-1.2446 |
|
139 |
T |
A |
-1.0583 |
|
140 |
S |
A |
-1.0472 |
|
141 |
G |
A |
-1.1589 |
|
142 |
G |
A |
-0.9205 |
|
143 |
T |
A |
-0.6203 |
|
144 |
A |
A |
-0.2929 |
|
145 |
A |
A |
0.0000 |
|
146 |
L |
A |
0.0000 |
|
147 |
G |
A |
0.0000 |
|
148 |
C |
A |
0.0000 |
|
149 |
L |
A |
0.0000 |
|
150 |
V |
A |
0.0000 |
|
151 |
K |
A |
0.0000 |
|
152 |
D |
A |
-0.3372 |
|
153 |
Y |
A |
0.0000 |
|
154 |
F |
A |
-0.2465 |
|
155 |
P |
A |
0.0000 |
|
156 |
E |
A |
-1.0775 |
|
157 |
P |
A |
-1.0343 |
|
158 |
V |
A |
-0.7212 |
|
159 |
T |
A |
-0.5304 |
|
160 |
V |
A |
0.1784 |
|
161 |
S |
A |
-0.1517 |
|
162 |
W |
A |
0.0000 |
|
163 |
N |
A |
-0.8543 |
|
164 |
S |
A |
-0.6998 |
|
165 |
G |
A |
-0.5492 |
|
166 |
A |
A |
-0.2861 |
|
167 |
L |
A |
-0.0855 |
|
168 |
T |
A |
-0.1950 |
|
169 |
S |
A |
-0.2271 |
|
170 |
G |
A |
-0.2384 |
|
171 |
V |
A |
0.0253 |
|
172 |
H |
A |
-0.2231 |
|
173 |
T |
A |
0.0051 |
|
174 |
F |
A |
0.0000 |
|
175 |
P |
A |
-0.1475 |
|
176 |
A |
A |
0.3767 |
|
177 |
V |
A |
0.5356 |
|
178 |
L |
A |
1.1504 |
|
179 |
Q |
A |
0.1242 |
|
180 |
S |
A |
-0.1052 |
|
181 |
S |
A |
-0.2262 |
|
182 |
G |
A |
0.1000 |
|
183 |
L |
A |
0.2540 |
|
184 |
Y |
A |
0.5413 |
|
185 |
S |
A |
0.0000 |
|
186 |
L |
A |
0.3885 |
|
187 |
S |
A |
0.0000 |
|
188 |
S |
A |
0.0000 |
|
189 |
V |
A |
0.0000 |
|
190 |
V |
A |
0.0000 |
|
191 |
T |
A |
-0.1719 |
|
192 |
V |
A |
0.0000 |
|
193 |
P |
A |
-0.5438 |
|
194 |
S |
A |
-0.6311 |
|
195 |
S |
A |
-0.7391 |
|
196 |
S |
A |
0.0000 |
|
197 |
L |
A |
-0.7149 |
|
198 |
G |
A |
-1.0480 |
|
199 |
T |
A |
-0.9034 |
|
200 |
Q |
A |
-1.3620 |
|
201 |
T |
A |
-1.1808 |
|
202 |
Y |
A |
0.0000 |
|
203 |
I |
A |
-1.1841 |
|
204 |
C |
A |
0.0000 |
|
205 |
N |
A |
-1.4820 |
|
206 |
V |
A |
0.0000 |
|
207 |
N |
A |
-1.8759 |
|
208 |
H |
A |
0.0000 |
|
209 |
K |
A |
-2.8436 |
|
210 |
P |
A |
-1.9239 |
|
211 |
S |
A |
-1.7725 |
|
212 |
N |
A |
-2.4769 |
|
213 |
T |
A |
-2.0053 |
|
214 |
K |
A |
-2.6256 |
|
215 |
V |
A |
-1.6096 |
|
216 |
D |
A |
-2.6025 |
|
217 |
K |
A |
-2.2585 |
|
218 |
K |
A |
-2.6068 |
|
219 |
V |
A |
-1.7407 |
|
220 |
E |
A |
-2.6301 |
|
221 |
P |
A |
-1.8279 |
|
222 |
K |
A |
-2.5579 |
|
223 |
S |
A |
-1.7781 |
|