Chain sequence(s) |
A: LRVAPTVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYSTLIDGLCKAGKLDEALKLFEEMVEKGIKPNVVTYSTLIDGLCKAGKLDEALKLFEMKGIKPNVVTYNTLIDGLCKAGKLDEALKLFEEMKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGLDEALKLFEEMVEKGIKPDELTYRRVVEY |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | VA52R, VA87R, VA122R, VA157R, VA192R, YA229R, VA262R, VA297R, VA332R, VA367R, VA408R |
Energy difference between WT (input) and mutated protein (by FoldX) | -0.860189 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
42 | L | A | 1.0142 | |
43 | R | A | -0.4649 | |
47 | V | A | 1.4696 | |
48 | A | A | 0.6918 | |
49 | P | A | -0.1281 | |
50 | T | A | -0.4964 | |
51 | V | A | -1.1710 | |
52 | R | A | -1.9517 | mutated: VA52R |
53 | T | A | -0.8196 | |
54 | Y | A | 0.0000 | |
55 | N | A | -1.3862 | |
56 | T | A | -0.9599 | |
57 | L | A | -0.0631 | |
58 | I | A | 0.0000 | |
59 | D | A | -2.3128 | |
60 | G | A | -1.6643 | |
61 | L | A | -2.0888 | |
62 | C | A | -2.5979 | |
63 | K | A | -2.8760 | |
64 | A | A | -2.2238 | |
65 | G | A | -2.6322 | |
66 | K | A | -3.2116 | |
67 | L | A | -2.9971 | |
68 | D | A | -3.4021 | |
69 | E | A | -3.4338 | |
70 | A | A | 0.0000 | |
71 | L | A | -2.0572 | |
72 | K | A | -3.0966 | |
73 | L | A | -1.6888 | |
74 | F | A | -1.3401 | |
75 | E | A | -2.5809 | |
76 | E | A | -2.2723 | |
77 | M | A | 0.0000 | |
78 | V | A | -1.1696 | |
79 | E | A | -2.7966 | |
80 | K | A | -2.8621 | |
81 | G | A | -1.7442 | |
82 | I | A | -1.4062 | |
83 | K | A | -1.7351 | |
84 | P | A | 0.0000 | |
85 | D | A | -1.7143 | |
86 | V | A | -1.4021 | |
87 | R | A | -2.5443 | mutated: VA87R |
88 | T | A | 0.0000 | |
89 | Y | A | 0.0000 | |
90 | N | A | 0.0000 | |
91 | T | A | -1.5757 | |
92 | L | A | 0.0000 | |
93 | I | A | 0.0000 | |
94 | D | A | -1.5232 | |
95 | G | A | 0.0000 | |
96 | L | A | 0.0000 | |
97 | C | A | -2.2027 | |
98 | K | A | -2.6489 | |
99 | A | A | -1.7826 | |
100 | G | A | -2.2818 | |
101 | K | A | -2.7483 | |
102 | L | A | 0.0000 | |
103 | D | A | -3.2696 | |
104 | E | A | -3.4114 | |
105 | A | A | 0.0000 | |
106 | L | A | -2.1900 | |
107 | K | A | -3.2180 | |
108 | L | A | 0.0000 | |
109 | F | A | -1.6708 | |
110 | E | A | -2.6511 | |
111 | E | A | -2.3149 | |
112 | M | A | 0.0000 | |
113 | V | A | -1.2409 | |
114 | E | A | -2.8485 | |
115 | K | A | -2.9381 | |
116 | G | A | -1.8936 | |
117 | I | A | 0.0000 | |
118 | K | A | -1.9705 | |
119 | P | A | 0.0000 | |
120 | D | A | -2.0010 | |
121 | V | A | -1.2720 | |
122 | R | A | -2.1731 | mutated: VA122R |
123 | T | A | 0.0000 | |
124 | Y | A | 0.0000 | |
125 | N | A | 0.0000 | |
126 | T | A | 0.0000 | |
127 | L | A | 0.0000 | |
128 | I | A | 0.0000 | |
129 | D | A | -1.1461 | |
130 | G | A | -1.4985 | |
131 | L | A | 0.0000 | |
132 | C | A | -1.8308 | |
133 | K | A | -2.4117 | |
134 | A | A | -1.6239 | |
135 | G | A | -1.9064 | |
136 | K | A | -2.3145 | |
137 | L | A | -2.2406 | |
138 | D | A | -3.1262 | |
139 | E | A | -3.3707 | |
140 | A | A | 0.0000 | |
141 | L | A | -2.1096 | |
142 | K | A | -3.1995 | |
143 | L | A | 0.0000 | |
144 | F | A | -1.5378 | |
145 | E | A | -2.3631 | |
146 | E | A | -1.8711 | |
147 | M | A | 0.0000 | |
148 | V | A | -0.5987 | |
149 | E | A | -2.3286 | |
150 | K | A | -2.2686 | |
151 | G | A | -1.3855 | |
152 | I | A | -1.2517 | |
153 | K | A | -1.7063 | |
154 | P | A | 0.0000 | |
155 | D | A | -1.2315 | |
156 | V | A | -0.6401 | |
157 | R | A | -0.8343 | mutated: VA157R |
158 | T | A | 0.0000 | |
159 | Y | A | 0.0000 | |
160 | N | A | 0.0000 | |
161 | T | A | -0.3494 | |
162 | L | A | 0.0000 | |
163 | I | A | 0.0000 | |
164 | D | A | 0.0000 | |
165 | G | A | 0.0000 | |
166 | L | A | 0.0000 | |
167 | C | A | -1.5486 | |
168 | K | A | -1.8583 | |
169 | A | A | -1.3059 | |
170 | G | A | -1.8491 | |
171 | K | A | -2.2776 | |
172 | L | A | -2.1712 | |
173 | D | A | -2.8703 | |
174 | E | A | -2.9408 | |
175 | A | A | 0.0000 | |
176 | L | A | -1.8588 | |
177 | K | A | -2.8064 | |
178 | L | A | 0.0000 | |
179 | F | A | -1.3276 | |
180 | E | A | -2.5336 | |
181 | E | A | -1.8576 | |
182 | M | A | 0.0000 | |
183 | V | A | -0.6846 | |
184 | E | A | -2.2795 | |
185 | K | A | -1.8858 | |
186 | G | A | -1.3592 | |
187 | I | A | -1.0342 | |
188 | K | A | -1.6531 | |
189 | P | A | -1.0126 | |
190 | D | A | -1.0503 | |
191 | V | A | -0.7919 | |
192 | R | A | -0.8391 | mutated: VA192R |
193 | T | A | 0.0000 | |
194 | Y | A | 0.0000 | |
195 | S | A | 0.0000 | |
196 | T | A | 0.0000 | |
197 | L | A | 0.0000 | |
198 | I | A | 0.0000 | |
199 | D | A | 0.0000 | |
200 | G | A | 0.0000 | |
201 | L | A | 0.0000 | |
202 | C | A | -1.8380 | |
203 | K | A | -2.3790 | |
204 | A | A | -1.5365 | |
205 | G | A | -1.9960 | |
206 | K | A | -2.2664 | |
207 | L | A | -2.1034 | |
208 | D | A | -2.9448 | |
209 | E | A | -3.1589 | |
210 | A | A | 0.0000 | |
211 | L | A | -1.9209 | |
212 | K | A | -3.1441 | |
213 | L | A | -1.8307 | |
214 | F | A | -2.0677 | |
215 | E | A | -3.1979 | |
216 | E | A | -2.9225 | |
217 | M | A | 0.0000 | |
218 | V | A | -2.1280 | |
219 | E | A | -3.3432 | |
220 | K | A | -3.2327 | |
221 | G | A | -2.3239 | |
222 | I | A | -1.7856 | |
223 | K | A | -1.9899 | |
224 | P | A | 0.0000 | |
225 | N | A | -1.0249 | |
226 | V | A | -0.4283 | |
227 | V | A | 0.0000 | |
228 | T | A | 0.0000 | |
229 | R | A | -0.1031 | mutated: YA229R |
230 | S | A | 0.0000 | |
231 | T | A | 0.0000 | |
232 | L | A | 0.0000 | |
233 | I | A | 0.0000 | |
234 | D | A | -1.1361 | |
235 | G | A | 0.0000 | |
236 | L | A | 0.0000 | |
237 | C | A | 0.0000 | |
238 | K | A | -2.6521 | |
239 | A | A | -1.5627 | |
240 | G | A | -1.9991 | |
241 | K | A | -2.3215 | |
242 | L | A | -2.0842 | |
243 | D | A | -2.9070 | |
244 | E | A | -2.7589 | |
245 | A | A | 0.0000 | |
246 | L | A | -1.8330 | |
247 | K | A | -2.8252 | |
248 | L | A | -1.5886 | |
249 | F | A | 0.0000 | |
250 | E | A | -2.3656 | |
252 | M | A | -1.6033 | |
255 | K | A | -2.2568 | |
256 | G | A | -1.8276 | |
257 | I | A | -1.4929 | |
258 | K | A | -1.9534 | |
259 | P | A | -1.3561 | |
260 | N | A | -1.1137 | |
261 | V | A | -0.9432 | |
262 | R | A | -0.9086 | mutated: VA262R |
263 | T | A | 0.0000 | |
264 | Y | A | 0.0000 | |
265 | N | A | 0.0000 | |
266 | T | A | 0.0000 | |
267 | L | A | 0.0000 | |
268 | I | A | 0.0000 | |
269 | D | A | -1.8785 | |
270 | G | A | 0.0000 | |
271 | L | A | 0.0000 | |
272 | C | A | 0.0000 | |
273 | K | A | -2.8187 | |
274 | A | A | -1.7096 | |
275 | G | A | -2.1091 | |
276 | K | A | -2.5893 | |
277 | L | A | 0.0000 | |
278 | D | A | -3.1794 | |
279 | E | A | -3.5225 | |
280 | A | A | 0.0000 | |
281 | L | A | -2.0309 | |
282 | K | A | -2.8245 | |
283 | L | A | 0.0000 | |
284 | F | A | -1.5725 | |
285 | E | A | -2.3989 | |
286 | E | A | -1.4601 | |
287 | M | A | -0.1597 | |
290 | K | A | -2.1913 | |
291 | G | A | -1.5682 | |
292 | I | A | -1.6402 | |
293 | K | A | -2.3768 | |
294 | P | A | -2.2343 | |
295 | D | A | -2.9261 | |
296 | V | A | -2.1323 | |
297 | R | A | -2.5501 | mutated: VA297R |
298 | T | A | 0.0000 | |
299 | Y | A | 0.0000 | |
300 | N | A | 0.0000 | |
301 | T | A | 0.0000 | |
302 | L | A | 0.0000 | |
303 | I | A | 0.0000 | |
304 | D | A | -2.4452 | |
305 | G | A | 0.0000 | |
306 | L | A | 0.0000 | |
307 | C | A | 0.0000 | |
308 | K | A | -2.8298 | |
309 | A | A | -1.7142 | |
310 | G | A | -2.0767 | |
311 | K | A | -2.3786 | |
312 | L | A | -2.1833 | |
313 | D | A | -2.8829 | |
314 | E | A | -2.8587 | |
315 | A | A | 0.0000 | |
316 | L | A | -1.8990 | |
317 | K | A | -3.1299 | |
318 | L | A | 0.0000 | |
319 | F | A | -1.7659 | |
320 | E | A | -2.8962 | |
321 | E | A | -2.5987 | |
322 | M | A | 0.0000 | |
323 | V | A | -1.1449 | |
324 | E | A | -2.7361 | |
325 | K | A | -2.7710 | |
326 | G | A | -1.8431 | |
327 | I | A | 0.0000 | |
328 | K | A | -2.3337 | |
329 | P | A | 0.0000 | |
330 | D | A | -3.0284 | |
331 | V | A | -2.3076 | |
332 | R | A | -2.8793 | mutated: VA332R |
333 | T | A | 0.0000 | |
334 | Y | A | 0.0000 | |
335 | N | A | 0.0000 | |
336 | T | A | -1.3966 | |
337 | L | A | 0.0000 | |
338 | I | A | 0.0000 | |
339 | D | A | -1.4607 | |
340 | G | A | -1.6743 | |
341 | L | A | 0.0000 | |
342 | C | A | 0.0000 | |
343 | K | A | -2.4643 | |
344 | A | A | -1.6206 | |
345 | G | A | -2.0538 | |
346 | K | A | -2.4260 | |
347 | L | A | -2.0686 | |
348 | D | A | -2.8721 | |
349 | E | A | -2.7941 | |
350 | A | A | 0.0000 | |
351 | L | A | -2.0884 | |
352 | K | A | -3.0227 | |
353 | L | A | 0.0000 | |
354 | F | A | 0.0000 | |
355 | E | A | -2.7141 | |
356 | E | A | -2.2799 | |
357 | M | A | 0.0000 | |
358 | V | A | -0.8423 | |
359 | E | A | -2.5551 | |
360 | K | A | -2.4599 | |
361 | G | A | -1.6084 | |
362 | I | A | -1.7834 | |
363 | K | A | -1.9435 | |
364 | P | A | 0.0000 | |
365 | D | A | -1.5063 | |
366 | V | A | -0.9944 | |
367 | R | A | -2.0447 | mutated: VA367R |
368 | T | A | 0.0000 | |
369 | Y | A | 0.0000 | |
370 | N | A | -0.9333 | |
371 | T | A | 0.0000 | |
372 | L | A | 0.0000 | |
373 | I | A | 0.0000 | |
374 | D | A | -0.9157 | |
375 | G | A | 0.0000 | |
376 | L | A | 0.0000 | |
377 | C | A | -1.1691 | |
378 | K | A | -1.9947 | |
379 | A | A | -1.2386 | |
380 | G | A | -1.0137 | |
382 | L | A | -0.8011 | |
383 | D | A | -2.1233 | |
384 | E | A | -2.2583 | |
385 | A | A | 0.0000 | |
386 | L | A | -1.7000 | |
387 | K | A | -2.9083 | |
388 | L | A | 0.0000 | |
389 | F | A | -1.2478 | |
390 | E | A | -2.4464 | |
391 | E | A | -1.9189 | |
392 | M | A | 0.0000 | |
393 | V | A | -0.7032 | |
394 | E | A | -2.2911 | |
395 | K | A | -2.1212 | |
396 | G | A | -1.3335 | |
397 | I | A | -1.0979 | |
398 | K | A | -1.6943 | |
399 | P | A | -1.0557 | |
400 | D | A | -1.8496 | |
401 | E | A | -2.1598 | |
402 | L | A | -1.4640 | |
403 | T | A | 0.0000 | |
404 | Y | A | -1.7229 | |
405 | R | A | -3.1498 | |
406 | R | A | -2.3817 | |
407 | V | A | 0.0000 | |
408 | R | A | -2.7542 | mutated: VA408R |
409 | E | A | -2.8981 | |
411 | Y | A | 0.0568 |