| Chain sequence(s) |
A: ILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICCIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMMNPASKVIALKAGKTLQIFNIEMKSKMMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEEL C: GDLLNLDL |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 4 | I | A | 2.1498 | |
| 5 | L | A | 1.4929 | |
| 6 | P | A | 0.0000 | |
| 7 | I | A | 0.0000 | |
| 8 | R | A | -1.2937 | |
| 9 | F | A | -0.4140 | |
| 10 | Q | A | -1.2567 | |
| 11 | E | A | -1.8851 | |
| 12 | H | A | -1.2143 | |
| 13 | L | A | -0.8875 | |
| 14 | Q | A | -1.3359 | |
| 15 | L | A | 0.0000 | |
| 16 | Q | A | -1.9427 | |
| 17 | N | A | -1.7545 | |
| 18 | L | A | -1.0900 | |
| 19 | G | A | -1.2627 | |
| 20 | I | A | 0.0000 | |
| 21 | N | A | -1.9546 | |
| 22 | P | A | -1.5926 | |
| 23 | A | A | -0.8545 | |
| 24 | N | A | -0.8588 | |
| 25 | I | A | 0.0000 | |
| 26 | G | A | 0.1331 | |
| 27 | F | A | 1.2723 | |
| 28 | S | A | 0.2987 | |
| 29 | T | A | 0.0083 | |
| 30 | L | A | 0.0000 | |
| 31 | T | A | 0.1173 | |
| 32 | M | A | 0.0000 | |
| 33 | E | A | -0.6471 | |
| 34 | S | A | -0.9712 | |
| 35 | D | A | -1.4333 | |
| 36 | K | A | -1.7448 | |
| 37 | F | A | 0.0000 | |
| 38 | I | A | 0.0000 | |
| 39 | C | A | 0.0000 | |
| 40 | I | A | 0.0000 | |
| 41 | R | A | -0.8196 | |
| 42 | E | A | 0.0000 | |
| 43 | K | A | -1.8480 | |
| 44 | V | A | -0.1142 | |
| 45 | G | A | -1.1572 | |
| 46 | E | A | -2.2937 | |
| 47 | Q | A | -1.7309 | |
| 48 | A | A | -1.4427 | |
| 49 | Q | A | -1.1872 | |
| 50 | V | A | 0.0000 | |
| 51 | V | A | 0.0000 | |
| 52 | I | A | 0.0000 | |
| 53 | I | A | 0.0000 | |
| 54 | D | A | -1.7051 | |
| 55 | M | A | -1.6625 | |
| 56 | N | A | -2.3928 | |
| 57 | D | A | -2.6563 | |
| 58 | P | A | -1.6063 | |
| 59 | S | A | -1.4680 | |
| 60 | N | A | -1.8737 | |
| 61 | P | A | -0.9202 | |
| 62 | I | A | -0.2040 | |
| 63 | R | A | -0.9815 | |
| 64 | R | A | -1.2335 | |
| 65 | P | A | -1.2103 | |
| 66 | I | A | 0.0000 | |
| 67 | S | A | -1.0993 | |
| 68 | A | A | -0.9127 | |
| 69 | D | A | -1.2316 | |
| 70 | S | A | -0.6434 | |
| 71 | A | A | 0.0000 | |
| 72 | I | A | 0.0000 | |
| 73 | M | A | 0.0000 | |
| 74 | N | A | 0.0000 | |
| 75 | P | A | -0.1512 | |
| 76 | A | A | -0.1368 | |
| 77 | S | A | -0.4640 | |
| 78 | K | A | -0.8174 | |
| 79 | V | A | -0.4197 | |
| 80 | I | A | 0.0000 | |
| 81 | A | A | 0.0000 | |
| 82 | L | A | 0.0000 | |
| 83 | K | A | 0.0000 | |
| 84 | A | A | -0.9343 | |
| 85 | G | A | -1.4593 | |
| 86 | K | A | -1.7740 | |
| 87 | T | A | -0.8485 | |
| 88 | L | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | I | A | 0.0000 | |
| 91 | F | A | 0.0000 | |
| 92 | N | A | -0.7854 | |
| 93 | I | A | -1.2148 | |
| 94 | E | A | -1.6589 | |
| 95 | M | A | -0.4165 | |
| 96 | K | A | -1.3400 | |
| 97 | S | A | -1.0008 | |
| 98 | K | A | -1.4383 | |
| 99 | M | A | -0.2093 | |
| 100 | K | A | -0.7634 | |
| 101 | A | A | -0.6513 | |
| 102 | H | A | -0.6713 | |
| 103 | T | A | -0.7691 | |
| 104 | M | A | 0.0000 | |
| 105 | T | A | -0.9234 | |
| 106 | D | A | -2.2576 | |
| 107 | D | A | -2.8889 | |
| 108 | V | A | 0.0000 | |
| 109 | T | A | -1.2537 | |
| 110 | F | A | -0.4220 | |
| 111 | W | A | 0.0000 | |
| 112 | K | A | -0.3127 | |
| 113 | W | A | 0.0000 | |
| 114 | I | A | 0.2133 | |
| 115 | S | A | 0.3984 | |
| 116 | L | A | 1.1185 | |
| 117 | N | A | -0.4675 | |
| 118 | T | A | -0.2818 | |
| 119 | V | A | 0.0000 | |
| 120 | A | A | 0.0000 | |
| 121 | L | A | 0.0000 | |
| 122 | V | A | 0.0000 | |
| 123 | T | A | 0.0000 | |
| 124 | D | A | -3.1017 | |
| 125 | N | A | -3.0437 | |
| 126 | A | A | 0.0000 | |
| 127 | V | A | 0.0000 | |
| 128 | Y | A | -0.1411 | |
| 129 | H | A | 0.0000 | |
| 130 | W | A | 0.0000 | |
| 131 | S | A | -1.0790 | |
| 132 | M | A | 0.0000 | |
| 133 | E | A | -2.8562 | |
| 134 | G | A | -2.4201 | |
| 135 | E | A | -2.8708 | |
| 136 | S | A | -1.9840 | |
| 137 | Q | A | -1.7193 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.8386 | |
| 140 | K | A | -0.8999 | |
| 141 | M | A | -0.5517 | |
| 142 | F | A | 0.0000 | |
| 143 | D | A | -2.7655 | |
| 144 | R | A | -2.0727 | |
| 145 | H | A | -1.4697 | |
| 146 | S | A | -0.9571 | |
| 147 | S | A | -0.6329 | |
| 148 | L | A | 0.0000 | |
| 149 | A | A | -0.9783 | |
| 150 | G | A | -0.9274 | |
| 151 | C | A | -0.7487 | |
| 152 | Q | A | -1.1085 | |
| 153 | I | A | 0.0000 | |
| 154 | I | A | 0.1429 | |
| 155 | N | A | -0.4135 | |
| 156 | Y | A | 0.0000 | |
| 157 | R | A | -0.3734 | |
| 158 | T | A | -0.6653 | |
| 159 | D | A | 0.0000 | |
| 160 | A | A | -1.0695 | |
| 161 | K | A | -2.1503 | |
| 162 | Q | A | -1.6040 | |
| 163 | K | A | -2.3578 | |
| 164 | W | A | -1.2361 | |
| 165 | L | A | 0.0000 | |
| 166 | L | A | 0.0000 | |
| 167 | L | A | 0.0000 | |
| 168 | T | A | 0.0000 | |
| 169 | G | A | 0.0000 | |
| 170 | I | A | -0.2623 | |
| 171 | S | A | -0.5222 | |
| 172 | A | A | -1.1042 | |
| 173 | Q | A | -2.0728 | |
| 174 | Q | A | -2.5090 | |
| 175 | N | A | -2.4295 | |
| 176 | R | A | -2.0437 | |
| 177 | V | A | -0.6303 | |
| 178 | V | A | -0.7065 | |
| 179 | G | A | 0.0000 | |
| 180 | A | A | -0.5254 | |
| 181 | M | A | 0.0000 | |
| 182 | Q | A | 0.0000 | |
| 183 | L | A | 0.0000 | |
| 184 | Y | A | 0.0000 | |
| 185 | S | A | 0.0000 | |
| 186 | V | A | -2.0002 | |
| 187 | D | A | -3.2418 | |
| 188 | R | A | -3.3993 | |
| 189 | K | A | -2.6837 | |
| 190 | V | A | -1.2683 | |
| 191 | S | A | -1.1983 | |
| 192 | Q | A | -1.1115 | |
| 193 | P | A | -0.9937 | |
| 194 | I | A | -0.7584 | |
| 195 | E | A | -1.3314 | |
| 196 | G | A | 0.0000 | |
| 197 | H | A | 0.0000 | |
| 198 | A | A | 0.0000 | |
| 199 | A | A | 0.0000 | |
| 200 | S | A | 0.0000 | |
| 201 | F | A | 0.0000 | |
| 202 | A | A | 0.0000 | |
| 203 | Q | A | -1.5186 | |
| 204 | F | A | 0.0000 | |
| 205 | K | A | -3.2817 | |
| 206 | M | A | -2.5911 | |
| 207 | E | A | -2.5824 | |
| 208 | G | A | -2.0117 | |
| 209 | N | A | 0.0000 | |
| 210 | A | A | -1.8693 | |
| 211 | E | A | -2.8902 | |
| 212 | E | A | -3.1028 | |
| 213 | S | A | 0.0000 | |
| 214 | T | A | 0.0000 | |
| 215 | L | A | 0.0000 | |
| 216 | F | A | 0.0000 | |
| 217 | C | A | 0.0000 | |
| 218 | F | A | 0.0000 | |
| 219 | A | A | 0.0000 | |
| 220 | V | A | 0.0000 | |
| 221 | R | A | -1.1614 | |
| 222 | G | A | -1.2991 | |
| 223 | Q | A | -1.5255 | |
| 224 | A | A | -0.9088 | |
| 225 | G | A | -0.9794 | |
| 226 | G | A | -0.9078 | |
| 227 | K | A | -1.3934 | |
| 228 | L | A | 0.0000 | |
| 229 | H | A | -0.7905 | |
| 230 | I | A | 0.0000 | |
| 231 | I | A | -0.4976 | |
| 232 | E | A | -0.5419 | |
| 233 | V | A | -0.0451 | |
| 234 | G | A | -0.8045 | |
| 235 | T | A | -0.5260 | |
| 236 | P | A | -1.1123 | |
| 237 | P | A | -1.1959 | |
| 238 | T | A | -0.7597 | |
| 239 | G | A | -1.1268 | |
| 240 | N | A | -2.0416 | |
| 241 | Q | A | -1.9757 | |
| 242 | P | A | -1.2476 | |
| 243 | F | A | 0.0000 | |
| 244 | P | A | -1.3460 | |
| 245 | K | A | -1.9363 | |
| 246 | K | A | -1.1183 | |
| 247 | A | A | -0.8955 | |
| 248 | V | A | -0.6636 | |
| 249 | D | A | -1.5302 | |
| 250 | V | A | 0.0000 | |
| 251 | F | A | 1.3888 | |
| 252 | F | A | 0.1142 | |
| 253 | P | A | -0.3917 | |
| 254 | P | A | -1.3265 | |
| 255 | E | A | -2.4566 | |
| 256 | A | A | -1.8177 | |
| 257 | Q | A | -2.4255 | |
| 258 | N | A | -2.3064 | |
| 259 | D | A | 0.0000 | |
| 260 | F | A | 0.0000 | |
| 261 | P | A | 0.0000 | |
| 262 | V | A | 0.3450 | |
| 263 | A | A | 0.1656 | |
| 264 | M | A | 0.0000 | |
| 265 | Q | A | 0.0000 | |
| 266 | I | A | -0.5335 | |
| 267 | S | A | 0.0000 | |
| 268 | E | A | -2.6993 | |
| 269 | K | A | -2.6333 | |
| 270 | H | A | 0.0000 | |
| 271 | D | A | -1.4530 | |
| 272 | V | A | 0.0000 | |
| 273 | V | A | 0.0000 | |
| 274 | F | A | 0.0000 | |
| 275 | L | A | 0.0000 | |
| 276 | I | A | 0.0000 | |
| 277 | T | A | 0.0000 | |
| 278 | K | A | -0.3496 | |
| 279 | Y | A | -0.4004 | |
| 280 | G | A | 0.0000 | |
| 281 | Y | A | -0.7151 | |
| 282 | I | A | 0.0000 | |
| 283 | H | A | 0.0000 | |
| 284 | L | A | 0.0000 | |
| 285 | Y | A | 0.0000 | |
| 286 | D | A | 0.0000 | |
| 287 | L | A | 0.0000 | |
| 288 | E | A | -0.8486 | |
| 289 | T | A | -0.4331 | |
| 290 | G | A | 0.0000 | |
| 291 | T | A | -0.0902 | |
| 292 | C | A | 0.4521 | |
| 293 | I | A | 0.0000 | |
| 294 | Y | A | 0.0000 | |
| 295 | M | A | -0.1499 | |
| 296 | N | A | -1.5057 | |
| 297 | R | A | -1.7717 | |
| 298 | I | A | -0.6331 | |
| 299 | S | A | 0.0000 | |
| 300 | G | A | -1.3361 | |
| 301 | E | A | -1.8041 | |
| 302 | T | A | -0.9737 | |
| 303 | I | A | 0.0000 | |
| 304 | F | A | 0.3924 | |
| 305 | V | A | 0.5126 | |
| 306 | T | A | -0.0077 | |
| 307 | A | A | 0.0000 | |
| 308 | P | A | -0.9087 | |
| 309 | H | A | -1.2932 | |
| 310 | E | A | -2.0795 | |
| 311 | A | A | -0.9440 | |
| 312 | T | A | -0.9640 | |
| 313 | A | A | -1.4073 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | I | A | 0.0000 | |
| 317 | G | A | 0.0000 | |
| 318 | V | A | 0.0000 | |
| 319 | N | A | 0.0000 | |
| 320 | R | A | -1.8845 | |
| 321 | K | A | -2.4880 | |
| 322 | G | A | 0.0000 | |
| 323 | Q | A | -1.5964 | |
| 324 | V | A | 0.0000 | |
| 325 | L | A | 0.0000 | |
| 326 | S | A | 0.0000 | |
| 327 | V | A | 0.0000 | |
| 328 | C | A | 0.0000 | |
| 329 | V | A | 0.0000 | |
| 330 | E | A | -1.4856 | |
| 331 | E | A | -2.6456 | |
| 332 | E | A | -2.2908 | |
| 333 | N | A | -1.0689 | |
| 334 | I | A | 0.0000 | |
| 335 | I | A | 0.0000 | |
| 336 | P | A | -0.3480 | |
| 337 | Y | A | 0.4301 | |
| 338 | I | A | 0.0000 | |
| 339 | T | A | 0.0000 | |
| 340 | N | A | -0.6133 | |
| 341 | V | A | 1.0971 | |
| 342 | L | A | 0.2760 | |
| 343 | Q | A | -1.1374 | |
| 344 | N | A | -1.0760 | |
| 345 | P | A | -1.2092 | |
| 346 | D | A | -1.7442 | |
| 347 | L | A | 0.0000 | |
| 348 | A | A | 0.0000 | |
| 349 | L | A | 0.2226 | |
| 350 | R | A | -0.0999 | |
| 351 | M | A | 0.0000 | |
| 352 | A | A | 0.0000 | |
| 353 | V | A | 1.2705 | |
| 354 | R | A | -0.0727 | |
| 355 | N | A | -0.9644 | |
| 356 | N | A | -0.9105 | |
| 357 | L | A | -0.7694 | |
| 358 | A | A | -0.8988 | |
| 359 | G | A | -1.1422 | |
| 360 | A | A | -0.6215 | |
| 361 | E | A | -2.2495 | |
| 362 | E | A | -1.9096 | |
| 363 | L | A | -0.2523 | |
| 2 | G | C | -1.5070 | |
| 3 | D | C | -2.5065 | |
| 4 | L | C | 0.0000 | |
| 5 | L | C | 0.0000 | |
| 6 | N | C | -2.0095 | |
| 7 | L | C | -1.2997 | |
| 8 | D | C | -1.3531 | |
| 9 | L | C | 0.5080 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine