| Chain sequence(s) |
A: LSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKY B: HLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 2 | L | A | 0.4603 | |
| 3 | S | A | 0.0865 | |
| 4 | P | A | -0.1804 | |
| 5 | A | A | -0.2647 | |
| 6 | D | A | 0.0000 | |
| 7 | K | A | -1.1160 | |
| 8 | T | A | -0.9660 | |
| 9 | N | A | -0.9614 | |
| 10 | V | A | 0.0000 | |
| 11 | K | A | -2.1480 | |
| 12 | A | A | -1.4852 | |
| 13 | A | A | 0.0000 | |
| 14 | W | A | -1.4489 | |
| 15 | G | A | -1.8702 | |
| 16 | K | A | -2.4617 | |
| 17 | V | A | 0.0000 | |
| 18 | G | A | -1.4228 | |
| 19 | A | A | -1.1086 | |
| 20 | H | A | -1.8842 | |
| 21 | A | A | -1.7588 | |
| 22 | G | A | -2.3205 | |
| 23 | E | A | -2.2767 | |
| 24 | Y | A | 0.0000 | |
| 25 | G | A | 0.0000 | |
| 26 | A | A | 0.0000 | |
| 27 | E | A | -1.0253 | |
| 28 | A | A | 0.0000 | |
| 29 | L | A | 0.0000 | |
| 30 | E | A | -0.5855 | |
| 31 | R | A | 0.0000 | |
| 32 | M | A | 0.0000 | |
| 33 | F | A | 0.0000 | |
| 34 | L | A | 0.5182 | |
| 35 | S | A | 0.2583 | |
| 36 | F | A | 0.1157 | |
| 37 | P | A | -0.2647 | |
| 38 | T | A | -0.2573 | |
| 39 | T | A | 0.0000 | |
| 40 | K | A | -0.6220 | |
| 41 | T | A | -0.3252 | |
| 42 | Y | A | 0.0132 | |
| 43 | F | A | -0.2361 | |
| 44 | P | A | -0.7519 | |
| 45 | H | A | -1.2352 | |
| 46 | F | A | -1.0102 | |
| 47 | D | A | -2.0370 | |
| 48 | L | A | -1.3054 | |
| 49 | S | A | -1.1821 | |
| 50 | H | A | -1.6990 | |
| 51 | G | A | -1.5659 | |
| 52 | S | A | 0.0000 | |
| 53 | A | A | -1.3448 | |
| 54 | Q | A | -1.8979 | |
| 55 | V | A | 0.0000 | |
| 56 | K | A | -2.7439 | |
| 57 | G | A | -2.2419 | |
| 58 | H | A | -1.9399 | |
| 59 | G | A | 0.0000 | |
| 60 | K | A | -2.9961 | |
| 61 | K | A | -2.3546 | |
| 62 | V | A | -1.3726 | |
| 63 | A | A | 0.0000 | |
| 64 | D | A | -1.7520 | |
| 65 | A | A | -1.1653 | |
| 66 | L | A | 0.0000 | |
| 67 | T | A | -1.3274 | |
| 68 | N | A | -1.5187 | |
| 69 | A | A | 0.0000 | |
| 70 | V | A | 0.0000 | |
| 71 | A | A | -1.3613 | |
| 72 | H | A | -2.1592 | |
| 73 | V | A | -1.7593 | |
| 74 | D | A | -2.6346 | |
| 75 | D | A | -2.8463 | |
| 76 | M | A | 0.0000 | |
| 77 | P | A | -1.6257 | |
| 78 | N | A | -2.0780 | |
| 79 | A | A | -1.5729 | |
| 80 | L | A | 0.0000 | |
| 81 | S | A | -0.7605 | |
| 82 | A | A | -0.2853 | |
| 83 | L | A | -0.2479 | |
| 84 | S | A | 0.0000 | |
| 85 | D | A | -1.4153 | |
| 86 | L | A | -1.1009 | |
| 87 | H | A | -1.2599 | |
| 88 | A | A | 0.0000 | |
| 89 | H | A | -2.1785 | |
| 90 | K | A | -2.4635 | |
| 91 | L | A | -1.4443 | |
| 92 | R | A | -2.4536 | |
| 93 | V | A | -1.0328 | |
| 94 | D | A | -1.1419 | |
| 95 | P | A | -0.3164 | |
| 96 | V | A | 0.8621 | |
| 97 | N | A | 0.0125 | |
| 98 | F | A | -0.2766 | |
| 99 | K | A | -1.1303 | |
| 100 | L | A | -0.1231 | |
| 101 | L | A | 0.0328 | |
| 102 | S | A | -0.4580 | |
| 103 | H | A | 0.0000 | |
| 104 | C | A | 0.0000 | |
| 105 | L | A | 0.0000 | |
| 106 | L | A | 0.0000 | |
| 107 | V | A | 0.0000 | |
| 108 | T | A | 0.0000 | |
| 109 | L | A | 0.0000 | |
| 110 | A | A | 0.0000 | |
| 111 | A | A | 0.0000 | |
| 112 | H | A | -1.0471 | |
| 113 | L | A | 0.0000 | |
| 114 | P | A | -0.5653 | |
| 115 | A | A | -0.5034 | |
| 116 | E | A | -0.7685 | |
| 117 | F | A | 0.0000 | |
| 118 | T | A | -0.3694 | |
| 119 | P | A | -0.2633 | |
| 120 | A | A | -0.2334 | |
| 121 | V | A | -0.2402 | |
| 122 | H | A | 0.0000 | |
| 123 | A | A | -0.3566 | |
| 124 | S | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | D | A | -1.1381 | |
| 127 | K | A | -1.5088 | |
| 128 | F | A | 0.0000 | |
| 129 | L | A | 0.0000 | |
| 130 | A | A | -0.9631 | |
| 131 | S | A | -0.3789 | |
| 132 | V | A | 0.0000 | |
| 133 | S | A | -0.3820 | |
| 134 | T | A | -0.2664 | |
| 135 | V | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | T | A | -0.4326 | |
| 138 | S | A | -0.3842 | |
| 139 | K | A | -0.6936 | |
| 140 | Y | A | 0.2241 | |
| 2 | H | B | -1.5015 | |
| 3 | L | B | -1.3971 | |
| 4 | T | B | -1.3411 | |
| 5 | P | B | -1.7363 | |
| 6 | E | B | -2.4680 | |
| 7 | E | B | -1.9499 | |
| 8 | K | B | -1.9697 | |
| 9 | S | B | -1.5009 | |
| 10 | A | B | -1.0322 | |
| 11 | V | B | 0.0000 | |
| 12 | T | B | -0.7032 | |
| 13 | A | B | -0.6486 | |
| 14 | L | B | 0.0000 | |
| 15 | W | B | -0.6207 | |
| 16 | G | B | -1.2153 | |
| 17 | K | B | -1.9182 | |
| 18 | V | B | 0.0000 | |
| 19 | N | B | -1.9249 | |
| 20 | V | B | -0.6851 | |
| 21 | D | B | -2.4022 | |
| 22 | E | B | -2.1534 | |
| 23 | V | B | 0.0000 | |
| 24 | G | B | 0.0000 | |
| 25 | G | B | 0.0000 | |
| 26 | E | B | -0.9406 | |
| 27 | A | B | 0.0000 | |
| 28 | L | B | 0.0000 | |
| 29 | G | B | 0.0000 | |
| 30 | R | B | 0.0000 | |
| 31 | L | B | 0.0000 | |
| 32 | L | B | 0.0000 | |
| 33 | V | B | 0.1608 | |
| 34 | V | B | 0.1797 | |
| 35 | Y | B | 0.3844 | |
| 36 | P | B | 0.1713 | |
| 37 | W | B | 0.6213 | |
| 38 | T | B | 0.0000 | |
| 39 | Q | B | -0.8970 | |
| 40 | R | B | -1.8272 | |
| 41 | F | B | -0.6563 | |
| 42 | F | B | -1.1174 | |
| 43 | E | B | -2.4725 | |
| 44 | S | B | -1.5952 | |
| 45 | F | B | -1.3987 | |
| 46 | G | B | -1.9258 | |
| 47 | D | B | -2.6448 | |
| 48 | L | B | -1.4682 | |
| 49 | S | B | -1.0286 | |
| 50 | T | B | -1.0319 | |
| 51 | P | B | -1.1277 | |
| 52 | D | B | -2.1210 | |
| 53 | A | B | -1.5936 | |
| 54 | V | B | 0.0000 | |
| 55 | M | B | -1.0275 | |
| 56 | G | B | -1.4941 | |
| 57 | N | B | 0.0000 | |
| 58 | P | B | -1.4551 | |
| 59 | K | B | -2.0777 | |
| 60 | V | B | 0.0000 | |
| 61 | K | B | -2.1084 | |
| 62 | A | B | -1.8835 | |
| 63 | H | B | -1.5848 | |
| 64 | G | B | 0.0000 | |
| 65 | K | B | -2.2003 | |
| 66 | K | B | -2.0082 | |
| 67 | V | B | -0.5059 | |
| 68 | L | B | 0.0000 | |
| 69 | G | B | -1.2616 | |
| 70 | A | B | -0.9449 | |
| 71 | F | B | 0.0000 | |
| 72 | S | B | -0.8676 | |
| 73 | D | B | -1.8598 | |
| 74 | G | B | 0.0000 | |
| 75 | L | B | -0.9525 | |
| 76 | A | B | -1.1530 | |
| 77 | H | B | -2.1938 | |
| 78 | L | B | -1.9959 | |
| 79 | D | B | -2.9311 | |
| 80 | N | B | -2.8857 | |
| 81 | L | B | -2.3408 | |
| 82 | K | B | -2.9438 | |
| 83 | G | B | -1.9202 | |
| 84 | T | B | -1.5847 | |
| 85 | F | B | 0.0000 | |
| 86 | A | B | -1.1084 | |
| 87 | T | B | -0.6718 | |
| 88 | L | B | -0.5744 | |
| 89 | S | B | 0.0000 | |
| 90 | E | B | -2.4967 | |
| 91 | L | B | -1.4065 | |
| 92 | H | B | -1.5783 | |
| 93 | C | B | 0.0000 | |
| 94 | D | B | -3.2357 | |
| 95 | K | B | -2.7110 | |
| 96 | L | B | -1.3973 | |
| 97 | H | B | -2.1169 | |
| 98 | V | B | -1.9049 | |
| 99 | D | B | -2.6408 | |
| 100 | P | B | -2.4137 | |
| 101 | E | B | -2.9818 | |
| 102 | N | B | -1.7174 | |
| 103 | F | B | 0.0000 | |
| 104 | R | B | -2.3445 | |
| 105 | L | B | -0.9173 | |
| 106 | L | B | -0.4223 | |
| 107 | G | B | -0.4726 | |
| 108 | N | B | -0.4950 | |
| 109 | V | B | 0.0000 | |
| 110 | L | B | 0.0000 | |
| 111 | V | B | 0.0000 | |
| 112 | C | B | 0.0000 | |
| 113 | V | B | 0.0000 | |
| 114 | L | B | 0.0000 | |
| 115 | A | B | 0.0000 | |
| 116 | H | B | -0.7607 | |
| 117 | H | B | -1.1617 | |
| 118 | F | B | -1.3711 | |
| 119 | G | B | -1.7097 | |
| 120 | K | B | -2.6960 | |
| 121 | E | B | -2.6172 | |
| 122 | F | B | 0.0000 | |
| 123 | T | B | -1.0990 | |
| 124 | P | B | 0.0000 | |
| 125 | P | B | -0.2747 | |
| 126 | V | B | -0.5501 | |
| 127 | Q | B | 0.0000 | |
| 128 | A | B | 0.0000 | |
| 129 | A | B | 0.0000 | |
| 130 | Y | B | 0.0000 | |
| 131 | Q | B | 0.0000 | |
| 132 | K | B | -0.5867 | |
| 133 | V | B | 0.0000 | |
| 134 | V | B | 0.0000 | |
| 135 | A | B | -0.8036 | |
| 136 | G | B | -1.2625 | |
| 137 | V | B | -0.6717 | |
| 138 | A | B | 0.0000 | |
| 139 | N | B | -2.0862 | |
| 140 | A | B | 0.0000 | |
| 141 | L | B | 0.0000 | |
| 142 | A | B | 0.0000 | |
| 143 | H | B | -2.0674 | |
| 144 | K | B | -2.5168 | |
| 145 | Y | B | -1.5462 | |
| 146 | H | B | -1.3992 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine