Project name: 5dk3:B
Status: done
submitted: 2019-03-21 13:16:45, status changed: 2019-03-21 13:33:47
Settings
Chain sequence(s)
|
B: QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.8244
-
Maximal score value
-
2.4451
-
Average score
-
-0.7356
-
Total score value
-
-324.3971
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
Q |
B |
-1.3765 |
|
2 |
V |
B |
-0.7509 |
|
3 |
Q |
B |
-0.6522 |
|
4 |
L |
B |
0.0000 |
|
5 |
V |
B |
0.8063 |
|
6 |
Q |
B |
0.0000 |
|
7 |
S |
B |
-0.3116 |
|
8 |
G |
B |
-0.4580 |
|
9 |
V |
B |
-0.4121 |
|
10 |
E |
B |
-0.7782 |
|
11 |
V |
B |
-0.4387 |
|
12 |
K |
B |
-1.2163 |
|
13 |
K |
B |
-1.9347 |
|
14 |
P |
B |
-1.3559 |
|
15 |
G |
B |
-1.3013 |
|
16 |
A |
B |
-1.4409 |
|
17 |
S |
B |
-1.8130 |
|
18 |
V |
B |
0.0000 |
|
19 |
K |
B |
-2.2596 |
|
20 |
V |
B |
0.0000 |
|
21 |
S |
B |
-0.4144 |
|
22 |
C |
B |
0.0000 |
|
23 |
K |
B |
-0.3561 |
|
24 |
A |
B |
0.0000 |
|
25 |
S |
B |
-0.5609 |
|
26 |
G |
B |
-0.8948 |
|
27 |
Y |
B |
-0.4638 |
|
28 |
T |
B |
-0.3943 |
|
29 |
F |
B |
0.0000 |
|
30 |
T |
B |
-0.6895 |
|
31 |
N |
B |
-1.2495 |
|
32 |
Y |
B |
-0.0771 |
|
33 |
Y |
B |
-0.1185 |
|
34 |
M |
B |
0.0000 |
|
35 |
Y |
B |
0.3754 |
|
36 |
W |
B |
0.0000 |
|
37 |
V |
B |
0.0000 |
|
38 |
R |
B |
0.0000 |
|
39 |
Q |
B |
-0.4302 |
|
40 |
A |
B |
-0.9840 |
|
41 |
P |
B |
-1.2235 |
|
42 |
G |
B |
-1.3389 |
|
43 |
Q |
B |
-1.5645 |
|
44 |
G |
B |
-0.6606 |
|
45 |
L |
B |
0.8612 |
|
46 |
E |
B |
0.2079 |
|
47 |
W |
B |
0.4419 |
|
48 |
M |
B |
0.0000 |
|
49 |
G |
B |
0.0000 |
|
50 |
G |
B |
0.0000 |
|
51 |
I |
B |
0.0000 |
|
52 |
N |
B |
0.0000 |
|
53 |
P |
B |
-0.8689 |
|
54 |
S |
B |
-1.0916 |
|
55 |
N |
B |
-1.6597 |
|
56 |
G |
B |
-1.1819 |
|
57 |
G |
B |
-1.1255 |
|
58 |
T |
B |
-0.9339 |
|
59 |
N |
B |
-1.6684 |
|
60 |
F |
B |
-1.7746 |
|
61 |
N |
B |
-2.2377 |
|
62 |
E |
B |
-3.6669 |
|
63 |
K |
B |
-3.2463 |
|
64 |
F |
B |
0.0000 |
|
65 |
K |
B |
-3.6866 |
|
66 |
N |
B |
-2.9288 |
|
67 |
R |
B |
-2.4247 |
|
68 |
V |
B |
0.0000 |
|
69 |
T |
B |
-1.1872 |
|
70 |
L |
B |
0.0000 |
|
71 |
T |
B |
-0.3876 |
|
72 |
T |
B |
-0.6616 |
|
73 |
D |
B |
-0.9474 |
|
74 |
S |
B |
-0.7208 |
|
75 |
S |
B |
-0.5567 |
|
76 |
T |
B |
-0.5738 |
|
77 |
T |
B |
-0.5871 |
|
78 |
T |
B |
0.0000 |
|
79 |
A |
B |
0.0000 |
|
80 |
Y |
B |
-0.6235 |
|
81 |
M |
B |
0.0000 |
|
82 |
E |
B |
-1.8526 |
|
83 |
L |
B |
0.0000 |
|
84 |
K |
B |
-2.3586 |
|
85 |
S |
B |
-1.6060 |
|
86 |
L |
B |
0.0000 |
|
87 |
Q |
B |
-1.0050 |
|
88 |
F |
B |
0.3319 |
|
89 |
D |
B |
-1.1291 |
|
90 |
D |
B |
0.0000 |
|
91 |
T |
B |
-0.3168 |
|
92 |
A |
B |
0.0000 |
|
93 |
V |
B |
0.2061 |
|
94 |
Y |
B |
0.0000 |
|
95 |
Y |
B |
0.3671 |
|
96 |
C |
B |
0.0000 |
|
97 |
A |
B |
0.0000 |
|
98 |
R |
B |
0.0000 |
|
99 |
R |
B |
-0.2584 |
|
100 |
D |
B |
-0.4069 |
|
101 |
Y |
B |
0.0468 |
|
102 |
R |
B |
-0.9173 |
|
103 |
F |
B |
0.6463 |
|
104 |
D |
B |
-0.7455 |
|
105 |
M |
B |
0.2341 |
|
106 |
G |
B |
-0.2025 |
|
107 |
F |
B |
-0.0018 |
|
108 |
D |
B |
-0.9748 |
|
109 |
Y |
B |
0.0729 |
|
110 |
W |
B |
0.4196 |
|
111 |
G |
B |
0.0189 |
|
112 |
Q |
B |
-0.7478 |
|
113 |
G |
B |
-0.2753 |
|
114 |
T |
B |
0.0000 |
|
115 |
T |
B |
-0.1561 |
|
116 |
V |
B |
0.0000 |
|
117 |
T |
B |
0.0000 |
|
118 |
V |
B |
0.0000 |
|
119 |
S |
B |
-0.6254 |
|
120 |
S |
B |
-0.6965 |
|
121 |
A |
B |
-0.5057 |
|
122 |
S |
B |
-0.5283 |
|
123 |
T |
B |
-0.4631 |
|
124 |
K |
B |
-1.0076 |
|
125 |
G |
B |
-1.4716 |
|
126 |
P |
B |
-0.6205 |
|
127 |
S |
B |
-0.0822 |
|
128 |
V |
B |
0.0000 |
|
129 |
F |
B |
0.8733 |
|
130 |
P |
B |
0.2400 |
|
131 |
L |
B |
0.7300 |
|
132 |
A |
B |
0.2881 |
|
133 |
P |
B |
-0.0020 |
|
134 |
C |
B |
0.3686 |
|
135 |
S |
B |
-0.3803 |
|
136 |
R |
B |
-1.2718 |
|
137 |
S |
B |
-1.1591 |
|
138 |
T |
B |
-1.3475 |
|
139 |
S |
B |
-1.6619 |
|
140 |
E |
B |
-2.4460 |
|
141 |
S |
B |
-1.3277 |
|
142 |
T |
B |
-0.9004 |
|
143 |
A |
B |
0.0000 |
|
144 |
A |
B |
0.0292 |
|
145 |
L |
B |
0.0000 |
|
146 |
G |
B |
0.0000 |
|
147 |
C |
B |
0.0000 |
|
148 |
L |
B |
0.7026 |
|
149 |
V |
B |
0.0000 |
|
150 |
K |
B |
-0.2151 |
|
151 |
D |
B |
-0.3278 |
|
152 |
Y |
B |
0.0000 |
|
153 |
F |
B |
-0.1493 |
|
154 |
P |
B |
0.0000 |
|
155 |
E |
B |
-0.5936 |
|
156 |
P |
B |
-0.7787 |
|
157 |
V |
B |
0.0000 |
|
158 |
T |
B |
-0.8759 |
|
159 |
V |
B |
-0.4612 |
|
160 |
S |
B |
-0.4956 |
|
161 |
W |
B |
0.0000 |
|
162 |
N |
B |
-1.0793 |
|
163 |
S |
B |
-0.7631 |
|
164 |
G |
B |
-0.5728 |
|
165 |
A |
B |
-0.2480 |
|
166 |
L |
B |
-0.0819 |
|
167 |
T |
B |
-0.2682 |
|
168 |
S |
B |
-0.3240 |
|
169 |
G |
B |
-0.3694 |
|
170 |
V |
B |
0.1418 |
|
171 |
H |
B |
-0.2668 |
|
172 |
T |
B |
0.2490 |
|
173 |
F |
B |
0.9565 |
|
174 |
P |
B |
0.6682 |
|
175 |
A |
B |
1.2265 |
|
176 |
V |
B |
2.4451 |
|
177 |
L |
B |
2.1713 |
|
178 |
Q |
B |
0.6498 |
|
179 |
S |
B |
0.0530 |
|
180 |
S |
B |
-0.2424 |
|
181 |
G |
B |
0.1892 |
|
182 |
L |
B |
0.3715 |
|
183 |
Y |
B |
0.8589 |
|
184 |
S |
B |
0.0000 |
|
185 |
L |
B |
0.0000 |
|
186 |
S |
B |
0.6593 |
|
187 |
S |
B |
0.0000 |
|
188 |
V |
B |
0.5147 |
|
189 |
V |
B |
0.0000 |
|
190 |
T |
B |
-0.1738 |
|
191 |
V |
B |
0.0000 |
|
192 |
P |
B |
-0.6951 |
|
193 |
S |
B |
-1.0258 |
|
194 |
S |
B |
-0.6067 |
|
195 |
S |
B |
-0.8753 |
|
196 |
L |
B |
0.0000 |
|
197 |
G |
B |
-0.9877 |
|
198 |
T |
B |
-1.0698 |
|
199 |
K |
B |
-1.8004 |
|
200 |
T |
B |
-1.5763 |
|
201 |
Y |
B |
0.0000 |
|
202 |
T |
B |
-1.8016 |
|
203 |
C |
B |
0.0000 |
|
204 |
N |
B |
-1.8881 |
|
205 |
V |
B |
0.0000 |
|
206 |
D |
B |
-2.6223 |
|
207 |
H |
B |
0.0000 |
|
208 |
K |
B |
-2.9627 |
|
209 |
P |
B |
-1.5851 |
|
210 |
S |
B |
-1.8331 |
|
211 |
N |
B |
-2.6617 |
|
212 |
T |
B |
-2.2612 |
|
213 |
K |
B |
-3.0012 |
|
214 |
V |
B |
-2.0141 |
|
215 |
D |
B |
-2.9394 |
|
216 |
K |
B |
-2.3701 |
|
217 |
R |
B |
-2.5597 |
|
218 |
V |
B |
0.0000 |
|
219 |
E |
B |
-1.4509 |
|
220 |
S |
B |
-1.5831 |
|
221 |
K |
B |
-1.7960 |
|
222 |
Y |
B |
0.2010 |
|
223 |
G |
B |
-0.4771 |
|
224 |
P |
B |
-0.5338 |
|
225 |
P |
B |
-0.4747 |
|
226 |
C |
B |
-0.1197 |
|
227 |
P |
B |
0.0051 |
|
228 |
P |
B |
0.1615 |
|
229 |
C |
B |
0.6255 |
|
233 |
E |
B |
-0.9601 |
|
234 |
F |
B |
1.6076 |
|
235 |
L |
B |
1.4210 |
|
236 |
G |
B |
0.2946 |
|
237 |
G |
B |
0.0445 |
|
238 |
P |
B |
-0.1682 |
|
239 |
S |
B |
-0.0829 |
|
240 |
V |
B |
0.0000 |
|
241 |
F |
B |
1.2423 |
|
242 |
L |
B |
0.0000 |
|
243 |
F |
B |
1.0916 |
|
244 |
P |
B |
-0.1991 |
|
245 |
P |
B |
-1.4170 |
|
246 |
K |
B |
-2.7987 |
|
247 |
P |
B |
-2.5839 |
|
248 |
K |
B |
-2.9630 |
|
249 |
D |
B |
-2.5971 |
|
250 |
T |
B |
-0.7168 |
|
251 |
L |
B |
1.5440 |
|
252 |
M |
B |
2.2436 |
|
253 |
I |
B |
2.0293 |
|
254 |
S |
B |
0.3157 |
|
255 |
R |
B |
-0.9586 |
|
256 |
T |
B |
-0.7516 |
|
257 |
P |
B |
-1.2093 |
|
258 |
E |
B |
-1.1854 |
|
259 |
V |
B |
0.0000 |
|
260 |
T |
B |
0.0653 |
|
261 |
C |
B |
0.0000 |
|
262 |
V |
B |
0.8513 |
|
263 |
V |
B |
0.0000 |
|
264 |
V |
B |
-0.0835 |
|
265 |
D |
B |
-0.7054 |
|
266 |
V |
B |
0.0000 |
|
267 |
S |
B |
-1.7327 |
|
268 |
Q |
B |
-2.7385 |
|
269 |
E |
B |
-3.2301 |
|
270 |
D |
B |
-2.7758 |
|
271 |
P |
B |
-2.9612 |
|
272 |
E |
B |
-3.2695 |
|
273 |
V |
B |
-2.0045 |
|
274 |
Q |
B |
-1.7882 |
|
275 |
F |
B |
-0.8365 |
|
276 |
N |
B |
-1.0930 |
|
277 |
W |
B |
0.0000 |
|
278 |
Y |
B |
-0.6916 |
|
279 |
V |
B |
0.0000 |
|
280 |
D |
B |
-1.2191 |
|
281 |
G |
B |
-0.6178 |
|
282 |
V |
B |
0.4645 |
|
283 |
E |
B |
-0.8404 |
|
284 |
V |
B |
-0.8089 |
|
285 |
H |
B |
-1.9254 |
|
286 |
N |
B |
-2.1461 |
|
287 |
A |
B |
-1.8785 |
|
288 |
K |
B |
-2.3952 |
|
289 |
T |
B |
-1.8338 |
|
290 |
K |
B |
-2.3423 |
|
291 |
P |
B |
-2.2506 |
|
292 |
R |
B |
-3.7607 |
|
293 |
E |
B |
-3.8244 |
|
294 |
E |
B |
-3.3474 |
|
295 |
Q |
B |
-2.0006 |
|
296 |
F |
B |
-0.2934 |
|
297 |
N |
B |
-1.0327 |
|
298 |
S |
B |
-1.0691 |
|
299 |
T |
B |
0.0000 |
|
300 |
Y |
B |
-2.4747 |
|
301 |
R |
B |
-2.1603 |
|
302 |
V |
B |
0.0000 |
|
303 |
V |
B |
-0.8114 |
|
304 |
S |
B |
0.0000 |
|
305 |
V |
B |
0.0000 |
|
306 |
L |
B |
0.0000 |
|
307 |
T |
B |
-0.6829 |
|
308 |
V |
B |
-0.2614 |
|
309 |
L |
B |
-0.4429 |
|
310 |
H |
B |
-1.3877 |
|
311 |
Q |
B |
-1.4869 |
|
312 |
D |
B |
0.0000 |
|
313 |
W |
B |
-0.4540 |
|
314 |
L |
B |
-0.3552 |
|
315 |
N |
B |
0.0000 |
|
316 |
G |
B |
-1.3132 |
|
317 |
K |
B |
0.0000 |
|
318 |
E |
B |
-1.6532 |
|
319 |
Y |
B |
0.0000 |
|
320 |
K |
B |
-1.4203 |
|
321 |
C |
B |
0.0000 |
|
322 |
K |
B |
-1.1858 |
|
323 |
V |
B |
0.0000 |
|
324 |
S |
B |
-1.2496 |
|
325 |
N |
B |
0.0000 |
|
326 |
K |
B |
-2.8523 |
|
327 |
G |
B |
-2.0867 |
|
328 |
L |
B |
-0.7658 |
|
329 |
P |
B |
-0.7384 |
|
330 |
S |
B |
-0.5453 |
|
331 |
S |
B |
-0.6793 |
|
332 |
I |
B |
-0.7666 |
|
333 |
E |
B |
-1.6177 |
|
334 |
K |
B |
-1.1237 |
|
335 |
T |
B |
-0.8122 |
|
336 |
I |
B |
-0.3225 |
|
337 |
S |
B |
-0.9251 |
|
338 |
K |
B |
-1.3042 |
|
339 |
A |
B |
-1.1244 |
|
340 |
K |
B |
-2.1040 |
|
341 |
G |
B |
-1.5130 |
|
342 |
Q |
B |
-1.7045 |
|
343 |
P |
B |
-1.6907 |
|
344 |
R |
B |
-1.9395 |
|
345 |
E |
B |
-2.8163 |
|
346 |
P |
B |
0.0000 |
|
347 |
Q |
B |
-1.2881 |
|
348 |
V |
B |
-0.4248 |
|
349 |
Y |
B |
0.5160 |
|
350 |
T |
B |
0.3388 |
|
351 |
L |
B |
0.5580 |
|
352 |
P |
B |
-0.1132 |
|
353 |
P |
B |
-0.8318 |
|
354 |
S |
B |
-1.4207 |
|
355 |
Q |
B |
-2.2626 |
|
356 |
E |
B |
-2.7860 |
|
357 |
E |
B |
-2.3662 |
|
358 |
M |
B |
-2.0836 |
|
359 |
T |
B |
-1.8968 |
|
360 |
K |
B |
-2.8439 |
|
361 |
N |
B |
-2.9527 |
|
362 |
Q |
B |
-2.8983 |
|
363 |
V |
B |
0.0000 |
|
364 |
S |
B |
-0.7501 |
|
365 |
L |
B |
0.0000 |
|
366 |
T |
B |
0.0893 |
|
367 |
C |
B |
0.0000 |
|
368 |
L |
B |
0.5450 |
|
369 |
V |
B |
0.0000 |
|
370 |
K |
B |
-0.5269 |
|
371 |
G |
B |
-1.1127 |
|
372 |
F |
B |
0.0000 |
|
373 |
Y |
B |
0.0000 |
|
374 |
P |
B |
-1.3175 |
|
375 |
S |
B |
-0.7158 |
|
376 |
D |
B |
-1.9124 |
|
377 |
I |
B |
-0.8777 |
|
378 |
A |
B |
-0.1709 |
|
379 |
V |
B |
0.0000 |
|
380 |
E |
B |
-1.3030 |
|
381 |
W |
B |
0.0000 |
|
382 |
E |
B |
-1.6951 |
|
383 |
S |
B |
0.0000 |
|
384 |
N |
B |
-1.7811 |
|
385 |
G |
B |
-1.7343 |
|
386 |
Q |
B |
-2.1478 |
|
387 |
P |
B |
-1.9002 |
|
388 |
E |
B |
-2.0094 |
|
389 |
N |
B |
-2.4142 |
|
390 |
N |
B |
-2.2961 |
|
391 |
Y |
B |
-1.8682 |
|
392 |
K |
B |
-2.2706 |
|
393 |
T |
B |
-0.9971 |
|
394 |
T |
B |
-0.2860 |
|
395 |
P |
B |
-0.0867 |
|
396 |
P |
B |
0.4352 |
|
397 |
V |
B |
1.4571 |
|
398 |
L |
B |
0.8676 |
|
399 |
D |
B |
-0.3194 |
|
400 |
S |
B |
-0.8937 |
|
401 |
D |
B |
-1.7640 |
|
402 |
G |
B |
0.0000 |
|
403 |
S |
B |
0.0000 |
|
404 |
F |
B |
0.2407 |
|
405 |
F |
B |
0.6881 |
|
406 |
L |
B |
0.0000 |
|
407 |
Y |
B |
0.4599 |
|
408 |
S |
B |
0.0000 |
|
409 |
R |
B |
-1.4387 |
|
410 |
L |
B |
0.0000 |
|
411 |
T |
B |
-1.5134 |
|
412 |
V |
B |
0.0000 |
|
413 |
D |
B |
-3.0135 |
|
414 |
K |
B |
-2.8962 |
|
415 |
S |
B |
-2.3376 |
|
416 |
R |
B |
-2.1282 |
|
417 |
W |
B |
0.0000 |
|
418 |
Q |
B |
-2.3740 |
|
419 |
Q |
B |
-2.1106 |
|
420 |
G |
B |
-1.3171 |
|
421 |
N |
B |
-0.9251 |
|
422 |
V |
B |
-0.1481 |
|
423 |
F |
B |
0.0000 |
|
424 |
S |
B |
0.0000 |
|
425 |
C |
B |
0.0000 |
|
426 |
S |
B |
0.0000 |
|
427 |
V |
B |
0.0000 |
|
428 |
M |
B |
-0.7849 |
|
429 |
H |
B |
0.0000 |
|
430 |
E |
B |
-2.7952 |
|
431 |
A |
B |
-2.1455 |
|
432 |
L |
B |
-1.9909 |
|
433 |
H |
B |
-2.1657 |
|
434 |
N |
B |
-2.2229 |
|
435 |
H |
B |
-2.2210 |
|
436 |
Y |
B |
-0.9911 |
|
437 |
T |
B |
-0.9828 |
|
438 |
Q |
B |
-1.2445 |
|
439 |
K |
B |
-1.1602 |
|
440 |
S |
B |
-0.5814 |
|
441 |
L |
B |
0.0000 |
|
442 |
S |
B |
-0.1530 |
|
443 |
L |
B |
-0.2286 |
|
444 |
S |
B |
-0.2007 |
|