Need help?

• Read more about the Aggrescan3D method on our about page.
• To learn more about how to use the server and interpret the results please take a look at our tutorials .
• Don't hesitate to contact us if you need more help. See how to reach us.

News on Aggrescan3D development:

• Automated mutations are here! Analyze potential mutations on your proteins with the enhance protein solubility option. Read more in our tutorial.
• Dynamic mode has been extended to support multichain proteins and proteins longer than 400 AA
• Aggrescan3D standalone is now available. Check out our bitbucket repository to learn more!

Papers describing Aggrescan3D server and its example applications:

• Aggrescan3D (A3D) 2.0: prediction and engineering of protein solubility, Nucleic Acids Research, gkz321, 2019
• Aggrescan3D standalone package for structure-based prediction of protein aggregation properties Bioinformatics, btz143, 2019
• AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures, Nucleic Acids Research, 43, W306-W313, 2015
• Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility, Molecular Pharmaceutics, 10.1021/acs.molpharmaceut.8b00341, 2018
• The example guide for A3D 2.0: A3D 2.0 update for the prediction and optimization of protein solubility, Methods in Molecular Biology (biorxiv preprint), 2021