Help and News

• Find out more about the A3D method and how to use the server.
• A3D method is also available as the A3D standalone package.
• Check out the new database of A3D predictions for the human proteome.

Papers describing Aggrescan3D server and its example applications:

• Aggrescan3D (A3D) 2.0: prediction and engineering of protein solubility, Nucleic Acids Research, gkz321, 2019
• Aggrescan3D standalone package for structure-based prediction of protein aggregation properties Bioinformatics, btz143, 2019
• AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures, Nucleic Acids Research, 43, W306-W313, 2015
• Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility, Molecular Pharmaceutics, 10.1021/acs.molpharmaceut.8b00341, 2018
• The example guide for A3D 2.0: A3D 2.0 update for the prediction and optimization of protein solubility, Methods in Molecular Biology (biorxiv preprint), 2021