Aggrescan3D 2.0

Aggrescan3D 2.0 server for prediction of aggregation propensity in protein structures and rational design of protein solubility. In the dynamic mode, A3D takes into account protein flexibility.

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Read more about the Aggrescan3D method on our about page.
To learn more about how to use the server and interpret the results please take a look at our tutorials .
Don't hesitate to contact us if you need more help. See how to reach us.

News on Aggrescan3D development:

Automated mutations are here! Analyze potential mutations on your proteins with the enhance protein solubility option. Read more in our tutorial.
Dynamic mode has been extended to support multichain proteins and proteins longer than 400 AA
Aggrescan3D standalone is now available. Check out our bitbucket repository to learn more!

Papers describing Aggrescan3D server and its example applications:

Aggrescan3D (A3D) 2.0: prediction and engineering of protein solubility, Nucleic Acids Research, gkz321, 2019
Aggrescan3D standalone package for structure-based prediction of protein aggregation properties Bioinformatics, btz143, 2019
AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures, Nucleic Acids Research, 43, W306-W313, 2015
Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility, Molecular Pharmaceutics, 10.1021/acs.molpharmaceut.8b00341, 2018