| Chain sequence(s) |
A: QSVLTQPPSASGTPGQRVTISCSGSSSNIGSTSVYWYQQFPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCEAWDDSLSGYVFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECQVRLVQSGGGIVKPGGSLRLSCEASGFTSSDLWIHWVRQAPGKGLEWVSRISPDGGITNYTDSVKGRFTISRDNAKNTVYLQIGSLRAEDTAVYFCTRPWGRWGQGAQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:10)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -0.1645 | |
| 2 | S | A | 0.4981 | |
| 3 | V | A | 1.5241 | |
| 4 | L | A | 0.0000 | |
| 5 | T | A | 0.0541 | |
| 6 | Q | A | 0.0000 | |
| 7 | P | A | -0.4969 | |
| 8 | P | A | -0.6526 | |
| 10 | S | A | -0.6405 | |
| 11 | A | A | -0.4031 | |
| 12 | S | A | -0.4982 | |
| 13 | G | A | 0.0000 | |
| 14 | T | A | -1.1583 | |
| 15 | P | A | -1.9450 | |
| 16 | G | A | -2.0591 | |
| 17 | Q | A | -2.5518 | |
| 18 | R | A | -2.6080 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.6670 | |
| 21 | I | A | 0.0000 | |
| 22 | S | A | -0.2912 | |
| 23 | C | A | 0.0000 | |
| 24 | S | A | -0.3623 | |
| 25 | G | A | -0.4912 | |
| 26 | S | A | -0.5264 | |
| 27 | S | A | -0.8335 | |
| 28 | S | A | -0.7842 | |
| 29 | N | A | 0.0000 | |
| 30 | I | A | 0.0000 | |
| 30A | G | A | -0.9580 | |
| 30B | S | A | -0.7304 | |
| 31 | T | A | -0.4454 | |
| 32 | S | A | -0.1776 | |
| 33 | V | A | 0.0000 | |
| 34 | Y | A | -0.0421 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | -0.4575 | |
| 38 | Q | A | -0.2454 | |
| 39 | F | A | 0.3228 | |
| 40 | P | A | -0.1048 | |
| 41 | G | A | -0.4307 | |
| 42 | T | A | -0.3946 | |
| 43 | A | A | -0.6367 | |
| 44 | P | A | 0.0000 | |
| 45 | K | A | -0.9962 | |
| 46 | L | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | -0.2304 | |
| 50 | S | A | -0.6986 | |
| 51 | N | A | -1.1953 | |
| 52 | N | A | -2.0391 | |
| 53 | Q | A | -1.8658 | |
| 54 | R | A | -1.8502 | |
| 55 | P | A | -0.9057 | |
| 56 | S | A | -0.8455 | |
| 57 | G | A | -0.7752 | |
| 58 | V | A | -1.0763 | |
| 59 | P | A | -1.3735 | |
| 60 | D | A | -2.1708 | |
| 61 | R | A | -1.7929 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -1.3116 | |
| 64 | G | A | -1.1723 | |
| 65 | S | A | -1.1619 | |
| 65A | K | A | -1.2051 | |
| 67 | S | A | -0.8182 | |
| 68 | G | A | -0.9670 | |
| 69 | T | A | -0.8143 | |
| 70 | S | A | -0.7249 | |
| 71 | A | A | 0.0000 | |
| 72 | S | A | -0.5164 | |
| 73 | L | A | 0.0000 | |
| 74 | A | A | -0.6979 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -2.0131 | |
| 77 | G | A | -2.1113 | |
| 78 | L | A | 0.0000 | |
| 79 | R | A | -2.7888 | |
| 80 | S | A | -2.0373 | |
| 81 | E | A | -1.8473 | |
| 82 | D | A | 0.0000 | |
| 83 | E | A | -1.1117 | |
| 84 | A | A | 0.0000 | |
| 85 | D | A | -0.5618 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | E | A | 0.0000 | |
| 90 | A | A | 0.0000 | |
| 91 | W | A | 0.1788 | |
| 93A | D | A | 0.0000 | |
| 93B | D | A | -1.3630 | |
| 93C | S | A | -0.4210 | |
| 93D | L | A | 0.8125 | |
| 94 | S | A | -0.0046 | |
| 95 | G | A | -0.1089 | |
| 96 | Y | A | 0.4822 | |
| 97 | V | A | 0.6667 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | T | A | -0.2324 | |
| 101 | G | A | -0.7616 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -0.8465 | |
| 104 | V | A | 0.0000 | |
| 105 | T | A | 0.0000 | |
| 106 | V | A | 0.0000 | |
| 107 | L | A | -0.4642 | |
| 108 | G | A | -0.8012 | |
| 112 | Q | A | -1.2297 | |
| 113 | P | A | -1.3767 | |
| 114 | K | A | -1.8798 | |
| 115 | A | A | -1.0215 | |
| 116 | A | A | -0.7042 | |
| 117 | P | A | 0.0000 | |
| 118 | S | A | -0.1854 | |
| 119 | V | A | 0.0000 | |
| 120 | T | A | -0.3782 | |
| 121 | L | A | 0.0000 | |
| 122 | F | A | 0.0000 | |
| 123 | P | A | 0.0000 | |
| 124 | P | A | 0.0000 | |
| 125 | S | A | 0.0000 | |
| 126 | S | A | -1.1194 | |
| 127 | E | A | -1.6632 | |
| 128 | E | A | 0.0000 | |
| 129 | L | A | -1.5929 | |
| 130 | Q | A | -2.0284 | |
| 131 | A | A | -1.5799 | |
| 132 | N | A | -2.3509 | |
| 133 | K | A | -1.9450 | |
| 134 | A | A | 0.0000 | |
| 135 | T | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | V | A | 0.0000 | |
| 138 | C | A | 0.0000 | |
| 139 | L | A | 0.0000 | |
| 140 | I | A | 0.0000 | |
| 141 | S | A | 0.0000 | |
| 142 | D | A | -0.8246 | |
| 143 | F | A | 0.0000 | |
| 144 | Y | A | -0.9143 | |
| 145 | P | A | -0.5868 | |
| 146 | G | A | -0.3706 | |
| 147 | A | A | 0.0604 | |
| 148 | V | A | -0.0792 | |
| 149 | T | A | -0.0277 | |
| 150 | V | A | -0.0469 | |
| 151 | A | A | -0.4020 | |
| 152 | W | A | 0.0000 | |
| 153 | K | A | -0.9270 | |
| 154 | A | A | 0.0000 | |
| 155 | D | A | -1.8055 | |
| 156 | S | A | -1.1257 | |
| 157 | S | A | -0.7692 | |
| 158 | P | A | -0.8373 | |
| 159 | V | A | -0.8058 | |
| 160 | K | A | -1.5595 | |
| 161 | A | A | -0.6583 | |
| 162 | G | A | -0.5523 | |
| 163 | V | A | -0.1776 | |
| 164 | E | A | -0.5716 | |
| 165 | T | A | -0.2984 | |
| 166 | T | A | -0.2826 | |
| 167 | T | A | 0.0000 | |
| 168 | P | A | -0.6295 | |
| 169 | S | A | -1.0581 | |
| 170 | K | A | -1.5729 | |
| 171 | Q | A | -1.9472 | |
| 172 | S | A | -1.7209 | |
| 173 | N | A | -2.0781 | |
| 174 | N | A | -1.6650 | |
| 175 | K | A | -1.4955 | |
| 176 | Y | A | -0.5359 | |
| 177 | A | A | 0.0000 | |
| 178 | A | A | 0.0000 | |
| 179 | S | A | 0.0000 | |
| 180 | S | A | 0.0000 | |
| 181 | Y | A | 0.0000 | |
| 182 | L | A | 0.0000 | |
| 183 | S | A | -0.0845 | |
| 184 | L | A | -0.3988 | |
| 185 | T | A | -1.5241 | |
| 186 | P | A | -2.1866 | |
| 187 | E | A | -2.9374 | |
| 188 | Q | A | -2.2099 | |
| 189 | W | A | 0.0000 | |
| 190 | K | A | -2.9270 | |
| 191 | S | A | -2.2296 | |
| 192 | H | A | -2.1213 | |
| 193 | R | A | -2.3335 | |
| 194 | S | A | -1.6574 | |
| 195 | Y | A | 0.0000 | |
| 196 | S | A | 0.0000 | |
| 197 | C | A | 0.0000 | |
| 198 | Q | A | -0.7291 | |
| 199 | V | A | 0.0000 | |
| 200 | T | A | -0.5731 | |
| 201 | H | A | -0.7814 | |
| 202 | E | A | -1.6548 | |
| 203 | G | A | -1.2289 | |
| 204 | S | A | -0.9796 | |
| 205 | T | A | -0.6901 | |
| 206 | V | A | -0.6041 | |
| 207 | E | A | -1.2043 | |
| 208 | K | A | -1.2067 | |
| 209 | T | A | -0.8467 | |
| 210 | V | A | 0.0000 | |
| 211 | A | A | -1.2846 | |
| 212 | P | A | 0.0000 | |
| 213 | T | A | -1.5680 | |
| 214 | E | A | -1.9831 | |
| 215 | C | A | -0.8730 | |
| 1 | Q | A | -1.5441 | |
| 2 | V | A | -1.3218 | |
| 3 | R | A | -2.0804 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.5389 | |
| 6 | Q | A | -0.0603 | |
| 7 | S | A | -0.5693 | |
| 8 | G | A | -0.8448 | |
| 9 | G | A | -0.7129 | |
| 10 | G | A | -0.0813 | |
| 11 | I | A | 0.7665 | |
| 12 | V | A | -0.1522 | |
| 13 | K | A | -1.4027 | |
| 14 | P | A | -1.8620 | |
| 15 | G | A | -1.4174 | |
| 16 | G | A | -1.1242 | |
| 17 | S | A | -0.9414 | |
| 18 | L | A | -0.6693 | |
| 19 | R | A | -1.5334 | |
| 20 | L | A | 0.0000 | |
| 21 | S | A | -0.4114 | |
| 22 | C | A | 0.0000 | |
| 23 | E | A | -0.5646 | |
| 24 | A | A | -0.6348 | |
| 25 | S | A | -0.7506 | |
| 26 | G | A | -0.9901 | |
| 27 | F | A | -0.5731 | |
| 28 | T | A | -0.7915 | |
| 30A | S | A | 0.0000 | |
| 30B | S | A | -1.8612 | |
| 30C | D | A | -2.0638 | |
| 31 | L | A | -0.6126 | |
| 32 | W | A | -0.0220 | |
| 33 | I | A | 0.0000 | |
| 34 | H | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | R | A | 0.0000 | |
| 38 | Q | A | -0.7129 | |
| 39 | A | A | -1.1685 | |
| 40 | P | A | -1.1322 | |
| 41 | G | A | -1.4356 | |
| 42 | K | A | -2.1152 | |
| 43 | G | A | -1.1883 | |
| 44 | L | A | -0.4897 | |
| 45 | E | A | -0.6244 | |
| 46 | W | A | 0.0000 | |
| 47 | V | A | 0.0000 | |
| 48 | S | A | 0.0000 | |
| 49 | R | A | 0.0000 | |
| 50 | I | A | 0.0000 | |
| 51 | S | A | -0.1651 | |
| 51A | P | A | -1.3117 | |
| 52 | D | A | -2.4484 | |
| 53 | G | A | -1.3586 | |
| 54 | G | A | 0.0297 | |
| 55 | I | A | 1.4125 | |
| 56 | T | A | 0.5179 | |
| 57 | N | A | -0.6860 | |
| 58 | Y | A | -1.1310 | |
| 59 | T | A | -1.3768 | |
| 60 | D | A | -2.3854 | |
| 61 | S | A | -1.6065 | |
| 62 | V | A | 0.0000 | |
| 63 | K | A | -2.1280 | |
| 64 | G | A | -1.4202 | |
| 65 | R | A | -1.2870 | |
| 66 | F | A | 0.0000 | |
| 67 | T | A | -0.7717 | |
| 68 | I | A | 0.0000 | |
| 69 | S | A | -0.3667 | |
| 70 | R | A | -1.2170 | |
| 71 | D | A | -1.5313 | |
| 72 | N | A | -1.7999 | |
| 73 | A | A | -1.0027 | |
| 74 | K | A | -1.8341 | |
| 75 | N | A | -1.2498 | |
| 76 | T | A | 0.0000 | |
| 77 | V | A | 0.0000 | |
| 78 | Y | A | -0.4710 | |
| 79 | L | A | 0.0000 | |
| 80 | Q | A | -1.0083 | |
| 81 | I | A | 0.0000 | |
| 82 | G | A | -1.0435 | |
| 83 | S | A | -1.1837 | |
| 84 | L | A | 0.0000 | |
| 85 | R | A | -2.7193 | |
| 86 | A | A | -1.9278 | |
| 87 | E | A | -2.4252 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | -0.8091 | |
| 90 | A | A | 0.0000 | |
| 91 | V | A | -0.0432 | |
| 92 | Y | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | T | A | 0.0000 | |
| 96 | R | A | -0.7126 | |
| 97 | P | A | -0.2123 | |
| 98 | W | A | -0.2103 | |
| 99 | G | A | -0.8402 | |
| 100 | R | A | -1.6188 | |
| 105 | W | A | -1.0265 | |
| 106 | G | A | 0.0000 | |
| 107 | Q | A | -1.1738 | |
| 108 | G | A | -0.5590 | |
| 109 | A | A | 0.0000 | |
| 110 | Q | A | -0.5917 | |
| 111 | V | A | 0.0000 | |
| 112 | T | A | -0.2957 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.8213 | |
| 115 | S | A | -0.5928 | |
| 115! | A | A | -0.4488 | |
| "115""" | S | A | -0.4096 | |
| 116 | T | A | -0.6928 | |
| 117 | K | A | -0.9731 | |
| 118 | G | A | -1.2648 | |
| 119 | P | A | -0.5450 | |
| 120 | S | A | -0.2571 | |
| 121 | V | A | -0.2365 | |
| 122 | F | A | 0.0000 | |
| 123 | P | A | -0.5742 | |
| 124 | L | A | 0.0000 | |
| 125 | A | A | 0.0000 | |
| 126 | P | A | 0.0000 | |
| 127 | S | A | -0.5801 | |
| 128 | S | A | -0.6837 | |
| 129 | K | A | -0.7083 | |
| 130 | S | A | -0.7596 | |
| 131 | T | A | -0.7898 | |
| 132 | S | A | -0.7421 | |
| 133 | G | A | -0.8391 | |
| 134 | G | A | -0.8424 | |
| 135 | T | A | -0.5792 | |
| 136 | A | A | -0.3797 | |
| 137 | A | A | 0.0000 | |
| 138 | L | A | 0.0000 | |
| 139 | G | A | 0.0000 | |
| 140 | C | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | V | A | 0.0000 | |
| 143 | K | A | 0.0000 | |
| 144 | D | A | -0.1910 | |
| 145 | Y | A | 0.0000 | |
| 146 | F | A | 0.0000 | |
| 147 | P | A | -0.6946 | |
| 148 | E | A | -1.2827 | |
| 149 | P | A | -1.3587 | |
| 150 | V | A | 0.0000 | |
| 151 | T | A | -0.7639 | |
| 152 | V | A | -0.3648 | |
| 153 | S | A | -0.3113 | |
| 154 | W | A | 0.0000 | |
| 155 | N | A | -0.7516 | |
| 156 | S | A | -0.6845 | |
| 157 | G | A | -0.4438 | |
| 158 | A | A | -0.1956 | |
| 159 | L | A | -0.0556 | |
| 160 | T | A | -0.2042 | |
| 161 | S | A | -0.2379 | |
| 162 | G | A | -0.2376 | |
| 163 | V | A | 0.1612 | |
| 164 | H | A | 0.0000 | |
| 165 | T | A | 0.0326 | |
| 166 | F | A | 0.0000 | |
| 167 | P | A | -0.2136 | |
| 168 | A | A | 0.0559 | |
| 169 | V | A | 0.6584 | |
| 170 | L | A | 1.3321 | |
| 171 | Q | A | 0.5433 | |
| 172 | S | A | -0.0058 | |
| 173 | S | A | -0.1106 | |
| 174 | G | A | 0.1118 | |
| 175 | L | A | 0.1470 | |
| 176 | Y | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | L | A | 0.0000 | |
| 179 | S | A | 0.0000 | |
| 180 | S | A | 0.0000 | |
| 181 | V | A | 0.0000 | |
| 182 | V | A | 0.0000 | |
| 183 | T | A | -0.2055 | |
| 184 | V | A | 0.0000 | |
| 185 | P | A | -0.5545 | |
| 186 | S | A | 0.0000 | |
| 187 | S | A | -0.8233 | |
| 188 | S | A | -0.6371 | |
| 189 | L | A | -0.7545 | |
| 190 | G | A | -0.9064 | |
| 191 | T | A | -0.7740 | |
| 192 | Q | A | -1.1032 | |
| 193 | T | A | -0.9763 | |
| 194 | Y | A | 0.0000 | |
| 195 | I | A | -0.8489 | |
| 196 | C | A | 0.0000 | |
| 197 | N | A | 0.0000 | |
| 198 | V | A | 0.0000 | |
| 199 | N | A | -1.9540 | |
| 200 | H | A | 0.0000 | |
| 201 | K | A | -2.9045 | |
| 202 | P | A | -1.8070 | |
| 203 | S | A | -1.9255 | |
| 204 | N | A | -2.4855 | |
| 205 | T | A | -2.0041 | |
| 206 | K | A | -2.5414 | |
| 207 | V | A | -1.3248 | |
| 208 | D | A | -2.3894 | |
| 209 | K | A | -1.8758 | |
| 210 | R | A | -2.2269 | |
| 211 | V | A | 0.0000 | |
| 212 | E | A | -1.2993 | |
| 213 | P | A | -0.7716 | |
| 214 | K | A | -0.9102 | |
| 215 | S | A | -1.2257 | |
| 216 | C | A | -1.5328 | |
| 217 | D | A | -2.7218 | |
| 218 | K | A | -2.7368 | |
| 219 | T | A | -1.4522 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine