Project name: 58443739b5f4073

Chain sequence(s)	H: EVQLQESGPGLVKPSQSLSLTCTVTGYLITSDIVWTWIRQFPDNTLEWMGYITYSGSTGYNPSLNGRISVTRDTSKSQFFLQLNSVTSEDTATYYCVYGHFYSMDYWGQGTSVTVSS; L: DIVMTQSPVTLFVTPGHSVSLSCRASQSISSNLHWYQQESHESPRLLIKYASQSISGIPSRFSGSGSGTDFTLSINSVETEDFGLYFCQQSYSWPLTFGAGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:48)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:49)

• Minimal score value: -2.8597
• Maximal score value: 2.607
• Average score: -0.4095
• Total score value: -91.7382

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9900
2	V	H	-0.7906
3	Q	H	-1.4278
4	L	H	0.0000
5	Q	H	-1.3925
6	E	H	0.0000
7	S	H	-0.7406
8	G	H	-0.4950
9	P	H	-0.1331
10	G	H	0.0758
11	L	H	0.9251
12	V	H	0.0000
13	K	H	-1.4212
14	P	H	-1.5898
15	S	H	-1.4075
16	Q	H	-1.9681
17	S	H	-1.5211
18	L	H	0.0000
19	S	H	-0.7239
20	L	H	0.0000
21	T	H	-0.4109
22	C	H	0.0000
23	T	H	-0.9313
24	V	H	0.0000
25	T	H	-0.8673
26	G	H	-0.8707
27	Y	H	0.0304
28	L	H	0.7966
29	I	H	0.0000
30	T	H	0.1874
31	S	H	-0.1683
31A	D	H	-0.7629
32	I	H	0.1762
33	V	H	0.0000
34	W	H	0.0000
35	T	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	-0.5564
40	F	H	-0.8808
41	P	H	-1.3843
42	D	H	-2.0868
43	N	H	-1.4376
44	T	H	-0.8490
45	L	H	0.0000
46	E	H	-0.2371
47	W	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	Y	H	0.2555
51	I	H	0.0000
52	T	H	0.0376
53	Y	H	0.4228
54	S	H	-0.1543
55	G	H	-0.1843
56	S	H	-0.2156
57	T	H	-0.0383
58	G	H	0.0863
59	Y	H	-0.1018
60	N	H	0.0000
61	P	H	-0.9957
62	S	H	-0.9836
63	L	H	0.0000
64	N	H	-1.7258
65	G	H	-1.4286
66	R	H	-1.4684
67	I	H	0.0000
68	S	H	-0.6538
69	V	H	0.0000
70	T	H	-0.3585
71	R	H	-0.8515
72	D	H	-1.2245
73	T	H	-0.9134
74	S	H	-1.2747
75	K	H	-1.9729
76	S	H	-0.9453
77	Q	H	-0.9797
78	F	H	0.0000
79	F	H	-0.0854
80	L	H	0.0000
81	Q	H	-0.8466
82	L	H	0.0000
82A	N	H	-1.5192
82B	S	H	-1.3614
82C	V	H	0.0000
83	T	H	-1.3913
84	S	H	-1.3934
85	E	H	-1.9377
86	D	H	0.0000
87	T	H	-0.5781
88	A	H	0.0000
89	T	H	-0.3531
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	V	H	0.0000
94	Y	H	0.4764
95	G	H	0.0000
96	H	H	0.8799
97	F	H	2.6070
98	Y	H	2.2104
99	S	H	0.0000
100	M	H	0.0000
101	D	H	-0.0134
102	Y	H	0.4269
103	W	H	-0.3406
104	G	H	0.0000
105	Q	H	-1.9422
106	G	H	0.0000
107	T	H	-0.6960
108	S	H	-0.2114
109	V	H	0.0000
110	T	H	-0.1253
111	V	H	0.0000
112	S	H	-0.6353
113	S	H	-0.5653
1	D	L	-1.4346
2	I	L	0.0000
3	V	L	0.8792
4	M	L	0.0000
5	T	L	-0.1050
6	Q	L	0.0000
7	S	L	0.1286
8	P	L	0.5914
9	V	L	1.5269
10	T	L	0.7804
11	L	L	0.9485
12	F	L	1.1546
13	V	L	0.0000
14	T	L	-0.6721
15	P	L	-1.1952
16	G	L	-1.5341
17	H	L	-1.7579
18	S	L	-1.4962
19	V	L	0.0000
20	S	L	-0.4612
21	L	L	0.0000
22	S	L	-0.5814
23	C	L	0.0000
24	R	L	-1.8951
25	A	L	0.0000
26	S	L	-0.8987
27	Q	L	-1.5322
28	S	L	-1.1755
29	I	L	0.0000
30	S	L	-0.4750
31	S	L	-0.3275
32	N	L	0.6098
33	L	L	0.0000
34	H	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	E	L	-1.7148
40	S	L	-1.3590
41	H	L	-2.2430
42	E	L	-2.8597
43	S	L	-1.5835
44	P	L	0.0000
45	R	L	-0.9259
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	K	L	-0.3690
50	Y	L	-0.0546
51	A	L	0.0000
52	S	L	-0.9944
53	Q	L	-1.4008
54	S	L	-0.8804
55	I	L	-0.4720
56	S	L	-0.4553
57	G	L	-0.4487
58	I	L	-0.2026
59	P	L	-0.2865
60	S	L	-0.6174
61	R	L	-0.9941
62	F	L	0.0000
63	S	L	-0.8439
64	G	L	-0.6969
65	S	L	-0.8488
66	G	L	-1.1466
67	S	L	-1.1197
68	G	L	-1.2814
69	T	L	-1.7861
70	D	L	-2.3693
71	F	L	0.0000
72	T	L	-0.8254
73	L	L	0.0000
74	S	L	-0.6645
75	I	L	0.0000
76	N	L	-1.9576
77	S	L	-1.6561
78	V	L	0.0000
79	E	L	-1.8617
80	T	L	-1.2655
81	E	L	-2.1079
82	D	L	0.0000
83	F	L	-0.3637
84	G	L	0.0000
85	L	L	-0.2786
86	Y	L	0.0000
87	F	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	S	L	1.3648
92	Y	L	1.5098
93	S	L	0.3285
94	W	L	0.3922
95	P	L	0.0000
96	L	L	0.6408
97	T	L	0.3026
98	F	L	0.0000
99	G	L	0.0000
100	A	L	0.0357
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-0.3351
104	L	L	0.0000
105	E	L	-0.0484
106	L	L	0.5849
107	K	L	-0.7396