Project name: 5993746f8815327

Chain sequence(s)	H: EVQLLESGGGLVQPGGSLRLSCAASGYLITSDIVWTWVRQAPGKGLEWMGYITYSGSTGYNDSVKGRITVSRDTSKNTFYLQMNSLRAEDTAVYYCVYGHFYSMDYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQSISSNLHWYQQKPGKAPKLLIKYASQSISGIPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSWPLTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:51)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:52)

• Minimal score value: -2.7214
• Maximal score value: 1.6213
• Average score: -0.5114
• Total score value: -114.5548

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0405
2	V	H	-0.9703
3	Q	H	-1.2770
4	L	H	0.0000
5	L	H	0.8623
6	E	H	0.0000
7	S	H	-0.3205
8	G	H	-0.7170
9	G	H	0.0186
11	G	H	0.6897
12	L	H	1.3378
13	V	H	-0.0559
14	Q	H	-1.3228
15	P	H	-1.5977
16	G	H	-1.6239
17	G	H	-1.4213
18	S	H	-1.6840
19	L	H	0.0000
20	R	H	-1.8838
21	L	H	0.0000
22	S	H	-0.3926
23	C	H	0.0000
24	A	H	-0.1399
25	A	H	0.0000
26	S	H	-0.5214
27	G	H	-0.7965
28	Y	H	0.4540
29	L	H	1.5169
30	I	H	0.0000
31	T	H	0.3672
35	S	H	0.0633
36	D	H	-0.5644
37	I	H	0.0000
38	V	H	0.0000
39	W	H	0.0000
40	T	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5658
45	A	H	-0.9606
46	P	H	-0.8125
47	G	H	-1.4391
48	K	H	-2.2831
49	G	H	-1.4665
50	L	H	0.0000
51	E	H	-0.7802
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	Y	H	0.1920
56	I	H	0.0000
57	T	H	-0.1417
58	Y	H	0.2084
59	S	H	-0.2445
63	G	H	-0.3263
64	S	H	-0.2783
65	T	H	-0.0868
66	G	H	-0.2708
67	Y	H	-0.7117
68	N	H	-1.4817
69	D	H	-2.6686
70	S	H	-1.6246
71	V	H	0.0000
72	K	H	-2.5383
74	G	H	-1.8142
75	R	H	-1.6234
76	I	H	0.0000
77	T	H	-0.8774
78	V	H	0.0000
79	S	H	-0.4218
80	R	H	-0.8998
81	D	H	-1.2752
82	T	H	-0.9125
83	S	H	-1.2982
84	K	H	-2.1175
85	N	H	-0.8885
86	T	H	0.0000
87	F	H	0.0000
88	Y	H	-0.5207
89	L	H	0.0000
90	Q	H	-1.3651
91	M	H	0.0000
92	N	H	-2.1917
93	S	H	-1.6452
94	L	H	0.0000
95	R	H	-2.6501
96	A	H	-1.8154
97	E	H	-2.3209
98	D	H	0.0000
99	T	H	-0.4057
100	A	H	0.0000
101	V	H	0.7183
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	V	H	0.0000
106	Y	H	0.1923
107	G	H	0.0000
108	H	H	0.2839
109	F	H	1.5652
113	Y	H	1.2459
114	S	H	0.0000
115	M	H	0.0000
116	D	H	-0.0118
117	Y	H	-0.1460
118	W	H	-0.2659
119	G	H	0.0000
120	Q	H	-1.3553
121	G	H	-0.3735
122	T	H	0.4876
123	L	H	1.6213
124	V	H	0.0000
125	T	H	0.3222
126	V	H	0.0000
127	S	H	-0.4994
128	S	H	-0.4881
1	D	L	-2.2703
2	I	L	0.0000
3	Q	L	-2.2347
4	M	L	0.0000
5	T	L	-1.4284
6	Q	L	0.0000
7	S	L	-0.7137
8	P	L	-0.4760
9	S	L	-0.7689
10	S	L	-0.8550
11	L	L	-0.6857
12	S	L	-0.9942
13	A	L	0.0000
14	S	L	-0.7544
15	V	L	0.1151
16	G	L	-0.7524
17	D	L	-1.7216
18	R	L	-2.2665
19	V	L	0.0000
20	T	L	-0.6234
21	I	L	0.0000
22	T	L	-0.8182
23	C	L	0.0000
24	R	L	-2.7214
25	A	L	0.0000
26	S	L	-1.8091
27	Q	L	-1.6262
28	S	L	-0.9923
29	I	L	0.0000
36	S	L	-0.3663
37	S	L	-0.2220
38	N	L	0.3674
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7323
44	Q	L	0.0000
45	K	L	-1.4804
46	P	L	-1.0646
47	G	L	-1.6366
48	K	L	-2.5828
49	A	L	-1.5326
50	P	L	0.0000
51	K	L	-1.3026
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	K	L	-0.4731
56	Y	L	-0.1051
57	A	L	0.0000
65	S	L	-0.8760
66	Q	L	-1.3341
67	S	L	-0.8641
68	I	L	-0.5668
69	S	L	-0.4706
70	G	L	-0.4748
71	I	L	-0.3203
72	P	L	-0.3529
74	S	L	-0.5136
75	R	L	-0.8045
76	F	L	0.0000
77	S	L	-0.6820
78	G	L	-0.6064
79	S	L	-0.7014
80	G	L	-0.9468
83	S	L	-0.9757
84	G	L	-1.1241
85	T	L	-1.6153
86	D	L	-2.0828
87	F	L	0.0000
88	T	L	-0.7312
89	L	L	0.0000
90	T	L	-0.6361
91	I	L	0.0000
92	S	L	-1.4318
93	S	L	-1.1795
94	L	L	0.0000
95	Q	L	-0.6422
96	P	L	-0.9511
97	E	L	-1.5511
98	D	L	0.0000
99	F	L	-0.1465
100	A	L	0.0000
101	T	L	-0.6841
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	1.0197
108	Y	L	1.1030
109	S	L	0.4798
114	W	L	0.4656
115	P	L	-0.1827
116	L	L	0.1342
117	T	L	-0.5284
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.5415
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.2927
124	V	L	0.0000
125	E	L	-1.2139
126	I	L	-0.6048
127	K	L	-1.5520