| Chain sequence(s) |
A: VPMMTQSPSLLSASTGDRVTISCQASESIYSGLAWYQQKPGKAPKLLIYDASDLASGVPSRFSGSGSGTDFTLTISCLQSEDFATYYCQQGYTSGNVENNFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVQLVESGGGLVQPGGSLRLSCAVSGFSLNSYGVSWVRQAPGKGLEWIGDIYAGSSGTWYATWAKGRFTISKDSSKNTVYLQMNSLRAEDTAVYYCARGGDDVSRYLDLWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPC
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:01:32)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:01:32)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:01:32)
[INFO] runJob: Creating pdb object from: input.pdb (00:01:32)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:01:32)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:34)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:01:35)
[INFO] Main: Simulation completed successfully. (00:01:58)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | V | A | 0.7862 | |
| 2 | P | A | 0.0000 | |
| 3 | M | A | 0.8772 | |
| 4 | M | A | 0.0563 | |
| 5 | T | A | -0.3979 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.3965 | |
| 8 | P | A | -0.1166 | |
| 9 | S | A | -0.1153 | |
| 10 | L | A | 0.4711 | |
| 11 | L | A | 0.4378 | |
| 12 | S | A | -0.1364 | |
| 13 | A | A | 0.0000 | |
| 14 | S | A | -1.2381 | |
| 15 | T | A | -1.1969 | |
| 16 | G | A | -1.2046 | |
| 17 | D | A | -1.7676 | |
| 18 | R | A | -2.2315 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.5398 | |
| 21 | I | A | 0.0000 | |
| 22 | S | A | -0.6515 | |
| 23 | C | A | 0.0000 | |
| 24 | Q | A | -1.4798 | |
| 25 | A | A | 0.0000 | |
| 26 | S | A | -0.1179 | |
| 27 | E | A | -0.3730 | |
| 28 | S | A | -0.1382 | |
| 29 | I | A | 0.0000 | |
| 30A | Y | A | 0.9653 | |
| 31 | S | A | 0.0717 | |
| 32 | G | A | 0.1063 | |
| 33 | L | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | 0.0000 | |
| 38 | Q | A | 0.0000 | |
| 39 | K | A | -1.5279 | |
| 40 | P | A | -1.2099 | |
| 41 | G | A | -1.6972 | |
| 42 | K | A | -2.6170 | |
| 43 | A | A | -1.5220 | |
| 44 | P | A | 0.0000 | |
| 45 | K | A | -0.9882 | |
| 46 | L | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | -0.6317 | |
| 50 | D | A | -0.8953 | |
| 51 | A | A | 0.0000 | |
| 52 | S | A | -1.1484 | |
| 53 | D | A | -1.4843 | |
| 54 | L | A | -0.1425 | |
| 55 | A | A | -0.2059 | |
| 56 | S | A | -0.2310 | |
| 57 | G | A | -0.4896 | |
| 58 | V | A | -0.1403 | |
| 59 | P | A | -0.2677 | |
| 60 | S | A | -0.3026 | |
| 61 | R | A | -0.6327 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -0.4792 | |
| 64 | G | A | -0.5943 | |
| 65 | S | A | -0.8993 | |
| 66 | G | A | -0.8548 | |
| 67 | S | A | -0.5999 | |
| 68 | G | A | -0.4010 | |
| 69 | T | A | -0.9737 | |
| 70 | D | A | -1.6760 | |
| 71 | F | A | 0.0000 | |
| 72 | T | A | -0.6369 | |
| 73 | L | A | 0.0000 | |
| 74 | T | A | -0.5492 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.0742 | |
| 77 | C | A | -1.1773 | |
| 78 | L | A | 0.0000 | |
| 79 | Q | A | -1.1696 | |
| 80 | S | A | -1.2059 | |
| 81 | E | A | -1.7907 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | -0.1635 | |
| 84 | A | A | 0.0000 | |
| 85 | T | A | -0.1974 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 91 | G | A | 0.3084 | |
| 92 | Y | A | 0.7352 | |
| 93 | T | A | -0.1837 | |
| 93A | S | A | -0.4488 | |
| 93B | G | A | -0.8443 | |
| 93C | N | A | -1.3553 | |
| 93D | V | A | 0.0000 | |
| 94 | E | A | -1.4067 | |
| 95 | N | A | -0.9371 | |
| 96 | N | A | 0.0000 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | G | A | -0.8200 | |
| 101 | G | A | 0.0000 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | 0.0231 | |
| 104 | V | A | 0.0000 | |
| 105 | E | A | 0.0000 | |
| 106 | I | A | -0.5485 | |
| 107 | K | A | -1.4428 | |
| 108 | R | A | -0.7049 | |
| 112 | T | A | 0.2755 | |
| 113 | V | A | 1.2175 | |
| 114 | A | A | 0.3807 | |
| 115 | A | A | -0.0372 | |
| 116 | P | A | 0.0000 | |
| 117 | S | A | -0.2294 | |
| 118 | V | A | 0.0000 | |
| 119 | F | A | 0.0000 | |
| 120 | I | A | 0.0000 | |
| 121 | F | A | 0.0000 | |
| 122 | P | A | 0.0000 | |
| 123 | P | A | 0.0000 | |
| 124 | S | A | -1.2724 | |
| 125 | D | A | -2.5042 | |
| 126 | E | A | -2.0522 | |
| 127 | Q | A | 0.0000 | |
| 128 | L | A | -1.8267 | |
| 129 | K | A | -2.5238 | |
| 130 | S | A | -1.5518 | |
| 131 | G | A | -1.1235 | |
| 132 | T | A | -0.7273 | |
| 133 | A | A | 0.0000 | |
| 134 | S | A | 0.0000 | |
| 135 | V | A | 0.0000 | |
| 136 | V | A | 0.0000 | |
| 137 | C | A | 0.0000 | |
| 138 | L | A | 0.0000 | |
| 139 | L | A | 0.0000 | |
| 140 | N | A | -0.2579 | |
| 141 | N | A | -0.5245 | |
| 142 | F | A | 0.0000 | |
| 143 | Y | A | -0.0419 | |
| 144 | P | A | -0.6563 | |
| 145 | R | A | -1.3165 | |
| 146 | E | A | -2.2812 | |
| 147 | A | A | -1.4433 | |
| 148 | K | A | -1.1107 | |
| 149 | V | A | -0.5351 | |
| 150 | Q | A | -0.3723 | |
| 151 | W | A | 0.0000 | |
| 152 | K | A | -0.5531 | |
| 153 | V | A | 0.0000 | |
| 154 | D | A | -2.0789 | |
| 155 | N | A | -1.5445 | |
| 156 | A | A | -0.3775 | |
| 157 | L | A | 0.5529 | |
| 158 | Q | A | -0.1107 | |
| 159 | S | A | -0.5429 | |
| 160 | G | A | -1.0982 | |
| 161 | N | A | -0.9366 | |
| 162 | S | A | -0.9903 | |
| 163 | Q | A | -1.0287 | |
| 164 | E | A | -0.8767 | |
| 165 | S | A | -0.0939 | |
| 166 | V | A | 0.1294 | |
| 167 | T | A | -0.3947 | |
| 168 | E | A | -1.0436 | |
| 169 | Q | A | -1.0704 | |
| 170 | D | A | -1.6045 | |
| 171 | S | A | -1.5287 | |
| 172 | K | A | -2.3476 | |
| 173 | D | A | -1.9608 | |
| 174 | S | A | -1.3376 | |
| 175 | T | A | 0.0000 | |
| 176 | Y | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | L | A | 0.0000 | |
| 179 | S | A | 0.0000 | |
| 180 | S | A | 0.0000 | |
| 181 | T | A | -0.4730 | |
| 182 | L | A | 0.0000 | |
| 183 | T | A | -0.4517 | |
| 184 | L | A | -0.3938 | |
| 185 | S | A | -0.6545 | |
| 186 | K | A | -1.4181 | |
| 187 | A | A | -1.1821 | |
| 188 | D | A | -1.6244 | |
| 189 | Y | A | 0.0000 | |
| 190 | E | A | -2.3562 | |
| 191 | K | A | -2.9717 | |
| 192 | H | A | -2.3478 | |
| 193 | K | A | -2.3993 | |
| 194 | V | A | -1.0177 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -0.3866 | |
| 197 | C | A | 0.0000 | |
| 198 | E | A | -0.3840 | |
| 199 | V | A | 0.0000 | |
| 200 | T | A | -0.7302 | |
| 201 | H | A | 0.0000 | |
| 202 | Q | A | -1.4958 | |
| 203 | G | A | -0.5868 | |
| 204 | L | A | -0.4791 | |
| 205 | S | A | -0.6779 | |
| 206 | S | A | -0.4085 | |
| 207 | P | A | -0.1646 | |
| 208 | V | A | 0.4460 | |
| 209 | T | A | -0.0490 | |
| 210 | K | A | -0.4827 | |
| 211 | S | A | -0.5327 | |
| 212 | F | A | 0.0000 | |
| 213 | N | A | -1.4586 | |
| 214 | R | A | -2.2528 | |
| 215 | G | A | -1.4271 | |
| 216 | E | A | -1.4732 | |
| 217 | C | A | -0.9275 | |
| 1 | E | A | -1.7804 | |
| 2 | V | A | -0.4185 | |
| 3 | Q | A | -1.1009 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.3831 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.3189 | |
| 8 | G | A | -0.6483 | |
| 9 | G | A | -0.0336 | |
| 10 | G | A | 0.3585 | |
| 11 | L | A | 0.5851 | |
| 12 | V | A | -0.4426 | |
| 13 | Q | A | -1.4836 | |
| 14 | P | A | -1.9464 | |
| 15 | G | A | -1.5359 | |
| 16 | G | A | -1.1216 | |
| 17 | S | A | -1.0956 | |
| 18 | L | A | -0.5661 | |
| 19 | R | A | -1.5427 | |
| 20 | L | A | 0.0000 | |
| 21 | S | A | -0.4005 | |
| 22 | C | A | 0.0000 | |
| 23 | A | A | -0.2093 | |
| 24 | V | A | -0.3059 | |
| 25 | S | A | -0.5983 | |
| 26 | G | A | -0.7507 | |
| 27 | F | A | -0.3458 | |
| 28 | S | A | -0.5334 | |
| 29 | L | A | 0.0000 | |
| 30 | N | A | -1.3698 | |
| 30A | S | A | -0.7741 | |
| 31 | Y | A | -0.1591 | |
| 32 | G | A | 0.0000 | |
| 33 | V | A | 0.0000 | |
| 34 | S | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | R | A | 0.0000 | |
| 38 | Q | A | -0.6121 | |
| 39 | A | A | -0.9844 | |
| 40 | P | A | -0.9677 | |
| 41 | G | A | -1.4631 | |
| 42 | K | A | -2.2439 | |
| 43 | G | A | -1.4249 | |
| 44 | L | A | 0.0000 | |
| 45 | E | A | -1.0576 | |
| 46 | W | A | 0.0000 | |
| 47 | I | A | 0.0000 | |
| 48 | G | A | 0.0000 | |
| 49 | D | A | 0.3008 | |
| 50 | I | A | 0.0000 | |
| 51A | Y | A | 0.6021 | |
| 51B | A | A | 0.0000 | |
| 52 | G | A | -0.7685 | |
| 53 | S | A | -0.5474 | |
| 54 | S | A | -0.4436 | |
| 55 | G | A | -0.0777 | |
| 56 | T | A | 0.4826 | |
| 57 | W | A | 0.8991 | |
| 58 | Y | A | 0.1456 | |
| 59 | A | A | 0.0000 | |
| 60 | T | A | -0.6828 | |
| 61 | W | A | -0.5743 | |
| 62 | A | A | 0.0000 | |
| 63 | K | A | -1.7392 | |
| 64 | G | A | -1.4974 | |
| 65 | R | A | -1.2967 | |
| 66 | F | A | 0.0000 | |
| 67 | T | A | -0.7657 | |
| 68 | I | A | 0.0000 | |
| 69 | S | A | -0.5866 | |
| 70 | K | A | -1.0239 | |
| 71 | D | A | -1.5255 | |
| 72 | S | A | -1.6300 | |
| 73 | S | A | -1.4215 | |
| 74 | K | A | -2.2139 | |
| 75 | N | A | -1.6522 | |
| 76 | T | A | 0.0000 | |
| 77 | V | A | 0.0000 | |
| 78 | Y | A | -0.4912 | |
| 79 | L | A | 0.0000 | |
| 80 | Q | A | -1.0146 | |
| 81 | M | A | 0.0000 | |
| 82 | N | A | -1.4746 | |
| 83 | S | A | -1.3609 | |
| 84 | L | A | 0.0000 | |
| 85 | R | A | -2.9409 | |
| 86 | A | A | -1.9300 | |
| 87 | E | A | -2.4420 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | -0.5404 | |
| 90 | A | A | 0.0000 | |
| 91 | V | A | 0.6920 | |
| 92 | Y | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | A | A | 0.0000 | |
| 96 | R | A | -0.3671 | |
| 97 | G | A | 0.0000 | |
| 98 | G | A | -0.3706 | |
| 102A | D | A | -0.5244 | |
| 102B | D | A | 0.0090 | |
| 102C | V | A | 1.3816 | |
| 102D | S | A | 0.4574 | |
| 102E | R | A | -0.3695 | |
| 102F | Y | A | -0.1383 | |
| 102G | L | A | 0.0000 | |
| 103 | D | A | -0.4079 | |
| 104 | L | A | 0.0604 | |
| 105 | W | A | -0.4932 | |
| 106 | G | A | -0.7441 | |
| 107 | Q | A | -1.4871 | |
| 108 | G | A | -0.4922 | |
| 109 | T | A | 0.4110 | |
| 110 | L | A | 1.3187 | |
| 111 | V | A | 0.0000 | |
| 112 | T | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.5690 | |
| 115 | S | A | -0.3151 | |
| 121 | A | A | -0.3163 | |
| 122 | S | A | -0.4063 | |
| 123 | T | A | -0.6145 | |
| 124 | K | A | -0.9768 | |
| 125 | G | A | -1.2699 | |
| 126 | P | A | -0.5130 | |
| 127 | S | A | -0.3060 | |
| 128 | V | A | 0.0000 | |
| 129 | F | A | 0.0000 | |
| 130 | P | A | -0.8147 | |
| 131 | L | A | 0.0000 | |
| 132 | A | A | -0.0610 | |
| 133 | P | A | -0.3557 | |
| 134 | C | A | 0.0000 | |
| 135 | S | A | -1.3428 | |
| 136 | R | A | -2.2136 | |
| 137 | S | A | 0.0000 | |
| 138 | T | A | -1.3099 | |
| 139 | S | A | -1.5004 | |
| 140 | E | A | -2.3198 | |
| 141 | S | A | -1.2247 | |
| 142 | T | A | -0.8831 | |
| 143 | A | A | 0.0000 | |
| 144 | A | A | 0.0000 | |
| 145 | L | A | 0.0000 | |
| 146 | G | A | 0.0000 | |
| 147 | C | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | V | A | 0.0000 | |
| 150 | K | A | 0.0000 | |
| 151 | D | A | -0.2612 | |
| 152 | Y | A | 0.0000 | |
| 153 | F | A | 0.0000 | |
| 154 | P | A | -0.6753 | |
| 155 | E | A | -0.9252 | |
| 156 | P | A | -0.9356 | |
| 157 | V | A | -0.7411 | |
| 158 | T | A | -0.6037 | |
| 159 | V | A | -0.2113 | |
| 160 | S | A | -0.3598 | |
| 161 | W | A | 0.0000 | |
| 162 | N | A | -0.8937 | |
| 163 | S | A | -0.6703 | |
| 164 | G | A | -0.4749 | |
| 165 | A | A | -0.1586 | |
| 166 | L | A | 0.0609 | |
| 167 | T | A | -0.1411 | |
| 168 | S | A | -0.4585 | |
| 169 | G | A | -0.3230 | |
| 170 | V | A | -0.0166 | |
| 171 | H | A | -0.2812 | |
| 172 | T | A | 0.0055 | |
| 173 | F | A | 0.0000 | |
| 174 | P | A | -0.1194 | |
| 175 | A | A | 0.2055 | |
| 176 | V | A | 0.5760 | |
| 177 | L | A | 0.7688 | |
| 178 | Q | A | 0.0601 | |
| 179 | S | A | -0.3200 | |
| 180 | S | A | -0.2166 | |
| 181 | G | A | 0.0526 | |
| 182 | L | A | 0.1542 | |
| 183 | Y | A | 0.3499 | |
| 184 | S | A | 0.0000 | |
| 185 | L | A | 0.0000 | |
| 186 | S | A | 0.0000 | |
| 187 | S | A | 0.0000 | |
| 188 | V | A | 0.0000 | |
| 189 | V | A | 0.0000 | |
| 190 | T | A | -0.0741 | |
| 191 | V | A | -0.2180 | |
| 192 | P | A | -0.8223 | |
| 193 | S | A | -0.9929 | |
| 194 | S | A | -0.6647 | |
| 195 | S | A | -0.6609 | |
| 196 | L | A | 0.0000 | |
| 197 | G | A | 0.0000 | |
| 198 | T | A | -0.9051 | |
| 199 | K | A | -1.4579 | |
| 200 | T | A | -1.4483 | |
| 201 | Y | A | 0.0000 | |
| 202 | T | A | 0.0000 | |
| 203 | C | A | 0.0000 | |
| 204 | N | A | -1.4019 | |
| 205 | V | A | 0.0000 | |
| 206 | D | A | -1.7376 | |
| 207 | H | A | 0.0000 | |
| 208 | K | A | -2.8197 | |
| 209 | P | A | -1.6420 | |
| 210 | S | A | -1.8678 | |
| 211 | N | A | -2.5384 | |
| 212 | T | A | -2.0478 | |
| 213 | K | A | -2.4950 | |
| 214 | V | A | -1.1374 | |
| 215 | D | A | -1.9987 | |
| 216 | K | A | -1.6410 | |
| 217 | R | A | -2.3782 | |
| 218 | V | A | 0.0000 | |
| 219 | E | A | -1.3343 | |
| 220 | S | A | -1.3054 | |
| 221 | K | A | -1.5277 | |
| 222 | Y | A | -0.0038 | |
| 223 | G | A | -0.4070 | |
| 224 | P | A | -0.2877 | |
| 225 | P | A | -0.1306 | |
| 226 | C | A | 0.4626 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine