| Chain sequence(s) |
A: DIQMTQSPSSLSASVGDRVTITCQASQDIRNFLNWYQQKPGKAPKLLIHDASTLETGVPPRFSGGGSGTDFSFTISNLQPEDFATYYCQQYDNLPTFTFGPGTKVEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVQLVESGGGLVQPGGSLRLSCSASGFTFSTYWMSWVRQAPGKGLEWVANIKQDGSEKNYVDAVKGRFTISRDNAKNSLHLQMNSLRAEDTAMYYCARDYFDSDINYLSLNWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:01:27)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:01:27)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:01:27)
[INFO] runJob: Creating pdb object from: input.pdb (00:01:27)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:01:28)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:30)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:01:31)
[INFO] Main: Simulation completed successfully. (00:01:52)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -2.0167 | |
| 2 | I | A | 0.0000 | |
| 3 | Q | A | -1.8366 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -0.9411 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.6003 | |
| 8 | P | A | -0.4236 | |
| 9 | S | A | -0.5158 | |
| 10 | S | A | -0.4698 | |
| 11 | L | A | -0.1207 | |
| 12 | S | A | -0.7403 | |
| 13 | A | A | 0.0000 | |
| 14 | S | A | -1.0010 | |
| 15 | V | A | -0.2464 | |
| 16 | G | A | -1.2148 | |
| 17 | D | A | -2.1470 | |
| 18 | R | A | -2.7249 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.6385 | |
| 21 | I | A | 0.0000 | |
| 22 | T | A | -0.6360 | |
| 23 | C | A | 0.0000 | |
| 24 | Q | A | -1.8857 | |
| 25 | A | A | 0.0000 | |
| 26 | S | A | -1.6735 | |
| 27 | Q | A | -2.2205 | |
| 28 | D | A | -2.7574 | |
| 29 | I | A | 0.0000 | |
| 30 | R | A | -2.8694 | |
| 31 | N | A | -1.6708 | |
| 32 | F | A | -0.9649 | |
| 33 | L | A | 0.0000 | |
| 34 | N | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | -0.9694 | |
| 38 | Q | A | 0.0000 | |
| 39 | K | A | -1.6445 | |
| 40 | P | A | -1.4104 | |
| 41 | G | A | -1.6639 | |
| 42 | K | A | -2.6244 | |
| 43 | A | A | -1.7496 | |
| 44 | P | A | 0.0000 | |
| 45 | K | A | -2.0715 | |
| 46 | L | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | H | A | 0.0000 | |
| 50 | D | A | -0.5920 | |
| 51 | A | A | 0.0000 | |
| 52 | S | A | -0.4823 | |
| 53 | T | A | -0.1166 | |
| 54 | L | A | 0.1969 | |
| 55 | E | A | -0.2670 | |
| 56 | T | A | -0.2612 | |
| 57 | G | A | -0.4327 | |
| 58 | V | A | -0.3092 | |
| 59 | P | A | -0.3045 | |
| 60 | P | A | -0.5305 | |
| 61 | R | A | -1.0885 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -0.2612 | |
| 64 | G | A | -0.3991 | |
| 65 | G | A | -0.7495 | |
| 66 | G | A | -1.3049 | |
| 67 | S | A | -1.6514 | |
| 68 | G | A | -2.1587 | |
| 69 | T | A | -2.0833 | |
| 70 | D | A | -1.9894 | |
| 71 | F | A | 0.0000 | |
| 72 | S | A | -0.6605 | |
| 73 | F | A | 0.0000 | |
| 74 | T | A | -0.7420 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.9429 | |
| 77 | N | A | -2.4104 | |
| 78 | L | A | 0.0000 | |
| 79 | Q | A | -1.1045 | |
| 80 | P | A | -0.7246 | |
| 81 | E | A | -1.2729 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | -0.5981 | |
| 84 | A | A | 0.0000 | |
| 85 | T | A | -0.3838 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 91 | Y | A | 0.0000 | |
| 92 | D | A | -1.2002 | |
| 93 | N | A | -0.9585 | |
| 93A | L | A | 0.5010 | |
| 93B | P | A | -0.3262 | |
| 93C | T | A | -0.5117 | |
| 96 | F | A | 0.0475 | |
| 97 | T | A | -0.5260 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | P | A | -0.7785 | |
| 101 | G | A | -0.6336 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -0.4697 | |
| 104 | V | A | 0.0000 | |
| 105 | E | A | 0.0000 | |
| 106 | M | A | 0.0000 | |
| 107 | K | A | -1.8651 | |
| 108 | R | A | -1.8093 | |
| 110 | T | A | -0.4565 | |
| 111 | V | A | 1.1521 | |
| 112 | A | A | 0.5575 | |
| 113 | A | A | -0.2902 | |
| 114 | P | A | 0.0000 | |
| 115 | S | A | -0.1403 | |
| 116 | V | A | 0.0000 | |
| 117 | F | A | -0.0314 | |
| 118 | I | A | 0.0000 | |
| 119 | F | A | 0.0000 | |
| 120 | P | A | 0.0000 | |
| 121 | P | A | 0.0000 | |
| 122 | S | A | 0.0000 | |
| 123 | D | A | -2.5868 | |
| 124 | E | A | -2.1022 | |
| 125 | Q | A | 0.0000 | |
| 126 | L | A | -1.8486 | |
| 127 | K | A | -2.5611 | |
| 128 | S | A | -1.5784 | |
| 129 | G | A | -1.3622 | |
| 130 | T | A | -0.9878 | |
| 131 | A | A | 0.0000 | |
| 132 | S | A | 0.0000 | |
| 133 | V | A | 0.0000 | |
| 134 | V | A | 0.0000 | |
| 135 | C | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | L | A | 0.0000 | |
| 138 | N | A | 0.0000 | |
| 139 | N | A | -0.6601 | |
| 140 | F | A | 0.0000 | |
| 141 | Y | A | 0.0000 | |
| 142 | P | A | -0.9700 | |
| 143 | R | A | -1.7172 | |
| 144 | E | A | -2.1990 | |
| 145 | A | A | -1.6753 | |
| 146 | K | A | -2.1196 | |
| 147 | V | A | 0.0000 | |
| 148 | Q | A | -0.8177 | |
| 149 | W | A | 0.0000 | |
| 150 | K | A | 0.0000 | |
| 151 | V | A | 0.0000 | |
| 152 | D | A | -1.7487 | |
| 153 | N | A | -1.3561 | |
| 154 | A | A | -0.0480 | |
| 155 | L | A | 0.8895 | |
| 156 | Q | A | 0.0171 | |
| 157 | S | A | -0.5173 | |
| 158 | G | A | -0.9822 | |
| 159 | N | A | -0.9048 | |
| 160 | S | A | -0.9903 | |
| 161 | Q | A | -1.0674 | |
| 162 | E | A | -1.3411 | |
| 163 | S | A | 0.0000 | |
| 164 | V | A | -0.2059 | |
| 165 | T | A | -0.7207 | |
| 166 | E | A | -1.5756 | |
| 167 | Q | A | -1.7973 | |
| 168 | D | A | -2.6272 | |
| 169 | S | A | -2.2921 | |
| 170 | K | A | -2.8011 | |
| 171 | D | A | -2.5907 | |
| 172 | S | A | 0.0000 | |
| 173 | T | A | 0.0000 | |
| 174 | Y | A | 0.0000 | |
| 175 | S | A | 0.0000 | |
| 176 | L | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | S | A | 0.0000 | |
| 179 | T | A | -0.5136 | |
| 180 | L | A | 0.0000 | |
| 181 | T | A | -0.3200 | |
| 182 | L | A | -0.1183 | |
| 183 | S | A | -0.7922 | |
| 184 | K | A | -1.8243 | |
| 185 | A | A | -1.3508 | |
| 186 | D | A | -1.6887 | |
| 187 | Y | A | -1.7793 | |
| 188 | E | A | -2.7769 | |
| 189 | K | A | -3.0339 | |
| 190 | H | A | -2.7309 | |
| 191 | K | A | -3.2824 | |
| 192 | V | A | -1.8627 | |
| 193 | Y | A | 0.0000 | |
| 194 | A | A | 0.0000 | |
| 195 | C | A | 0.0000 | |
| 196 | E | A | -0.5740 | |
| 197 | V | A | 0.0000 | |
| 198 | T | A | -1.1143 | |
| 199 | H | A | 0.0000 | |
| 200 | Q | A | -1.9851 | |
| 201 | G | A | -0.8932 | |
| 202 | L | A | -0.4419 | |
| 203 | S | A | -0.4776 | |
| 204 | S | A | -0.3384 | |
| 205 | P | A | -0.4974 | |
| 206 | V | A | -0.0292 | |
| 207 | T | A | -0.4315 | |
| 208 | K | A | -0.7145 | |
| 209 | S | A | -0.6382 | |
| 210 | F | A | 0.0000 | |
| 211 | N | A | -2.1267 | |
| 212 | R | A | -2.8811 | |
| 213 | G | A | -2.3819 | |
| 214 | E | A | -2.4278 | |
| 215 | C | A | -1.3258 | |
| 1 | E | A | -1.6350 | |
| 2 | V | A | -0.3241 | |
| 3 | Q | A | -0.6653 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.7762 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.4019 | |
| 8 | G | A | -0.8842 | |
| 9 | G | A | -0.1888 | |
| 10 | G | A | 0.2482 | |
| 11 | L | A | 0.6760 | |
| 12 | V | A | -0.3205 | |
| 13 | Q | A | -1.2767 | |
| 14 | P | A | -1.4469 | |
| 15 | G | A | -1.3751 | |
| 16 | G | A | -1.0001 | |
| 17 | S | A | -1.1012 | |
| 18 | L | A | -0.9345 | |
| 19 | R | A | -2.0367 | |
| 20 | L | A | 0.0000 | |
| 21 | S | A | -0.5791 | |
| 22 | C | A | 0.0000 | |
| 23 | S | A | -0.2824 | |
| 24 | A | A | 0.0000 | |
| 25 | S | A | -0.4661 | |
| 26 | G | A | -0.7923 | |
| 27 | F | A | -0.2131 | |
| 28 | T | A | -0.1704 | |
| 29 | F | A | 0.0000 | |
| 30 | S | A | -1.1497 | |
| 30A | T | A | -0.2738 | |
| 31 | Y | A | 0.1459 | |
| 32 | W | A | 0.0000 | |
| 33 | M | A | 0.0000 | |
| 34 | S | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | R | A | 0.0000 | |
| 38 | Q | A | -0.7011 | |
| 39 | A | A | -1.0910 | |
| 40 | P | A | -0.8732 | |
| 41 | G | A | -1.4606 | |
| 42 | K | A | -2.2001 | |
| 43 | G | A | -1.3291 | |
| 44 | L | A | 0.0000 | |
| 45 | E | A | -0.6862 | |
| 46 | W | A | 0.0000 | |
| 47 | V | A | 0.0000 | |
| 48 | A | A | 0.0000 | |
| 49 | N | A | 0.0000 | |
| 50 | I | A | 0.0000 | |
| 51 | K | A | -1.7003 | |
| 51A | Q | A | -1.5369 | |
| 52 | D | A | -2.4890 | |
| 53 | G | A | -1.8820 | |
| 54 | S | A | -1.4725 | |
| 55 | E | A | -2.0812 | |
| 56 | K | A | -1.4905 | |
| 57 | N | A | -1.1023 | |
| 58 | Y | A | -1.0696 | |
| 59 | V | A | 0.0000 | |
| 60 | D | A | -2.4274 | |
| 61 | A | A | -1.5589 | |
| 62 | V | A | 0.0000 | |
| 63 | K | A | -2.5806 | |
| 64 | G | A | -1.7447 | |
| 65 | R | A | -1.5244 | |
| 66 | F | A | 0.0000 | |
| 67 | T | A | -1.0844 | |
| 68 | I | A | 0.0000 | |
| 69 | S | A | -0.9197 | |
| 70 | R | A | -1.4341 | |
| 71 | D | A | -1.8846 | |
| 72 | N | A | -2.1296 | |
| 73 | A | A | -1.4049 | |
| 74 | K | A | -2.2958 | |
| 75 | N | A | -1.6551 | |
| 76 | S | A | 0.0000 | |
| 77 | L | A | 0.0000 | |
| 78 | H | A | -0.8414 | |
| 79 | L | A | 0.0000 | |
| 80 | Q | A | -1.3521 | |
| 81 | M | A | 0.0000 | |
| 82 | N | A | -1.3857 | |
| 83 | S | A | -1.2171 | |
| 84 | L | A | 0.0000 | |
| 85 | R | A | -2.1420 | |
| 86 | A | A | -1.5546 | |
| 87 | E | A | -2.0657 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | -0.4731 | |
| 90 | A | A | 0.0000 | |
| 91 | M | A | 0.4948 | |
| 92 | Y | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | A | A | 0.0000 | |
| 96 | R | A | 0.0000 | |
| 102A | D | A | 0.0000 | |
| 102B | Y | A | 0.9451 | |
| 102C | F | A | 1.3705 | |
| 102D | D | A | 0.0000 | |
| 102E | S | A | 0.2180 | |
| 102F | D | A | 0.0856 | |
| 102G | I | A | 1.4675 | |
| 102H | N | A | 0.3818 | |
| 102I | Y | A | 1.5553 | |
| 102J | L | A | 1.2474 | |
| 102K | S | A | 0.5928 | |
| 102L | L | A | 0.8237 | |
| 102M | N | A | 0.6248 | |
| 102N | W | A | 0.0000 | |
| 102O | F | A | 0.0000 | |
| 103 | D | A | -0.5828 | |
| 104 | P | A | -0.4213 | |
| 105 | W | A | 0.0000 | |
| 106 | G | A | -0.4086 | |
| 107 | Q | A | -1.3120 | |
| 108 | G | A | -0.4108 | |
| 109 | T | A | 0.0000 | |
| 110 | L | A | 1.0680 | |
| 111 | V | A | 0.0000 | |
| 112 | T | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.6910 | |
| 115 | S | A | -0.5122 | |
| 127 | A | A | -0.3744 | |
| 128 | S | A | -0.4376 | |
| 129 | T | A | -0.5400 | |
| 130 | K | A | -1.0056 | |
| 131 | G | A | -1.2779 | |
| 132 | P | A | 0.0000 | |
| 133 | S | A | -0.2101 | |
| 134 | V | A | -0.1122 | |
| 135 | F | A | -0.4049 | |
| 136 | P | A | -0.6959 | |
| 137 | L | A | 0.0000 | |
| 138 | A | A | 0.0000 | |
| 139 | P | A | 0.0000 | |
| 140 | S | A | -0.6552 | |
| 141 | S | A | -0.6854 | |
| 142 | K | A | -0.5917 | |
| 143 | S | A | -0.7217 | |
| 144 | T | A | -0.7643 | |
| 145 | S | A | -0.7249 | |
| 146 | G | A | -0.8289 | |
| 147 | G | A | -0.8340 | |
| 148 | T | A | -0.5979 | |
| 149 | A | A | 0.0000 | |
| 150 | A | A | 0.0000 | |
| 151 | L | A | 0.0000 | |
| 152 | G | A | 0.0000 | |
| 153 | C | A | 0.0000 | |
| 154 | L | A | 0.0000 | |
| 155 | V | A | 0.0000 | |
| 156 | K | A | 0.0000 | |
| 157 | D | A | -0.3630 | |
| 158 | Y | A | 0.0000 | |
| 159 | F | A | 0.0000 | |
| 160 | P | A | -0.5255 | |
| 161 | E | A | -0.7511 | |
| 162 | P | A | -0.9988 | |
| 163 | V | A | 0.0000 | |
| 164 | T | A | -0.7267 | |
| 165 | V | A | -0.4063 | |
| 166 | S | A | -0.3492 | |
| 167 | W | A | 0.0000 | |
| 168 | N | A | -0.7496 | |
| 169 | S | A | -0.6986 | |
| 170 | G | A | -0.4470 | |
| 171 | A | A | -0.2007 | |
| 172 | L | A | -0.0293 | |
| 173 | T | A | -0.1807 | |
| 174 | S | A | -0.1854 | |
| 175 | G | A | -0.2706 | |
| 176 | V | A | 0.1773 | |
| 177 | H | A | 0.0309 | |
| 178 | T | A | 0.0312 | |
| 179 | F | A | 0.0000 | |
| 180 | P | A | -0.4348 | |
| 181 | A | A | -0.0091 | |
| 182 | V | A | 0.0000 | |
| 183 | L | A | 0.8853 | |
| 184 | Q | A | 0.0472 | |
| 185 | S | A | -0.2441 | |
| 186 | S | A | -0.2156 | |
| 187 | G | A | -0.0670 | |
| 188 | L | A | 0.0126 | |
| 189 | Y | A | 0.0000 | |
| 190 | S | A | 0.0000 | |
| 191 | L | A | 0.0000 | |
| 192 | S | A | 0.0000 | |
| 193 | S | A | 0.0000 | |
| 194 | V | A | 0.0000 | |
| 195 | V | A | 0.0000 | |
| 196 | T | A | -0.1752 | |
| 197 | V | A | 0.0000 | |
| 198 | P | A | -0.5724 | |
| 199 | S | A | 0.0000 | |
| 200 | S | A | -0.8033 | |
| 201 | S | A | -0.6176 | |
| 202 | L | A | -0.7251 | |
| 203 | G | A | -0.8739 | |
| 204 | T | A | -0.7395 | |
| 205 | Q | A | -1.0342 | |
| 206 | T | A | -0.9450 | |
| 207 | Y | A | 0.0000 | |
| 208 | I | A | -0.8587 | |
| 209 | C | A | 0.0000 | |
| 210 | N | A | 0.0000 | |
| 211 | V | A | 0.0000 | |
| 212 | N | A | -1.9938 | |
| 213 | H | A | 0.0000 | |
| 214 | K | A | -2.8137 | |
| 215 | P | A | -1.6592 | |
| 216 | S | A | -1.8619 | |
| 217 | N | A | -2.4928 | |
| 218 | T | A | -2.0247 | |
| 219 | K | A | -2.5876 | |
| 220 | V | A | -1.3417 | |
| 221 | D | A | -2.4191 | |
| 222 | K | A | -1.8828 | |
| 223 | R | A | -2.2283 | |
| 224 | V | A | 0.0000 | |
| 225 | E | A | -1.2738 | |
| 226 | P | A | -0.7399 | |
| 227 | K | A | -0.7334 | |
| 228 | S | A | -1.2355 | |
| 229 | C | A | -1.5494 | |
| 230 | D | A | -2.5294 | |
| 231 | K | A | -2.5861 | |
| 232 | T | A | -1.4485 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine