Project name: a2bf18d6b18e220

Chain sequence(s)	H: EVQLQESGPGLVKPSQSLSLTCTVTGYLITSDIVWTWIRQFPDNTLEWMGYITYSGSTGYNPSLNGRISVTRDTSKSQFFLQLNSVTSEDTATYYCVYGHFYSMDYWGQGTSVTVSS; L: SPVTLFVTPGHSVSLSCRASQSISSNLHWYQQESHESPRLLIKYASQSISGIPSRFSGSGSGTDFTLSINSVETEDFGLYFCQQSYSWPLTFGAGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:07)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:07)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:07)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:07)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:07)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:47)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:49)

• Minimal score value: -2.5627
• Maximal score value: 1.9942
• Average score: -0.4105
• Total score value: -89.4964

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9811
2	V	H	-0.8179
3	Q	H	-1.4326
4	L	H	-0.9212
5	Q	H	-1.6901
6	E	H	0.0000
7	S	H	-0.7639
8	G	H	-0.5927
9	P	H	-0.3101
11	G	H	-0.1528
12	L	H	0.5686
13	V	H	0.0000
14	K	H	-1.0273
15	P	H	-1.3149
16	S	H	-1.2224
17	Q	H	-1.6748
18	S	H	-1.3736
19	L	H	0.0000
20	S	H	-0.7153
21	L	H	0.0000
22	T	H	-0.5040
23	C	H	0.0000
24	T	H	-1.0124
25	V	H	0.0000
26	T	H	-0.8395
27	G	H	-0.8167
28	Y	H	0.1619
29	L	H	0.8407
30	I	H	0.0000
31	T	H	0.2660
35	S	H	0.0189
36	D	H	-0.3456
37	I	H	0.0000
38	V	H	0.0000
39	W	H	0.0000
40	T	H	0.0000
41	W	H	0.0000
42	I	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5282
45	F	H	-0.8382
46	P	H	-1.3300
47	D	H	-2.0392
48	N	H	-1.3421
49	T	H	-0.8295
50	L	H	0.0000
51	E	H	-0.2138
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	Y	H	0.2333
56	I	H	0.0000
57	T	H	-0.0328
58	Y	H	0.3357
59	S	H	-0.1951
63	G	H	-0.2685
64	S	H	-0.2590
65	T	H	-0.0715
66	G	H	-0.0211
67	Y	H	-0.1104
68	N	H	0.0000
69	P	H	-0.7401
70	S	H	-0.8001
71	L	H	0.0000
72	N	H	-1.7321
74	G	H	-1.4277
75	R	H	-1.4588
76	I	H	0.0000
77	S	H	-0.6583
78	V	H	0.0000
79	T	H	-0.3789
80	R	H	-0.8821
81	D	H	-1.2791
82	T	H	-0.9764
83	S	H	-1.2961
84	K	H	-2.0027
85	S	H	-0.9735
86	Q	H	-1.0335
87	F	H	0.0000
88	F	H	-0.1148
89	L	H	0.0000
90	Q	H	-0.8319
91	L	H	0.0000
92	N	H	-1.4740
93	S	H	-1.2493
94	V	H	0.0000
95	T	H	-1.2713
96	S	H	-1.3040
97	E	H	-1.9293
98	D	H	0.0000
99	T	H	-0.6379
100	A	H	0.0000
101	T	H	-0.3708
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	V	H	0.0000
106	Y	H	0.1964
107	G	H	0.0000
108	H	H	0.2590
109	F	H	1.3925
113	Y	H	1.4935
114	S	H	0.0000
115	M	H	0.0000
116	D	H	-0.1472
117	Y	H	0.1149
118	W	H	-0.4700
119	G	H	0.0000
120	Q	H	-1.9456
121	G	H	-1.2722
122	T	H	-0.7984
123	S	H	-0.2931
124	V	H	0.0000
125	T	H	-0.2332
126	V	H	0.0000
127	S	H	-0.5597
128	S	H	-0.4557
7	S	L	-0.0620
8	P	L	0.3272
9	V	L	1.8816
10	T	L	1.4409
11	L	L	1.6027
12	F	L	1.9942
13	V	L	0.5932
14	T	L	-0.4993
15	P	L	-1.3043
16	G	L	-1.7153
17	H	L	-1.8683
18	S	L	-1.6443
19	V	L	0.0000
20	S	L	-0.5791
21	L	L	0.0000
22	S	L	-0.9641
23	C	L	0.0000
24	R	L	-2.5627
25	A	L	-1.6992
26	S	L	-1.3468
27	Q	L	-1.6611
28	S	L	-1.1493
29	I	L	0.0000
36	S	L	-0.3696
37	S	L	-0.1771
38	N	L	0.5424
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	E	L	-1.4366
46	S	L	-1.2347
47	H	L	-2.0008
48	E	L	-2.3250
49	S	L	-1.3999
50	P	L	0.0000
51	R	L	-0.7618
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	K	L	-0.3093
56	Y	L	0.1624
57	A	L	0.0000
65	S	L	-0.8772
66	Q	L	-1.2709
67	S	L	-0.6925
68	I	L	-0.3897
69	S	L	-0.3806
70	G	L	-0.3985
71	I	L	-0.1203
72	P	L	-0.2496
74	S	L	-0.5843
75	R	L	-1.1204
76	F	L	0.0000
77	S	L	-0.8845
78	G	L	-0.6498
79	S	L	-0.7471
80	G	L	-0.9436
83	S	L	-0.9326
84	G	L	-1.1588
85	T	L	-1.6409
86	D	L	-1.9831
87	F	L	0.0000
88	T	L	-0.8448
89	L	L	0.0000
90	S	L	-0.7346
91	I	L	0.0000
92	N	L	-2.1118
93	S	L	-1.8937
94	V	L	0.0000
95	E	L	-2.5229
96	T	L	-1.2506
97	E	L	-1.7034
98	D	L	0.0000
99	F	L	-0.1020
100	G	L	0.0000
101	L	L	-0.0877
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.4607
107	S	L	1.2021
108	Y	L	1.4435
109	S	L	0.8089
114	W	L	1.1269
115	P	L	0.6159
116	L	L	0.7237
117	T	L	0.2621
118	F	L	0.0200
119	G	L	-0.5052
120	A	L	-0.3238
121	G	L	0.0000
122	T	L	0.2964
123	K	L	0.5926
124	L	L	0.0000
125	E	L	0.5704
126	L	L	1.0731
127	K	L	-0.3571