| Chain sequence(s) |
A: EVLLTQSPGTLSLSPGERASLSCRASQSVSSSYLAWYQQKPGQAPRLLIHGASNRATGIPDRFSSSGSGTDFTLTINRVEPEDFVVYFCQLYGNSPKYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVQLVQSGAEVKKPGESLKISCKGSGYSFSSYWIGWVRQMPGKGLEWMGIIYPGDSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARSGRIFCSRGCWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:01:27)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:01:27)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:01:27)
[INFO] runJob: Creating pdb object from: input.pdb (00:01:27)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:01:27)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:29)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:01:30)
[INFO] Main: Simulation completed successfully. (00:01:51)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -1.7392 | |
| 2 | V | A | 0.0000 | |
| 3 | L | A | 0.5379 | |
| 4 | L | A | 0.0000 | |
| 5 | T | A | -0.7568 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.8598 | |
| 8 | P | A | -0.4764 | |
| 9 | G | A | -0.7461 | |
| 10 | T | A | -0.3103 | |
| 11 | L | A | -0.0041 | |
| 12 | S | A | -0.3458 | |
| 13 | L | A | -0.8155 | |
| 14 | S | A | -1.3742 | |
| 15 | P | A | -1.6655 | |
| 16 | G | A | -2.0848 | |
| 17 | E | A | -2.8146 | |
| 18 | R | A | -3.4810 | |
| 19 | A | A | 0.0000 | |
| 20 | S | A | -0.8785 | |
| 21 | L | A | 0.0000 | |
| 22 | S | A | -0.9327 | |
| 23 | C | A | 0.0000 | |
| 24 | R | A | -2.1165 | |
| 25 | A | A | 0.0000 | |
| 26 | S | A | -1.0694 | |
| 27 | Q | A | -1.5816 | |
| 28 | S | A | -1.0556 | |
| 29 | V | A | -0.6650 | |
| 30A | S | A | -0.5147 | |
| 30B | S | A | -0.8597 | |
| 31 | S | A | -0.6189 | |
| 32 | Y | A | -0.3048 | |
| 33 | L | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | 0.0000 | |
| 38 | Q | A | -0.8395 | |
| 39 | K | A | -1.4114 | |
| 40 | P | A | -1.4811 | |
| 41 | G | A | -1.3348 | |
| 42 | Q | A | -1.9971 | |
| 43 | A | A | -1.2421 | |
| 44 | P | A | 0.0000 | |
| 45 | R | A | -1.0240 | |
| 46 | L | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | H | A | -0.8402 | |
| 50 | G | A | -0.9802 | |
| 51 | A | A | 0.0000 | |
| 52 | S | A | -1.1871 | |
| 53 | N | A | -1.8592 | |
| 54 | R | A | -1.7715 | |
| 55 | A | A | -0.9060 | |
| 56 | T | A | -0.5176 | |
| 57 | G | A | -0.8678 | |
| 58 | I | A | 0.0000 | |
| 59 | P | A | -1.2037 | |
| 60 | D | A | -2.3351 | |
| 61 | R | A | -2.0525 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -1.0160 | |
| 64 | S | A | -0.7715 | |
| 65 | S | A | -0.9255 | |
| 66 | G | A | -1.3784 | |
| 67 | S | A | -1.2385 | |
| 68 | G | A | -1.4528 | |
| 69 | T | A | -1.7785 | |
| 70 | D | A | -2.1503 | |
| 71 | F | A | 0.0000 | |
| 72 | T | A | -0.8270 | |
| 73 | L | A | 0.0000 | |
| 74 | T | A | -0.9317 | |
| 75 | I | A | 0.0000 | |
| 76 | N | A | -2.6766 | |
| 77 | R | A | -3.7711 | |
| 78 | V | A | 0.0000 | |
| 79 | E | A | -2.0592 | |
| 80 | P | A | -1.3465 | |
| 81 | E | A | -1.5517 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | 0.0000 | |
| 84 | V | A | 0.0000 | |
| 85 | V | A | 0.1679 | |
| 86 | Y | A | 0.0000 | |
| 87 | F | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | Y | A | 0.0000 | |
| 92 | G | A | 0.0000 | |
| 93 | N | A | -0.7192 | |
| 93A | S | A | -0.6720 | |
| 93B | P | A | -0.8624 | |
| 93C | K | A | -0.7317 | |
| 93D | Y | A | 0.0000 | |
| 97 | T | A | -0.2157 | |
| 98 | F | A | 0.0135 | |
| 99 | G | A | 0.0000 | |
| 100 | Q | A | -1.4498 | |
| 101 | G | A | -0.9394 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -0.2032 | |
| 104 | L | A | 0.0000 | |
| 105 | E | A | 0.0000 | |
| 106 | I | A | -1.0028 | |
| 107 | K | A | -1.0381 | |
| 108 | R | A | -1.1057 | |
| 111 | T | A | 0.1216 | |
| 112 | V | A | 1.2144 | |
| 113 | A | A | 0.4042 | |
| 114 | A | A | 0.0110 | |
| 115 | P | A | 0.0000 | |
| 116 | S | A | -0.1867 | |
| 117 | V | A | 0.0000 | |
| 118 | F | A | -0.0236 | |
| 119 | I | A | 0.0000 | |
| 120 | F | A | 0.0000 | |
| 121 | P | A | -0.4691 | |
| 122 | P | A | 0.0000 | |
| 123 | S | A | 0.0000 | |
| 124 | D | A | -2.5575 | |
| 125 | E | A | -2.0662 | |
| 126 | Q | A | 0.0000 | |
| 127 | L | A | -1.9265 | |
| 128 | K | A | -2.5382 | |
| 129 | S | A | -1.5676 | |
| 130 | G | A | -1.3484 | |
| 131 | T | A | -0.9674 | |
| 132 | A | A | 0.0000 | |
| 133 | S | A | 0.0000 | |
| 134 | V | A | 0.0000 | |
| 135 | V | A | 0.0000 | |
| 136 | C | A | 0.0000 | |
| 137 | L | A | 0.0000 | |
| 138 | L | A | 0.0000 | |
| 139 | N | A | 0.0000 | |
| 140 | N | A | -1.1728 | |
| 141 | F | A | 0.0000 | |
| 142 | Y | A | 0.0000 | |
| 143 | P | A | 0.0000 | |
| 144 | R | A | -1.8106 | |
| 145 | E | A | -2.4118 | |
| 146 | A | A | -1.8605 | |
| 147 | K | A | -2.4385 | |
| 148 | V | A | 0.0000 | |
| 149 | Q | A | -0.8730 | |
| 150 | W | A | 0.0000 | |
| 151 | K | A | 0.0000 | |
| 152 | V | A | 0.0000 | |
| 153 | D | A | -2.0435 | |
| 154 | N | A | -1.4468 | |
| 155 | A | A | -0.1010 | |
| 156 | L | A | 0.8602 | |
| 157 | Q | A | 0.0121 | |
| 158 | S | A | -0.5169 | |
| 159 | G | A | -0.9746 | |
| 160 | N | A | -0.8778 | |
| 161 | S | A | -1.0175 | |
| 162 | Q | A | -1.1263 | |
| 163 | E | A | -1.4698 | |
| 164 | S | A | 0.0000 | |
| 165 | V | A | -0.4557 | |
| 166 | T | A | -1.1007 | |
| 167 | E | A | -2.2835 | |
| 168 | Q | A | -2.1132 | |
| 169 | D | A | -2.6270 | |
| 170 | S | A | -2.1189 | |
| 171 | K | A | -2.7631 | |
| 172 | D | A | -2.7168 | |
| 173 | S | A | 0.0000 | |
| 174 | T | A | 0.0000 | |
| 175 | Y | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | L | A | 0.0000 | |
| 178 | S | A | 0.0000 | |
| 179 | S | A | 0.0000 | |
| 180 | T | A | -0.5403 | |
| 181 | L | A | 0.0000 | |
| 182 | T | A | -0.2747 | |
| 183 | L | A | -0.0959 | |
| 184 | S | A | -0.7811 | |
| 185 | K | A | -1.8114 | |
| 186 | A | A | -1.3371 | |
| 187 | D | A | -1.6949 | |
| 188 | Y | A | -1.7137 | |
| 189 | E | A | -2.7514 | |
| 190 | K | A | -3.0692 | |
| 191 | H | A | -2.7835 | |
| 192 | K | A | -3.4137 | |
| 193 | V | A | -2.0249 | |
| 194 | Y | A | 0.0000 | |
| 195 | A | A | 0.0000 | |
| 196 | C | A | 0.0000 | |
| 197 | E | A | -0.6111 | |
| 198 | V | A | 0.0000 | |
| 199 | T | A | -1.1816 | |
| 200 | H | A | 0.0000 | |
| 201 | Q | A | -1.6035 | |
| 202 | G | A | -0.4163 | |
| 203 | L | A | -0.3620 | |
| 204 | S | A | -0.4435 | |
| 205 | S | A | -0.4226 | |
| 206 | P | A | -0.4190 | |
| 207 | V | A | -0.0639 | |
| 208 | T | A | -0.4432 | |
| 209 | K | A | -0.6851 | |
| 210 | S | A | -0.6629 | |
| 211 | F | A | 0.0000 | |
| 212 | N | A | -2.3512 | |
| 213 | R | A | -3.1980 | |
| 214 | G | A | -2.5626 | |
| 215 | E | A | -2.8885 | |
| 216 | C | A | -1.5794 | |
| 1 | E | A | -1.9179 | |
| 2 | V | A | -0.9072 | |
| 3 | Q | A | -1.1204 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.8683 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.2765 | |
| 8 | G | A | -0.3889 | |
| 9 | A | A | 0.2715 | |
| 10 | E | A | 0.3542 | |
| 11 | V | A | 1.3545 | |
| 12 | K | A | -0.2488 | |
| 13 | K | A | -1.1493 | |
| 14 | P | A | -1.4702 | |
| 15 | G | A | -1.4462 | |
| 16 | E | A | -1.5055 | |
| 17 | S | A | -1.0907 | |
| 18 | L | A | -0.8649 | |
| 19 | K | A | -1.0953 | |
| 20 | I | A | 0.0000 | |
| 21 | S | A | -0.2737 | |
| 22 | C | A | 0.0000 | |
| 23 | K | A | -0.4339 | |
| 24 | G | A | 0.0000 | |
| 25 | S | A | -0.5121 | |
| 26 | G | A | -1.1656 | |
| 27 | Y | A | -0.4377 | |
| 28 | S | A | -0.3303 | |
| 29 | F | A | 0.0000 | |
| 30 | S | A | -0.9657 | |
| 30A | S | A | -0.3214 | |
| 31 | Y | A | 0.5729 | |
| 32 | W | A | 0.2003 | |
| 33 | I | A | 0.0000 | |
| 34 | G | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | R | A | -0.3805 | |
| 38 | Q | A | -0.6488 | |
| 39 | M | A | -0.5312 | |
| 40 | P | A | -0.8334 | |
| 41 | G | A | -1.4034 | |
| 42 | K | A | -2.2113 | |
| 43 | G | A | -1.3942 | |
| 44 | L | A | 0.0000 | |
| 45 | E | A | -0.7248 | |
| 46 | W | A | 0.0000 | |
| 47 | M | A | 0.0000 | |
| 48 | G | A | 0.0000 | |
| 49 | I | A | 0.0000 | |
| 50 | I | A | 0.0000 | |
| 51 | Y | A | -0.8443 | |
| 51A | P | A | 0.0000 | |
| 51B | G | A | -1.4778 | |
| 51C | D | A | -2.3834 | |
| 51D | S | A | -1.7539 | |
| 51E | D | A | -1.5775 | |
| 56 | T | A | -1.3661 | |
| 57 | R | A | -2.0389 | |
| 58 | Y | A | -1.3035 | |
| 59 | S | A | 0.0000 | |
| 60 | P | A | -1.2827 | |
| 61 | S | A | -0.8160 | |
| 62 | F | A | -1.0921 | |
| 63 | Q | A | -2.0249 | |
| 64 | G | A | -1.5824 | |
| 65 | Q | A | -1.8431 | |
| 66 | V | A | 0.0000 | |
| 67 | T | A | -0.7641 | |
| 68 | I | A | 0.0000 | |
| 69 | S | A | -0.3651 | |
| 70 | A | A | -0.8598 | |
| 71 | D | A | -1.3518 | |
| 72 | K | A | -1.9463 | |
| 73 | S | A | -0.2719 | |
| 74 | I | A | 1.0131 | |
| 75 | S | A | -0.4383 | |
| 76 | T | A | 0.0000 | |
| 77 | A | A | 0.0000 | |
| 78 | Y | A | -0.3952 | |
| 79 | L | A | 0.0000 | |
| 80 | Q | A | -0.8952 | |
| 81 | W | A | 0.0000 | |
| 82 | S | A | -0.8737 | |
| 83 | S | A | -1.2314 | |
| 84 | L | A | 0.0000 | |
| 85 | K | A | -1.4371 | |
| 86 | A | A | -0.7552 | |
| 87 | S | A | -0.4505 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | 0.0742 | |
| 90 | A | A | 0.0000 | |
| 91 | M | A | 0.1614 | |
| 92 | Y | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | A | A | 0.0000 | |
| 96 | R | A | -0.2523 | |
| 97 | S | A | 0.0000 | |
| 98 | G | A | 0.3780 | |
| 99 | R | A | 1.0990 | |
| 100 | I | A | 2.6793 | |
| 101 | F | A | 2.7401 | |
| 102A | C | A | 1.6510 | |
| 102B | S | A | 0.6168 | |
| 102C | R | A | 0.2532 | |
| 102D | G | A | 0.0000 | |
| 102E | C | A | 0.0000 | |
| 102F | W | A | 0.0935 | |
| 102G | F | A | 0.0000 | |
| 103 | D | A | -0.7325 | |
| 104 | P | A | -0.5136 | |
| 105 | W | A | -0.4046 | |
| 106 | G | A | 0.0000 | |
| 107 | Q | A | -0.8815 | |
| 108 | G | A | 0.0000 | |
| 109 | T | A | 0.0000 | |
| 110 | L | A | 0.6351 | |
| 111 | V | A | 0.0000 | |
| 112 | T | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.3138 | |
| 115 | S | A | -0.5533 | |
| 124 | A | A | -0.4185 | |
| 125 | S | A | -0.2783 | |
| 126 | T | A | -0.3931 | |
| 127 | K | A | -0.9704 | |
| 128 | G | A | -1.2371 | |
| 129 | P | A | 0.0000 | |
| 130 | S | A | -0.1954 | |
| 131 | V | A | -0.1138 | |
| 132 | F | A | -0.4068 | |
| 133 | P | A | -0.6896 | |
| 134 | L | A | 0.0000 | |
| 135 | A | A | 0.0000 | |
| 136 | P | A | 0.0000 | |
| 137 | S | A | -0.5399 | |
| 138 | S | A | -0.6922 | |
| 139 | K | A | -0.5701 | |
| 140 | S | A | -0.7240 | |
| 141 | T | A | -0.7673 | |
| 142 | S | A | -0.7332 | |
| 143 | G | A | -0.8475 | |
| 144 | G | A | -0.8416 | |
| 145 | T | A | -0.5991 | |
| 146 | A | A | 0.0000 | |
| 147 | A | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | G | A | 0.0000 | |
| 150 | C | A | 0.0000 | |
| 151 | L | A | 0.0000 | |
| 152 | V | A | 0.0000 | |
| 153 | K | A | 0.0000 | |
| 154 | D | A | -0.3467 | |
| 155 | Y | A | 0.0000 | |
| 156 | F | A | 0.0000 | |
| 157 | P | A | 0.0000 | |
| 158 | E | A | -0.7603 | |
| 159 | P | A | -1.0273 | |
| 160 | V | A | 0.0000 | |
| 161 | T | A | -0.6985 | |
| 162 | V | A | -0.3695 | |
| 163 | S | A | -0.3375 | |
| 164 | W | A | 0.0000 | |
| 165 | N | A | -0.7403 | |
| 166 | S | A | -0.6769 | |
| 167 | G | A | -0.4240 | |
| 168 | A | A | -0.1894 | |
| 169 | L | A | -0.0207 | |
| 170 | T | A | -0.1812 | |
| 171 | S | A | -0.1894 | |
| 172 | G | A | -0.3022 | |
| 173 | V | A | 0.1667 | |
| 174 | H | A | 0.0157 | |
| 175 | T | A | 0.0243 | |
| 176 | F | A | 0.0000 | |
| 177 | P | A | -0.4782 | |
| 178 | A | A | 0.1640 | |
| 179 | V | A | 0.4161 | |
| 180 | L | A | 1.0452 | |
| 181 | Q | A | 0.1000 | |
| 182 | S | A | -0.2593 | |
| 183 | S | A | -0.2655 | |
| 184 | G | A | -0.1901 | |
| 185 | L | A | -0.0465 | |
| 186 | Y | A | 0.0000 | |
| 187 | S | A | 0.0000 | |
| 188 | L | A | 0.0000 | |
| 189 | S | A | 0.0000 | |
| 190 | S | A | 0.0000 | |
| 191 | V | A | 0.0000 | |
| 192 | V | A | 0.0000 | |
| 193 | T | A | -0.2013 | |
| 194 | V | A | 0.0000 | |
| 195 | P | A | -0.5772 | |
| 196 | S | A | 0.0000 | |
| 197 | S | A | -0.8145 | |
| 198 | S | A | -0.6516 | |
| 199 | L | A | -0.7372 | |
| 200 | G | A | -0.8856 | |
| 201 | T | A | -0.7766 | |
| 202 | Q | A | -1.1142 | |
| 203 | T | A | -0.9698 | |
| 204 | Y | A | 0.0000 | |
| 205 | I | A | -0.8423 | |
| 206 | C | A | 0.0000 | |
| 207 | N | A | 0.0000 | |
| 208 | V | A | 0.0000 | |
| 209 | N | A | -1.9426 | |
| 210 | H | A | 0.0000 | |
| 211 | K | A | -2.7931 | |
| 212 | P | A | -1.6580 | |
| 213 | S | A | -1.8193 | |
| 214 | N | A | -2.4735 | |
| 215 | T | A | -1.9622 | |
| 216 | K | A | -2.4713 | |
| 217 | V | A | -1.2797 | |
| 218 | D | A | -2.3816 | |
| 219 | K | A | -1.8705 | |
| 220 | R | A | -2.2177 | |
| 221 | V | A | 0.0000 | |
| 222 | E | A | -1.2567 | |
| 223 | P | A | -0.7531 | |
| 224 | K | A | -0.7206 | |
| 225 | S | A | -1.0500 | |
| 226 | C | A | -1.5664 | |
| 227 | D | A | -2.7180 | |
| 228 | K | A | -2.7689 | |
| 229 | T | A | -1.4482 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine