| Chain sequence(s) |
A: EIVLTQSPSSLSASVGDRVTITCRASEDIYNTLAWYQQKPGKAPKLLVYNANSLHTGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYYNYHRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVKLVESGGGLVQPGGSLRLSCAASGFTFSDYNMAWVRQAPGKGLEWVASISYGGSKIHHGDSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCARHERYGYNVFVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:01:33)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:01:33)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:01:33)
[INFO] runJob: Creating pdb object from: input.pdb (00:01:33)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:01:33)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:36)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:01:36)
[INFO] Main: Simulation completed successfully. (00:01:58)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -1.3945 | |
| 2 | I | A | 0.0000 | |
| 3 | V | A | 0.9239 | |
| 4 | L | A | 0.0000 | |
| 5 | T | A | -0.5298 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.6024 | |
| 8 | P | A | -0.3641 | |
| 9 | S | A | -0.5505 | |
| 10 | S | A | -0.2719 | |
| 11 | L | A | 0.1463 | |
| 12 | S | A | -0.5280 | |
| 13 | A | A | 0.0000 | |
| 14 | S | A | -0.4645 | |
| 15 | V | A | 0.2593 | |
| 16 | G | A | -0.7321 | |
| 17 | D | A | -1.5252 | |
| 18 | R | A | -2.1178 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.5400 | |
| 21 | I | A | 0.0000 | |
| 22 | T | A | -0.6848 | |
| 23 | C | A | 0.0000 | |
| 24 | R | A | -1.6705 | |
| 25 | A | A | 0.0000 | |
| 26 | S | A | -0.7204 | |
| 30A | E | A | -0.9185 | |
| 30B | D | A | -1.0480 | |
| 30C | I | A | 0.0000 | |
| 30D | Y | A | 0.5737 | |
| 31 | N | A | -0.5460 | |
| 32 | T | A | 0.0412 | |
| 33 | L | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | -0.7476 | |
| 38 | Q | A | -1.1803 | |
| 39 | K | A | -1.5982 | |
| 40 | P | A | -1.5728 | |
| 41 | G | A | -1.6712 | |
| 42 | K | A | -2.5384 | |
| 43 | A | A | -1.5359 | |
| 44 | P | A | 0.0000 | |
| 45 | K | A | -1.0528 | |
| 46 | L | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | V | A | 0.0000 | |
| 49 | Y | A | -0.4455 | |
| 50 | N | A | -0.8990 | |
| 51 | A | A | 0.0000 | |
| 52 | N | A | -1.5547 | |
| 53 | S | A | -0.6670 | |
| 54 | L | A | -0.1107 | |
| 55 | H | A | -0.1572 | |
| 56 | T | A | -0.2318 | |
| 57 | G | A | -0.5468 | |
| 58 | V | A | -0.2522 | |
| 59 | P | A | -0.4110 | |
| 60 | S | A | -0.3563 | |
| 61 | R | A | -0.7044 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -0.4929 | |
| 64 | G | A | -0.8524 | |
| 65 | S | A | -1.1458 | |
| 66 | G | A | -1.3411 | |
| 67 | S | A | -0.9232 | |
| 68 | G | A | -0.7127 | |
| 69 | T | A | -1.5228 | |
| 70 | D | A | -2.3516 | |
| 71 | Y | A | 0.0000 | |
| 72 | T | A | -0.8619 | |
| 73 | L | A | 0.0000 | |
| 74 | T | A | -0.7063 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.1961 | |
| 77 | S | A | -1.2345 | |
| 78 | L | A | 0.0000 | |
| 79 | Q | A | -1.0895 | |
| 80 | P | A | -0.7159 | |
| 81 | E | A | -1.2888 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | -0.1187 | |
| 84 | A | A | 0.0000 | |
| 85 | T | A | -0.3828 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 91 | Y | A | 0.0000 | |
| 92 | Y | A | 0.9044 | |
| 93 | N | A | 0.3384 | |
| 93A | Y | A | 1.0053 | |
| 93B | H | A | -0.2819 | |
| 96 | R | A | 0.0000 | |
| 97 | T | A | -0.0444 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | Q | A | -1.3478 | |
| 101 | G | A | 0.0000 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -0.5919 | |
| 104 | L | A | 0.0000 | |
| 105 | E | A | 0.0000 | |
| 106 | I | A | -0.2568 | |
| 107 | K | A | -1.2044 | |
| 108 | R | A | -0.8895 | |
| 109 | T | A | 0.1240 | |
| 110 | V | A | 1.0492 | |
| 111 | A | A | 0.4709 | |
| 112 | A | A | 0.1168 | |
| 113 | P | A | 0.0000 | |
| 114 | S | A | -0.1166 | |
| 115 | V | A | 0.0000 | |
| 116 | F | A | -0.0352 | |
| 117 | I | A | 0.0000 | |
| 118 | F | A | 0.0000 | |
| 119 | P | A | 0.0000 | |
| 120 | P | A | 0.0000 | |
| 121 | S | A | 0.0000 | |
| 122 | D | A | -2.5681 | |
| 123 | E | A | -2.0970 | |
| 124 | Q | A | 0.0000 | |
| 125 | L | A | -1.8173 | |
| 126 | K | A | -2.5444 | |
| 127 | S | A | -1.5705 | |
| 128 | G | A | -1.3579 | |
| 129 | T | A | -0.9893 | |
| 130 | A | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | V | A | 0.0000 | |
| 133 | V | A | 0.0000 | |
| 134 | C | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | N | A | 0.0000 | |
| 138 | N | A | -0.9296 | |
| 139 | F | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | P | A | -1.0434 | |
| 142 | R | A | -1.9877 | |
| 143 | E | A | -2.8222 | |
| 144 | A | A | 0.0000 | |
| 145 | K | A | -2.2622 | |
| 146 | V | A | 0.0000 | |
| 147 | Q | A | -0.8115 | |
| 148 | W | A | 0.0000 | |
| 149 | K | A | 0.0000 | |
| 150 | V | A | 0.0000 | |
| 151 | D | A | -1.7276 | |
| 152 | N | A | -1.3558 | |
| 153 | A | A | -0.0495 | |
| 154 | L | A | 0.8859 | |
| 155 | Q | A | 0.0109 | |
| 156 | S | A | -0.5176 | |
| 157 | G | A | -0.9692 | |
| 158 | N | A | -0.8597 | |
| 159 | S | A | -0.9907 | |
| 160 | Q | A | -1.0905 | |
| 161 | E | A | -1.3378 | |
| 162 | S | A | 0.0000 | |
| 163 | V | A | -0.4620 | |
| 164 | T | A | -1.0558 | |
| 165 | E | A | -2.3023 | |
| 166 | Q | A | -1.9597 | |
| 167 | D | A | -2.4300 | |
| 168 | S | A | -1.9172 | |
| 169 | K | A | -2.5029 | |
| 170 | D | A | -2.1488 | |
| 171 | S | A | -1.9343 | |
| 172 | T | A | 0.0000 | |
| 173 | Y | A | 0.0000 | |
| 174 | S | A | 0.0000 | |
| 175 | L | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | T | A | -0.4973 | |
| 179 | L | A | 0.0000 | |
| 180 | T | A | -0.2813 | |
| 181 | L | A | -0.1298 | |
| 182 | S | A | -0.8272 | |
| 183 | K | A | -1.8715 | |
| 184 | A | A | -1.4145 | |
| 185 | D | A | -1.7708 | |
| 186 | Y | A | -1.9145 | |
| 187 | E | A | -2.9213 | |
| 188 | K | A | -3.0863 | |
| 189 | H | A | -2.7342 | |
| 190 | K | A | -3.2436 | |
| 191 | V | A | -1.8253 | |
| 192 | Y | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | C | A | 0.0000 | |
| 195 | E | A | -0.5454 | |
| 196 | V | A | 0.0000 | |
| 197 | T | A | -1.1539 | |
| 198 | H | A | 0.0000 | |
| 199 | Q | A | -1.7793 | |
| 200 | G | A | -0.5763 | |
| 201 | L | A | -0.3204 | |
| 202 | S | A | -0.4191 | |
| 203 | S | A | -0.4128 | |
| 204 | P | A | -0.4898 | |
| 205 | V | A | -0.0345 | |
| 206 | T | A | -0.4239 | |
| 207 | K | A | -0.6967 | |
| 208 | S | A | -0.6301 | |
| 209 | F | A | 0.0000 | |
| 210 | N | A | -2.0790 | |
| 211 | R | A | -2.7730 | |
| 212 | G | A | -2.5870 | |
| 213 | E | A | -2.8670 | |
| 214 | C | A | -1.5367 | |
| 1 | E | A | -2.0724 | |
| 2 | V | A | -1.1106 | |
| 3 | K | A | -1.3599 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.0367 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.4130 | |
| 8 | G | A | -0.7523 | |
| 9 | G | A | -0.0054 | |
| 10 | G | A | 0.4300 | |
| 11 | L | A | 1.0123 | |
| 12 | V | A | -0.1314 | |
| 13 | Q | A | -1.3728 | |
| 14 | P | A | -1.5166 | |
| 15 | G | A | -1.3660 | |
| 16 | G | A | -1.0995 | |
| 17 | S | A | -1.1501 | |
| 18 | L | A | -0.9214 | |
| 19 | R | A | -1.9234 | |
| 20 | L | A | 0.0000 | |
| 21 | S | A | -0.4881 | |
| 22 | C | A | 0.0000 | |
| 23 | A | A | -0.2390 | |
| 24 | A | A | 0.0000 | |
| 25 | S | A | -0.9190 | |
| 26 | G | A | -1.1022 | |
| 27 | F | A | -0.3642 | |
| 28 | T | A | -0.1271 | |
| 29 | F | A | 0.0000 | |
| 30 | S | A | -0.6521 | |
| 30A | D | A | -0.2743 | |
| 31 | Y | A | 0.1267 | |
| 32 | N | A | -0.0245 | |
| 33 | M | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | R | A | 0.0000 | |
| 38 | Q | A | -0.7344 | |
| 39 | A | A | -0.8034 | |
| 40 | P | A | -0.8337 | |
| 41 | G | A | -1.4874 | |
| 42 | K | A | -2.3415 | |
| 43 | G | A | -1.6696 | |
| 44 | L | A | 0.0000 | |
| 45 | E | A | -1.1142 | |
| 46 | W | A | 0.0000 | |
| 47 | V | A | 0.0000 | |
| 48 | A | A | 0.0000 | |
| 49 | S | A | 0.0150 | |
| 50 | I | A | 0.0000 | |
| 51 | S | A | -0.4656 | |
| 51A | Y | A | -0.1913 | |
| 52 | G | A | -0.8678 | |
| 53 | G | A | -0.8117 | |
| 54 | S | A | -0.8918 | |
| 55 | K | A | -1.3998 | |
| 56 | I | A | 0.1437 | |
| 57 | H | A | -0.2568 | |
| 58 | H | A | -0.9425 | |
| 59 | G | A | 0.0000 | |
| 60 | D | A | -2.3247 | |
| 61 | S | A | -1.5950 | |
| 62 | V | A | 0.0000 | |
| 63 | K | A | -2.3910 | |
| 64 | G | A | -1.5599 | |
| 65 | R | A | 0.0000 | |
| 66 | F | A | 0.0000 | |
| 67 | T | A | -0.4532 | |
| 68 | I | A | 0.0000 | |
| 69 | S | A | -0.3906 | |
| 70 | R | A | -0.8004 | |
| 71 | D | A | -1.3158 | |
| 72 | N | A | -1.5526 | |
| 73 | A | A | -1.2698 | |
| 74 | K | A | -2.0484 | |
| 75 | S | A | -1.2722 | |
| 76 | S | A | -0.7359 | |
| 77 | L | A | 0.0000 | |
| 78 | Y | A | -0.4436 | |
| 79 | L | A | 0.0000 | |
| 80 | Q | A | -1.1520 | |
| 81 | M | A | 0.0000 | |
| 82 | N | A | -1.2611 | |
| 83 | S | A | -1.1333 | |
| 84 | L | A | 0.0000 | |
| 85 | R | A | -1.6798 | |
| 86 | A | A | -0.9744 | |
| 87 | E | A | -0.9375 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | 0.0391 | |
| 90 | A | A | 0.0000 | |
| 91 | V | A | 0.7119 | |
| 92 | Y | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | A | A | 0.0000 | |
| 96 | R | A | 0.0000 | |
| 97 | H | A | 0.0000 | |
| 98 | E | A | 0.2341 | |
| 99 | R | A | 0.1537 | |
| 100 | Y | A | 0.9577 | |
| 101 | G | A | 0.2883 | |
| 102A | Y | A | 0.5787 | |
| 102B | N | A | 0.0216 | |
| 102C | V | A | 0.0000 | |
| 102D | F | A | 0.0000 | |
| 103 | V | A | 0.2250 | |
| 104 | Y | A | 0.4183 | |
| 105 | W | A | -0.0158 | |
| 106 | G | A | -0.6067 | |
| 107 | Q | A | -1.3328 | |
| 108 | G | A | -0.3550 | |
| 109 | T | A | 0.0000 | |
| 110 | L | A | 1.2495 | |
| 111 | V | A | 0.0000 | |
| 112 | T | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.4163 | |
| 115 | S | A | -0.5109 | |
| 121 | A | A | -0.3449 | |
| 122 | S | A | -0.3589 | |
| 123 | T | A | -0.5149 | |
| 124 | K | A | -1.1271 | |
| 125 | G | A | -1.2773 | |
| 126 | P | A | 0.0000 | |
| 127 | S | A | -0.1995 | |
| 128 | V | A | -0.1195 | |
| 129 | F | A | -0.4179 | |
| 130 | P | A | -0.7067 | |
| 131 | L | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | P | A | 0.0000 | |
| 134 | S | A | -0.7311 | |
| 135 | S | A | -0.7039 | |
| 136 | K | A | -0.6188 | |
| 137 | S | A | -0.7323 | |
| 138 | T | A | -0.7721 | |
| 139 | S | A | -0.7347 | |
| 140 | G | A | -0.8451 | |
| 141 | G | A | -0.8400 | |
| 142 | T | A | -0.5785 | |
| 143 | A | A | 0.0000 | |
| 144 | A | A | 0.0000 | |
| 145 | L | A | 0.0000 | |
| 146 | G | A | 0.0000 | |
| 147 | C | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | V | A | 0.0000 | |
| 150 | K | A | 0.0000 | |
| 151 | D | A | -0.3430 | |
| 152 | Y | A | 0.0000 | |
| 153 | F | A | 0.0000 | |
| 154 | P | A | -0.4445 | |
| 155 | E | A | -0.6264 | |
| 156 | P | A | -0.9117 | |
| 157 | V | A | 0.0000 | |
| 158 | T | A | -0.6909 | |
| 159 | V | A | -0.4049 | |
| 160 | S | A | -0.3448 | |
| 161 | W | A | 0.0000 | |
| 162 | N | A | -0.7548 | |
| 163 | S | A | -0.6944 | |
| 164 | G | A | -0.4297 | |
| 165 | A | A | -0.1940 | |
| 166 | L | A | -0.0301 | |
| 167 | T | A | -0.1854 | |
| 168 | S | A | -0.1867 | |
| 169 | G | A | -0.2603 | |
| 170 | V | A | 0.1585 | |
| 171 | H | A | -0.0322 | |
| 172 | T | A | 0.0234 | |
| 173 | F | A | 0.0000 | |
| 174 | P | A | -0.4632 | |
| 175 | A | A | 0.0254 | |
| 176 | V | A | 0.2827 | |
| 177 | L | A | 0.8740 | |
| 178 | Q | A | 0.0540 | |
| 179 | S | A | -0.2334 | |
| 180 | S | A | -0.2096 | |
| 181 | G | A | -0.0850 | |
| 182 | L | A | 0.0262 | |
| 183 | Y | A | 0.0000 | |
| 184 | S | A | 0.0000 | |
| 185 | L | A | 0.0000 | |
| 186 | S | A | 0.0000 | |
| 187 | S | A | 0.0000 | |
| 188 | V | A | 0.0000 | |
| 189 | V | A | 0.0000 | |
| 190 | T | A | -0.1743 | |
| 191 | V | A | 0.0000 | |
| 192 | P | A | -0.5733 | |
| 193 | S | A | 0.0000 | |
| 194 | S | A | -0.8158 | |
| 195 | S | A | -0.6508 | |
| 196 | L | A | -0.7492 | |
| 197 | G | A | -0.8963 | |
| 198 | T | A | -0.7827 | |
| 199 | Q | A | -1.1255 | |
| 200 | T | A | -0.9866 | |
| 201 | Y | A | 0.0000 | |
| 202 | I | A | -0.8843 | |
| 203 | C | A | 0.0000 | |
| 204 | N | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | N | A | -1.9800 | |
| 207 | H | A | 0.0000 | |
| 208 | K | A | -2.7979 | |
| 209 | P | A | -1.6257 | |
| 210 | S | A | -1.8478 | |
| 211 | N | A | -2.5814 | |
| 212 | T | A | -2.0361 | |
| 213 | K | A | -2.5543 | |
| 214 | V | A | -1.3293 | |
| 215 | D | A | -2.4091 | |
| 216 | K | A | -1.7308 | |
| 217 | R | A | -2.2345 | |
| 218 | V | A | 0.0000 | |
| 219 | E | A | -1.2750 | |
| 220 | P | A | -0.7428 | |
| 221 | K | A | -0.9245 | |
| 222 | S | A | -1.2448 | |
| 223 | C | A | -1.6324 | |
| 224 | D | A | -2.7743 | |
| 225 | K | A | -2.7804 | |
| 226 | T | A | -1.4499 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine