| Chain sequence(s) |
A: DIQMTQSPSTLSASVGDRVTITCRASEGIYSGLAWYQQKPGKAPKVLIYNAKTLQSGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYHKYPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVQLVESGGGLVQPGGSLRLSCAASGFTFNNFPMAWVRQAPGKGLEWVAVISISGGNTYYRDSVKGRFTISRDDAKGSLYLQMNSLRAEDTAVYYCTRDDYGYNLFDYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:08)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -2.2970 | |
| 2 | I | A | 0.0000 | |
| 3 | Q | A | -1.9766 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -0.9775 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.5081 | |
| 8 | P | A | -0.4064 | |
| 9 | S | A | -0.4870 | |
| 10 | T | A | -0.3239 | |
| 11 | L | A | -0.0688 | |
| 12 | S | A | -0.4175 | |
| 13 | A | A | 0.0000 | |
| 14 | S | A | -0.3237 | |
| 15 | V | A | 0.5805 | |
| 16 | G | A | -0.6736 | |
| 17 | D | A | -1.6278 | |
| 18 | R | A | -2.1984 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.5978 | |
| 21 | I | A | 0.0000 | |
| 22 | T | A | -0.5616 | |
| 23 | C | A | 0.0000 | |
| 24 | R | A | -1.6445 | |
| 25 | A | A | 0.0000 | |
| 26 | S | A | -1.5035 | |
| 27 | E | A | -1.1490 | |
| 28 | G | A | -0.6217 | |
| 29 | I | A | 0.0000 | |
| 30A | Y | A | 0.7867 | |
| 31 | S | A | 0.0000 | |
| 32 | G | A | -0.2391 | |
| 33 | L | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | 0.0000 | |
| 38 | Q | A | 0.0000 | |
| 39 | K | A | -1.5359 | |
| 40 | P | A | -1.4356 | |
| 41 | G | A | -1.6249 | |
| 42 | K | A | -2.5119 | |
| 43 | A | A | -1.5788 | |
| 44 | P | A | 0.0000 | |
| 45 | K | A | -1.4400 | |
| 46 | V | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | -0.1674 | |
| 50 | N | A | -0.8234 | |
| 51 | A | A | 0.0000 | |
| 51A | K | A | -1.1497 | |
| 53 | T | A | -0.2970 | |
| 54 | L | A | 0.1112 | |
| 55 | Q | A | 0.0000 | |
| 56 | S | A | -0.3082 | |
| 57 | G | A | -0.5395 | |
| 58 | V | A | -0.1796 | |
| 59 | P | A | -0.3047 | |
| 60 | S | A | -0.2319 | |
| 61 | R | A | 0.0000 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -0.3414 | |
| 64 | G | A | -0.6529 | |
| 65 | S | A | -0.8762 | |
| 66 | G | A | -1.0840 | |
| 67 | S | A | -0.8004 | |
| 68 | G | A | -0.5388 | |
| 69 | T | A | -1.0256 | |
| 70 | E | A | -1.6456 | |
| 71 | F | A | 0.0000 | |
| 72 | T | A | -0.6616 | |
| 73 | L | A | 0.0000 | |
| 74 | T | A | 0.0000 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.2196 | |
| 77 | S | A | -1.2121 | |
| 78 | L | A | 0.0000 | |
| 79 | Q | A | -0.9418 | |
| 80 | P | A | -0.6739 | |
| 81 | D | A | -1.2517 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | -0.1270 | |
| 84 | A | A | 0.0000 | |
| 85 | T | A | -0.2956 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 91 | Y | A | 0.0000 | |
| 93A | H | A | -0.3748 | |
| 93B | K | A | -0.8836 | |
| 94 | Y | A | -0.0248 | |
| 95 | P | A | -0.5209 | |
| 96 | R | A | 0.0000 | |
| 97 | T | A | -0.7047 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | G | A | -1.0046 | |
| 101 | G | A | 0.0000 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -0.3362 | |
| 104 | V | A | 0.0000 | |
| 105 | E | A | 0.0000 | |
| 106 | I | A | -0.3680 | |
| 107 | K | A | -0.6992 | |
| 108 | R | A | -0.8902 | |
| 109 | T | A | 0.2102 | |
| 110 | V | A | 1.2096 | |
| 111 | A | A | 0.4501 | |
| 112 | A | A | 0.0729 | |
| 113 | P | A | 0.0000 | |
| 114 | S | A | -0.1209 | |
| 115 | V | A | 0.0000 | |
| 116 | F | A | -0.0348 | |
| 117 | I | A | 0.0000 | |
| 118 | F | A | 0.0000 | |
| 119 | P | A | 0.0000 | |
| 120 | P | A | 0.0000 | |
| 121 | S | A | 0.0000 | |
| 122 | D | A | -2.5314 | |
| 123 | E | A | -2.0697 | |
| 124 | Q | A | 0.0000 | |
| 125 | L | A | -1.9428 | |
| 126 | K | A | -2.5387 | |
| 127 | S | A | -1.5692 | |
| 128 | G | A | -1.1704 | |
| 129 | T | A | -0.9583 | |
| 130 | A | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | V | A | 0.0000 | |
| 133 | V | A | 0.0000 | |
| 134 | C | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | N | A | 0.0000 | |
| 138 | N | A | -0.8870 | |
| 139 | F | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | P | A | 0.0000 | |
| 142 | R | A | -1.9016 | |
| 143 | E | A | -2.5266 | |
| 144 | A | A | -1.8764 | |
| 145 | K | A | -2.3743 | |
| 146 | V | A | 0.0000 | |
| 147 | Q | A | -0.8643 | |
| 148 | W | A | 0.0000 | |
| 149 | K | A | 0.0000 | |
| 150 | V | A | 0.0000 | |
| 151 | D | A | -2.1443 | |
| 152 | N | A | -1.4959 | |
| 153 | A | A | -0.1405 | |
| 154 | L | A | 0.8376 | |
| 155 | Q | A | -0.0036 | |
| 156 | S | A | -0.5270 | |
| 157 | G | A | -0.9775 | |
| 158 | N | A | -0.8751 | |
| 159 | S | A | -1.0269 | |
| 160 | Q | A | -1.0792 | |
| 161 | E | A | -1.4280 | |
| 162 | S | A | 0.0000 | |
| 163 | V | A | -0.4234 | |
| 164 | T | A | -1.0552 | |
| 165 | E | A | -2.2252 | |
| 166 | Q | A | -1.9176 | |
| 167 | D | A | -2.3558 | |
| 168 | S | A | -1.8784 | |
| 169 | K | A | -2.3861 | |
| 170 | D | A | -1.9993 | |
| 171 | S | A | 0.0000 | |
| 172 | T | A | 0.0000 | |
| 173 | Y | A | 0.0000 | |
| 174 | S | A | 0.0000 | |
| 175 | L | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | T | A | -0.5149 | |
| 179 | L | A | 0.0000 | |
| 180 | T | A | -0.2599 | |
| 181 | L | A | -0.0842 | |
| 182 | S | A | -0.7797 | |
| 183 | K | A | -1.8209 | |
| 184 | A | A | -1.3504 | |
| 185 | D | A | -1.7316 | |
| 186 | Y | A | -1.7611 | |
| 187 | E | A | -2.8268 | |
| 188 | K | A | -3.1590 | |
| 189 | H | A | -2.8420 | |
| 190 | K | A | -3.3299 | |
| 191 | V | A | -2.0928 | |
| 192 | Y | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | C | A | 0.0000 | |
| 195 | E | A | -0.5870 | |
| 196 | V | A | 0.0000 | |
| 197 | T | A | -1.1693 | |
| 198 | H | A | 0.0000 | |
| 199 | Q | A | -1.6372 | |
| 200 | G | A | -0.4408 | |
| 201 | L | A | -0.3669 | |
| 202 | S | A | -0.4487 | |
| 203 | S | A | -0.4251 | |
| 204 | P | A | -0.5205 | |
| 205 | V | A | -0.0552 | |
| 206 | T | A | -0.4422 | |
| 207 | K | A | -0.7204 | |
| 208 | S | A | -0.6731 | |
| 209 | F | A | 0.0000 | |
| 210 | N | A | -2.3784 | |
| 211 | R | A | -3.2937 | |
| 212 | G | A | -2.5551 | |
| 213 | E | A | -2.3722 | |
| 214 | C | A | -1.5619 | |
| 1 | E | A | -1.7958 | |
| 2 | V | A | -0.9328 | |
| 3 | Q | A | -0.8978 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.9111 | |
| 6 | E | A | 0.0779 | |
| 7 | S | A | -0.3989 | |
| 8 | G | A | -0.6163 | |
| 9 | G | A | -0.1532 | |
| 10 | G | A | 0.4020 | |
| 11 | L | A | 1.0619 | |
| 12 | V | A | -0.0980 | |
| 13 | Q | A | -1.4089 | |
| 14 | P | A | -1.6028 | |
| 15 | G | A | -1.4305 | |
| 16 | G | A | -1.1902 | |
| 17 | S | A | -0.9526 | |
| 18 | L | A | -0.5000 | |
| 19 | R | A | -1.2567 | |
| 20 | L | A | 0.0000 | |
| 21 | S | A | -0.2640 | |
| 22 | C | A | 0.0000 | |
| 23 | A | A | -0.0636 | |
| 24 | A | A | 0.0000 | |
| 25 | S | A | -0.1398 | |
| 26 | G | A | -0.2880 | |
| 27 | F | A | 0.1117 | |
| 28 | T | A | -0.2961 | |
| 29 | F | A | -0.4196 | |
| 30 | N | A | -1.2588 | |
| 30A | N | A | -1.0678 | |
| 30B | F | A | 0.0000 | |
| 30C | P | A | 0.4000 | |
| 33 | M | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | R | A | 0.0000 | |
| 38 | Q | A | -0.7645 | |
| 39 | A | A | -0.8609 | |
| 40 | P | A | -1.0741 | |
| 41 | G | A | -1.4696 | |
| 42 | K | A | -2.2444 | |
| 43 | G | A | -1.4332 | |
| 44 | L | A | 0.0000 | |
| 45 | E | A | -0.7819 | |
| 46 | W | A | 0.0000 | |
| 47 | V | A | 0.0000 | |
| 48 | A | A | 0.0000 | |
| 49 | V | A | 0.0000 | |
| 50 | I | A | 0.0000 | |
| 51 | S | A | 0.1193 | |
| 51A | I | A | 0.9556 | |
| 52 | S | A | -0.0486 | |
| 53 | G | A | -0.4604 | |
| 54 | G | A | -0.8407 | |
| 55 | N | A | -0.9785 | |
| 56 | T | A | -0.3305 | |
| 57 | Y | A | 0.0550 | |
| 58 | Y | A | -0.6254 | |
| 59 | R | A | -1.4490 | |
| 60 | D | A | -2.6503 | |
| 61 | S | A | -1.6156 | |
| 62 | V | A | 0.0000 | |
| 63 | K | A | -2.4265 | |
| 64 | G | A | -1.6866 | |
| 65 | R | A | 0.0000 | |
| 66 | F | A | 0.0000 | |
| 67 | T | A | -0.5920 | |
| 68 | I | A | 0.0000 | |
| 69 | S | A | -0.4729 | |
| 70 | R | A | -0.6191 | |
| 71 | D | A | -1.2171 | |
| 72 | D | A | -1.2925 | |
| 73 | A | A | -1.2181 | |
| 74 | K | A | -1.9361 | |
| 75 | G | A | 0.0000 | |
| 76 | S | A | 0.0000 | |
| 77 | L | A | 0.0000 | |
| 78 | Y | A | -0.3134 | |
| 79 | L | A | 0.0000 | |
| 80 | Q | A | -0.7877 | |
| 81 | M | A | 0.0000 | |
| 82 | N | A | -1.3098 | |
| 83 | S | A | -1.2671 | |
| 84 | L | A | 0.0000 | |
| 85 | R | A | -1.9693 | |
| 86 | A | A | -1.0981 | |
| 87 | E | A | -1.2405 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | -0.1601 | |
| 90 | A | A | 0.0000 | |
| 91 | V | A | 0.1581 | |
| 92 | Y | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | T | A | 0.0000 | |
| 96 | R | A | 0.0000 | |
| 102A | D | A | 0.0000 | |
| 102B | D | A | 0.1811 | |
| 102C | Y | A | 1.0181 | |
| 102D | G | A | 0.5920 | |
| 102E | Y | A | 1.0902 | |
| 102F | N | A | 0.4738 | |
| 102G | L | A | 0.0000 | |
| 102H | F | A | 0.0000 | |
| 103 | D | A | -0.2629 | |
| 104 | Y | A | -0.3142 | |
| 105 | W | A | -0.2104 | |
| 106 | G | A | 0.0000 | |
| 107 | Q | A | -1.3479 | |
| 108 | G | A | -0.7016 | |
| 109 | T | A | -0.0393 | |
| 110 | M | A | 0.4993 | |
| 111 | V | A | 0.0000 | |
| 112 | T | A | 0.1880 | |
| 113 | V | A | -0.4970 | |
| 114 | S | A | -0.5046 | |
| 115 | S | A | -0.5612 | |
| 120 | A | A | -0.5093 | |
| 121 | S | A | -0.4237 | |
| 122 | T | A | -0.4755 | |
| 123 | K | A | -0.9886 | |
| 124 | G | A | -1.2448 | |
| 125 | P | A | 0.0000 | |
| 126 | S | A | -0.2012 | |
| 127 | V | A | -0.1301 | |
| 128 | F | A | -0.4115 | |
| 129 | P | A | -0.6869 | |
| 130 | L | A | 0.0000 | |
| 131 | A | A | 0.0000 | |
| 132 | P | A | 0.0000 | |
| 133 | S | A | -0.6007 | |
| 134 | S | A | -0.6873 | |
| 135 | K | A | -0.5591 | |
| 136 | S | A | -0.7179 | |
| 137 | T | A | -0.7630 | |
| 138 | S | A | -0.7282 | |
| 139 | G | A | -0.8395 | |
| 140 | G | A | -0.8380 | |
| 141 | T | A | -0.5963 | |
| 142 | A | A | 0.0000 | |
| 143 | A | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | G | A | 0.0000 | |
| 146 | C | A | 0.0000 | |
| 147 | L | A | 0.0000 | |
| 148 | V | A | 0.0000 | |
| 149 | K | A | 0.0000 | |
| 150 | D | A | -0.3347 | |
| 151 | Y | A | 0.0000 | |
| 152 | F | A | 0.0000 | |
| 153 | P | A | -0.4398 | |
| 154 | E | A | -0.6951 | |
| 155 | P | A | -0.9797 | |
| 156 | V | A | 0.0000 | |
| 157 | T | A | -0.7099 | |
| 158 | V | A | -0.4109 | |
| 159 | S | A | -0.3712 | |
| 160 | W | A | 0.0000 | |
| 161 | N | A | -0.7515 | |
| 162 | S | A | -0.7030 | |
| 163 | G | A | -0.4350 | |
| 164 | A | A | -0.1833 | |
| 165 | L | A | -0.0154 | |
| 166 | T | A | -0.1775 | |
| 167 | S | A | -0.1832 | |
| 168 | G | A | -0.2568 | |
| 169 | V | A | 0.1765 | |
| 170 | H | A | 0.0240 | |
| 171 | T | A | -0.1543 | |
| 172 | F | A | 0.0000 | |
| 173 | P | A | -0.4834 | |
| 174 | A | A | 0.1385 | |
| 175 | V | A | 0.4417 | |
| 176 | L | A | 1.1135 | |
| 177 | Q | A | 0.1339 | |
| 178 | S | A | -0.2489 | |
| 179 | S | A | -0.2467 | |
| 180 | G | A | -0.1394 | |
| 181 | L | A | 0.0148 | |
| 182 | Y | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | L | A | 0.0000 | |
| 185 | S | A | 0.0000 | |
| 186 | S | A | 0.0000 | |
| 187 | V | A | 0.0000 | |
| 188 | V | A | 0.0000 | |
| 189 | T | A | -0.1689 | |
| 190 | V | A | 0.0000 | |
| 191 | P | A | -0.5730 | |
| 192 | S | A | 0.0000 | |
| 193 | S | A | -0.8117 | |
| 194 | S | A | -0.6475 | |
| 195 | L | A | -0.7322 | |
| 196 | G | A | -0.8842 | |
| 197 | T | A | -0.7770 | |
| 198 | Q | A | -1.1158 | |
| 199 | T | A | -0.9690 | |
| 200 | Y | A | 0.0000 | |
| 201 | I | A | -0.8547 | |
| 202 | C | A | 0.0000 | |
| 203 | N | A | -1.4293 | |
| 204 | V | A | 0.0000 | |
| 205 | N | A | -1.9761 | |
| 206 | H | A | 0.0000 | |
| 207 | K | A | -2.7940 | |
| 208 | P | A | -1.6470 | |
| 209 | S | A | -1.8152 | |
| 210 | N | A | -2.4773 | |
| 211 | T | A | -1.9841 | |
| 212 | K | A | -2.5338 | |
| 213 | V | A | -1.3352 | |
| 214 | D | A | -2.4384 | |
| 215 | K | A | -1.9032 | |
| 216 | R | A | -2.2272 | |
| 217 | V | A | 0.0000 | |
| 218 | E | A | -1.2514 | |
| 219 | P | A | -0.7385 | |
| 220 | K | A | -0.6943 | |
| 221 | S | A | -1.2432 | |
| 222 | C | A | -1.5800 | |
| 223 | D | A | -2.5302 | |
| 224 | K | A | -2.5698 | |
| 225 | T | A | -1.4437 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine