| Chain sequence(s) |
A: DIVMTQSPLSLPVTPGEPASISCRSSRSLLHSSGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEADDVGVYYCMQALQAPPTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLVQSGTEVKNPGASVKVSCKASGYTFTGHYMHWVRQAPGQGPEWMGWIDPKRPDTKYAQNFQGRVTMTRDRSISTAYLELTNLTPDDTAVYYCARDPGRPGYFWYFDLWGRGTMVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:01:27)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:01:27)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:01:27)
[INFO] runJob: Creating pdb object from: input.pdb (00:01:27)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:01:28)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:30)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:01:30)
[INFO] Main: Simulation completed successfully. (00:01:51)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -1.9042 | |
| 2 | I | A | 0.0000 | |
| 3 | V | A | 0.8087 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -0.4494 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | 0.0150 | |
| 8 | P | A | 0.5063 | |
| 9 | L | A | 1.4205 | |
| 10 | S | A | 0.4735 | |
| 11 | L | A | 0.3400 | |
| 12 | P | A | -0.2628 | |
| 13 | V | A | 0.0000 | |
| 14 | T | A | -1.6019 | |
| 15 | P | A | -1.7641 | |
| 16 | G | A | -2.0094 | |
| 17 | E | A | -2.5805 | |
| 18 | P | A | -1.8713 | |
| 19 | A | A | -1.0424 | |
| 20 | S | A | -0.5831 | |
| 21 | I | A | 0.0000 | |
| 22 | S | A | -0.9908 | |
| 23 | C | A | 0.0000 | |
| 24 | R | A | -2.2820 | |
| 25 | S | A | 0.0000 | |
| 26 | S | A | -1.3208 | |
| 27 | R | A | -2.2611 | |
| 28 | S | A | -1.4503 | |
| 29 | L | A | 0.0000 | |
| 30 | L | A | 0.3332 | |
| 30A | H | A | -0.1644 | |
| 30B | S | A | -0.2707 | |
| 30C | S | A | -0.1824 | |
| 30D | G | A | -0.0186 | |
| 30E | Y | A | 0.9537 | |
| 31 | N | A | 0.4143 | |
| 32 | Y | A | 0.0000 | |
| 33 | L | A | 0.0000 | |
| 34 | D | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | L | A | 0.0000 | |
| 38 | Q | A | -0.4651 | |
| 39 | K | A | -0.7998 | |
| 40 | P | A | -0.9896 | |
| 41 | G | A | -0.9489 | |
| 42 | Q | A | -1.2669 | |
| 43 | S | A | -0.9373 | |
| 44 | P | A | 0.0000 | |
| 45 | Q | A | -0.5378 | |
| 46 | L | A | -0.3441 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | -0.2815 | |
| 50 | L | A | 0.0000 | |
| 51 | G | A | 0.0000 | |
| 52 | S | A | -0.9359 | |
| 53 | N | A | -1.7817 | |
| 54 | R | A | -2.0161 | |
| 55 | A | A | -1.0367 | |
| 56 | S | A | -0.8286 | |
| 57 | G | A | -0.8613 | |
| 58 | V | A | -0.9645 | |
| 59 | P | A | -1.3295 | |
| 60 | D | A | -2.1574 | |
| 61 | R | A | 0.0000 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -1.3147 | |
| 64 | G | A | -0.9820 | |
| 65 | S | A | -0.9828 | |
| 66 | G | A | -1.3429 | |
| 67 | S | A | -0.8987 | |
| 68 | G | A | -1.0202 | |
| 69 | T | A | -1.9097 | |
| 70 | D | A | -2.7508 | |
| 71 | F | A | 0.0000 | |
| 72 | T | A | -1.0693 | |
| 73 | L | A | 0.0000 | |
| 74 | K | A | -1.1515 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.7630 | |
| 77 | R | A | -2.4067 | |
| 78 | V | A | 0.0000 | |
| 79 | E | A | -1.5886 | |
| 80 | A | A | -1.1632 | |
| 81 | D | A | -1.1503 | |
| 82 | D | A | 0.0000 | |
| 83 | V | A | -0.5650 | |
| 84 | G | A | 0.0000 | |
| 85 | V | A | 0.3810 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | M | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 93A | A | A | 0.0000 | |
| 93B | L | A | -0.1260 | |
| 93C | Q | A | -0.8473 | |
| 94 | A | A | -0.5384 | |
| 95 | P | A | 0.0000 | |
| 96 | P | A | 0.0000 | |
| 97 | T | A | -0.1789 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | P | A | -0.0759 | |
| 101 | G | A | 0.0000 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | 0.3274 | |
| 104 | V | A | 0.0000 | |
| 105 | D | A | 0.0000 | |
| 106 | I | A | 0.0000 | |
| 107 | K | A | 0.0000 | |
| 108 | R | A | -1.7018 | |
| 114 | T | A | -0.1063 | |
| 115 | V | A | 1.1434 | |
| 116 | A | A | 0.3114 | |
| 117 | A | A | 0.1067 | |
| 118 | P | A | 0.0000 | |
| 119 | S | A | -0.1830 | |
| 120 | V | A | 0.0000 | |
| 121 | F | A | -0.0385 | |
| 122 | I | A | 0.0000 | |
| 123 | F | A | 0.0000 | |
| 124 | P | A | -0.4694 | |
| 125 | P | A | 0.0000 | |
| 126 | S | A | 0.0000 | |
| 127 | D | A | -2.5748 | |
| 128 | E | A | -2.0971 | |
| 129 | Q | A | 0.0000 | |
| 130 | L | A | -1.8187 | |
| 131 | K | A | -2.5474 | |
| 132 | S | A | -1.5704 | |
| 133 | G | A | -1.3505 | |
| 134 | T | A | -0.9711 | |
| 135 | A | A | 0.0000 | |
| 136 | S | A | 0.0000 | |
| 137 | V | A | 0.0000 | |
| 138 | V | A | 0.0000 | |
| 139 | C | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | N | A | 0.0000 | |
| 143 | N | A | -1.0202 | |
| 144 | F | A | 0.0000 | |
| 145 | Y | A | 0.0000 | |
| 146 | P | A | -0.5678 | |
| 147 | R | A | -1.0160 | |
| 148 | E | A | -1.7766 | |
| 149 | A | A | 0.0000 | |
| 150 | K | A | -2.0118 | |
| 151 | V | A | 0.0000 | |
| 152 | Q | A | -0.7221 | |
| 153 | W | A | 0.0000 | |
| 154 | K | A | 0.0000 | |
| 155 | V | A | 0.0000 | |
| 156 | D | A | -1.7341 | |
| 157 | N | A | -1.3571 | |
| 158 | A | A | -0.0460 | |
| 159 | L | A | 0.8955 | |
| 160 | Q | A | 0.0244 | |
| 161 | S | A | -0.5039 | |
| 162 | G | A | -0.9652 | |
| 163 | N | A | -0.8588 | |
| 164 | S | A | -0.9602 | |
| 165 | Q | A | -1.0719 | |
| 166 | E | A | -1.3188 | |
| 167 | S | A | 0.0000 | |
| 168 | V | A | -0.2418 | |
| 169 | T | A | -0.9764 | |
| 170 | E | A | -2.1577 | |
| 171 | Q | A | -2.0376 | |
| 172 | D | A | -2.6057 | |
| 173 | S | A | -2.1924 | |
| 174 | K | A | -2.5490 | |
| 175 | D | A | -2.4145 | |
| 176 | S | A | 0.0000 | |
| 177 | T | A | -1.5530 | |
| 178 | Y | A | 0.0000 | |
| 179 | S | A | 0.0000 | |
| 180 | L | A | 0.0000 | |
| 181 | S | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | T | A | -0.4989 | |
| 184 | L | A | 0.0000 | |
| 185 | T | A | -0.2692 | |
| 186 | L | A | -0.1062 | |
| 187 | S | A | -0.7898 | |
| 188 | K | A | -1.8158 | |
| 189 | A | A | -1.3552 | |
| 190 | D | A | -1.7047 | |
| 191 | Y | A | -1.8009 | |
| 192 | E | A | -2.8157 | |
| 193 | K | A | -3.0524 | |
| 194 | H | A | -2.7455 | |
| 195 | K | A | -3.3173 | |
| 196 | V | A | -1.8988 | |
| 197 | Y | A | 0.0000 | |
| 198 | A | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | E | A | -0.5373 | |
| 201 | V | A | 0.0000 | |
| 202 | T | A | -0.9983 | |
| 203 | H | A | 0.0000 | |
| 204 | Q | A | -1.4576 | |
| 205 | G | A | -0.3456 | |
| 206 | L | A | -0.1090 | |
| 207 | S | A | -0.4030 | |
| 208 | S | A | -0.4089 | |
| 209 | P | A | -0.4407 | |
| 210 | V | A | -0.0412 | |
| 211 | T | A | -0.4386 | |
| 212 | K | A | -0.7406 | |
| 213 | S | A | -0.6625 | |
| 214 | F | A | 0.0000 | |
| 215 | N | A | -2.1819 | |
| 216 | R | A | -2.9806 | |
| 217 | G | A | -2.4636 | |
| 218 | E | A | -2.4830 | |
| 219 | C | A | -1.5440 | |
| 1 | Q | A | -0.7976 | |
| 2 | V | A | 0.5109 | |
| 3 | Q | A | -0.2896 | |
| 4 | L | A | 0.0000 | |
| 5 | V | A | 0.3579 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.5218 | |
| 8 | G | A | -0.5907 | |
| 9 | T | A | -0.1004 | |
| 10 | E | A | -0.2419 | |
| 11 | V | A | 0.5493 | |
| 12 | K | A | -0.6952 | |
| 13 | N | A | -1.6799 | |
| 14 | P | A | -1.4865 | |
| 15 | G | A | -1.5424 | |
| 16 | A | A | -1.1755 | |
| 17 | S | A | -1.2449 | |
| 18 | V | A | 0.0000 | |
| 19 | K | A | -1.1979 | |
| 20 | V | A | 0.0000 | |
| 21 | S | A | -0.4035 | |
| 22 | C | A | 0.0000 | |
| 23 | K | A | -0.6360 | |
| 24 | A | A | 0.0000 | |
| 25 | S | A | -0.1163 | |
| 26 | G | A | -0.3491 | |
| 27 | Y | A | -0.0603 | |
| 28 | T | A | -0.1143 | |
| 29 | F | A | 0.0000 | |
| 30A | T | A | -1.3093 | |
| 30B | G | A | -0.7240 | |
| 31 | H | A | -0.4230 | |
| 32 | Y | A | 0.0200 | |
| 33 | M | A | 0.0000 | |
| 34 | H | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | R | A | 0.0000 | |
| 38 | Q | A | -0.4185 | |
| 39 | A | A | 0.0000 | |
| 40 | P | A | -0.9582 | |
| 41 | G | A | -1.1413 | |
| 42 | Q | A | -1.3328 | |
| 43 | G | A | -0.7056 | |
| 44 | P | A | 0.0000 | |
| 45 | E | A | 0.0000 | |
| 46 | W | A | 0.0000 | |
| 47 | M | A | 0.0000 | |
| 48 | G | A | 0.0000 | |
| 49 | W | A | -0.1016 | |
| 50 | I | A | 0.0000 | |
| 51A | D | A | 0.0000 | |
| 51B | P | A | 0.0000 | |
| 52 | K | A | -3.0864 | |
| 53 | R | A | -3.1418 | |
| 54 | P | A | -2.3841 | |
| 55 | D | A | -1.7738 | |
| 56 | T | A | -1.0293 | |
| 57 | K | A | -1.3807 | |
| 58 | Y | A | 0.0000 | |
| 59 | A | A | 0.0000 | |
| 60 | Q | A | -2.7059 | |
| 61 | N | A | -2.2879 | |
| 62 | F | A | 0.0000 | |
| 63 | Q | A | -2.4299 | |
| 64 | G | A | -1.7808 | |
| 65 | R | A | -1.6082 | |
| 66 | V | A | 0.0000 | |
| 67 | T | A | -0.7176 | |
| 68 | M | A | 0.0000 | |
| 69 | T | A | -0.6718 | |
| 70 | R | A | -1.2484 | |
| 71 | D | A | -1.3319 | |
| 72 | R | A | -1.8962 | |
| 73 | S | A | -0.1505 | |
| 74 | I | A | 1.0700 | |
| 75 | S | A | -0.2656 | |
| 76 | T | A | 0.0000 | |
| 77 | A | A | 0.0000 | |
| 78 | Y | A | -0.4729 | |
| 79 | L | A | 0.0000 | |
| 80 | E | A | -0.9501 | |
| 81 | L | A | 0.0000 | |
| 82 | T | A | -1.2265 | |
| 83 | N | A | -1.8335 | |
| 84 | L | A | 0.0000 | |
| 85 | T | A | -1.1441 | |
| 86 | P | A | -0.9967 | |
| 87 | D | A | -1.1908 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | -0.2115 | |
| 90 | A | A | 0.0000 | |
| 91 | V | A | 0.4455 | |
| 92 | Y | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | A | A | 0.0000 | |
| 96 | R | A | 0.0000 | |
| 97 | D | A | 0.0000 | |
| 98 | P | A | -0.4014 | |
| 99 | G | A | -0.9819 | |
| 102A | R | A | -2.0446 | |
| 102B | P | A | -1.2834 | |
| 102C | G | A | -0.8388 | |
| 102D | Y | A | 0.0413 | |
| 102E | F | A | 0.9309 | |
| 102F | W | A | 0.9944 | |
| 102G | Y | A | 0.0000 | |
| 102H | F | A | 0.0000 | |
| 103 | D | A | -0.7513 | |
| 104 | L | A | -0.2048 | |
| 105 | W | A | 0.0000 | |
| 106 | G | A | 0.0000 | |
| 107 | R | A | -1.2989 | |
| 108 | G | A | -0.5943 | |
| 109 | T | A | 0.0000 | |
| 110 | M | A | 0.4827 | |
| 111 | V | A | 0.0000 | |
| 112 | I | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.6018 | |
| 115 | S | A | -0.7998 | |
| 123 | A | A | -0.5846 | |
| 124 | S | A | -0.5409 | |
| 125 | T | A | -0.4908 | |
| 126 | K | A | -1.1131 | |
| 127 | G | A | -1.3057 | |
| 128 | P | A | 0.0000 | |
| 129 | S | A | -0.1980 | |
| 130 | V | A | -0.1125 | |
| 131 | F | A | -0.4141 | |
| 132 | P | A | -0.7033 | |
| 133 | L | A | 0.0000 | |
| 134 | A | A | 0.0000 | |
| 135 | P | A | 0.0000 | |
| 136 | S | A | -0.6189 | |
| 137 | S | A | -0.6991 | |
| 138 | K | A | -0.6077 | |
| 139 | S | A | -0.7253 | |
| 140 | T | A | -0.7701 | |
| 141 | S | A | -0.7355 | |
| 142 | G | A | -0.8489 | |
| 143 | G | A | -0.8437 | |
| 144 | T | A | -0.6054 | |
| 145 | A | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | L | A | 0.0000 | |
| 148 | G | A | 0.0000 | |
| 149 | C | A | 0.0000 | |
| 150 | L | A | 0.0000 | |
| 151 | V | A | 0.0000 | |
| 152 | K | A | 0.0000 | |
| 153 | D | A | -0.3351 | |
| 154 | Y | A | 0.0000 | |
| 155 | F | A | 0.0000 | |
| 156 | P | A | 0.0000 | |
| 157 | E | A | -0.8207 | |
| 158 | P | A | -1.0366 | |
| 159 | V | A | 0.0000 | |
| 160 | T | A | -0.7083 | |
| 161 | V | A | -0.3737 | |
| 162 | S | A | -0.3359 | |
| 163 | W | A | 0.0000 | |
| 164 | N | A | -0.7489 | |
| 165 | S | A | -0.6810 | |
| 166 | G | A | -0.4102 | |
| 167 | A | A | -0.1867 | |
| 168 | L | A | -0.0327 | |
| 169 | T | A | -0.1947 | |
| 170 | S | A | -0.2054 | |
| 171 | G | A | -0.3396 | |
| 172 | V | A | 0.1368 | |
| 173 | H | A | 0.0142 | |
| 174 | T | A | -0.1542 | |
| 175 | F | A | 0.0000 | |
| 176 | P | A | -0.4419 | |
| 177 | A | A | 0.1030 | |
| 178 | V | A | 0.3110 | |
| 179 | L | A | 0.9011 | |
| 180 | Q | A | 0.0676 | |
| 181 | S | A | -0.2466 | |
| 182 | S | A | -0.2222 | |
| 183 | G | A | -0.1116 | |
| 184 | L | A | 0.0019 | |
| 185 | Y | A | 0.0000 | |
| 186 | S | A | 0.0000 | |
| 187 | L | A | 0.0000 | |
| 188 | S | A | 0.0000 | |
| 189 | S | A | 0.0000 | |
| 190 | V | A | 0.0000 | |
| 191 | V | A | 0.0000 | |
| 192 | T | A | -0.2195 | |
| 193 | V | A | 0.0000 | |
| 194 | P | A | -0.5798 | |
| 195 | S | A | 0.0000 | |
| 196 | S | A | -0.8181 | |
| 197 | S | A | -0.6520 | |
| 198 | L | A | -0.7483 | |
| 199 | G | A | -0.8956 | |
| 200 | T | A | -0.7845 | |
| 201 | Q | A | -1.1306 | |
| 202 | T | A | -0.9879 | |
| 203 | Y | A | 0.0000 | |
| 204 | I | A | -0.8765 | |
| 205 | C | A | 0.0000 | |
| 206 | N | A | 0.0000 | |
| 207 | V | A | 0.0000 | |
| 208 | N | A | -1.9483 | |
| 209 | H | A | 0.0000 | |
| 210 | K | A | -2.8012 | |
| 211 | P | A | -1.6664 | |
| 212 | S | A | -1.8270 | |
| 213 | N | A | -2.5506 | |
| 214 | T | A | -1.9812 | |
| 215 | K | A | -2.4894 | |
| 216 | V | A | -1.2724 | |
| 217 | D | A | -2.3823 | |
| 218 | K | A | -1.8711 | |
| 219 | R | A | -2.2297 | |
| 220 | V | A | 0.0000 | |
| 221 | E | A | -1.2849 | |
| 222 | P | A | -0.7579 | |
| 223 | K | A | -0.7429 | |
| 224 | S | A | -1.2408 | |
| 225 | C | A | -1.5795 | |
| 226 | D | A | -2.5348 | |
| 227 | K | A | -2.5712 | |
| 228 | T | A | -1.4467 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine