| Chain sequence(s) |
A: PSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS
B: GGPSVFLFPPKPKDTLMISRRTPEVVTCVVVDVSHEEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS input PDB |
| Selected Chain(s) | A,B |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:08)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:08)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:08)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:08)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:08)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:20)
[INFO] Main: Simulation completed successfully. (00:04:23)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 238 | P | A | -1.0816 | |
| 239 | S | A | -0.3332 | |
| 240 | V | A | 0.0000 | |
| 241 | F | A | 1.4241 | |
| 242 | L | A | 1.1062 | |
| 243 | F | A | 1.3571 | |
| 244 | P | A | -0.0208 | |
| 245 | P | A | -1.1525 | |
| 246 | K | A | -2.0656 | |
| 247 | P | A | -1.3885 | |
| 248 | K | A | -0.9879 | |
| 249 | D | A | -1.0923 | |
| 250 | T | A | 0.0000 | |
| 251 | L | A | 0.0000 | |
| 252 | M | A | 0.5569 | |
| 253 | I | A | 1.6548 | |
| 254 | S | A | 0.2965 | |
| 255 | R | A | -0.7230 | |
| 256 | T | A | -0.5510 | |
| 257 | P | A | 0.0000 | |
| 258 | E | A | -0.8620 | |
| 259 | V | A | 0.0000 | |
| 260 | T | A | 0.3638 | |
| 261 | C | A | 0.0000 | |
| 262 | V | A | 0.0000 | |
| 263 | V | A | 0.0000 | |
| 264 | V | A | -1.2957 | |
| 265 | D | A | -2.5904 | |
| 266 | V | A | 0.0000 | |
| 267 | S | A | -2.3826 | |
| 268 | H | A | -2.5169 | |
| 269 | E | A | -2.9543 | |
| 270 | D | A | -2.5809 | |
| 271 | P | A | -2.5909 | |
| 272 | E | A | -2.9441 | |
| 273 | V | A | -1.9533 | |
| 274 | K | A | -2.1870 | |
| 275 | F | A | -0.9248 | |
| 276 | N | A | -1.1012 | |
| 277 | W | A | 0.0000 | |
| 278 | Y | A | -0.7212 | |
| 279 | V | A | -0.8909 | |
| 280 | D | A | -2.1529 | |
| 281 | G | A | -0.8814 | |
| 282 | V | A | 0.7012 | |
| 283 | E | A | -0.6550 | |
| 284 | V | A | -0.5169 | |
| 285 | H | A | -1.8586 | |
| 286 | N | A | -2.1969 | |
| 287 | A | A | -1.8524 | |
| 288 | K | A | -2.4260 | |
| 289 | T | A | -1.8403 | |
| 290 | K | A | -2.2321 | |
| 291 | P | A | -2.1361 | |
| 292 | R | A | -3.3046 | |
| 293 | E | A | -3.9193 | |
| 294 | E | A | -3.8604 | |
| 295 | Q | A | -2.1839 | |
| 296 | Y | A | -0.8575 | |
| 297 | N | A | -1.6519 | |
| 298 | S | A | -1.5154 | |
| 299 | T | A | -2.2711 | |
| 300 | Y | A | 0.0000 | |
| 301 | R | A | -3.2757 | |
| 302 | V | A | 0.0000 | |
| 303 | V | A | -1.0502 | |
| 304 | S | A | 0.0000 | |
| 305 | V | A | 0.0000 | |
| 306 | L | A | 0.0000 | |
| 307 | T | A | -0.4969 | |
| 308 | V | A | 0.0000 | |
| 309 | L | A | 0.9792 | |
| 310 | H | A | 0.0539 | |
| 311 | Q | A | -1.0209 | |
| 312 | D | A | -1.2267 | |
| 313 | W | A | 0.0000 | |
| 314 | L | A | -0.8108 | |
| 315 | N | A | -1.9624 | |
| 316 | G | A | -2.0287 | |
| 317 | K | A | -2.2614 | |
| 318 | E | A | -2.3925 | |
| 319 | Y | A | 0.0000 | |
| 320 | K | A | -1.6549 | |
| 321 | C | A | 0.0000 | |
| 322 | K | A | -1.4092 | |
| 323 | V | A | 0.0000 | |
| 324 | S | A | -1.4399 | |
| 325 | N | A | -1.7572 | |
| 326 | K | A | -2.5644 | |
| 327 | A | A | -1.3620 | |
| 328 | L | A | -0.5070 | |
| 329 | P | A | -0.4188 | |
| 330 | A | A | -0.4058 | |
| 331 | P | A | -0.8242 | |
| 332 | I | A | -0.6622 | |
| 333 | E | A | -1.7401 | |
| 334 | K | A | -1.1070 | |
| 335 | T | A | -1.0130 | |
| 336 | I | A | -0.2407 | |
| 337 | S | A | -1.0877 | |
| 338 | K | A | 0.0000 | |
| 339 | A | A | -1.1291 | |
| 340 | K | A | -2.3637 | |
| 341 | G | A | -2.0575 | |
| 342 | Q | A | -2.3252 | |
| 343 | P | A | -2.1706 | |
| 344 | R | A | -2.8746 | |
| 345 | E | A | -2.9895 | |
| 346 | P | A | 0.0000 | |
| 347 | Q | A | -1.2911 | |
| 348 | V | A | 0.0000 | |
| 349 | Y | A | 0.0000 | |
| 350 | T | A | -0.7283 | |
| 351 | L | A | 0.0000 | |
| 352 | P | A | -0.3493 | |
| 353 | P | A | -0.8629 | |
| 354 | S | A | -1.5500 | |
| 355 | R | A | -2.7931 | |
| 356 | E | A | -2.8350 | |
| 357 | E | A | 0.0000 | |
| 358 | M | A | -1.8713 | |
| 359 | T | A | -1.5950 | |
| 360 | K | A | -2.1661 | |
| 361 | N | A | -2.3682 | |
| 362 | Q | A | -2.2359 | |
| 363 | V | A | 0.0000 | |
| 364 | S | A | 0.0000 | |
| 365 | L | A | 0.0000 | |
| 366 | T | A | 0.0000 | |
| 367 | C | A | 0.0000 | |
| 368 | L | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | K | A | -0.6598 | |
| 371 | G | A | -1.2041 | |
| 372 | F | A | 0.0000 | |
| 373 | Y | A | -1.4058 | |
| 374 | P | A | 0.0000 | |
| 375 | S | A | -0.4572 | |
| 376 | D | A | -1.2798 | |
| 377 | I | A | -0.6166 | |
| 378 | A | A | -0.4131 | |
| 379 | V | A | -0.2401 | |
| 380 | E | A | -1.3324 | |
| 381 | W | A | 0.0000 | |
| 382 | E | A | -1.6582 | |
| 383 | S | A | 0.0000 | |
| 384 | N | A | -1.8059 | |
| 385 | G | A | -1.6777 | |
| 386 | Q | A | -2.2746 | |
| 387 | P | A | -1.9635 | |
| 388 | E | A | -1.9553 | |
| 389 | N | A | -2.2588 | |
| 390 | N | A | -1.8501 | |
| 391 | Y | A | -1.1244 | |
| 392 | K | A | -0.8788 | |
| 393 | T | A | -0.2658 | |
| 394 | T | A | 0.0000 | |
| 395 | P | A | -0.0984 | |
| 396 | P | A | -0.0438 | |
| 397 | V | A | 0.0000 | |
| 398 | L | A | 0.5422 | |
| 399 | D | A | -0.6768 | |
| 400 | S | A | -1.3049 | |
| 401 | D | A | -1.9496 | |
| 402 | G | A | -0.9535 | |
| 403 | S | A | 0.0000 | |
| 404 | F | A | -0.1398 | |
| 405 | F | A | 0.0000 | |
| 406 | L | A | 0.0000 | |
| 407 | Y | A | 0.0000 | |
| 408 | S | A | 0.0000 | |
| 409 | K | A | 0.0000 | |
| 410 | L | A | 0.0000 | |
| 411 | T | A | -1.0459 | |
| 412 | V | A | 0.0000 | |
| 413 | D | A | -2.6718 | |
| 414 | K | A | -2.5016 | |
| 415 | S | A | -2.0534 | |
| 416 | R | A | -2.1424 | |
| 417 | W | A | 0.0000 | |
| 418 | Q | A | -1.9653 | |
| 419 | Q | A | -1.8013 | |
| 420 | G | A | -0.8674 | |
| 421 | N | A | -0.5432 | |
| 422 | V | A | 0.7076 | |
| 423 | F | A | 0.0000 | |
| 424 | S | A | 0.0000 | |
| 425 | C | A | 0.0000 | |
| 426 | S | A | 0.0000 | |
| 427 | V | A | 0.0000 | |
| 428 | M | A | -0.2448 | |
| 429 | H | A | 0.0000 | |
| 430 | E | A | -1.1418 | |
| 431 | A | A | -1.6512 | |
| 432 | L | A | -1.4247 | |
| 433 | H | A | -1.6871 | |
| 434 | N | A | -1.5656 | |
| 435 | H | A | -0.9877 | |
| 436 | Y | A | -0.1132 | |
| 437 | T | A | -0.5485 | |
| 438 | Q | A | -1.0148 | |
| 439 | K | A | -1.2271 | |
| 440 | S | A | -0.4455 | |
| 441 | L | A | 0.0000 | |
| 442 | S | A | 0.2050 | |
| 443 | L | A | 0.0237 | |
| 444 | S | A | -0.2174 | |
| 236 | G | B | -0.8237 | |
| 237 | G | B | -1.0371 | |
| 238 | P | B | 0.0000 | |
| 239 | S | B | -0.2982 | |
| 240 | V | B | 0.0000 | |
| 241 | F | B | 1.3834 | |
| 242 | L | B | 1.0709 | |
| 243 | F | B | 1.3244 | |
| 244 | P | B | -0.0331 | |
| 245 | P | B | 0.0000 | |
| 246 | K | B | -2.0872 | |
| 247 | P | B | -1.4884 | |
| 248 | K | B | -1.5197 | |
| 249 | D | B | -1.5870 | |
| 250 | T | B | 0.0000 | |
| 251 | L | B | 0.0000 | |
| 252 | M | B | 0.2467 | |
| 253 | I | B | 1.3292 | |
| 254 | S | B | -0.0698 | |
| 255 | R | B | -1.5284 | |
| 256 | T | B | -0.9065 | |
| 257 | P | B | 0.0000 | |
| 258 | E | B | -0.6724 | |
| 259 | V | B | 0.0000 | |
| 260 | T | B | 0.4355 | |
| 261 | C | B | 0.0000 | |
| 262 | V | B | 0.0000 | |
| 263 | V | B | 0.0000 | |
| 264 | V | B | -0.7704 | |
| 265 | D | B | -2.2984 | |
| 266 | V | B | 0.0000 | |
| 267 | S | B | -2.4331 | |
| 268 | H | B | -2.6115 | |
| 269 | E | B | -2.9912 | |
| 270 | D | B | -2.6200 | |
| 271 | P | B | -2.7371 | |
| 272 | E | B | -3.1767 | |
| 273 | V | B | -2.1195 | |
| 274 | K | B | -2.2155 | |
| 275 | F | B | -0.9561 | |
| 276 | N | B | -1.2710 | |
| 277 | W | B | 0.0000 | |
| 278 | Y | B | -0.9017 | |
| 279 | V | B | -0.9289 | |
| 280 | D | B | -1.9673 | |
| 281 | G | B | -0.9167 | |
| 282 | V | B | 0.4196 | |
| 283 | E | B | -1.3965 | |
| 284 | V | B | -0.8795 | |
| 285 | H | B | -2.0277 | |
| 286 | N | B | -2.2637 | |
| 287 | A | B | -1.8278 | |
| 288 | K | B | -2.4329 | |
| 289 | T | B | -2.0295 | |
| 290 | K | B | -2.5875 | |
| 291 | P | B | -2.5702 | |
| 292 | R | B | -3.8382 | |
| 293 | E | B | -3.6869 | |
| 294 | E | B | -3.0674 | |
| 295 | Q | B | -1.6664 | |
| 296 | Y | B | 0.0813 | |
| 297 | N | B | -1.1686 | |
| 298 | S | B | -1.4253 | |
| 299 | T | B | -1.9828 | |
| 300 | Y | B | -2.8154 | |
| 301 | R | B | -2.7743 | |
| 302 | V | B | 0.0000 | |
| 303 | V | B | -0.9669 | |
| 304 | S | B | 0.0000 | |
| 305 | V | B | 0.0000 | |
| 306 | L | B | 0.0000 | |
| 307 | T | B | -0.3564 | |
| 308 | V | B | 0.0000 | |
| 309 | L | B | 0.9590 | |
| 310 | H | B | -0.1459 | |
| 311 | Q | B | -1.0893 | |
| 312 | D | B | -1.2492 | |
| 313 | W | B | 0.0000 | |
| 314 | L | B | -0.9317 | |
| 315 | N | B | -1.8732 | |
| 316 | G | B | -2.0467 | |
| 317 | K | B | -2.1168 | |
| 318 | E | B | -2.4107 | |
| 319 | Y | B | 0.0000 | |
| 320 | K | B | -1.6806 | |
| 321 | C | B | 0.0000 | |
| 322 | K | B | -1.4959 | |
| 323 | V | B | 0.0000 | |
| 324 | S | B | -1.4281 | |
| 325 | N | B | 0.0000 | |
| 326 | K | B | -2.5660 | |
| 327 | A | B | -1.4730 | |
| 328 | L | B | -0.5810 | |
| 329 | P | B | -0.4362 | |
| 330 | A | B | -0.3875 | |
| 331 | P | B | -0.7992 | |
| 332 | I | B | -0.6626 | |
| 333 | E | B | -1.7847 | |
| 334 | K | B | -1.1374 | |
| 335 | T | B | -0.9950 | |
| 336 | I | B | -0.3299 | |
| 337 | S | B | -1.2362 | |
| 338 | K | B | -1.2865 | |
| 339 | A | B | -1.1614 | |
| 340 | K | B | -2.1663 | |
| 341 | G | B | -1.8548 | |
| 342 | Q | B | -1.9779 | |
| 343 | P | B | -1.9108 | |
| 344 | R | B | -2.3503 | |
| 345 | E | B | -2.6186 | |
| 346 | P | B | 0.0000 | |
| 347 | Q | B | -1.1158 | |
| 348 | V | B | 0.0000 | |
| 349 | Y | B | 0.0000 | |
| 350 | T | B | -0.7151 | |
| 351 | L | B | 0.0000 | |
| 352 | P | B | -0.3780 | |
| 353 | P | B | -0.8816 | |
| 354 | S | B | -1.5496 | |
| 355 | R | B | -2.8220 | |
| 356 | E | B | -2.8926 | |
| 357 | E | B | 0.0000 | |
| 358 | M | B | -1.9778 | |
| 359 | T | B | -1.7276 | |
| 360 | K | B | -2.4534 | |
| 361 | N | B | -2.5288 | |
| 362 | Q | B | -2.4037 | |
| 363 | V | B | 0.0000 | |
| 364 | S | B | 0.0000 | |
| 365 | L | B | 0.0000 | |
| 366 | T | B | 0.0000 | |
| 367 | C | B | 0.0000 | |
| 368 | L | B | 0.0000 | |
| 369 | V | B | 0.0000 | |
| 370 | K | B | -0.4946 | |
| 371 | G | B | 0.0000 | |
| 372 | F | B | 0.0000 | |
| 373 | Y | B | -1.1491 | |
| 374 | P | B | 0.0000 | |
| 375 | S | B | -0.1150 | |
| 376 | D | B | -0.8924 | |
| 377 | I | B | -0.4955 | |
| 378 | A | B | -0.2622 | |
| 379 | V | B | 0.0000 | |
| 380 | E | B | -1.4896 | |
| 381 | W | B | 0.0000 | |
| 382 | E | B | -1.6556 | |
| 383 | S | B | 0.0000 | |
| 384 | N | B | -1.7763 | |
| 385 | G | B | -1.8082 | |
| 386 | Q | B | -2.2536 | |
| 387 | P | B | -1.9973 | |
| 388 | E | B | -2.0077 | |
| 389 | N | B | -2.3829 | |
| 390 | N | B | -2.0346 | |
| 391 | Y | B | -1.3792 | |
| 392 | K | B | -1.2107 | |
| 393 | T | B | -0.4569 | |
| 394 | T | B | 0.0000 | |
| 395 | P | B | -0.1105 | |
| 396 | P | B | 0.1333 | |
| 397 | V | B | 0.4641 | |
| 398 | L | B | 0.6652 | |
| 399 | D | B | -0.6124 | |
| 400 | S | B | -1.2289 | |
| 401 | D | B | -1.9309 | |
| 402 | G | B | -0.9846 | |
| 403 | S | B | 0.0000 | |
| 404 | F | B | 0.0688 | |
| 405 | F | B | 0.0000 | |
| 406 | L | B | 0.0000 | |
| 407 | Y | B | 0.0000 | |
| 408 | S | B | 0.0000 | |
| 409 | K | B | 0.0000 | |
| 410 | L | B | 0.0000 | |
| 411 | T | B | -1.0949 | |
| 412 | V | B | 0.0000 | |
| 413 | D | B | -2.8813 | |
| 414 | K | B | -2.7264 | |
| 415 | S | B | -2.2708 | |
| 416 | R | B | -2.5261 | |
| 417 | W | B | 0.0000 | |
| 418 | Q | B | -2.2290 | |
| 419 | Q | B | -1.9556 | |
| 420 | G | B | -0.9967 | |
| 421 | N | B | -0.5944 | |
| 422 | V | B | 0.7333 | |
| 423 | F | B | 0.0000 | |
| 424 | S | B | 0.0000 | |
| 425 | C | B | 0.0000 | |
| 426 | S | B | -0.5686 | |
| 427 | V | B | 0.0000 | |
| 428 | M | B | -0.1355 | |
| 429 | H | B | 0.0000 | |
| 430 | E | B | -0.9553 | |
| 431 | A | B | -1.3510 | |
| 432 | L | B | -1.3208 | |
| 433 | H | B | -1.6700 | |
| 434 | N | B | -1.5923 | |
| 435 | H | B | -1.0228 | |
| 436 | Y | B | 0.1353 | |
| 437 | T | B | -0.3767 | |
| 438 | Q | B | -0.8797 | |
| 439 | K | B | -1.1410 | |
| 440 | S | B | -0.4123 | |
| 441 | L | B | 0.0000 | |
| 442 | S | B | 0.1078 | |
| 443 | L | B | -0.2042 | |
| 444 | S | B | -0.3162 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine