Chain sequence(s) |
A: DVVMTQSPSSVSASVGDRVTITCQASQSIGNEFSWYQQKPGKAPKLLIYRASTLASGVPSRFKGSGSGTDFTLTISSLQPEDFATYYCQATYYLTTYGAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVQLVESGGGLVQPGGSLRLSCAASGFSLSNYDMSWVRQAPGKGLEWIGIIYADNEGTWYATWAKGRFTISKDSAKNSVYLQMNSLRDEDTAVYYCARGYSSGSGGSREGFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | No |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:01:32) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:01:32) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:01:33) [INFO] runJob: Creating pdb object from: input.pdb (00:01:33) [INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:01:33) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:35) [CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie creation failed. (00:01:36) [INFO] Main: Simulation completed successfully. (00:01:57) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | D | A | -1.4239 | |
2 | V | A | 0.0000 | |
3 | V | A | 0.8829 | |
4 | M | A | 0.0000 | |
5 | T | A | -0.2306 | |
6 | Q | A | -0.4405 | |
7 | S | A | -0.5358 | |
8 | P | A | -0.3473 | |
9 | S | A | -0.4579 | |
10 | S | A | -0.2177 | |
11 | V | A | 0.1344 | |
12 | S | A | -0.2966 | |
13 | A | A | 0.0000 | |
14 | S | A | -0.4965 | |
15 | V | A | 0.3006 | |
16 | G | A | -0.6580 | |
17 | D | A | -1.5790 | |
18 | R | A | -2.1614 | |
19 | V | A | 0.0000 | |
20 | T | A | -0.8879 | |
21 | I | A | 0.0000 | |
22 | T | A | -0.5978 | |
23 | C | A | 0.0000 | |
24 | Q | A | -1.3262 | |
25 | A | A | 0.0000 | |
26 | S | A | -0.7165 | |
27 | Q | A | -1.1714 | |
28 | S | A | -1.1662 | |
29 | I | A | 0.0000 | |
30 | G | A | -0.8855 | |
30A | N | A | -1.3738 | |
30B | E | A | -0.7850 | |
30C | F | A | 0.0000 | |
30D | S | A | 0.0000 | |
35 | W | A | 0.0000 | |
36 | Y | A | 0.0000 | |
37 | Q | A | 0.0000 | |
38 | Q | A | -1.0334 | |
39 | K | A | -1.5106 | |
40 | P | A | -1.4067 | |
41 | G | A | -1.7021 | |
42 | K | A | -2.5551 | |
43 | A | A | -1.5928 | |
44 | P | A | 0.0000 | |
45 | K | A | -0.9652 | |
46 | L | A | 0.0000 | |
47 | L | A | 0.0000 | |
48 | I | A | 0.0000 | |
49 | Y | A | -0.0970 | |
50 | R | A | -1.0852 | |
51 | A | A | 0.0000 | |
52 | S | A | -0.8784 | |
53 | T | A | -0.3882 | |
54 | L | A | -0.0657 | |
55 | A | A | 0.0000 | |
56 | S | A | -0.3218 | |
57 | G | A | -0.5515 | |
58 | V | A | -0.1863 | |
59 | P | A | -0.3412 | |
60 | S | A | -0.6252 | |
61 | R | A | -0.9926 | |
62 | F | A | 0.0000 | |
63 | K | A | -1.8211 | |
64 | G | A | -1.0912 | |
65 | S | A | -1.1026 | |
66 | G | A | -1.0903 | |
67 | S | A | -1.1576 | |
68 | G | A | -1.3018 | |
69 | T | A | -1.4911 | |
70 | D | A | -1.9321 | |
71 | F | A | 0.0000 | |
72 | T | A | -0.8556 | |
73 | L | A | 0.0000 | |
74 | T | A | -1.0906 | |
75 | I | A | 0.0000 | |
76 | S | A | -1.4838 | |
77 | S | A | -1.0460 | |
78 | L | A | 0.0000 | |
79 | Q | A | -0.6110 | |
80 | P | A | -0.7029 | |
81 | E | A | -1.5902 | |
82 | D | A | 0.0000 | |
83 | F | A | -0.4892 | |
84 | A | A | 0.0000 | |
85 | T | A | -0.3309 | |
86 | Y | A | 0.0000 | |
87 | Y | A | 0.0000 | |
88 | C | A | 0.0000 | |
89 | Q | A | 0.0000 | |
90 | A | A | 0.0000 | |
91 | T | A | 0.0000 | |
93A | Y | A | 0.5213 | |
93B | Y | A | 1.2974 | |
93C | L | A | 1.5550 | |
93D | T | A | 0.8221 | |
94 | T | A | 0.1489 | |
95 | Y | A | 0.3452 | |
96 | G | A | 0.1826 | |
97 | A | A | 0.0419 | |
98 | F | A | 0.0720 | |
99 | G | A | 0.0000 | |
100 | G | A | -0.7017 | |
101 | G | A | 0.0000 | |
102 | T | A | 0.0000 | |
103 | K | A | -0.2986 | |
104 | V | A | 0.0000 | |
105 | E | A | 0.0000 | |
106 | I | A | -0.1815 | |
107 | K | A | -0.9129 | |
108 | R | A | -0.6743 | |
111 | T | A | 0.2224 | |
112 | V | A | 1.1825 | |
113 | A | A | 0.4852 | |
114 | A | A | 0.1351 | |
115 | P | A | 0.0000 | |
116 | S | A | -0.0479 | |
117 | V | A | 0.0000 | |
118 | F | A | -0.0575 | |
119 | I | A | 0.0000 | |
120 | F | A | 0.0000 | |
121 | P | A | 0.0000 | |
122 | P | A | 0.0000 | |
123 | S | A | 0.0000 | |
124 | D | A | -2.5864 | |
125 | E | A | -2.1073 | |
126 | Q | A | 0.0000 | |
127 | L | A | -1.9700 | |
128 | K | A | -2.5691 | |
129 | S | A | -1.5932 | |
130 | G | A | -1.3752 | |
131 | T | A | -0.9925 | |
132 | A | A | 0.0000 | |
133 | S | A | 0.0000 | |
134 | V | A | 0.0000 | |
135 | V | A | 0.0000 | |
136 | C | A | 0.0000 | |
137 | L | A | 0.0000 | |
138 | L | A | 0.0000 | |
139 | N | A | 0.0000 | |
140 | N | A | -0.6407 | |
141 | F | A | 0.0000 | |
142 | Y | A | 0.0000 | |
143 | P | A | -0.6437 | |
144 | R | A | -1.2737 | |
145 | E | A | -1.8365 | |
146 | A | A | 0.0000 | |
147 | K | A | -1.8206 | |
148 | V | A | 0.0000 | |
149 | Q | A | -0.7595 | |
150 | W | A | 0.0000 | |
151 | K | A | -0.3097 | |
152 | V | A | 0.0000 | |
153 | D | A | -1.7989 | |
154 | N | A | -1.4361 | |
155 | A | A | -0.1267 | |
156 | L | A | 0.8191 | |
157 | Q | A | -0.0309 | |
158 | S | A | -0.5257 | |
159 | G | A | -0.9630 | |
160 | N | A | -0.8459 | |
161 | S | A | -0.9625 | |
162 | Q | A | -1.0627 | |
163 | E | A | -1.2766 | |
164 | S | A | 0.0000 | |
165 | V | A | -0.3199 | |
166 | T | A | -0.8625 | |
167 | E | A | -1.9650 | |
168 | Q | A | 0.0000 | |
169 | D | A | -1.9009 | |
170 | S | A | -1.6709 | |
171 | K | A | -2.2825 | |
172 | D | A | -1.8110 | |
173 | S | A | -1.7161 | |
174 | T | A | 0.0000 | |
175 | Y | A | 0.0000 | |
176 | S | A | 0.0000 | |
177 | L | A | 0.0000 | |
178 | S | A | 0.0000 | |
179 | S | A | 0.0000 | |
180 | T | A | -0.5007 | |
181 | L | A | 0.0000 | |
182 | T | A | -0.2503 | |
183 | L | A | -0.0858 | |
184 | S | A | -0.7642 | |
185 | K | A | -1.7898 | |
186 | A | A | -1.3052 | |
187 | D | A | -1.6534 | |
188 | Y | A | -1.7202 | |
189 | E | A | -2.6501 | |
190 | K | A | -2.9886 | |
191 | H | A | -2.6873 | |
192 | K | A | -3.2703 | |
193 | V | A | -1.9010 | |
194 | Y | A | 0.0000 | |
195 | A | A | 0.0000 | |
196 | C | A | 0.0000 | |
197 | E | A | -0.5226 | |
198 | V | A | 0.0000 | |
199 | T | A | -0.9766 | |
200 | H | A | 0.0000 | |
201 | Q | A | -1.5819 | |
202 | G | A | -0.6204 | |
203 | L | A | -0.3578 | |
204 | S | A | -0.4264 | |
205 | S | A | -0.4341 | |
206 | P | A | -0.4508 | |
207 | V | A | 0.0053 | |
208 | T | A | -0.4420 | |
209 | K | A | -0.7593 | |
210 | S | A | -0.6726 | |
211 | F | A | 0.0000 | |
212 | N | A | -2.0798 | |
213 | R | A | -2.8069 | |
214 | G | A | -2.3184 | |
215 | E | A | -2.3927 | |
216 | C | A | -1.2953 | |
1 | E | A | -1.9075 | |
2 | V | A | -0.6957 | |
3 | Q | A | -1.3708 | |
4 | L | A | 0.0000 | |
5 | V | A | 0.2557 | |
6 | E | A | 0.0000 | |
7 | S | A | -0.3889 | |
8 | G | A | -0.6280 | |
9 | G | A | -0.1104 | |
10 | G | A | 0.5121 | |
11 | L | A | 0.8136 | |
12 | V | A | -0.3225 | |
13 | Q | A | -1.3556 | |
14 | P | A | -2.0573 | |
15 | G | A | -1.5587 | |
16 | G | A | -1.0773 | |
17 | S | A | -1.0681 | |
18 | L | A | -0.5324 | |
19 | R | A | -1.4604 | |
20 | L | A | 0.0000 | |
21 | S | A | -0.3977 | |
22 | C | A | 0.0000 | |
23 | A | A | -0.3069 | |
24 | A | A | 0.0000 | |
25 | S | A | -0.8172 | |
26 | G | A | -1.0762 | |
27 | F | A | 0.0000 | |
30A | S | A | -0.5800 | |
30B | L | A | 0.0000 | |
30C | S | A | -1.3424 | |
30D | N | A | -1.2550 | |
31 | Y | A | -0.0309 | |
32 | D | A | 0.0000 | |
33 | M | A | 0.0000 | |
34 | S | A | 0.0000 | |
35 | W | A | 0.0000 | |
36 | V | A | 0.0000 | |
37 | R | A | -0.4656 | |
38 | Q | A | -0.8169 | |
39 | A | A | -1.0836 | |
40 | P | A | -1.0003 | |
41 | G | A | -1.5060 | |
42 | K | A | -2.3167 | |
43 | G | A | -1.5440 | |
44 | L | A | 0.0000 | |
45 | E | A | -1.0827 | |
46 | W | A | 0.0000 | |
47 | I | A | 0.0000 | |
48 | G | A | 0.0000 | |
49 | I | A | 0.0000 | |
50 | I | A | 0.0000 | |
51A | Y | A | 0.0678 | |
51B | A | A | -1.0745 | |
52 | D | A | -2.7047 | |
53 | N | A | -2.6705 | |
54 | E | A | -2.2236 | |
55 | G | A | -0.9651 | |
56 | T | A | 0.1415 | |
57 | W | A | 1.1611 | |
58 | Y | A | 0.3223 | |
59 | A | A | 0.0065 | |
60 | T | A | -0.3270 | |
61 | W | A | -0.3059 | |
62 | A | A | 0.0000 | |
63 | K | A | -1.7317 | |
64 | G | A | -1.5479 | |
65 | R | A | -1.3651 | |
66 | F | A | 0.0000 | |
67 | T | A | -0.7346 | |
68 | I | A | 0.0000 | |
69 | S | A | -0.6934 | |
70 | K | A | 0.0000 | |
71 | D | A | -1.3076 | |
72 | S | A | -1.2945 | |
73 | A | A | -1.0622 | |
74 | K | A | -1.9844 | |
75 | N | A | -1.3996 | |
76 | S | A | 0.0000 | |
77 | V | A | 0.0000 | |
78 | Y | A | -0.3796 | |
79 | L | A | 0.0000 | |
80 | Q | A | -1.0778 | |
81 | M | A | 0.0000 | |
82 | N | A | -1.3133 | |
83 | S | A | -1.3209 | |
84 | L | A | 0.0000 | |
85 | R | A | -3.4297 | |
86 | D | A | -2.9676 | |
87 | E | A | -2.9478 | |
88 | D | A | 0.0000 | |
89 | T | A | -0.8903 | |
90 | A | A | 0.0000 | |
91 | V | A | 0.5325 | |
92 | Y | A | 0.0000 | |
93 | Y | A | 0.0000 | |
94 | C | A | 0.0000 | |
95 | A | A | 0.0000 | |
96 | R | A | -0.1684 | |
97 | G | A | 0.0000 | |
98 | Y | A | 1.2063 | |
99 | S | A | 0.6487 | |
100 | S | A | -0.1705 | |
101 | G | A | -0.6580 | |
102 | S | A | -0.2241 | |
102A | G | A | 0.1817 | |
102B | G | A | 0.0000 | |
102C | S | A | 0.0000 | |
102D | R | A | 0.0000 | |
102E | E | A | 0.0000 | |
102F | G | A | 0.3188 | |
102G | F | A | 0.0000 | |
103 | D | A | -0.6147 | |
104 | P | A | -0.7053 | |
105 | W | A | 0.0000 | |
106 | G | A | -0.9652 | |
107 | Q | A | -1.4880 | |
108 | G | A | -0.5807 | |
109 | T | A | 0.2006 | |
110 | L | A | 0.9320 | |
111 | V | A | 0.0000 | |
112 | T | A | 0.0000 | |
113 | V | A | 0.0000 | |
114 | S | A | 0.0000 | |
115 | S | A | -0.9188 | |
125 | A | A | -0.5342 | |
126 | S | A | -0.4134 | |
127 | T | A | -0.5099 | |
128 | K | A | -1.0162 | |
129 | G | A | -1.2778 | |
130 | P | A | -0.5438 | |
131 | S | A | -0.2192 | |
132 | V | A | -0.1114 | |
133 | F | A | -0.4136 | |
134 | P | A | -0.6982 | |
135 | L | A | 0.0000 | |
136 | A | A | 0.0000 | |
137 | P | A | 0.0000 | |
138 | S | A | -0.6626 | |
139 | S | A | -0.6847 | |
140 | K | A | -0.6005 | |
141 | S | A | -0.7269 | |
142 | T | A | -0.7644 | |
143 | S | A | -0.7193 | |
144 | G | A | -0.8116 | |
145 | G | A | -0.8278 | |
146 | T | A | -0.5744 | |
147 | A | A | 0.0000 | |
148 | A | A | 0.0000 | |
149 | L | A | 0.0000 | |
150 | G | A | 0.0000 | |
151 | C | A | 0.0000 | |
152 | L | A | 0.0000 | |
153 | V | A | 0.0000 | |
154 | K | A | 0.0000 | |
155 | D | A | -0.3763 | |
156 | Y | A | 0.0000 | |
157 | F | A | 0.0000 | |
158 | P | A | -0.4618 | |
159 | E | A | -0.6691 | |
160 | P | A | -0.9414 | |
161 | V | A | 0.0000 | |
162 | T | A | -0.7415 | |
163 | V | A | -0.4369 | |
164 | S | A | -0.3891 | |
165 | W | A | 0.0000 | |
166 | N | A | -0.7607 | |
167 | S | A | -0.7182 | |
168 | G | A | -0.4674 | |
169 | A | A | -0.1967 | |
170 | L | A | -0.0263 | |
171 | T | A | -0.1802 | |
172 | S | A | -0.1748 | |
173 | G | A | -0.1974 | |
174 | V | A | 0.1773 | |
175 | H | A | -0.0142 | |
176 | T | A | 0.0497 | |
177 | F | A | 0.0000 | |
178 | P | A | -0.4051 | |
179 | A | A | 0.0496 | |
180 | V | A | 0.0000 | |
181 | L | A | 0.9550 | |
182 | Q | A | 0.0975 | |
183 | S | A | -0.2261 | |
184 | S | A | -0.1944 | |
185 | G | A | -0.1145 | |
186 | L | A | 0.0194 | |
187 | Y | A | 0.0000 | |
188 | S | A | 0.0000 | |
189 | L | A | 0.0000 | |
190 | S | A | 0.0000 | |
191 | S | A | 0.0000 | |
192 | V | A | 0.0000 | |
193 | V | A | 0.0000 | |
194 | T | A | -0.1296 | |
195 | V | A | 0.0000 | |
196 | P | A | -0.5669 | |
197 | S | A | 0.0000 | |
198 | S | A | -0.8117 | |
199 | S | A | -0.6323 | |
200 | L | A | -0.7470 | |
201 | G | A | -0.8950 | |
202 | T | A | -0.7811 | |
203 | Q | A | -1.1168 | |
204 | T | A | -0.9785 | |
205 | Y | A | 0.0000 | |
206 | I | A | -0.9041 | |
207 | C | A | 0.0000 | |
208 | N | A | -1.4524 | |
209 | V | A | 0.0000 | |
210 | N | A | -1.9972 | |
211 | H | A | 0.0000 | |
212 | K | A | -2.7836 | |
213 | P | A | -1.6338 | |
214 | S | A | -1.8171 | |
215 | N | A | -2.4749 | |
216 | T | A | -1.9772 | |
217 | K | A | -2.5229 | |
218 | V | A | -1.3115 | |
219 | D | A | -2.4286 | |
220 | K | A | -1.8861 | |
221 | R | A | -2.2385 | |
222 | V | A | 0.0000 | |
223 | E | A | -1.2804 | |
224 | P | A | -0.7407 | |
225 | K | A | -0.7328 | |
226 | S | A | -1.2284 | |
227 | C | A | -1.5421 | |
228 | D | A | -2.5364 | |
229 | K | A | -2.5881 | |
230 | T | A | -1.4492 |