Chain sequence(s) |
A: HHHHHHFNNINDSKILSLQNRKNTLVDTSGYNAEVSEEGDVQLNPIFPFDFKLGSSGEDRGKVIVTQNENIVYNSMYESFSISFWIRINKWVSNLPGYTIIDSVKNNSGWSIGIISNFLVFTLKQNEDSEQSINFSYDISNNAPGYNKWFFVTVTNNMMGNMKIYINGKLIDTIKVKELTGINFSKTITFEINKIPDTGLITSDSDNINMWIRDFYIFAKELDGKDINILFNSLQYTNVVKDYWGNDLRYNKEYYMVNIDYLNRYMYANSRQIVFNTRRNNNDFNEGYKIIIKRIRGNTNDTRVRGGDILYFDMTINNKAYNLFMKNETMYADNHSTEDIYAIGLREQTKDINDNIIFQIQPMNNTYYYASQIFKSNFNGENISGICSIGTYRFRLGGDWYRHNYLVPTVKQGNYASLLESTSTHWGFVPVSE
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:01) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01) [INFO] runJob: Creating pdb object from: input.pdb (00:00:01) [INFO] FoldX: Starting FoldX energy minimalization (00:00:02) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:18:30) [CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie creation failed. (00:18:30) [INFO] Main: Simulation completed successfully. (00:18:36) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | H | A | -2.1217 | |
2 | H | A | -2.2935 | |
3 | H | A | -2.4941 | |
4 | H | A | -2.2468 | |
5 | H | A | -1.9317 | |
6 | H | A | -1.7469 | |
7 | F | A | -0.6059 | |
8 | N | A | -2.1889 | |
9 | N | A | -2.5461 | |
10 | I | A | 0.0000 | |
11 | N | A | -2.1302 | |
12 | D | A | -2.8100 | |
13 | S | A | -1.8254 | |
14 | K | A | -1.2455 | |
15 | I | A | 0.0000 | |
16 | L | A | 0.0000 | |
17 | S | A | 0.0000 | |
18 | L | A | 0.0000 | |
19 | Q | A | -0.7757 | |
20 | N | A | 0.0000 | |
21 | R | A | -2.8000 | |
22 | K | A | -3.1017 | |
23 | N | A | -2.6773 | |
24 | T | A | -1.6025 | |
25 | L | A | 0.0000 | |
26 | V | A | -0.9503 | |
27 | D | A | -0.9602 | |
28 | T | A | -0.5678 | |
29 | S | A | -0.8124 | |
30 | G | A | -0.8298 | |
31 | Y | A | -1.1722 | |
32 | N | A | -1.8085 | |
33 | A | A | 0.0000 | |
34 | E | A | -2.1291 | |
35 | V | A | -0.9394 | |
36 | S | A | -1.0198 | |
37 | E | A | -1.4362 | |
38 | E | A | -2.3674 | |
39 | G | A | -2.6005 | |
40 | D | A | -2.7158 | |
41 | V | A | -1.9234 | |
42 | Q | A | -1.5880 | |
43 | L | A | -0.8717 | |
44 | N | A | -0.7709 | |
45 | P | A | -0.6327 | |
46 | I | A | 0.1795 | |
47 | F | A | 0.0000 | |
48 | P | A | -0.8588 | |
49 | F | A | -0.4743 | |
50 | D | A | 0.0000 | |
51 | F | A | 0.0000 | |
52 | K | A | -1.1086 | |
53 | L | A | 0.0000 | |
54 | G | A | -1.9938 | |
55 | S | A | 0.0000 | |
56 | S | A | -2.6901 | |
57 | G | A | -3.1104 | |
58 | E | A | -3.6146 | |
59 | D | A | -3.9498 | |
60 | R | A | -3.8855 | |
61 | G | A | 0.0000 | |
62 | K | A | -1.5735 | |
63 | V | A | 0.0000 | |
64 | I | A | -0.5373 | |
65 | V | A | 0.0000 | |
66 | T | A | -1.5718 | |
67 | Q | A | 0.0000 | |
68 | N | A | -3.2500 | |
69 | E | A | -3.5995 | |
70 | N | A | -2.7606 | |
71 | I | A | 0.0000 | |
72 | V | A | -2.1109 | |
73 | Y | A | 0.0000 | |
74 | N | A | -2.1776 | |
75 | S | A | -0.8669 | |
76 | M | A | -0.3878 | |
77 | Y | A | 0.3923 | |
78 | E | A | -1.2714 | |
79 | S | A | -0.8201 | |
80 | F | A | 0.0000 | |
81 | S | A | 0.0000 | |
82 | I | A | 0.0000 | |
83 | S | A | 0.0000 | |
84 | F | A | 0.0000 | |
85 | W | A | 0.0000 | |
86 | I | A | 0.0000 | |
87 | R | A | -0.4544 | |
88 | I | A | 0.0000 | |
89 | N | A | -1.3865 | |
90 | K | A | -2.0882 | |
91 | W | A | 0.0000 | |
92 | V | A | 0.0000 | |
93 | S | A | -1.0715 | |
94 | N | A | -1.5572 | |
95 | L | A | 0.0000 | |
96 | P | A | -0.5301 | |
97 | G | A | -0.0709 | |
98 | Y | A | 0.0000 | |
99 | T | A | 0.1491 | |
100 | I | A | 0.0000 | |
101 | I | A | 0.0000 | |
102 | D | A | -0.3301 | |
103 | S | A | 0.0000 | |
104 | V | A | -1.3892 | |
105 | K | A | -2.9406 | |
106 | N | A | -3.2657 | |
107 | N | A | -3.1898 | |
108 | S | A | 0.0000 | |
109 | G | A | 0.0000 | |
110 | W | A | 0.0000 | |
111 | S | A | -0.1141 | |
112 | I | A | 0.0000 | |
113 | G | A | 0.0000 | |
114 | I | A | 0.0000 | |
115 | I | A | 0.0432 | |
116 | S | A | -0.5610 | |
117 | N | A | -0.8566 | |
118 | F | A | -0.4489 | |
119 | L | A | 0.0000 | |
120 | V | A | -0.1146 | |
121 | F | A | 0.0000 | |
122 | T | A | -0.4925 | |
123 | L | A | 0.0000 | |
124 | K | A | -1.6016 | |
125 | Q | A | -2.2536 | |
126 | N | A | -3.1060 | |
127 | E | A | -4.3799 | |
128 | D | A | -3.6250 | |
129 | S | A | -2.9771 | |
130 | E | A | -3.1968 | |
131 | Q | A | -2.8053 | |
132 | S | A | -2.4429 | |
133 | I | A | -1.6519 | |
134 | N | A | -1.4225 | |
135 | F | A | -0.6850 | |
136 | S | A | -0.5723 | |
137 | Y | A | 0.0000 | |
138 | D | A | -1.2747 | |
139 | I | A | 0.0000 | |
140 | S | A | -1.3656 | |
141 | N | A | -2.1014 | |
142 | N | A | -1.8422 | |
143 | A | A | -0.8472 | |
144 | P | A | -0.1330 | |
145 | G | A | 0.0000 | |
146 | Y | A | -0.1678 | |
147 | N | A | -0.6898 | |
148 | K | A | -0.4033 | |
149 | W | A | 0.0000 | |
150 | F | A | 0.0000 | |
151 | F | A | 0.0000 | |
152 | V | A | 0.0000 | |
153 | T | A | 0.0000 | |
154 | V | A | 0.0000 | |
155 | T | A | 0.0000 | |
156 | N | A | 0.0000 | |
157 | N | A | -0.7821 | |
158 | M | A | 0.1193 | |
159 | M | A | 0.1642 | |
160 | G | A | 0.0000 | |
161 | N | A | -1.3617 | |
162 | M | A | 0.0000 | |
163 | K | A | -0.9140 | |
164 | I | A | 0.0000 | |
165 | Y | A | 0.0000 | |
166 | I | A | -0.0346 | |
167 | N | A | 0.0000 | |
168 | G | A | 0.0000 | |
169 | K | A | -1.4025 | |
170 | L | A | -0.1528 | |
171 | I | A | -0.0037 | |
172 | D | A | -0.6145 | |
173 | T | A | -0.7458 | |
174 | I | A | -1.1043 | |
175 | K | A | -2.2790 | |
176 | V | A | 0.0000 | |
177 | K | A | -2.6302 | |
178 | E | A | -2.1524 | |
179 | L | A | -0.9679 | |
180 | T | A | -0.4113 | |
181 | G | A | -0.6275 | |
182 | I | A | 0.0000 | |
183 | N | A | -2.2342 | |
184 | F | A | 0.0000 | |
185 | S | A | 0.0000 | |
186 | K | A | -3.1660 | |
187 | T | A | -1.8028 | |
188 | I | A | 0.0000 | |
189 | T | A | 0.0000 | |
190 | F | A | 0.0000 | |
191 | E | A | -0.2469 | |
192 | I | A | 0.0000 | |
193 | N | A | 0.0000 | |
194 | K | A | 0.0000 | |
195 | I | A | 0.7496 | |
196 | P | A | -0.0432 | |
197 | D | A | -1.1635 | |
198 | T | A | -1.5597 | |
199 | G | A | -0.2426 | |
200 | L | A | 1.3473 | |
201 | I | A | 0.9854 | |
202 | T | A | 0.0000 | |
203 | S | A | -0.7180 | |
204 | D | A | -2.2391 | |
205 | S | A | -2.4226 | |
206 | D | A | -2.4978 | |
207 | N | A | -2.4841 | |
208 | I | A | 0.0000 | |
209 | N | A | -1.3306 | |
210 | M | A | 0.0000 | |
211 | W | A | -0.3792 | |
212 | I | A | 0.0000 | |
213 | R | A | 0.0000 | |
214 | D | A | 0.0000 | |
215 | F | A | 0.0000 | |
216 | Y | A | 0.0000 | |
217 | I | A | 0.0000 | |
218 | F | A | 0.0000 | |
219 | A | A | -1.0507 | |
220 | K | A | -1.3821 | |
221 | E | A | -1.8064 | |
222 | L | A | 0.0000 | |
223 | D | A | -2.3137 | |
224 | G | A | -2.0921 | |
225 | K | A | -2.5643 | |
226 | D | A | -1.8899 | |
227 | I | A | 0.0000 | |
228 | N | A | -2.0017 | |
229 | I | A | -1.1206 | |
230 | L | A | 0.0000 | |
231 | F | A | 0.0000 | |
232 | N | A | -0.7264 | |
233 | S | A | -0.3921 | |
234 | L | A | 0.1009 | |
235 | Q | A | 0.0092 | |
236 | Y | A | 0.1797 | |
237 | T | A | -0.8739 | |
238 | N | A | -1.5937 | |
239 | V | A | 0.0000 | |
240 | V | A | 0.0000 | |
241 | K | A | 0.0000 | |
242 | D | A | 0.0000 | |
243 | Y | A | 0.0000 | |
244 | W | A | -0.0509 | |
245 | G | A | 0.0000 | |
246 | N | A | -0.4131 | |
247 | D | A | 0.0000 | |
248 | L | A | 0.0000 | |
249 | R | A | -1.7873 | |
250 | Y | A | 0.0000 | |
251 | N | A | -2.2842 | |
252 | K | A | -1.7576 | |
253 | E | A | -1.5292 | |
254 | Y | A | 0.0000 | |
255 | Y | A | 0.0000 | |
256 | M | A | 0.0000 | |
257 | V | A | 0.0000 | |
258 | N | A | 0.0000 | |
259 | I | A | 0.2396 | |
260 | D | A | -0.9504 | |
261 | Y | A | -0.1556 | |
262 | L | A | 0.6059 | |
263 | N | A | -1.4482 | |
264 | R | A | -1.4553 | |
265 | Y | A | 0.0000 | |
266 | M | A | 0.0000 | |
267 | Y | A | -0.3741 | |
268 | A | A | -0.9066 | |
269 | N | A | -1.4807 | |
270 | S | A | -1.3171 | |
271 | R | A | -1.9398 | |
272 | Q | A | 0.0000 | |
273 | I | A | 0.0000 | |
274 | V | A | 0.0000 | |
275 | F | A | 0.0000 | |
276 | N | A | -1.8615 | |
277 | T | A | -1.9245 | |
278 | R | A | -3.4273 | |
279 | R | A | -3.8679 | |
280 | N | A | -3.3682 | |
281 | N | A | -3.4934 | |
282 | N | A | -2.8913 | |
283 | D | A | -2.4758 | |
284 | F | A | -0.7563 | |
285 | N | A | -1.6147 | |
286 | E | A | -2.0116 | |
287 | G | A | -0.7995 | |
288 | Y | A | -0.5856 | |
289 | K | A | -1.0977 | |
290 | I | A | 0.0000 | |
291 | I | A | -0.9762 | |
292 | I | A | 0.0000 | |
293 | K | A | -1.7263 | |
294 | R | A | -2.6473 | |
295 | I | A | -1.1648 | |
296 | R | A | -1.6540 | |
297 | G | A | -2.0340 | |
298 | N | A | -2.3191 | |
299 | T | A | -2.0677 | |
300 | N | A | -2.0284 | |
301 | D | A | -1.4347 | |
302 | T | A | -1.6656 | |
303 | R | A | -1.4331 | |
304 | V | A | 0.0000 | |
305 | R | A | -2.0116 | |
306 | G | A | -1.8902 | |
307 | G | A | -1.4895 | |
308 | D | A | 0.0000 | |
309 | I | A | -0.8617 | |
310 | L | A | 0.0000 | |
311 | Y | A | -0.4640 | |
312 | F | A | 0.0000 | |
313 | D | A | 0.0000 | |
314 | M | A | 0.0000 | |
315 | T | A | -1.3607 | |
316 | I | A | 0.0000 | |
317 | N | A | -2.3545 | |
318 | N | A | -2.6174 | |
319 | K | A | -2.7611 | |
320 | A | A | -1.7416 | |
321 | Y | A | -1.4155 | |
322 | N | A | 0.0000 | |
323 | L | A | 0.0000 | |
324 | F | A | 0.0000 | |
325 | M | A | 0.0000 | |
326 | K | A | -1.8896 | |
327 | N | A | -2.4981 | |
328 | E | A | -2.5473 | |
329 | T | A | -1.4241 | |
330 | M | A | 0.0000 | |
331 | Y | A | -0.5826 | |
332 | A | A | -1.4746 | |
333 | D | A | -2.6976 | |
334 | N | A | -2.5468 | |
335 | H | A | -2.2594 | |
336 | S | A | -1.7229 | |
337 | T | A | -1.5729 | |
338 | E | A | -2.4193 | |
339 | D | A | -2.3121 | |
340 | I | A | 0.0000 | |
341 | Y | A | -1.3045 | |
342 | A | A | 0.0000 | |
343 | I | A | 0.0000 | |
344 | G | A | 0.0000 | |
345 | L | A | 0.0000 | |
346 | R | A | -2.0306 | |
347 | E | A | -2.5183 | |
348 | Q | A | -2.6248 | |
349 | T | A | -2.5064 | |
350 | K | A | -3.1788 | |
351 | D | A | -3.0144 | |
352 | I | A | -1.7014 | |
353 | N | A | -2.3446 | |
354 | D | A | -1.8208 | |
355 | N | A | -1.3612 | |
356 | I | A | 0.0000 | |
357 | I | A | 0.0000 | |
358 | F | A | 0.0000 | |
359 | Q | A | -0.2220 | |
360 | I | A | 0.0000 | |
361 | Q | A | -1.0629 | |
362 | P | A | -1.0071 | |
363 | M | A | 0.0000 | |
364 | N | A | -1.6434 | |
365 | N | A | -0.6320 | |
366 | T | A | 0.1207 | |
367 | Y | A | 1.0393 | |
368 | Y | A | 0.4575 | |
369 | Y | A | 0.0000 | |
370 | A | A | 0.0000 | |
371 | S | A | 0.0000 | |
372 | Q | A | 0.0000 | |
373 | I | A | 0.0000 | |
374 | F | A | 0.0000 | |
375 | K | A | 0.0000 | |
376 | S | A | 0.0000 | |
377 | N | A | -1.6690 | |
378 | F | A | -1.1361 | |
379 | N | A | -2.0801 | |
380 | G | A | -1.8595 | |
381 | E | A | -2.5293 | |
382 | N | A | -1.9480 | |
383 | I | A | -0.3426 | |
384 | S | A | -0.4551 | |
385 | G | A | 0.0000 | |
386 | I | A | 0.0000 | |
387 | C | A | 0.0000 | |
388 | S | A | 0.0000 | |
389 | I | A | 0.0000 | |
390 | G | A | -0.2223 | |
391 | T | A | -0.7877 | |
392 | Y | A | 0.0000 | |
393 | R | A | -1.4414 | |
394 | F | A | 0.0000 | |
395 | R | A | -2.4317 | |
396 | L | A | -1.4063 | |
397 | G | A | -1.0785 | |
398 | G | A | 0.0000 | |
399 | D | A | -1.7576 | |
400 | W | A | 0.3505 | |
401 | Y | A | 0.2355 | |
402 | R | A | -1.6680 | |
403 | H | A | -1.6485 | |
404 | N | A | -1.6214 | |
405 | Y | A | -0.8246 | |
406 | L | A | 0.0000 | |
407 | V | A | 0.0000 | |
408 | P | A | 0.0000 | |
409 | T | A | 0.0000 | |
410 | V | A | 0.0000 | |
411 | K | A | -0.9283 | |
412 | Q | A | -1.1572 | |
413 | G | A | -1.6462 | |
414 | N | A | -1.4223 | |
415 | Y | A | -0.2312 | |
416 | A | A | -0.1388 | |
417 | S | A | -0.4274 | |
418 | L | A | -0.1755 | |
419 | L | A | -0.0392 | |
420 | E | A | -1.5107 | |
421 | S | A | -0.8678 | |
422 | T | A | -0.7432 | |
423 | S | A | -0.5942 | |
424 | T | A | 0.0000 | |
425 | H | A | -0.3512 | |
426 | W | A | 0.0000 | |
427 | G | A | 0.0000 | |
428 | F | A | 0.0000 | |
429 | V | A | 0.0000 | |
430 | P | A | 0.0000 | |
431 | V | A | -0.0570 | |
432 | S | A | -0.8130 | |
433 | E | A | -1.9270 |