| Chain sequence(s) |
A: SFTLSVTVQQPQLTLTAAVIGDGAPANGKTAITVEFTVADFEGKPLAGQEVVITTNNGALPNKITEKTDANGVARIALTNTTDGVTVVTAEVEGQRQSVDTHFVKGTIAADKSTLAAVPTSIIADGLMASTITLELKDTYGDPQAGANVAFDTTLGNMGVITDHNDGTYSAPLTSTTLGVATVTVKVDGAAFSVPSVTVNFTADPIPDAGRSSFTVSTPDILADGTMSSTLSFVPVDKNGHFISGMQGLSFTQNGVPVSISPITEQPDSYTATVVGNTAGDVTITPQVDTLILSTLQKKISLFPVPTLTGILVNGQNFATDKGFPKTIFKNATFQLQMDNDVANNTQYEWSSSFTPNVSVNDQGQVTITYQTYSEVAVTAKSKKFPSYSVSYRFYPNRWIYDGGTSLVSSLEASRQCQGSDMSAVLESSRATNGTRAPDGTLWGEWGSLTAYSSDWQSGEYWVKKTSTDFETMNMDTGALVQGPAYLAFPLCALAI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:35)
[INFO] Main: Simulation completed successfully. (00:02:38)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 490 | S | A | 0.7108 | |
| 491 | F | A | 2.1233 | |
| 492 | T | A | 1.7013 | |
| 493 | L | A | 2.2592 | |
| 494 | S | A | 1.5508 | |
| 495 | V | A | 2.3701 | |
| 496 | T | A | 1.2960 | |
| 497 | V | A | 1.2988 | |
| 498 | Q | A | -1.1135 | |
| 499 | Q | A | -1.7994 | |
| 500 | P | A | -1.2936 | |
| 501 | Q | A | -1.1269 | |
| 502 | L | A | 0.1777 | |
| 503 | T | A | -0.2226 | |
| 504 | L | A | -0.4199 | |
| 505 | T | A | -0.3058 | |
| 506 | A | A | -0.3765 | |
| 507 | A | A | -0.0411 | |
| 508 | V | A | 0.2168 | |
| 509 | I | A | 0.9359 | |
| 510 | G | A | -0.4348 | |
| 511 | D | A | -1.4208 | |
| 512 | G | A | -0.9253 | |
| 513 | A | A | 0.0000 | |
| 514 | P | A | -1.0809 | |
| 515 | A | A | -1.5344 | |
| 516 | N | A | -1.4296 | |
| 517 | G | A | -1.1028 | |
| 518 | K | A | -1.8961 | |
| 519 | T | A | -1.1861 | |
| 520 | A | A | -0.4583 | |
| 521 | I | A | 0.0000 | |
| 522 | T | A | -0.1749 | |
| 523 | V | A | 0.0000 | |
| 524 | E | A | -0.8584 | |
| 525 | F | A | 0.0000 | |
| 526 | T | A | -0.5261 | |
| 527 | V | A | 0.0000 | |
| 528 | A | A | -0.7526 | |
| 529 | D | A | -0.7729 | |
| 530 | F | A | 0.3145 | |
| 531 | E | A | -1.7209 | |
| 532 | G | A | -1.5960 | |
| 533 | K | A | -2.3852 | |
| 534 | P | A | -1.5190 | |
| 535 | L | A | -0.5694 | |
| 536 | A | A | -1.1245 | |
| 537 | G | A | -1.6587 | |
| 538 | Q | A | -2.1063 | |
| 539 | E | A | -3.1969 | |
| 540 | V | A | 0.0000 | |
| 541 | V | A | -1.3708 | |
| 542 | I | A | 0.0000 | |
| 543 | T | A | -1.0605 | |
| 544 | T | A | 0.0000 | |
| 545 | N | A | -1.5146 | |
| 546 | N | A | -1.1828 | |
| 547 | G | A | -1.1034 | |
| 548 | A | A | 0.0000 | |
| 549 | L | A | 0.4326 | |
| 550 | P | A | -0.3809 | |
| 551 | N | A | -1.9292 | |
| 552 | K | A | -1.9686 | |
| 553 | I | A | -1.0301 | |
| 554 | T | A | -1.5076 | |
| 555 | E | A | -2.4869 | |
| 556 | K | A | -3.2868 | |
| 557 | T | A | 0.0000 | |
| 558 | D | A | -1.6182 | |
| 559 | A | A | -0.9123 | |
| 560 | N | A | -1.5179 | |
| 561 | G | A | 0.0000 | |
| 562 | V | A | -1.2830 | |
| 563 | A | A | 0.0000 | |
| 564 | R | A | -2.3599 | |
| 565 | I | A | 0.0000 | |
| 566 | A | A | -0.0097 | |
| 567 | L | A | 0.0000 | |
| 568 | T | A | -0.2909 | |
| 569 | N | A | 0.0000 | |
| 570 | T | A | -0.9977 | |
| 571 | T | A | -1.2168 | |
| 572 | D | A | -2.0877 | |
| 573 | G | A | -1.0441 | |
| 574 | V | A | -0.1454 | |
| 575 | T | A | 0.0000 | |
| 576 | V | A | -0.2578 | |
| 577 | V | A | 0.0000 | |
| 578 | T | A | -1.0467 | |
| 579 | A | A | 0.0000 | |
| 580 | E | A | -2.4566 | |
| 581 | V | A | 0.0000 | |
| 582 | E | A | -2.9760 | |
| 583 | G | A | -2.3977 | |
| 584 | Q | A | -2.7276 | |
| 585 | R | A | -3.0425 | |
| 586 | Q | A | -1.6726 | |
| 587 | S | A | -0.9267 | |
| 588 | V | A | -0.4470 | |
| 589 | D | A | -0.9751 | |
| 590 | T | A | 0.0000 | |
| 591 | H | A | -1.2168 | |
| 592 | F | A | 0.0000 | |
| 593 | V | A | -0.9835 | |
| 594 | K | A | -1.9776 | |
| 595 | G | A | 0.0000 | |
| 596 | T | A | -0.1743 | |
| 597 | I | A | -0.2545 | |
| 598 | A | A | -0.8121 | |
| 599 | A | A | -1.3968 | |
| 600 | D | A | -2.5117 | |
| 601 | K | A | -2.3302 | |
| 602 | S | A | -1.6387 | |
| 603 | T | A | -1.0474 | |
| 604 | L | A | 0.0000 | |
| 605 | A | A | 0.2753 | |
| 606 | A | A | 0.0000 | |
| 607 | V | A | 1.6347 | |
| 608 | P | A | 0.7870 | |
| 609 | T | A | 0.3407 | |
| 610 | S | A | -0.0281 | |
| 611 | I | A | 0.0000 | |
| 612 | I | A | 0.4892 | |
| 613 | A | A | 0.0000 | |
| 614 | D | A | -0.1630 | |
| 615 | G | A | 0.3011 | |
| 616 | L | A | 1.6377 | |
| 617 | M | A | 1.1951 | |
| 618 | A | A | 0.6390 | |
| 619 | S | A | 0.0000 | |
| 620 | T | A | 0.5110 | |
| 621 | I | A | 0.0000 | |
| 622 | T | A | 0.0496 | |
| 623 | L | A | 0.0000 | |
| 624 | E | A | -1.4205 | |
| 625 | L | A | 0.0000 | |
| 626 | K | A | -1.3080 | |
| 627 | D | A | 0.0000 | |
| 628 | T | A | -0.3941 | |
| 629 | Y | A | 0.5955 | |
| 630 | G | A | -0.5362 | |
| 631 | D | A | -1.1700 | |
| 632 | P | A | -1.5198 | |
| 633 | Q | A | -1.4058 | |
| 634 | A | A | -1.9504 | |
| 635 | G | A | -1.6848 | |
| 636 | A | A | -1.5697 | |
| 637 | N | A | -2.1929 | |
| 638 | V | A | -1.1904 | |
| 639 | A | A | -0.7827 | |
| 640 | F | A | 0.0000 | |
| 641 | D | A | -1.7614 | |
| 642 | T | A | -0.7484 | |
| 643 | T | A | -0.2154 | |
| 644 | L | A | 0.0074 | |
| 645 | G | A | -0.4578 | |
| 646 | N | A | -1.2847 | |
| 647 | M | A | -0.3314 | |
| 648 | G | A | 0.4819 | |
| 649 | V | A | 1.7939 | |
| 650 | I | A | 1.1284 | |
| 651 | T | A | 0.0550 | |
| 652 | D | A | -1.5548 | |
| 653 | H | A | -2.0982 | |
| 654 | N | A | -2.7938 | |
| 655 | D | A | -3.0374 | |
| 656 | G | A | 0.0000 | |
| 657 | T | A | -1.6931 | |
| 658 | Y | A | 0.0000 | |
| 659 | S | A | 0.0482 | |
| 660 | A | A | 0.0000 | |
| 661 | P | A | 0.4836 | |
| 662 | L | A | 0.0000 | |
| 663 | T | A | -0.0091 | |
| 664 | S | A | 0.0000 | |
| 665 | T | A | -0.1563 | |
| 666 | T | A | 0.1968 | |
| 667 | L | A | 0.7437 | |
| 668 | G | A | 0.5946 | |
| 669 | V | A | 1.1347 | |
| 670 | A | A | 0.0000 | |
| 671 | T | A | -0.0272 | |
| 672 | V | A | 0.0000 | |
| 673 | T | A | -0.8021 | |
| 674 | V | A | 0.0000 | |
| 675 | K | A | -1.6508 | |
| 676 | V | A | 0.0000 | |
| 677 | D | A | -2.6313 | |
| 678 | G | A | -1.7244 | |
| 679 | A | A | -1.0252 | |
| 680 | A | A | -0.7080 | |
| 681 | F | A | -0.3806 | |
| 682 | S | A | -0.5805 | |
| 683 | V | A | 0.0000 | |
| 684 | P | A | -0.5304 | |
| 685 | S | A | -0.4047 | |
| 686 | V | A | 0.2088 | |
| 687 | T | A | 0.2626 | |
| 688 | V | A | 0.0000 | |
| 689 | N | A | -0.1248 | |
| 690 | F | A | 0.0000 | |
| 691 | T | A | 0.1067 | |
| 692 | A | A | 0.0000 | |
| 693 | D | A | 0.0000 | |
| 694 | P | A | 0.3888 | |
| 695 | I | A | 1.4552 | |
| 696 | P | A | 0.0000 | |
| 697 | D | A | -1.3332 | |
| 698 | A | A | -0.6950 | |
| 699 | G | A | -1.6822 | |
| 700 | R | A | -2.5928 | |
| 701 | S | A | 0.0000 | |
| 702 | S | A | -0.6020 | |
| 703 | F | A | 0.0000 | |
| 704 | T | A | -0.2709 | |
| 705 | V | A | -0.4800 | |
| 706 | S | A | -0.2998 | |
| 707 | T | A | -0.5634 | |
| 708 | P | A | -1.1691 | |
| 709 | D | A | -1.0471 | |
| 710 | I | A | 0.0000 | |
| 711 | L | A | 0.0000 | |
| 712 | A | A | 0.0000 | |
| 713 | D | A | -0.7754 | |
| 714 | G | A | -0.8663 | |
| 715 | T | A | -0.4034 | |
| 716 | M | A | -0.2182 | |
| 717 | S | A | -0.0962 | |
| 718 | S | A | 0.0000 | |
| 719 | T | A | -0.0522 | |
| 720 | L | A | 0.0000 | |
| 721 | S | A | -0.2965 | |
| 722 | F | A | 0.0000 | |
| 723 | V | A | -0.3526 | |
| 724 | P | A | 0.0000 | |
| 725 | V | A | -0.8687 | |
| 726 | D | A | 0.0000 | |
| 727 | K | A | -2.3921 | |
| 728 | N | A | -1.9964 | |
| 729 | G | A | -1.6935 | |
| 730 | H | A | -0.8164 | |
| 731 | F | A | -0.5141 | |
| 732 | I | A | 0.0000 | |
| 733 | S | A | -1.0326 | |
| 734 | G | A | -0.9896 | |
| 735 | M | A | -0.7190 | |
| 736 | Q | A | -1.7551 | |
| 737 | G | A | -1.5974 | |
| 738 | L | A | -0.6791 | |
| 739 | S | A | -0.4875 | |
| 740 | F | A | 0.0000 | |
| 741 | T | A | -0.5446 | |
| 742 | Q | A | -1.7144 | |
| 743 | N | A | -2.1468 | |
| 744 | G | A | -1.7179 | |
| 745 | V | A | -1.0076 | |
| 746 | P | A | -0.9088 | |
| 747 | V | A | 0.0000 | |
| 748 | S | A | -0.2905 | |
| 749 | I | A | 0.2531 | |
| 750 | S | A | 0.1280 | |
| 751 | P | A | -0.0986 | |
| 752 | I | A | 0.1116 | |
| 753 | T | A | -0.6208 | |
| 754 | E | A | -1.8605 | |
| 755 | Q | A | -1.7878 | |
| 756 | P | A | -1.6066 | |
| 757 | D | A | -2.1151 | |
| 758 | S | A | -1.2623 | |
| 759 | Y | A | 0.0000 | |
| 760 | T | A | -0.4717 | |
| 761 | A | A | 0.0000 | |
| 762 | T | A | 0.1280 | |
| 763 | V | A | 0.0000 | |
| 764 | V | A | -0.1362 | |
| 765 | G | A | 0.0000 | |
| 766 | N | A | -1.4241 | |
| 767 | T | A | -0.7606 | |
| 768 | A | A | -0.3842 | |
| 769 | G | A | -0.7380 | |
| 770 | D | A | -1.7762 | |
| 771 | V | A | 0.0000 | |
| 772 | T | A | -2.1517 | |
| 773 | I | A | 0.0000 | |
| 774 | T | A | 0.0000 | |
| 775 | P | A | 0.0000 | |
| 776 | Q | A | -0.1413 | |
| 777 | V | A | 0.0000 | |
| 778 | D | A | -1.6274 | |
| 779 | T | A | -0.4051 | |
| 780 | L | A | 0.8242 | |
| 781 | I | A | 1.0819 | |
| 782 | L | A | 0.0000 | |
| 783 | S | A | -0.0804 | |
| 784 | T | A | -0.3425 | |
| 785 | L | A | -0.5073 | |
| 786 | Q | A | -1.6375 | |
| 787 | K | A | -2.0476 | |
| 788 | K | A | -2.8643 | |
| 789 | I | A | 0.0000 | |
| 790 | S | A | -1.0988 | |
| 791 | L | A | 0.0000 | |
| 792 | F | A | 0.2086 | |
| 793 | P | A | -0.0572 | |
| 794 | V | A | 0.1995 | |
| 795 | P | A | 0.0000 | |
| 796 | T | A | -0.2933 | |
| 797 | L | A | -0.5570 | |
| 798 | T | A | -1.0903 | |
| 799 | G | A | 0.0000 | |
| 800 | I | A | 0.0000 | |
| 801 | L | A | -0.5852 | |
| 802 | V | A | 0.0000 | |
| 803 | N | A | -1.1325 | |
| 804 | G | A | -1.2498 | |
| 805 | Q | A | -1.5178 | |
| 806 | N | A | -1.5899 | |
| 807 | F | A | 0.0000 | |
| 808 | A | A | -1.1676 | |
| 809 | T | A | -1.6962 | |
| 810 | D | A | -2.7486 | |
| 811 | K | A | -2.8036 | |
| 812 | G | A | -1.7536 | |
| 813 | F | A | 0.0000 | |
| 814 | P | A | 0.0000 | |
| 815 | K | A | -0.6758 | |
| 816 | T | A | 0.0000 | |
| 817 | I | A | 0.0000 | |
| 818 | F | A | 0.0000 | |
| 819 | K | A | -2.0190 | |
| 820 | N | A | -1.7329 | |
| 821 | A | A | 0.0000 | |
| 822 | T | A | -0.6306 | |
| 823 | F | A | 0.0000 | |
| 824 | Q | A | -0.5145 | |
| 825 | L | A | 0.0000 | |
| 826 | Q | A | 0.0000 | |
| 827 | M | A | 0.0000 | |
| 828 | D | A | -1.6767 | |
| 829 | N | A | -2.1478 | |
| 830 | D | A | -1.8970 | |
| 831 | V | A | -0.7376 | |
| 832 | A | A | -0.8277 | |
| 833 | N | A | -1.4011 | |
| 834 | N | A | 0.0000 | |
| 835 | T | A | -1.8933 | |
| 836 | Q | A | -2.8419 | |
| 837 | Y | A | 0.0000 | |
| 838 | E | A | -3.2980 | |
| 839 | W | A | -2.1004 | |
| 840 | S | A | -1.0533 | |
| 841 | S | A | -0.4575 | |
| 842 | S | A | -0.7209 | |
| 843 | F | A | -0.2334 | |
| 844 | T | A | -0.1769 | |
| 845 | P | A | -0.2267 | |
| 846 | N | A | -0.2342 | |
| 847 | V | A | 0.0000 | |
| 848 | S | A | -0.3869 | |
| 849 | V | A | -1.0300 | |
| 850 | N | A | -2.0194 | |
| 851 | D | A | -2.9577 | |
| 852 | Q | A | -1.9776 | |
| 853 | G | A | 0.0000 | |
| 854 | Q | A | -1.0854 | |
| 855 | V | A | 0.0000 | |
| 856 | T | A | -0.6710 | |
| 857 | I | A | 0.0000 | |
| 858 | T | A | -0.6528 | |
| 859 | Y | A | 0.0640 | |
| 860 | Q | A | 0.2441 | |
| 861 | T | A | 0.0000 | |
| 862 | Y | A | 1.1919 | |
| 863 | S | A | -0.0139 | |
| 864 | E | A | -1.5871 | |
| 865 | V | A | 0.0000 | |
| 866 | A | A | -1.1046 | |
| 867 | V | A | 0.0000 | |
| 868 | T | A | -0.8709 | |
| 869 | A | A | 0.0000 | |
| 870 | K | A | -2.2740 | |
| 871 | S | A | 0.0000 | |
| 872 | K | A | -3.2361 | |
| 873 | K | A | -2.5785 | |
| 874 | F | A | 0.0000 | |
| 875 | P | A | -1.5644 | |
| 876 | S | A | -0.7525 | |
| 877 | Y | A | -0.5833 | |
| 878 | S | A | -0.8521 | |
| 879 | V | A | -0.1579 | |
| 880 | S | A | -0.6544 | |
| 881 | Y | A | 0.0000 | |
| 882 | R | A | -2.2411 | |
| 883 | F | A | 0.0000 | |
| 884 | Y | A | 0.1785 | |
| 885 | P | A | 0.0000 | |
| 886 | N | A | -0.2474 | |
| 887 | R | A | -0.0812 | |
| 888 | W | A | 0.0000 | |
| 889 | I | A | 0.0000 | |
| 890 | Y | A | -0.6072 | |
| 891 | D | A | -1.2848 | |
| 892 | G | A | -1.0701 | |
| 893 | G | A | -0.5678 | |
| 894 | T | A | -0.4603 | |
| 895 | S | A | 0.3874 | |
| 896 | L | A | 1.5515 | |
| 897 | V | A | 1.2011 | |
| 898 | S | A | 0.8785 | |
| 899 | S | A | 0.3166 | |
| 900 | L | A | 0.4189 | |
| 901 | E | A | -1.1175 | |
| 902 | A | A | 0.0000 | |
| 903 | S | A | -1.4197 | |
| 904 | R | A | -2.8003 | |
| 905 | Q | A | -2.3919 | |
| 906 | C | A | 0.0000 | |
| 907 | Q | A | -2.4012 | |
| 908 | G | A | -1.6586 | |
| 909 | S | A | -0.8981 | |
| 910 | D | A | -1.0161 | |
| 911 | M | A | 0.1115 | |
| 912 | S | A | 0.0000 | |
| 913 | A | A | -0.8313 | |
| 914 | V | A | 0.0000 | |
| 915 | L | A | 0.0000 | |
| 916 | E | A | -1.6505 | |
| 917 | S | A | 0.0000 | |
| 918 | S | A | -1.2342 | |
| 919 | R | A | -1.4606 | |
| 920 | A | A | 0.0000 | |
| 921 | T | A | -1.1521 | |
| 922 | N | A | -1.3198 | |
| 923 | G | A | -1.0573 | |
| 924 | T | A | -0.7006 | |
| 925 | R | A | -0.9981 | |
| 926 | A | A | -1.1545 | |
| 927 | P | A | 0.0000 | |
| 928 | D | A | -2.2442 | |
| 929 | G | A | 0.0000 | |
| 930 | T | A | -1.1350 | |
| 931 | L | A | 0.0000 | |
| 932 | W | A | -0.4380 | |
| 933 | G | A | 0.0000 | |
| 934 | E | A | 0.0000 | |
| 935 | W | A | 0.0000 | |
| 936 | G | A | 0.0000 | |
| 937 | S | A | -0.5214 | |
| 938 | L | A | 0.0000 | |
| 939 | T | A | -0.6945 | |
| 940 | A | A | -0.3269 | |
| 941 | Y | A | -0.7015 | |
| 942 | S | A | -1.1855 | |
| 943 | S | A | -1.1728 | |
| 944 | D | A | -2.4320 | |
| 945 | W | A | 0.0000 | |
| 946 | Q | A | -1.2851 | |
| 947 | S | A | -1.0103 | |
| 948 | G | A | -0.6551 | |
| 949 | E | A | 0.0503 | |
| 950 | Y | A | 0.0000 | |
| 951 | W | A | 0.0000 | |
| 952 | V | A | 0.0000 | |
| 953 | K | A | -1.9045 | |
| 954 | K | A | -2.7144 | |
| 955 | T | A | -1.6925 | |
| 956 | S | A | -1.1071 | |
| 957 | T | A | -0.9783 | |
| 958 | D | A | -2.2726 | |
| 959 | F | A | -1.3606 | |
| 960 | E | A | 0.0000 | |
| 961 | T | A | 0.0000 | |
| 962 | M | A | 0.0000 | |
| 963 | N | A | -0.6613 | |
| 964 | M | A | 0.0000 | |
| 965 | D | A | -1.2086 | |
| 966 | T | A | -0.8635 | |
| 967 | G | A | 0.0000 | |
| 968 | A | A | -0.4288 | |
| 969 | L | A | 0.0191 | |
| 970 | V | A | 0.3727 | |
| 971 | Q | A | -0.9182 | |
| 972 | G | A | -0.1516 | |
| 973 | P | A | -0.0567 | |
| 974 | A | A | 0.6900 | |
| 975 | Y | A | 1.9586 | |
| 976 | L | A | 2.3691 | |
| 977 | A | A | 0.0000 | |
| 978 | F | A | 0.3528 | |
| 979 | P | A | 0.0000 | |
| 980 | L | A | 0.0000 | |
| 981 | C | A | 0.0000 | |
| 982 | A | A | 0.0000 | |
| 983 | L | A | 0.1373 | |
| 984 | A | A | 0.4470 | |
| 985 | I | A | 1.0557 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine