Chain sequence(s) |
A: DIVMTQSPSSLSASVGDRVTITCLASEGISNDLAWYQQKPGKVPKLLIYATSRLQDGVPSRFSGSGSGTRYTLTISSLQPEDVADYYCQQSYKFPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQITLKESGPTLVKPTQTLTLTCTFSGFSLTTYGMAVSWIRQPPGKALEWLASIWWNGNTYNNPSLKSRLTITKDTSKNQAVLTMTNMDPVDTATYYCVHQVDNYLFDHWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | No |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:01:32) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:01:32) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:01:32) [INFO] runJob: Creating pdb object from: input.pdb (00:01:32) [INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:01:33) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:36) [CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie creation failed. (00:01:36) [INFO] Main: Simulation completed successfully. (00:01:58) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | D | A | -1.6194 | |
2 | I | A | 0.0000 | |
3 | V | A | 1.1355 | |
4 | M | A | 0.0000 | |
5 | T | A | 0.1716 | |
6 | Q | A | 0.0000 | |
7 | S | A | -0.2376 | |
8 | P | A | -0.3303 | |
9 | S | A | -0.6701 | |
10 | S | A | -0.4361 | |
11 | L | A | -0.1084 | |
12 | S | A | -0.5128 | |
13 | A | A | 0.0000 | |
14 | S | A | -0.5543 | |
15 | V | A | 0.1993 | |
16 | G | A | -0.8038 | |
17 | D | A | -1.7218 | |
18 | R | A | -2.2853 | |
19 | V | A | 0.0000 | |
20 | T | A | -0.5951 | |
21 | I | A | 0.0000 | |
22 | T | A | -0.2283 | |
23 | C | A | 0.0000 | |
24 | L | A | 0.3781 | |
25 | A | A | 0.0000 | |
26 | S | A | -0.3143 | |
27 | E | A | -0.8569 | |
28 | G | A | -1.1133 | |
29 | I | A | 0.0000 | |
30A | S | A | -1.1741 | |
31 | N | A | -1.6801 | |
32 | D | A | -0.8325 | |
33 | L | A | 0.0000 | |
34 | A | A | 0.0000 | |
35 | W | A | 0.0000 | |
36 | Y | A | 0.0000 | |
37 | Q | A | 0.0000 | |
38 | Q | A | -1.0473 | |
39 | K | A | -1.4882 | |
40 | P | A | -1.3179 | |
41 | G | A | -1.4061 | |
42 | K | A | -2.1915 | |
43 | V | A | -1.0377 | |
44 | P | A | 0.0000 | |
45 | K | A | -1.2068 | |
46 | L | A | 0.0000 | |
47 | L | A | 0.0000 | |
48 | I | A | 0.0000 | |
49 | Y | A | -0.8521 | |
50 | A | A | -1.1486 | |
51 | T | A | 0.0000 | |
52 | S | A | -1.2677 | |
53 | R | A | -1.8766 | |
54 | L | A | -0.9232 | |
55 | Q | A | -1.5255 | |
56 | D | A | -2.1699 | |
57 | G | A | -1.3629 | |
58 | V | A | -0.7167 | |
59 | P | A | -0.4889 | |
60 | S | A | -0.4279 | |
61 | R | A | 0.0000 | |
62 | F | A | 0.0000 | |
63 | S | A | -0.4778 | |
64 | G | A | -0.5704 | |
65 | S | A | -1.0439 | |
66 | G | A | -1.1581 | |
67 | S | A | -1.3773 | |
68 | G | A | -1.3144 | |
69 | T | A | -1.2793 | |
70 | R | A | -1.6733 | |
71 | Y | A | 0.0000 | |
72 | T | A | -0.4299 | |
73 | L | A | 0.0000 | |
74 | T | A | -0.5080 | |
75 | I | A | 0.0000 | |
76 | S | A | -1.0583 | |
77 | S | A | -1.1538 | |
78 | L | A | 0.0000 | |
79 | Q | A | -0.7932 | |
80 | P | A | -0.6895 | |
81 | E | A | -1.4229 | |
82 | D | A | 0.0000 | |
83 | V | A | -0.5832 | |
84 | A | A | 0.0000 | |
85 | D | A | -0.6583 | |
86 | Y | A | 0.0000 | |
87 | Y | A | 0.0000 | |
88 | C | A | 0.0000 | |
89 | Q | A | 0.0000 | |
90 | Q | A | 0.0000 | |
91 | S | A | 0.3617 | |
93A | Y | A | 0.6032 | |
93B | K | A | -0.2971 | |
94 | F | A | 0.0455 | |
95 | P | A | 0.0000 | |
96 | Y | A | 0.0000 | |
97 | T | A | -0.0101 | |
98 | F | A | 0.0000 | |
99 | G | A | 0.0000 | |
100 | Q | A | -1.3681 | |
101 | G | A | -1.1986 | |
102 | T | A | 0.0000 | |
103 | K | A | -0.6234 | |
104 | L | A | 0.0000 | |
105 | E | A | 0.0000 | |
106 | I | A | -0.6722 | |
107 | K | A | -0.9832 | |
108 | R | A | -1.4796 | |
109 | T | A | -0.0629 | |
110 | V | A | 1.0921 | |
111 | A | A | 0.3403 | |
112 | A | A | 0.0672 | |
113 | P | A | 0.0000 | |
114 | S | A | -0.1275 | |
115 | V | A | 0.0000 | |
116 | F | A | -0.0411 | |
117 | I | A | 0.0000 | |
118 | F | A | 0.0000 | |
119 | P | A | -0.4765 | |
120 | P | A | 0.0000 | |
121 | S | A | 0.0000 | |
122 | D | A | -2.5398 | |
123 | E | A | -2.0824 | |
124 | Q | A | 0.0000 | |
125 | L | A | -1.9368 | |
126 | K | A | -2.5443 | |
127 | S | A | -1.5734 | |
128 | G | A | -1.1780 | |
129 | T | A | -0.9794 | |
130 | A | A | 0.0000 | |
131 | S | A | 0.0000 | |
132 | V | A | 0.0000 | |
133 | V | A | 0.0000 | |
134 | C | A | 0.0000 | |
135 | L | A | 0.0000 | |
136 | L | A | 0.0000 | |
137 | N | A | 0.0000 | |
138 | N | A | -0.9665 | |
139 | F | A | 0.0000 | |
140 | Y | A | 0.0000 | |
141 | P | A | -0.9404 | |
142 | R | A | -1.5633 | |
143 | E | A | -2.2809 | |
144 | A | A | -1.7900 | |
145 | K | A | -2.3782 | |
146 | V | A | 0.0000 | |
147 | Q | A | -0.8511 | |
148 | W | A | 0.0000 | |
149 | K | A | 0.0000 | |
150 | V | A | 0.0000 | |
151 | D | A | -2.0328 | |
152 | N | A | -1.4417 | |
153 | A | A | -0.1000 | |
154 | L | A | 0.8593 | |
155 | Q | A | 0.0101 | |
156 | S | A | -0.5215 | |
157 | G | A | -0.9765 | |
158 | N | A | -0.8788 | |
159 | S | A | -0.9957 | |
160 | Q | A | -1.0611 | |
161 | E | A | -1.3855 | |
162 | S | A | 0.0000 | |
163 | V | A | -0.2590 | |
164 | T | A | -0.8046 | |
165 | E | A | -1.6809 | |
166 | Q | A | -1.7332 | |
167 | D | A | -2.2532 | |
168 | S | A | -1.8135 | |
169 | K | A | -2.5032 | |
170 | D | A | -2.1920 | |
171 | S | A | -2.1408 | |
172 | T | A | 0.0000 | |
173 | Y | A | 0.0000 | |
174 | S | A | 0.0000 | |
175 | L | A | 0.0000 | |
176 | S | A | 0.0000 | |
177 | S | A | 0.0000 | |
178 | T | A | -0.5086 | |
179 | L | A | 0.0000 | |
180 | T | A | -0.2732 | |
181 | L | A | -0.1076 | |
182 | S | A | -0.7914 | |
183 | K | A | -1.8284 | |
184 | A | A | -1.3497 | |
185 | D | A | -1.7028 | |
186 | Y | A | -1.7416 | |
187 | E | A | -2.7600 | |
188 | K | A | -3.0805 | |
189 | H | A | -2.7892 | |
190 | K | A | -3.4017 | |
191 | V | A | -2.0046 | |
192 | Y | A | 0.0000 | |
193 | A | A | 0.0000 | |
194 | C | A | 0.0000 | |
195 | E | A | -0.6053 | |
196 | V | A | 0.0000 | |
197 | T | A | -1.1324 | |
198 | H | A | 0.0000 | |
199 | Q | A | -1.6111 | |
200 | G | A | -0.4338 | |
201 | L | A | -0.3633 | |
202 | S | A | -0.4446 | |
203 | S | A | -0.3037 | |
204 | P | A | -0.4876 | |
205 | V | A | -0.0630 | |
206 | T | A | -0.4556 | |
207 | K | A | -0.7487 | |
208 | S | A | -0.6805 | |
209 | F | A | 0.0000 | |
210 | N | A | -2.3067 | |
211 | R | A | -3.1745 | |
212 | G | A | -2.5189 | |
213 | E | A | -2.5534 | |
214 | C | A | -1.5482 | |
1 | Q | A | -1.0987 | |
2 | I | A | -0.3703 | |
3 | T | A | -0.7949 | |
4 | L | A | 0.0000 | |
5 | K | A | -2.1394 | |
6 | E | A | 0.0000 | |
7 | S | A | -0.7493 | |
8 | G | A | -0.2926 | |
9 | P | A | -0.1412 | |
10 | T | A | 0.1427 | |
11 | L | A | 0.3565 | |
12 | V | A | 0.0000 | |
13 | K | A | -1.2884 | |
14 | P | A | -1.3002 | |
15 | T | A | -1.6147 | |
16 | Q | A | -1.8440 | |
17 | T | A | -1.2515 | |
18 | L | A | 0.0000 | |
19 | T | A | -0.1313 | |
20 | L | A | 0.0000 | |
21 | T | A | -0.3302 | |
22 | C | A | 0.0000 | |
23 | T | A | -1.1373 | |
24 | F | A | 0.0000 | |
25 | S | A | -0.6346 | |
26 | G | A | -0.6015 | |
27 | F | A | -0.1461 | |
28 | S | A | -0.2191 | |
29 | L | A | 0.0000 | |
30A | T | A | -0.0464 | |
30B | T | A | 0.5495 | |
30C | Y | A | 1.0602 | |
30D | G | A | 0.0000 | |
31 | M | A | 0.4092 | |
32 | A | A | 0.0000 | |
33 | V | A | 0.0000 | |
34 | S | A | 0.0000 | |
35 | W | A | 0.0000 | |
36 | I | A | 0.0000 | |
37 | R | A | 0.0000 | |
38 | Q | A | -0.8002 | |
39 | P | A | -0.5581 | |
40 | P | A | -0.8007 | |
41 | G | A | -1.4337 | |
42 | K | A | -2.2849 | |
43 | A | A | -1.4857 | |
44 | L | A | 0.0000 | |
45 | E | A | -0.7711 | |
46 | W | A | 0.0000 | |
47 | L | A | 0.0000 | |
48 | A | A | 0.0000 | |
49 | S | A | 0.0000 | |
50 | I | A | 0.0000 | |
51 | W | A | -0.2900 | |
51A | W | A | -0.0353 | |
53 | N | A | -1.1310 | |
54 | G | A | -1.1071 | |
55 | N | A | -0.9607 | |
56 | T | A | -0.4226 | |
57 | Y | A | 0.1223 | |
58 | N | A | -0.5318 | |
59 | N | A | 0.0000 | |
60 | P | A | -0.9681 | |
61 | S | A | -0.9506 | |
62 | L | A | -1.0448 | |
63 | K | A | -2.0375 | |
64 | S | A | -1.4233 | |
65 | R | A | -1.3704 | |
66 | L | A | 0.0000 | |
67 | T | A | -0.3943 | |
68 | I | A | 0.0000 | |
69 | T | A | -0.3402 | |
70 | K | A | -0.8281 | |
71 | D | A | -1.3915 | |
72 | T | A | -1.0880 | |
73 | S | A | -1.3671 | |
74 | K | A | -2.1910 | |
75 | N | A | -1.4973 | |
76 | Q | A | -1.2855 | |
77 | A | A | 0.0000 | |
78 | V | A | 0.0664 | |
79 | L | A | 0.0000 | |
80 | T | A | -0.0977 | |
81 | M | A | 0.0000 | |
82 | T | A | -1.2695 | |
83 | N | A | -2.1268 | |
84 | M | A | 0.0000 | |
85 | D | A | -1.2131 | |
86 | P | A | -0.0422 | |
87 | V | A | 1.2956 | |
88 | D | A | 0.0000 | |
89 | T | A | 0.3601 | |
90 | A | A | 0.0000 | |
91 | T | A | -0.0364 | |
92 | Y | A | 0.0000 | |
93 | Y | A | 0.0000 | |
94 | C | A | 0.0000 | |
95 | V | A | 0.0000 | |
96 | H | A | 0.0000 | |
97 | Q | A | 0.0000 | |
98 | V | A | 0.1012 | |
102A | D | A | -1.3334 | |
102B | N | A | -1.0486 | |
102C | Y | A | 0.4078 | |
102D | L | A | 0.0000 | |
102E | F | A | 0.0000 | |
103 | D | A | -0.5282 | |
104 | H | A | -0.5223 | |
105 | W | A | 0.0000 | |
106 | G | A | -1.2343 | |
107 | Q | A | -1.8575 | |
108 | G | A | 0.0000 | |
109 | T | A | -0.3971 | |
110 | M | A | 0.2724 | |
111 | V | A | 0.0000 | |
112 | T | A | 0.0000 | |
113 | V | A | 0.0000 | |
114 | S | A | -0.3414 | |
115 | S | A | -0.6005 | |
120 | A | A | -0.3522 | |
121 | S | A | -0.4244 | |
122 | T | A | -0.5662 | |
123 | K | A | -0.9825 | |
124 | G | A | -1.2444 | |
125 | P | A | 0.0000 | |
126 | S | A | -0.1987 | |
127 | V | A | -0.1218 | |
128 | F | A | -0.4169 | |
129 | P | A | -0.7034 | |
130 | L | A | 0.0000 | |
131 | A | A | 0.0000 | |
132 | P | A | 0.0000 | |
133 | S | A | -0.6085 | |
134 | S | A | -0.6907 | |
135 | K | A | -0.5516 | |
136 | S | A | -0.7143 | |
137 | T | A | -0.7583 | |
138 | S | A | -0.7191 | |
139 | G | A | -0.8284 | |
140 | G | A | -0.8323 | |
141 | T | A | -0.5730 | |
142 | A | A | 0.0000 | |
143 | A | A | 0.0000 | |
144 | L | A | 0.0000 | |
145 | G | A | 0.0000 | |
146 | C | A | 0.0000 | |
147 | L | A | 0.0000 | |
148 | V | A | 0.0000 | |
149 | K | A | 0.0000 | |
150 | D | A | -0.3339 | |
151 | Y | A | 0.0000 | |
152 | F | A | 0.0000 | |
153 | P | A | -0.5269 | |
154 | E | A | -0.6618 | |
155 | P | A | -0.9794 | |
156 | V | A | 0.0000 | |
157 | T | A | -0.6964 | |
158 | V | A | -0.3790 | |
159 | S | A | -0.3356 | |
160 | W | A | 0.0000 | |
161 | N | A | -0.7419 | |
162 | S | A | -0.6795 | |
163 | G | A | -0.4240 | |
164 | A | A | -0.1886 | |
165 | L | A | -0.0228 | |
166 | T | A | -0.1820 | |
167 | S | A | -0.1867 | |
168 | G | A | -0.2597 | |
169 | V | A | 0.1703 | |
170 | H | A | 0.0239 | |
171 | T | A | 0.0306 | |
172 | F | A | 0.0000 | |
173 | P | A | -0.3881 | |
174 | A | A | 0.1997 | |
175 | V | A | 0.4556 | |
176 | L | A | 1.0995 | |
177 | Q | A | 0.1267 | |
178 | S | A | -0.2476 | |
179 | S | A | -0.2470 | |
180 | G | A | -0.1635 | |
181 | L | A | -0.0179 | |
182 | Y | A | 0.0000 | |
183 | S | A | 0.0000 | |
184 | L | A | 0.0000 | |
185 | S | A | 0.0000 | |
186 | S | A | 0.0000 | |
187 | V | A | 0.0000 | |
188 | V | A | 0.0000 | |
189 | T | A | -0.1728 | |
190 | V | A | 0.0000 | |
191 | P | A | -0.5704 | |
192 | S | A | 0.0000 | |
193 | S | A | -0.8081 | |
194 | S | A | -0.6583 | |
195 | L | A | -0.7455 | |
196 | G | A | -0.8898 | |
197 | T | A | -0.7870 | |
198 | Q | A | -1.1374 | |
199 | T | A | -0.9790 | |
200 | Y | A | 0.0000 | |
201 | I | A | -0.8706 | |
202 | C | A | 0.0000 | |
203 | N | A | 0.0000 | |
204 | V | A | 0.0000 | |
205 | N | A | -1.9765 | |
206 | H | A | 0.0000 | |
207 | K | A | -2.7945 | |
208 | P | A | -1.6409 | |
209 | S | A | -1.8495 | |
210 | N | A | -2.4982 | |
211 | T | A | -1.9973 | |
212 | K | A | -2.5547 | |
213 | V | A | -1.3302 | |
214 | D | A | -2.4106 | |
215 | K | A | -1.8911 | |
216 | R | A | -2.2212 | |
217 | V | A | 0.0000 | |
218 | E | A | -1.2483 | |
219 | P | A | -0.7479 | |
220 | K | A | -0.9025 | |
221 | S | A | -1.2325 | |
222 | C | A | -1.5754 | |
223 | D | A | -2.5365 | |
224 | K | A | -2.5718 | |
225 | T | A | -1.4243 |