Chain sequence(s) |
A: DTVMTQSPDSLAVSLGERATINCKTNQNVDYYGNSYLHWYQQKPGQPPKLLIFLHSNLASGIPDRFSGGGSGTDFTLTISSLQAEDVAVYYCQQSKNLPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVQLVESGGGLVQPGGSLRLSCAASGITFSNYGMAWVRQAPGKGLEWVASISTGGGNTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLDLTDPFMDAWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | No |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:01:32) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:01:32) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:01:32) [INFO] runJob: Creating pdb object from: input.pdb (00:01:32) [INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:01:33) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:35) [CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie creation failed. (00:01:35) [INFO] Main: Simulation completed successfully. (00:01:58) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | D | A | -1.3410 | |
2 | T | A | -0.7490 | |
3 | V | A | 0.4636 | |
4 | M | A | 0.0000 | |
5 | T | A | -0.8858 | |
6 | Q | A | 0.0000 | |
7 | S | A | -1.4204 | |
8 | P | A | -1.3714 | |
9 | D | A | -2.2368 | |
10 | S | A | -1.1403 | |
11 | L | A | -0.4614 | |
12 | A | A | -0.3290 | |
13 | V | A | -0.7490 | |
14 | S | A | -0.9439 | |
15 | L | A | -0.3305 | |
16 | G | A | -1.3954 | |
17 | E | A | -2.8049 | |
18 | R | A | -2.8006 | |
19 | A | A | 0.0000 | |
20 | T | A | -0.7154 | |
21 | I | A | 0.0000 | |
22 | N | A | -1.8064 | |
23 | C | A | 0.0000 | |
24 | K | A | -1.9607 | |
25 | T | A | 0.0000 | |
26 | N | A | -1.9303 | |
27 | Q | A | -2.3248 | |
28 | N | A | -2.3179 | |
30A | V | A | 0.0000 | |
30B | D | A | -0.5786 | |
30C | Y | A | 1.0715 | |
30D | Y | A | 1.3860 | |
30E | G | A | 0.1474 | |
30F | N | A | -0.1668 | |
31 | S | A | 0.0000 | |
32 | Y | A | 0.1112 | |
33 | L | A | 0.0000 | |
34 | H | A | 0.0000 | |
35 | W | A | 0.0000 | |
36 | Y | A | 0.0000 | |
37 | Q | A | 0.0000 | |
38 | Q | A | 0.0000 | |
39 | K | A | -1.0144 | |
40 | P | A | -0.9934 | |
41 | G | A | -1.3262 | |
42 | Q | A | -1.9023 | |
43 | P | A | -1.3275 | |
44 | P | A | 0.0000 | |
45 | K | A | -1.2180 | |
46 | L | A | 0.0000 | |
47 | L | A | 0.0000 | |
48 | I | A | 0.0000 | |
51A | F | A | 0.6259 | |
51 | L | A | 0.2686 | |
51B | H | A | -0.4797 | |
52 | S | A | -0.3126 | |
53 | N | A | -0.1932 | |
54 | L | A | 0.1019 | |
55 | A | A | -0.0403 | |
56 | S | A | -0.3388 | |
57 | G | A | -0.5644 | |
58 | I | A | -0.4700 | |
59 | P | A | -0.9928 | |
60 | D | A | -1.8694 | |
61 | R | A | -1.4691 | |
62 | F | A | 0.0000 | |
63 | S | A | -0.6014 | |
64 | G | A | -0.4061 | |
65 | G | A | -0.8458 | |
66 | G | A | -1.1628 | |
67 | S | A | -1.2574 | |
68 | G | A | -1.5766 | |
69 | T | A | -2.1871 | |
70 | D | A | -2.6298 | |
71 | F | A | 0.0000 | |
72 | T | A | -1.1056 | |
73 | L | A | 0.0000 | |
74 | T | A | -0.7027 | |
75 | I | A | 0.0000 | |
76 | S | A | -1.7738 | |
77 | S | A | -1.7388 | |
78 | L | A | 0.0000 | |
79 | Q | A | -1.2271 | |
80 | A | A | -0.4962 | |
81 | E | A | -1.1258 | |
82 | D | A | 0.0000 | |
83 | V | A | 0.0009 | |
84 | A | A | 0.0000 | |
85 | V | A | 0.1135 | |
86 | Y | A | 0.0000 | |
87 | Y | A | 0.0000 | |
88 | C | A | 0.0000 | |
89 | Q | A | 0.0000 | |
90 | Q | A | 0.0000 | |
91 | S | A | 0.0000 | |
92 | K | A | -0.4722 | |
93 | N | A | -0.6640 | |
94 | L | A | 0.0389 | |
95 | P | A | -0.5270 | |
96 | Y | A | 0.0000 | |
97 | T | A | -0.2609 | |
98 | F | A | 0.0000 | |
99 | G | A | 0.0000 | |
100 | Q | A | -1.5920 | |
101 | G | A | 0.0000 | |
102 | T | A | 0.0000 | |
103 | K | A | -0.5009 | |
104 | L | A | 0.0000 | |
105 | E | A | 0.0000 | |
106 | I | A | -0.2463 | |
107 | K | A | -0.9692 | |
108 | R | A | -0.8207 | |
113 | T | A | 0.1747 | |
114 | V | A | 1.1563 | |
115 | A | A | 0.3826 | |
116 | A | A | -0.0307 | |
117 | P | A | 0.0000 | |
118 | S | A | -0.1441 | |
119 | V | A | 0.0000 | |
120 | F | A | -0.0310 | |
121 | I | A | 0.0000 | |
122 | F | A | 0.0000 | |
123 | P | A | 0.0000 | |
124 | P | A | 0.0000 | |
125 | S | A | 0.0000 | |
126 | D | A | -2.5658 | |
127 | E | A | -2.0888 | |
128 | Q | A | 0.0000 | |
129 | L | A | -1.8057 | |
130 | K | A | -2.5402 | |
131 | S | A | -1.5646 | |
132 | G | A | -1.3409 | |
133 | T | A | -0.9597 | |
134 | A | A | 0.0000 | |
135 | S | A | 0.0000 | |
136 | V | A | 0.0000 | |
137 | V | A | 0.0000 | |
138 | C | A | 0.0000 | |
139 | L | A | 0.0000 | |
140 | L | A | 0.0000 | |
141 | N | A | 0.0000 | |
142 | N | A | -1.0026 | |
143 | F | A | 0.0000 | |
144 | Y | A | 0.0000 | |
145 | P | A | 0.0000 | |
146 | R | A | -1.9786 | |
147 | E | A | -2.6857 | |
148 | A | A | 0.0000 | |
149 | K | A | -2.4368 | |
150 | V | A | 0.0000 | |
151 | Q | A | -0.9077 | |
152 | W | A | 0.0000 | |
153 | K | A | -0.3417 | |
154 | V | A | 0.0000 | |
155 | D | A | -1.9062 | |
156 | N | A | -1.4790 | |
157 | A | A | -0.1390 | |
158 | L | A | 0.8052 | |
159 | Q | A | -0.0752 | |
160 | S | A | -0.5259 | |
161 | G | A | -0.9623 | |
162 | N | A | -0.8798 | |
163 | S | A | -1.0057 | |
164 | Q | A | -1.0982 | |
165 | E | A | -1.3517 | |
166 | S | A | 0.0000 | |
167 | V | A | -0.2445 | |
168 | T | A | -0.7125 | |
169 | E | A | -1.4378 | |
170 | Q | A | -1.6104 | |
171 | D | A | -2.3853 | |
172 | S | A | -1.8848 | |
173 | K | A | -2.5434 | |
174 | D | A | -2.2378 | |
175 | S | A | -2.1204 | |
176 | T | A | 0.0000 | |
177 | Y | A | 0.0000 | |
178 | S | A | 0.0000 | |
179 | L | A | 0.0000 | |
180 | S | A | 0.0000 | |
181 | S | A | 0.0000 | |
182 | T | A | -0.5106 | |
183 | L | A | 0.0000 | |
184 | T | A | -0.2735 | |
185 | L | A | -0.0909 | |
186 | S | A | -0.7779 | |
187 | K | A | -1.7950 | |
188 | A | A | -1.3477 | |
189 | D | A | -1.7070 | |
190 | Y | A | -1.7950 | |
191 | E | A | -2.8120 | |
192 | K | A | -3.0574 | |
193 | H | A | -2.7671 | |
194 | K | A | -3.3283 | |
195 | V | A | -1.9486 | |
196 | Y | A | 0.0000 | |
197 | A | A | 0.0000 | |
198 | C | A | 0.0000 | |
199 | E | A | -0.6162 | |
200 | V | A | 0.0000 | |
201 | T | A | -1.1778 | |
202 | H | A | 0.0000 | |
203 | Q | A | -1.6732 | |
204 | G | A | -0.5783 | |
205 | L | A | -0.4476 | |
206 | S | A | -0.5103 | |
207 | S | A | -0.4471 | |
208 | P | A | -0.5341 | |
209 | V | A | -0.0674 | |
210 | T | A | -0.4623 | |
211 | K | A | -0.7167 | |
212 | S | A | -0.6670 | |
213 | F | A | 0.0000 | |
214 | N | A | -2.1942 | |
215 | R | A | -2.9052 | |
216 | G | A | -2.4089 | |
217 | E | A | -2.4477 | |
218 | C | A | -1.3380 | |
1 | E | A | -1.7244 | |
2 | V | A | -0.4157 | |
3 | Q | A | -0.6962 | |
4 | L | A | 0.0000 | |
5 | V | A | 1.1700 | |
6 | E | A | 0.4128 | |
7 | S | A | -0.2470 | |
8 | G | A | -0.8240 | |
9 | G | A | -0.0815 | |
10 | G | A | 0.3602 | |
11 | L | A | 0.6792 | |
12 | V | A | -0.5153 | |
13 | Q | A | -1.5878 | |
14 | P | A | -1.7270 | |
15 | G | A | -1.6197 | |
16 | G | A | -1.2095 | |
17 | S | A | -1.3237 | |
18 | L | A | -1.0420 | |
19 | R | A | -2.0359 | |
20 | L | A | 0.0000 | |
21 | S | A | -0.4117 | |
22 | C | A | 0.0000 | |
23 | A | A | -0.0372 | |
24 | A | A | 0.0000 | |
25 | S | A | -0.5807 | |
26 | G | A | -0.8325 | |
27 | I | A | -0.2844 | |
28 | T | A | -0.3660 | |
29 | F | A | 0.0000 | |
30 | S | A | -1.2399 | |
30A | N | A | -1.3530 | |
31 | Y | A | -0.5201 | |
32 | G | A | 0.0000 | |
33 | M | A | 0.0000 | |
34 | A | A | 0.0000 | |
35 | W | A | 0.0000 | |
36 | V | A | 0.0000 | |
37 | R | A | 0.0000 | |
38 | Q | A | -0.5180 | |
39 | A | A | -0.8602 | |
40 | P | A | -0.9698 | |
41 | G | A | -1.4378 | |
42 | K | A | -2.2793 | |
43 | G | A | -1.3662 | |
44 | L | A | 0.0000 | |
45 | E | A | -0.7473 | |
46 | W | A | 0.0000 | |
47 | V | A | 0.0000 | |
48 | A | A | 0.0000 | |
49 | S | A | 0.0000 | |
50 | I | A | 0.0000 | |
51 | S | A | 0.0000 | |
51A | T | A | -0.9940 | |
51B | G | A | -1.2695 | |
53 | G | A | -1.1944 | |
54 | G | A | -1.3091 | |
55 | N | A | -1.5569 | |
56 | T | A | -0.6002 | |
57 | Y | A | 0.2297 | |
58 | Y | A | -0.0253 | |
59 | R | A | -1.1197 | |
60 | D | A | -2.2286 | |
61 | S | A | -1.5175 | |
62 | V | A | 0.0000 | |
63 | K | A | -2.4655 | |
64 | G | A | -1.6392 | |
65 | R | A | -1.3405 | |
66 | F | A | 0.0000 | |
67 | T | A | -0.3876 | |
68 | I | A | 0.0000 | |
69 | S | A | -0.4874 | |
70 | R | A | -0.9766 | |
71 | D | A | -1.4047 | |
72 | N | A | -1.7919 | |
73 | A | A | -1.3268 | |
74 | K | A | -2.2144 | |
75 | N | A | -1.5472 | |
76 | S | A | -1.1436 | |
77 | L | A | 0.0000 | |
78 | Y | A | -0.4261 | |
79 | L | A | 0.0000 | |
80 | Q | A | -1.1218 | |
81 | M | A | 0.0000 | |
82 | N | A | -1.4495 | |
83 | S | A | -1.4212 | |
84 | L | A | 0.0000 | |
85 | R | A | -2.7657 | |
86 | A | A | -1.7303 | |
87 | E | A | -1.9318 | |
88 | D | A | 0.0000 | |
89 | T | A | -0.3786 | |
90 | A | A | 0.0000 | |
91 | V | A | 0.7880 | |
92 | Y | A | 0.0000 | |
93 | Y | A | 0.0000 | |
94 | C | A | 0.0000 | |
95 | A | A | 0.0000 | |
96 | R | A | -0.2426 | |
102A | L | A | 0.0000 | |
102B | D | A | -1.2334 | |
102C | L | A | 0.0017 | |
102D | T | A | -0.2205 | |
102E | D | A | -0.2065 | |
102F | P | A | 0.0000 | |
102G | F | A | -0.1289 | |
102H | M | A | 0.0000 | |
103 | D | A | -0.6993 | |
104 | A | A | -0.4661 | |
105 | W | A | -0.2727 | |
106 | G | A | 0.0000 | |
107 | Q | A | -1.1591 | |
108 | G | A | -0.1484 | |
109 | T | A | 0.5301 | |
110 | L | A | 1.5448 | |
111 | V | A | 0.0000 | |
112 | T | A | 0.0000 | |
113 | V | A | 0.0000 | |
114 | S | A | -0.7929 | |
115 | S | A | -0.6282 | |
120 | A | A | -0.5147 | |
121 | S | A | -0.4273 | |
122 | T | A | -0.5110 | |
123 | K | A | -0.9737 | |
124 | G | A | -1.2752 | |
125 | P | A | -0.5421 | |
126 | S | A | -0.2165 | |
127 | V | A | -0.1194 | |
128 | F | A | -0.4064 | |
129 | P | A | -0.6813 | |
130 | L | A | 0.0000 | |
131 | A | A | 0.0000 | |
132 | P | A | 0.0000 | |
133 | S | A | -0.6008 | |
134 | S | A | -0.6927 | |
135 | K | A | -0.6057 | |
136 | S | A | -0.7285 | |
137 | T | A | -0.7666 | |
138 | S | A | -0.7241 | |
139 | G | A | -0.8246 | |
140 | G | A | -0.8319 | |
141 | T | A | -0.5755 | |
142 | A | A | 0.0000 | |
143 | A | A | 0.0000 | |
144 | L | A | 0.0000 | |
145 | G | A | 0.0000 | |
146 | C | A | 0.0000 | |
147 | L | A | 0.0000 | |
148 | V | A | 0.0000 | |
149 | K | A | 0.0000 | |
150 | D | A | -0.3722 | |
151 | Y | A | 0.0000 | |
152 | F | A | 0.0000 | |
153 | P | A | -0.5437 | |
154 | E | A | -0.8527 | |
155 | P | A | -1.0313 | |
156 | V | A | 0.0000 | |
157 | T | A | -0.7434 | |
158 | V | A | -0.4370 | |
159 | S | A | -0.3786 | |
160 | W | A | 0.0000 | |
161 | N | A | -0.7322 | |
162 | S | A | -0.6637 | |
163 | G | A | -0.4547 | |
164 | A | A | -0.1900 | |
165 | L | A | -0.0206 | |
166 | T | A | -0.1823 | |
167 | S | A | -0.1792 | |
168 | G | A | -0.2568 | |
169 | V | A | 0.1803 | |
170 | H | A | 0.0252 | |
171 | T | A | 0.0253 | |
172 | F | A | 0.0000 | |
173 | P | A | -0.3035 | |
174 | A | A | 0.0084 | |
175 | V | A | 0.0000 | |
176 | L | A | 0.8463 | |
177 | Q | A | 0.0260 | |
178 | S | A | -0.3271 | |
179 | S | A | -0.2559 | |
180 | G | A | -0.0822 | |
181 | L | A | -0.0292 | |
182 | Y | A | 0.0000 | |
183 | S | A | 0.0000 | |
184 | L | A | 0.0000 | |
185 | S | A | 0.0000 | |
186 | S | A | 0.0000 | |
187 | V | A | 0.0000 | |
188 | V | A | 0.0000 | |
189 | T | A | -0.1736 | |
190 | V | A | 0.0000 | |
191 | P | A | -0.5698 | |
192 | S | A | 0.0000 | |
193 | S | A | -0.8037 | |
194 | S | A | -0.6222 | |
195 | L | A | -0.7307 | |
196 | G | A | -0.8787 | |
197 | T | A | -0.7464 | |
198 | Q | A | -1.0509 | |
199 | T | A | -0.9356 | |
200 | Y | A | 0.0000 | |
201 | I | A | -0.8043 | |
202 | C | A | 0.0000 | |
203 | N | A | -1.4582 | |
204 | V | A | 0.0000 | |
205 | N | A | -2.0152 | |
206 | H | A | 0.0000 | |
207 | K | A | -2.8195 | |
208 | P | A | -1.6713 | |
209 | S | A | -1.8436 | |
210 | N | A | -2.4913 | |
211 | T | A | -2.0170 | |
212 | K | A | -2.5690 | |
213 | V | A | -1.3839 | |
214 | D | A | -2.4558 | |
215 | K | A | -1.7262 | |
216 | R | A | -2.2144 | |
217 | V | A | 0.0000 | |
218 | E | A | -1.2570 | |
219 | P | A | -0.7456 | |
220 | K | A | -0.7385 | |
221 | S | A | -1.2327 | |
222 | C | A | -1.5593 | |
223 | D | A | -2.5359 | |
224 | K | A | -2.5927 | |
225 | T | A | -1.4483 |