| Chain sequence(s) |
A: DIRMTQSPSSLSASVGDRAIITCQASQDISSRLNWYQQKPGKAPSLLIYDAFNLQAGVPSRFAGSGSGIRFTFTIDSLRPEDIATYYCQQSDNFPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQESGPGLVNPSEPLSLTCTVSGGSISSGTFYWGWIRQPPGKGLEWIGSIYHSGSTYYNPSLRGRVTISVDPSKNQFSLKLSSVTAADTAVYYCARRYSGYDHFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -2.4567 | |
| 2 | I | A | 0.0000 | |
| 3 | R | A | -2.5831 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -0.9936 | |
| 6 | Q | A | -0.6184 | |
| 7 | S | A | -0.2871 | |
| 8 | P | A | -0.1137 | |
| 9 | S | A | -0.6032 | |
| 10 | S | A | -0.4340 | |
| 11 | L | A | 0.2710 | |
| 12 | S | A | -0.6475 | |
| 13 | A | A | 0.0000 | |
| 14 | S | A | -0.5951 | |
| 15 | V | A | 0.4654 | |
| 16 | G | A | -0.6904 | |
| 17 | D | A | -1.6336 | |
| 18 | R | A | -2.0079 | |
| 19 | A | A | 0.0000 | |
| 20 | I | A | 1.3324 | |
| 21 | I | A | 0.0000 | |
| 22 | T | A | -0.0690 | |
| 23 | C | A | 0.0000 | |
| 24 | Q | A | -1.1897 | |
| 25 | A | A | 0.0000 | |
| 26 | S | A | -1.5582 | |
| 27 | Q | A | -1.7721 | |
| 28 | D | A | -2.2730 | |
| 29 | I | A | 0.0000 | |
| 30A | S | A | -1.2386 | |
| 31 | S | A | -0.9237 | |
| 32 | R | A | -1.3055 | |
| 33 | L | A | 0.0000 | |
| 34 | N | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | 0.0000 | |
| 38 | Q | A | -0.8861 | |
| 39 | K | A | -1.4474 | |
| 40 | P | A | -1.3148 | |
| 41 | G | A | -1.5091 | |
| 42 | K | A | -2.0537 | |
| 43 | A | A | -1.1185 | |
| 44 | P | A | 0.0000 | |
| 45 | S | A | -0.3996 | |
| 46 | L | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | 0.3920 | |
| 50 | D | A | -0.2454 | |
| 51 | A | A | 0.0000 | |
| 51A | F | A | 1.6160 | |
| 53 | N | A | 0.7496 | |
| 54 | L | A | 0.9650 | |
| 55 | Q | A | 0.3181 | |
| 56 | A | A | -0.0701 | |
| 57 | G | A | -0.2837 | |
| 58 | V | A | 0.0202 | |
| 59 | P | A | -0.1881 | |
| 60 | S | A | -0.3931 | |
| 61 | R | A | -0.8861 | |
| 62 | F | A | 0.0000 | |
| 63 | A | A | 0.4769 | |
| 64 | G | A | 0.8403 | |
| 65 | S | A | 0.0074 | |
| 66 | G | A | -0.4946 | |
| 67 | S | A | -1.0039 | |
| 68 | G | A | -1.1570 | |
| 69 | I | A | -0.8232 | |
| 70 | R | A | -1.3825 | |
| 71 | F | A | 0.0000 | |
| 72 | T | A | 0.1043 | |
| 73 | F | A | 0.0000 | |
| 74 | T | A | 0.1004 | |
| 75 | I | A | 0.0000 | |
| 76 | D | A | -1.6031 | |
| 77 | S | A | -1.3173 | |
| 78 | L | A | 0.0000 | |
| 79 | R | A | -0.9496 | |
| 80 | P | A | -0.9166 | |
| 81 | E | A | -1.8866 | |
| 82 | D | A | 0.0000 | |
| 83 | I | A | -0.4473 | |
| 84 | A | A | 0.0000 | |
| 85 | T | A | -0.5522 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 91 | S | A | 0.0000 | |
| 92 | D | A | -1.3921 | |
| 93 | N | A | -1.7713 | |
| 94 | F | A | -0.4187 | |
| 95 | P | A | -1.2449 | |
| 96 | W | A | 0.0000 | |
| 97 | T | A | -1.1673 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | Q | A | -1.6306 | |
| 101 | G | A | -1.0384 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -0.3487 | |
| 104 | V | A | 0.0000 | |
| 105 | E | A | 0.0000 | |
| 106 | I | A | -0.7992 | |
| 107 | K | A | -1.3022 | |
| 108 | R | A | -1.2501 | |
| 109 | T | A | -0.0179 | |
| 110 | V | A | 1.0604 | |
| 111 | A | A | 0.3945 | |
| 112 | A | A | 0.0566 | |
| 113 | P | A | 0.0000 | |
| 114 | S | A | -0.1496 | |
| 115 | V | A | 0.0000 | |
| 116 | F | A | -0.0276 | |
| 117 | I | A | 0.0000 | |
| 118 | F | A | 0.0000 | |
| 119 | P | A | 0.0000 | |
| 120 | P | A | 0.0000 | |
| 121 | S | A | 0.0000 | |
| 122 | D | A | -2.5651 | |
| 123 | E | A | -2.0897 | |
| 124 | Q | A | 0.0000 | |
| 125 | L | A | -1.8140 | |
| 126 | K | A | -2.5422 | |
| 127 | S | A | -1.5626 | |
| 128 | G | A | -1.3495 | |
| 129 | T | A | -0.9703 | |
| 130 | A | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | V | A | 0.0000 | |
| 133 | V | A | 0.0000 | |
| 134 | C | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | N | A | 0.0000 | |
| 138 | N | A | -1.0122 | |
| 139 | F | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | P | A | -1.1464 | |
| 142 | R | A | -1.9561 | |
| 143 | E | A | -2.7476 | |
| 144 | A | A | -1.9936 | |
| 145 | K | A | -2.3818 | |
| 146 | V | A | 0.0000 | |
| 147 | Q | A | -0.8499 | |
| 148 | W | A | 0.0000 | |
| 149 | K | A | 0.0000 | |
| 150 | V | A | 0.0000 | |
| 151 | D | A | -1.8691 | |
| 152 | N | A | -1.4191 | |
| 153 | A | A | -0.0876 | |
| 154 | L | A | 0.8627 | |
| 155 | Q | A | 0.0081 | |
| 156 | S | A | -0.5207 | |
| 157 | G | A | -0.9734 | |
| 158 | N | A | -0.8726 | |
| 159 | S | A | -1.0161 | |
| 160 | Q | A | -1.0747 | |
| 161 | E | A | -1.3402 | |
| 162 | S | A | 0.0000 | |
| 163 | V | A | -0.5335 | |
| 164 | T | A | -1.0689 | |
| 165 | E | A | -2.2248 | |
| 166 | Q | A | -1.8955 | |
| 167 | D | A | -2.3455 | |
| 168 | S | A | -1.8869 | |
| 169 | K | A | -2.4067 | |
| 170 | D | A | -2.2286 | |
| 171 | S | A | 0.0000 | |
| 172 | T | A | 0.0000 | |
| 173 | Y | A | 0.0000 | |
| 174 | S | A | 0.0000 | |
| 175 | L | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | T | A | -0.4991 | |
| 179 | L | A | 0.0000 | |
| 180 | T | A | -0.2730 | |
| 181 | L | A | -0.1012 | |
| 182 | S | A | -0.7779 | |
| 183 | K | A | -1.7975 | |
| 184 | A | A | -1.3348 | |
| 185 | D | A | -1.6871 | |
| 186 | Y | A | -1.7034 | |
| 187 | E | A | -2.7533 | |
| 188 | K | A | -3.0404 | |
| 189 | H | A | -2.7503 | |
| 190 | K | A | -3.3293 | |
| 191 | V | A | -1.9454 | |
| 192 | Y | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | C | A | 0.0000 | |
| 195 | E | A | -0.5920 | |
| 196 | V | A | 0.0000 | |
| 197 | T | A | -1.1691 | |
| 198 | H | A | 0.0000 | |
| 199 | Q | A | -1.6935 | |
| 200 | G | A | -0.4523 | |
| 201 | L | A | -0.3797 | |
| 202 | S | A | -0.4647 | |
| 203 | S | A | -0.4334 | |
| 204 | P | A | -0.4795 | |
| 205 | V | A | -0.0654 | |
| 206 | T | A | -0.4455 | |
| 207 | K | A | -0.7229 | |
| 208 | S | A | -0.6567 | |
| 209 | F | A | 0.0000 | |
| 210 | N | A | -2.2307 | |
| 211 | R | A | -2.9321 | |
| 212 | G | A | -2.4617 | |
| 213 | E | A | -2.4906 | |
| 214 | C | A | -1.5355 | |
| 1 | Q | A | -1.6255 | |
| 2 | V | A | -1.2451 | |
| 3 | Q | A | -1.8176 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.4139 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.6977 | |
| 8 | G | A | -0.5015 | |
| 9 | P | A | -0.3487 | |
| 10 | G | A | -0.0763 | |
| 11 | L | A | 0.0741 | |
| 12 | V | A | 0.0000 | |
| 13 | N | A | -1.4190 | |
| 14 | P | A | -1.1311 | |
| 15 | S | A | -1.1498 | |
| 16 | E | A | -1.6529 | |
| 17 | P | A | -1.2623 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.7238 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.4716 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.2046 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.4473 | |
| 26 | G | A | -1.3057 | |
| 27 | G | A | -0.9256 | |
| 28 | S | A | -0.8030 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.5096 | |
| 30A | S | A | -0.3860 | |
| 30B | G | A | -0.2739 | |
| 30C | T | A | 0.2576 | |
| 30D | F | A | 0.6825 | |
| 31 | Y | A | 0.5066 | |
| 33 | W | A | 0.0000 | |
| 34 | G | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | I | A | 0.0000 | |
| 37 | R | A | 0.0000 | |
| 38 | Q | A | -0.6380 | |
| 39 | P | A | -0.7329 | |
| 40 | P | A | -0.8700 | |
| 41 | G | A | -1.4551 | |
| 42 | K | A | -2.3094 | |
| 43 | G | A | -1.5095 | |
| 44 | L | A | 0.0000 | |
| 45 | E | A | -0.8105 | |
| 46 | W | A | 0.0000 | |
| 47 | I | A | 0.0000 | |
| 48 | G | A | 0.0000 | |
| 49 | S | A | 0.0000 | |
| 50 | I | A | 0.0000 | |
| 51A | Y | A | 0.2137 | |
| 52 | H | A | -0.2972 | |
| 53 | S | A | -0.3838 | |
| 54 | G | A | -0.2200 | |
| 55 | S | A | -0.0272 | |
| 56 | T | A | 0.3201 | |
| 57 | Y | A | 0.6159 | |
| 58 | Y | A | -0.2985 | |
| 59 | N | A | -0.8385 | |
| 60 | P | A | -1.1547 | |
| 61 | S | A | -1.1922 | |
| 62 | L | A | 0.0000 | |
| 63 | R | A | -2.0636 | |
| 64 | G | A | -1.5853 | |
| 65 | R | A | -1.4053 | |
| 66 | V | A | 0.0000 | |
| 67 | T | A | -0.6927 | |
| 68 | I | A | 0.0000 | |
| 69 | S | A | -0.1657 | |
| 70 | V | A | -0.3585 | |
| 71 | D | A | -1.2663 | |
| 72 | P | A | -1.3963 | |
| 73 | S | A | -1.4519 | |
| 74 | K | A | -2.2876 | |
| 75 | N | A | -1.7172 | |
| 76 | Q | A | -1.4015 | |
| 77 | F | A | 0.0000 | |
| 78 | S | A | -0.3491 | |
| 79 | L | A | 0.0000 | |
| 80 | K | A | -1.0056 | |
| 81 | L | A | 0.0000 | |
| 82 | S | A | -1.0285 | |
| 83 | S | A | -1.0974 | |
| 84 | V | A | 0.0000 | |
| 85 | T | A | -0.4791 | |
| 86 | A | A | -0.1621 | |
| 87 | A | A | 0.0378 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | 0.1585 | |
| 90 | A | A | 0.0000 | |
| 91 | V | A | 0.4014 | |
| 92 | Y | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | A | A | 0.0000 | |
| 96 | R | A | 0.1406 | |
| 97 | R | A | 0.0000 | |
| 102A | Y | A | 0.8274 | |
| 102B | S | A | 0.5148 | |
| 102C | G | A | 0.6609 | |
| 102D | Y | A | 1.0498 | |
| 102E | D | A | -0.1516 | |
| 102F | H | A | 0.0000 | |
| 102G | F | A | 0.0000 | |
| 102H | F | A | 0.0000 | |
| 103 | D | A | 0.2316 | |
| 104 | Y | A | 0.1258 | |
| 105 | W | A | -0.4772 | |
| 106 | G | A | 0.0000 | |
| 107 | Q | A | -1.6088 | |
| 108 | G | A | -0.7425 | |
| 109 | T | A | -0.1475 | |
| 110 | L | A | 0.5567 | |
| 111 | V | A | 0.0000 | |
| 112 | T | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.4419 | |
| 115 | S | A | -0.5605 | |
| 122 | A | A | -0.4725 | |
| 123 | S | A | -0.5274 | |
| 124 | T | A | -0.5595 | |
| 125 | K | A | -0.9634 | |
| 126 | G | A | -1.2314 | |
| 127 | P | A | 0.0000 | |
| 128 | S | A | -0.1664 | |
| 129 | V | A | -0.1233 | |
| 130 | F | A | -0.4046 | |
| 131 | P | A | -0.6811 | |
| 132 | L | A | 0.0000 | |
| 133 | A | A | 0.0000 | |
| 134 | P | A | 0.0000 | |
| 135 | S | A | -0.5926 | |
| 136 | S | A | -0.6898 | |
| 137 | K | A | -0.5574 | |
| 138 | S | A | -0.7153 | |
| 139 | T | A | -0.7582 | |
| 140 | S | A | -0.7220 | |
| 141 | G | A | -0.8337 | |
| 142 | G | A | -0.8345 | |
| 143 | T | A | -0.5925 | |
| 144 | A | A | 0.0000 | |
| 145 | A | A | 0.0000 | |
| 146 | L | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | V | A | 0.0000 | |
| 151 | K | A | 0.0000 | |
| 152 | D | A | -0.3404 | |
| 153 | Y | A | 0.0000 | |
| 154 | F | A | 0.0000 | |
| 155 | P | A | -0.5517 | |
| 156 | E | A | -0.5956 | |
| 157 | P | A | -0.9487 | |
| 158 | V | A | 0.0000 | |
| 159 | T | A | -0.7070 | |
| 160 | V | A | -0.4191 | |
| 161 | S | A | -0.3835 | |
| 162 | W | A | 0.0000 | |
| 163 | N | A | -0.7528 | |
| 164 | S | A | -0.7077 | |
| 165 | G | A | -0.4514 | |
| 166 | A | A | -0.1896 | |
| 167 | L | A | -0.0136 | |
| 168 | T | A | -0.1768 | |
| 169 | S | A | -0.1819 | |
| 170 | G | A | -0.2758 | |
| 171 | V | A | 0.1779 | |
| 172 | H | A | -0.0916 | |
| 173 | T | A | 0.0241 | |
| 174 | F | A | 0.0000 | |
| 175 | P | A | -0.3611 | |
| 176 | A | A | 0.1743 | |
| 177 | V | A | 0.4085 | |
| 178 | L | A | 0.9527 | |
| 179 | Q | A | 0.0606 | |
| 180 | S | A | -0.2747 | |
| 181 | S | A | -0.2584 | |
| 182 | G | A | -0.1613 | |
| 183 | L | A | -0.0356 | |
| 184 | Y | A | 0.0000 | |
| 185 | S | A | 0.0000 | |
| 186 | L | A | 0.0000 | |
| 187 | S | A | 0.0000 | |
| 188 | S | A | 0.0000 | |
| 189 | V | A | 0.0000 | |
| 190 | V | A | 0.0000 | |
| 191 | T | A | -0.1852 | |
| 192 | V | A | 0.0000 | |
| 193 | P | A | -0.5688 | |
| 194 | S | A | 0.0000 | |
| 195 | S | A | -0.8055 | |
| 196 | S | A | -0.6578 | |
| 197 | L | A | -0.7307 | |
| 198 | G | A | -0.8806 | |
| 199 | T | A | -0.7782 | |
| 200 | Q | A | -1.1239 | |
| 201 | T | A | -0.9608 | |
| 202 | Y | A | 0.0000 | |
| 203 | I | A | -0.8345 | |
| 204 | C | A | 0.0000 | |
| 205 | N | A | -1.4407 | |
| 206 | V | A | 0.0000 | |
| 207 | N | A | -2.0061 | |
| 208 | H | A | 0.0000 | |
| 209 | K | A | -2.8056 | |
| 210 | P | A | -1.6757 | |
| 211 | S | A | -1.8145 | |
| 212 | N | A | -2.5068 | |
| 213 | T | A | -2.0014 | |
| 214 | K | A | -2.5381 | |
| 215 | V | A | -1.3460 | |
| 216 | D | A | -2.4403 | |
| 217 | K | A | -1.8094 | |
| 218 | R | A | -2.2199 | |
| 219 | V | A | 0.0000 | |
| 220 | E | A | -1.2545 | |
| 221 | P | A | -0.7187 | |
| 222 | K | A | -0.6855 | |
| 223 | S | A | -1.2165 | |
| 224 | C | A | -1.5750 | |
| 225 | D | A | -2.5353 | |
| 226 | K | A | -2.5760 | |
| 227 | T | A | -1.4475 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine