| Chain sequence(s) |
A: NIVMTQTPLSLSVTPGQPASISCKSSQSLLHSDGKTYLYWYLQKPGQSPQLLIYEVSSRFSGVPDRFSGSGSGTDFALKISRVEAEDVGIYYCMQPSPFQTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNTMAWNWIRQSPSRGLEWLGRTYRGSIYYNDYVVSVRSRITINSDTFKNQLSLQLNSVTPEDTAVYYCARGNLNGFDIWGQGTKVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[CRITICAL] pyMol: Pymol encountered an error: /bin/sh: pymol: command not found Movie
creation failed. (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:08)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | N | A | -0.3965 | |
| 2 | I | A | 0.0000 | |
| 3 | V | A | 0.9487 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -0.2764 | |
| 6 | Q | A | 0.0000 | |
| 7 | T | A | 0.0032 | |
| 8 | P | A | 0.4335 | |
| 9 | L | A | 1.2954 | |
| 10 | S | A | 0.5707 | |
| 11 | L | A | 0.4358 | |
| 12 | S | A | -0.3651 | |
| 13 | V | A | -0.7927 | |
| 14 | T | A | -1.2055 | |
| 15 | P | A | -1.3459 | |
| 16 | G | A | -1.6135 | |
| 17 | Q | A | -2.0225 | |
| 18 | P | A | -1.7199 | |
| 19 | A | A | -0.8809 | |
| 20 | S | A | -0.5921 | |
| 21 | I | A | 0.0000 | |
| 22 | S | A | -0.7645 | |
| 23 | C | A | 0.0000 | |
| 24 | K | A | -1.7919 | |
| 25 | S | A | 0.0000 | |
| 26 | S | A | -0.8441 | |
| 27 | Q | A | -1.1671 | |
| 28 | S | A | -0.5693 | |
| 29 | L | A | 0.0000 | |
| 30 | L | A | 0.4628 | |
| 30A | H | A | -0.8063 | |
| 30B | S | A | -1.3430 | |
| 30C | D | A | -2.3315 | |
| 30D | G | A | -1.7811 | |
| 30E | K | A | -1.3434 | |
| 31 | T | A | -0.3427 | |
| 32 | Y | A | 0.1032 | |
| 33 | L | A | 0.0000 | |
| 34 | Y | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | L | A | 0.0000 | |
| 38 | Q | A | -0.5132 | |
| 39 | K | A | -0.9955 | |
| 40 | P | A | -1.0699 | |
| 41 | G | A | -1.3998 | |
| 42 | Q | A | -1.9507 | |
| 43 | S | A | -1.1617 | |
| 44 | P | A | 0.0000 | |
| 45 | Q | A | -0.4790 | |
| 46 | L | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | 0.2143 | |
| 51A | E | A | -0.4870 | |
| 51B | V | A | 0.0000 | |
| 52 | S | A | -0.3986 | |
| 53 | S | A | -0.0075 | |
| 54 | R | A | 0.2168 | |
| 55 | F | A | 1.0391 | |
| 56 | S | A | 0.5522 | |
| 57 | G | A | 0.4391 | |
| 58 | V | A | 1.2695 | |
| 59 | P | A | 0.0164 | |
| 60 | D | A | -0.6483 | |
| 61 | R | A | -1.1473 | |
| 62 | F | A | -0.7389 | |
| 63 | S | A | -0.6476 | |
| 64 | G | A | 0.0000 | |
| 65 | S | A | -0.8799 | |
| 66 | G | A | -1.3009 | |
| 67 | S | A | -0.8015 | |
| 68 | G | A | -0.6565 | |
| 69 | T | A | -1.4928 | |
| 70 | D | A | -2.6229 | |
| 71 | F | A | 0.0000 | |
| 72 | A | A | -1.0277 | |
| 73 | L | A | 0.0000 | |
| 74 | K | A | -1.2995 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.5455 | |
| 77 | R | A | -2.3905 | |
| 78 | V | A | 0.0000 | |
| 79 | E | A | -1.8086 | |
| 80 | A | A | -1.0964 | |
| 81 | E | A | -1.9089 | |
| 82 | D | A | 0.0000 | |
| 83 | V | A | -0.1153 | |
| 84 | G | A | 0.0000 | |
| 85 | I | A | 0.7097 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | M | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 93A | P | A | 0.2545 | |
| 93B | S | A | 0.1212 | |
| 94 | P | A | 0.0889 | |
| 95 | F | A | 0.8729 | |
| 96 | Q | A | -0.0127 | |
| 97 | T | A | -0.1094 | |
| 98 | F | A | 0.0000 | |
| 99 | G | A | 0.0000 | |
| 100 | Q | A | -0.8443 | |
| 101 | G | A | 0.0000 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | 0.5688 | |
| 104 | L | A | 0.0000 | |
| 105 | E | A | 0.0000 | |
| 106 | I | A | -0.9291 | |
| 107 | K | A | -1.2479 | |
| 108 | R | A | -1.2757 | |
| 113 | T | A | 0.0369 | |
| 114 | V | A | 1.1717 | |
| 115 | A | A | 0.3344 | |
| 116 | A | A | -0.0010 | |
| 117 | P | A | 0.0000 | |
| 118 | S | A | -0.1621 | |
| 119 | V | A | 0.0000 | |
| 120 | F | A | 0.0197 | |
| 121 | I | A | 0.0000 | |
| 122 | F | A | 0.0000 | |
| 123 | P | A | 0.0000 | |
| 124 | P | A | 0.0000 | |
| 125 | S | A | 0.0000 | |
| 126 | D | A | -2.5600 | |
| 127 | E | A | -2.0765 | |
| 128 | Q | A | 0.0000 | |
| 129 | L | A | -1.9332 | |
| 130 | K | A | -2.5409 | |
| 131 | S | A | -1.5691 | |
| 132 | G | A | -1.3527 | |
| 133 | T | A | -0.9761 | |
| 134 | A | A | 0.0000 | |
| 135 | S | A | 0.0000 | |
| 136 | V | A | 0.0000 | |
| 137 | V | A | 0.0000 | |
| 138 | C | A | 0.0000 | |
| 139 | L | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | N | A | 0.0000 | |
| 142 | N | A | -1.0864 | |
| 143 | F | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | P | A | -0.9944 | |
| 146 | R | A | -1.9159 | |
| 147 | E | A | -2.5302 | |
| 148 | A | A | -1.9093 | |
| 149 | K | A | -2.4453 | |
| 150 | V | A | 0.0000 | |
| 151 | Q | A | -0.8677 | |
| 152 | W | A | 0.0000 | |
| 153 | K | A | 0.0000 | |
| 154 | V | A | 0.0000 | |
| 155 | D | A | -1.8539 | |
| 156 | N | A | -1.4128 | |
| 157 | A | A | -0.0799 | |
| 158 | L | A | 0.8680 | |
| 159 | Q | A | 0.0112 | |
| 160 | S | A | -0.5192 | |
| 161 | G | A | -0.9779 | |
| 162 | N | A | -0.8836 | |
| 163 | S | A | -1.0186 | |
| 164 | Q | A | -1.1125 | |
| 165 | E | A | -1.4141 | |
| 166 | S | A | 0.0000 | |
| 167 | V | A | -0.3813 | |
| 168 | T | A | -1.0469 | |
| 169 | E | A | -2.2102 | |
| 170 | Q | A | -2.0161 | |
| 171 | D | A | -2.4507 | |
| 172 | S | A | -1.9770 | |
| 173 | K | A | -2.6895 | |
| 174 | D | A | -2.6328 | |
| 175 | S | A | 0.0000 | |
| 176 | T | A | 0.0000 | |
| 177 | Y | A | 0.0000 | |
| 178 | S | A | 0.0000 | |
| 179 | L | A | 0.0000 | |
| 180 | S | A | 0.0000 | |
| 181 | S | A | 0.0000 | |
| 182 | T | A | -0.5362 | |
| 183 | L | A | 0.0000 | |
| 184 | T | A | -0.2823 | |
| 185 | L | A | -0.1041 | |
| 186 | S | A | -0.7845 | |
| 187 | K | A | -1.8137 | |
| 188 | A | A | -1.3427 | |
| 189 | D | A | -1.6994 | |
| 190 | Y | A | -1.7287 | |
| 191 | E | A | -2.7581 | |
| 192 | K | A | -3.0608 | |
| 193 | H | A | -2.7642 | |
| 194 | K | A | -3.3571 | |
| 195 | V | A | -1.9612 | |
| 196 | Y | A | 0.0000 | |
| 197 | A | A | 0.0000 | |
| 198 | C | A | 0.0000 | |
| 199 | E | A | -0.6023 | |
| 200 | V | A | 0.0000 | |
| 201 | T | A | -1.1673 | |
| 202 | H | A | 0.0000 | |
| 203 | Q | A | -1.6867 | |
| 204 | G | A | -0.4969 | |
| 205 | L | A | -0.3874 | |
| 206 | S | A | -0.4676 | |
| 207 | S | A | -0.4325 | |
| 208 | P | A | -0.4863 | |
| 209 | V | A | -0.0448 | |
| 210 | T | A | -0.4399 | |
| 211 | K | A | -0.7035 | |
| 212 | S | A | -0.6496 | |
| 213 | F | A | 0.0000 | |
| 214 | N | A | -2.3350 | |
| 215 | R | A | -3.0504 | |
| 216 | G | A | -2.5390 | |
| 217 | E | A | -2.9629 | |
| 218 | C | A | -1.6615 | |
| 1 | Q | A | -1.4780 | |
| 2 | V | A | -0.9872 | |
| 3 | Q | A | -1.7795 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.9016 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.8551 | |
| 8 | G | A | -1.0398 | |
| 9 | P | A | -0.5656 | |
| 10 | G | A | -0.2531 | |
| 11 | L | A | 0.4373 | |
| 12 | V | A | -0.2526 | |
| 13 | K | A | -1.2113 | |
| 14 | P | A | -1.2073 | |
| 15 | S | A | -1.2959 | |
| 16 | Q | A | -1.8338 | |
| 17 | T | A | -1.2650 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.5486 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.5867 | |
| 22 | C | A | 0.0000 | |
| 23 | A | A | -1.2327 | |
| 24 | I | A | 0.0000 | |
| 25 | S | A | -1.2446 | |
| 26 | G | A | -1.1693 | |
| 27 | D | A | -0.9013 | |
| 28 | S | A | -0.7671 | |
| 29 | V | A | 0.0000 | |
| 30 | S | A | -0.1315 | |
| 30A | S | A | -0.8179 | |
| 30B | N | A | -1.1655 | |
| 30C | T | A | -0.4102 | |
| 31 | M | A | -0.2767 | |
| 32 | A | A | -0.2487 | |
| 33 | W | A | 0.0000 | |
| 34 | N | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | I | A | 0.0000 | |
| 37 | R | A | 0.0000 | |
| 38 | Q | A | -0.9803 | |
| 39 | S | A | -1.2745 | |
| 40 | P | A | -1.1411 | |
| 41 | S | A | -1.2767 | |
| 42 | R | A | -2.3828 | |
| 43 | G | A | -1.4908 | |
| 44 | L | A | 0.0000 | |
| 45 | E | A | -0.6571 | |
| 46 | W | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | G | A | 0.0000 | |
| 49 | R | A | -0.6348 | |
| 50 | T | A | 0.0000 | |
| 51 | Y | A | 0.0503 | |
| 51A | R | A | -0.1089 | |
| 51B | G | A | 0.0882 | |
| 51C | S | A | 0.5612 | |
| 51D | I | A | 2.0516 | |
| 51E | Y | A | 1.3205 | |
| 51F | Y | A | 0.7695 | |
| 52 | N | A | -0.7485 | |
| 57 | D | A | -0.5509 | |
| 58 | Y | A | -0.1212 | |
| 59 | V | A | 0.0000 | |
| 60 | V | A | 1.1033 | |
| 61 | S | A | 0.4630 | |
| 62 | V | A | 0.0000 | |
| 63 | R | A | -0.7125 | |
| 64 | S | A | -0.5693 | |
| 65 | R | A | -0.7313 | |
| 66 | I | A | -0.6963 | |
| 67 | T | A | -0.7729 | |
| 68 | I | A | 0.0000 | |
| 69 | N | A | -0.9665 | |
| 70 | S | A | -0.6165 | |
| 71 | D | A | -0.7164 | |
| 72 | T | A | -0.1304 | |
| 73 | F | A | 0.8193 | |
| 74 | K | A | -1.1801 | |
| 75 | N | A | -0.9212 | |
| 76 | Q | A | -1.1899 | |
| 77 | L | A | 0.0000 | |
| 78 | S | A | 0.0000 | |
| 79 | L | A | 0.0000 | |
| 80 | Q | A | -0.6161 | |
| 81 | L | A | 0.0000 | |
| 82 | N | A | -1.3180 | |
| 83 | S | A | -1.1755 | |
| 84 | V | A | 0.0000 | |
| 85 | T | A | -1.2313 | |
| 86 | P | A | -1.3399 | |
| 87 | E | A | -2.0127 | |
| 88 | D | A | 0.0000 | |
| 89 | T | A | -0.5865 | |
| 90 | A | A | 0.0000 | |
| 91 | V | A | 0.2600 | |
| 92 | Y | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | A | A | 0.0000 | |
| 96 | R | A | -0.2122 | |
| 97 | G | A | -0.0051 | |
| 98 | N | A | 0.1401 | |
| 102A | L | A | 1.1323 | |
| 102B | N | A | 0.1619 | |
| 102C | G | A | 0.0000 | |
| 102D | F | A | 0.0000 | |
| 103 | D | A | 0.0840 | |
| 104 | I | A | -0.1587 | |
| 105 | W | A | 0.0000 | |
| 106 | G | A | 0.0000 | |
| 107 | Q | A | -1.9495 | |
| 108 | G | A | -1.1232 | |
| 109 | T | A | 0.0000 | |
| 110 | K | A | -0.3056 | |
| 111 | V | A | 0.0000 | |
| 112 | T | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.3557 | |
| 115 | S | A | -0.5333 | |
| 121 | A | A | -0.3284 | |
| 122 | S | A | -0.4458 | |
| 123 | T | A | -0.5233 | |
| 124 | K | A | -0.9863 | |
| 125 | G | A | -1.2560 | |
| 126 | P | A | 0.0000 | |
| 127 | S | A | -0.2019 | |
| 128 | V | A | -0.1136 | |
| 129 | F | A | -0.4118 | |
| 130 | P | A | -0.6861 | |
| 131 | L | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | P | A | 0.0000 | |
| 134 | S | A | 0.0000 | |
| 135 | S | A | -0.7245 | |
| 136 | K | A | -0.6147 | |
| 137 | S | A | -0.7227 | |
| 138 | T | A | -0.7709 | |
| 139 | S | A | -0.7443 | |
| 140 | G | A | -0.8662 | |
| 141 | G | A | -0.8503 | |
| 142 | T | A | -0.6039 | |
| 143 | A | A | 0.0000 | |
| 144 | A | A | 0.0000 | |
| 145 | L | A | 0.0000 | |
| 146 | G | A | 0.0000 | |
| 147 | C | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | V | A | 0.0000 | |
| 150 | K | A | 0.0000 | |
| 151 | D | A | -0.3009 | |
| 152 | Y | A | 0.0000 | |
| 153 | F | A | 0.0000 | |
| 154 | P | A | -0.4883 | |
| 155 | E | A | -0.5924 | |
| 156 | P | A | -0.9095 | |
| 157 | V | A | 0.0000 | |
| 158 | T | A | -0.6836 | |
| 159 | V | A | -0.3789 | |
| 160 | S | A | -0.3388 | |
| 161 | W | A | 0.0000 | |
| 162 | N | A | -0.7418 | |
| 163 | S | A | -0.6866 | |
| 164 | G | A | -0.4276 | |
| 165 | A | A | -0.1902 | |
| 166 | L | A | -0.0249 | |
| 167 | T | A | -0.1858 | |
| 168 | S | A | -0.1980 | |
| 169 | G | A | -0.3002 | |
| 170 | V | A | 0.1597 | |
| 171 | H | A | 0.0145 | |
| 172 | T | A | 0.0285 | |
| 173 | F | A | 0.0000 | |
| 174 | P | A | -0.2725 | |
| 175 | A | A | 0.2208 | |
| 176 | V | A | 0.5368 | |
| 177 | L | A | 1.2110 | |
| 178 | Q | A | 0.1963 | |
| 179 | S | A | -0.1956 | |
| 180 | S | A | -0.1982 | |
| 181 | G | A | -0.1037 | |
| 182 | L | A | 0.1028 | |
| 183 | Y | A | 0.0000 | |
| 184 | S | A | 0.0000 | |
| 185 | L | A | 0.0000 | |
| 186 | S | A | 0.0000 | |
| 187 | S | A | 0.0000 | |
| 188 | V | A | 0.0000 | |
| 189 | V | A | 0.0000 | |
| 190 | T | A | -0.1924 | |
| 191 | V | A | 0.0000 | |
| 192 | P | A | -0.5813 | |
| 193 | S | A | 0.0000 | |
| 194 | S | A | -0.8202 | |
| 195 | S | A | -0.6550 | |
| 196 | L | A | -0.7278 | |
| 197 | G | A | -0.8855 | |
| 198 | T | A | -0.7779 | |
| 199 | Q | A | -1.1199 | |
| 200 | T | A | -0.9746 | |
| 201 | Y | A | 0.0000 | |
| 202 | I | A | -0.8557 | |
| 203 | C | A | 0.0000 | |
| 204 | N | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | N | A | -1.9680 | |
| 207 | H | A | 0.0000 | |
| 208 | K | A | -2.7888 | |
| 209 | P | A | -1.6335 | |
| 210 | S | A | -1.8444 | |
| 211 | N | A | -2.4953 | |
| 212 | T | A | -1.9923 | |
| 213 | K | A | -2.5274 | |
| 214 | V | A | -1.3082 | |
| 215 | D | A | -2.3964 | |
| 216 | K | A | -1.8792 | |
| 217 | R | A | -2.2209 | |
| 218 | V | A | 0.0000 | |
| 219 | E | A | -1.2432 | |
| 220 | P | A | -0.7318 | |
| 221 | K | A | -0.9125 | |
| 222 | S | A | -1.2652 | |
| 223 | C | A | -1.6228 | |
| 224 | D | A | -2.7198 | |
| 225 | K | A | -2.7755 | |
| 226 | T | A | -1.4376 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine