@article {559, title = {Isoxazole-containing 5' mRNA cap analogues as inhibitors of the translation initiation process}, journal = {Bioorganic Chemistry}, volume = {96}, year = {2020}, pages = {103583}, abstract = {Herein we describe a synthesis of new isoxazole-containing 5' mRNA cap analogues via a cycloaddition reaction. The obtained analogues show a capability to inhibit cap-dependent translation in vitro and are characterized by a new binding mode in which an isoxazolic ring, instead of guanine, is involved in the stacking effect. Our study provides valuable information toward designing new compounds that can be potentially used as anticancer therapeutics.}, keywords = {Cap analogue, Cycloaddition reaction, Isoxazol, mRNA, Translation initiation}, issn = {0045-2068}, doi = {https://doi.org/10.1016/j.bioorg.2020.103583}, url = {https://www.sciencedirect.com/science/article/pii/S004520681931819X}, author = {Karolina Piecyk and Maciej Lukaszewicz and Karol Kamel and Maria Janowska and Paulina Pietrow and Sebastian Kmiecik and Marzena Jankowska-Anyszka} }