@article {421, title = {Thermal unfolding of proteins.}, journal = {J Chem Phys}, volume = {123}, year = {2005}, month = {2005 Nov 15}, pages = {194908}, abstract = {Thermal unfolding of proteins is compared to folding and mechanical stretching in a simple topology-based dynamical model. We define the unfolding time and demonstrate its low-temperature divergence. Below a characteristic temperature, contacts break at separate time scales and unfolding proceeds approximately in a way reverse to folding. Features in these scenarios agree with experiments and atomic simulations on titin.}, keywords = {Chemistry, Physical, Computer Simulation, Connectin, Kinetics, Models, Molecular, Molecular Conformation, Muscle Proteins, Protein Conformation, Protein Denaturation, Protein Folding, Protein Kinases, Protein Structure, Secondary, Proteins, Temperature, Time Factors}, issn = {0021-9606}, doi = {10.1063/1.2121668}, author = {Cieplak, Marek and Joanna I. Sulkowska} }