TY - JOUR T1 - A numerical investigation into possible mechanisms by that the A629P mutant of ATP7A causes Menkes Disease JF - Phys Chem Chem Phys Y1 - 2010 A1 - Maksim Kouza A1 - S. Gowtham A1 - M. Seel A1 - Ulrich H. E. Hansmann AB - We study in silico possible mechanisms by that the A629P mutant of ATP7A causes Menkes Disease. Our results indicate that the mutation does not have appreciable affects on the stability of copper-bound states but rather destabilizes the characteristic end-to-end β-sheet. In this way, the mutation presumably increases the probability for aggregation and/or degradation leading to decreased concentration of the monomer. VL - 12 ER -