TY - JOUR T1 - Isoxazole-containing 5′ mRNA cap analogues as inhibitors of the translation initiation process JF - Bioorganic Chemistry Y1 - 2020 A1 - Karolina Piecyk A1 - Maciej Lukaszewicz A1 - Karol Kamel A1 - Maria Janowska A1 - Paulina Pietrow A1 - Sebastian Kmiecik A1 - Marzena Jankowska-Anyszka KW - Cap analogue KW - Cycloaddition reaction KW - Isoxazol KW - mRNA KW - Translation initiation AB - Herein we describe a synthesis of new isoxazole-containing 5′ mRNA cap analogues via a cycloaddition reaction. The obtained analogues show a capability to inhibit cap-dependent translation in vitro and are characterized by a new binding mode in which an isoxazolic ring, instead of guanine, is involved in the stacking effect. Our study provides valuable information toward designing new compounds that can be potentially used as anticancer therapeutics. VL - 96 UR - https://www.sciencedirect.com/science/article/pii/S004520681931819X ER -