%0 Journal Article %J Journal of Computational Chemistry %D 2007 %T Backbone building from quadrilaterals: a fast and accurate algorithm for protein backbone reconstruction from alpha carbon coordinates %A Dominik Gront %A Sebastian Kmiecik %A Andrzej Koliński %K Algorithms %K Carbon %K Carbon: chemistry %K Models %K Molecular %K Proteins %K Proteins: chemistry %X In this contribution, we present an algorithm for protein backbone reconstruction that comprises very high computational efficiency with high accuracy. Reconstruction of the main chain atomic coordinates from the alpha carbon trace is a common task in protein modeling, including de novo structure prediction, comparative modeling, and processing experimental data. The method employed in this work follows the main idea of some earlier approaches to the problem. The details and careful design of the present approach are new and lead to the algorithm that outperforms all commonly used earlier applications. BBQ (Backbone Building from Quadrilaterals) program has been extensively tested both on native structures as well as on near-native decoy models and compared with the different available existing methods. Obtained results provide a comprehensive benchmark of existing tools and evaluate their applicability to a large scale modeling using a reduced representation of protein conformational space. The BBQ package is available for downloading from our website at http://www.bioshell.pl/BBQ This webpage also provides a user manual that describes BBQ functions in detail. %B Journal of Computational Chemistry %V 28 %P 1593–7 %8 jul %G eng %U http://onlinelibrary.wiley.com/doi/10.1002/jcc.20624/full http://www.ncbi.nlm.nih.gov/pubmed/17342707 %R 10.1002/jcc.20624