%0 Conference Proceedings %B TASK Quarterly %D 2014 %T Mechanical unfolding of DDFLN4 studied by the coarse-grained knowledge-based CABS model %A Maksim Kouza %A Michal Jamroz %A Dominik Gront %A Sebastian Kmiecik %A Andrzej Koliński %X Mechanical unfolding of the fourth domain of Distyostelium discoideum filamin (DDFLN4) was studied using a CABS – coarse-grained knowledge-based protein model. Our study demonstrates that CABS is capable of reproducing the unfolding free energy landscape of protein unfolding and highlights an important role of non-native interactions in the protein unfolding process. The obtained three peaks in the force-extension profile suggest a four-state picture of DDFLN4 protein unfolding and correspond reasonably to the results of the all-atom simulation in explicit solvent. %B TASK Quarterly %V 18 %P 373–378 %G eng %6 4