Andrzej Kolinski Research Group

Coarse-grained protein modeling

Modeling Software & Servers

Biomolecules — dynamics & interactions

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A unified approach to the prediction of protein structure and function

Source:

Computational Methods for Protein Folding, 120, 2002

Abstract

The major focus of this review is to describe a unified approach to protein structure prediction that reduces to threading plus structure refinement when an example of the probe sequence is found; but if not, it incorporates information from weakly significant probe sequence-template structure matches and then does ab initio folding with the structural information gleaned from such matches. It has the advantage that it can predict a novel fold even though some of the information comes from threading on already solved structures.