| Chain sequence(s) |
A: SIGPVADLTISNGAVSPDGFSRQAILVNDVFPSPLITGNKGDRFQLNVIDNMTNHTMLKSTSIHWHGFFQHGTNWADGPAFVNQCPISTGHAFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPIVVYDPQDPHKSLYDVDDDSTVITLADWYHLAAKVGPAAPTADATLINGLGRSIDTLNADLAVITVTKGKRYRFRLVSLSCDPNYTFSIDGHSLTVIEADGVNLKPQTVDSIQIFPAQRYSFVLNADQDVDNYWIRALPNSGTRNFDGGVNSAILRYEGAAPVEPTTTQTPSTQPLVESALTTLEGTAAPGNPTPGGVDLALNMAFGFAGGRFTINGASFTPPTVPVLLQILSGAQSAQDLLPSGSVYSLPANADIEISLPATSAAPGFPHPFHLHGHTFAVVRSAGSSTYNYANPVYRDVVNTGSPGDNVTIRFRTDNPGPWFLHCHIDFHLEAGFTVVMAEDIPEVAATNPVPQAWSDLCPTYDALSPDDQ |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
| Mutated residues | FA392G |
| Energy difference between WT (input) and mutated protein (by FoldX) | 1.16274 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | -0.4351 | |
| 2 | I | A | 0.3970 | |
| 3 | G | A | 0.0548 | |
| 4 | P | A | -0.2606 | |
| 5 | V | A | 0.8397 | |
| 6 | A | A | -0.0075 | |
| 7 | D | A | -1.4046 | |
| 8 | L | A | 0.0000 | |
| 9 | T | A | -0.9585 | |
| 10 | I | A | 0.0000 | |
| 11 | S | A | -0.9343 | |
| 12 | N | A | -1.0107 | |
| 13 | G | A | -0.6916 | |
| 14 | A | A | -0.3270 | |
| 15 | V | A | -0.0037 | |
| 16 | S | A | -0.1285 | |
| 17 | P | A | 0.0000 | |
| 18 | D | A | 0.0000 | |
| 19 | G | A | -0.8773 | |
| 20 | F | A | -0.0029 | |
| 21 | S | A | -0.2523 | |
| 22 | R | A | 0.0000 | |
| 23 | Q | A | -1.1802 | |
| 24 | A | A | 0.0000 | |
| 25 | I | A | 0.0000 | |
| 26 | L | A | -0.4199 | |
| 27 | V | A | 0.0000 | |
| 28 | N | A | -1.0949 | |
| 29 | D | A | -1.3584 | |
| 30 | V | A | 0.3979 | |
| 31 | F | A | 0.4603 | |
| 32 | P | A | 0.2390 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.1025 | |
| 35 | L | A | -0.1564 | |
| 36 | I | A | 0.0000 | |
| 37 | T | A | -0.3851 | |
| 38 | G | A | -0.8076 | |
| 39 | N | A | -1.8261 | |
| 40 | K | A | -2.6710 | |
| 41 | G | A | -2.4207 | |
| 42 | D | A | -2.5451 | |
| 43 | R | A | -2.7972 | |
| 44 | F | A | 0.0000 | |
| 45 | Q | A | -0.6488 | |
| 46 | L | A | 0.0000 | |
| 47 | N | A | -0.3925 | |
| 48 | V | A | 0.0000 | |
| 49 | I | A | -0.4664 | |
| 50 | D | A | 0.0000 | |
| 51 | N | A | -1.5116 | |
| 52 | M | A | 0.0000 | |
| 53 | T | A | -1.2357 | |
| 54 | N | A | -1.3863 | |
| 55 | H | A | -1.4396 | |
| 56 | T | A | -0.6238 | |
| 57 | M | A | 0.0000 | |
| 58 | L | A | -0.8780 | |
| 59 | K | A | -1.3646 | |
| 60 | S | A | 0.0000 | |
| 61 | T | A | 0.0000 | |
| 62 | S | A | 0.0000 | |
| 63 | I | A | 0.0000 | |
| 64 | H | A | 0.0000 | |
| 65 | W | A | 0.0000 | |
| 66 | H | A | 0.0000 | |
| 67 | G | A | 0.0320 | |
| 68 | F | A | 0.0000 | |
| 69 | F | A | -0.4482 | |
| 70 | Q | A | 0.0000 | |
| 71 | H | A | -1.3443 | |
| 72 | G | A | -0.6070 | |
| 73 | T | A | -0.4649 | |
| 74 | N | A | 0.0000 | |
| 75 | W | A | 0.0000 | |
| 76 | A | A | 0.0000 | |
| 77 | D | A | 0.0000 | |
| 78 | G | A | 0.0000 | |
| 79 | P | A | 0.0000 | |
| 80 | A | A | 0.0000 | |
| 81 | F | A | 0.3289 | |
| 82 | V | A | 0.0000 | |
| 83 | N | A | 0.0000 | |
| 84 | Q | A | 0.0000 | |
| 85 | C | A | 0.0000 | |
| 86 | P | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | S | A | 0.0000 | |
| 89 | T | A | -1.0286 | |
| 90 | G | A | -1.1183 | |
| 91 | H | A | -0.9698 | |
| 92 | A | A | -0.4421 | |
| 93 | F | A | 0.0000 | |
| 94 | L | A | 0.1999 | |
| 95 | Y | A | 0.0000 | |
| 96 | D | A | -0.7197 | |
| 97 | F | A | 0.0000 | |
| 98 | Q | A | -2.8764 | |
| 99 | V | A | 0.0000 | |
| 100 | P | A | -2.4088 | |
| 101 | D | A | -2.3949 | |
| 102 | Q | A | -1.6206 | |
| 103 | A | A | -1.0349 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | 0.0000 | |
| 106 | F | A | 0.0000 | |
| 107 | W | A | 0.0000 | |
| 108 | Y | A | 0.0000 | |
| 109 | H | A | 0.0000 | |
| 110 | S | A | 0.0000 | |
| 111 | H | A | 0.0000 | |
| 112 | L | A | 0.0000 | |
| 113 | S | A | -0.6297 | |
| 114 | T | A | 0.0000 | |
| 115 | Q | A | 0.0000 | |
| 116 | Y | A | 0.0000 | |
| 117 | C | A | 0.0000 | |
| 118 | D | A | 0.0000 | |
| 119 | G | A | 0.0000 | |
| 120 | L | A | 0.0000 | |
| 121 | R | A | 0.0000 | |
| 122 | G | A | 0.0000 | |
| 123 | P | A | 0.0000 | |
| 124 | I | A | 0.0000 | |
| 125 | V | A | 0.0000 | |
| 126 | V | A | 0.0000 | |
| 127 | Y | A | -0.8686 | |
| 128 | D | A | -1.5055 | |
| 129 | P | A | -1.5039 | |
| 130 | Q | A | -1.9314 | |
| 131 | D | A | -1.6301 | |
| 132 | P | A | -1.1634 | |
| 133 | H | A | 0.0000 | |
| 134 | K | A | -2.1440 | |
| 135 | S | A | -1.0579 | |
| 136 | L | A | -0.5098 | |
| 137 | Y | A | -1.1444 | |
| 138 | D | A | -1.7746 | |
| 139 | V | A | -1.3740 | |
| 140 | D | A | -1.6731 | |
| 141 | D | A | -2.1926 | |
| 142 | D | A | -2.5071 | |
| 143 | S | A | -1.4439 | |
| 144 | T | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | T | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | A | A | 0.0000 | |
| 150 | D | A | 0.0000 | |
| 151 | W | A | 0.0000 | |
| 152 | Y | A | 0.0000 | |
| 153 | H | A | 0.5436 | |
| 154 | L | A | 1.4362 | |
| 155 | A | A | 0.0000 | |
| 156 | A | A | 0.0951 | |
| 157 | K | A | -0.4344 | |
| 158 | V | A | 1.3522 | |
| 159 | G | A | 0.7298 | |
| 160 | P | A | 0.0578 | |
| 161 | A | A | -0.3675 | |
| 162 | A | A | -0.4536 | |
| 163 | P | A | -0.0465 | |
| 164 | T | A | -0.2787 | |
| 165 | A | A | -0.3470 | |
| 166 | D | A | -0.3730 | |
| 167 | A | A | 0.0000 | |
| 168 | T | A | 0.0000 | |
| 169 | L | A | 0.0000 | |
| 170 | I | A | 0.0000 | |
| 171 | N | A | -0.1645 | |
| 172 | G | A | 0.0000 | |
| 173 | L | A | -0.1124 | |
| 174 | G | A | 0.0000 | |
| 175 | R | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | I | A | 0.7136 | |
| 178 | D | A | -0.9195 | |
| 179 | T | A | -0.6688 | |
| 180 | L | A | -0.6507 | |
| 181 | N | A | -1.6055 | |
| 182 | A | A | -1.5756 | |
| 183 | D | A | -1.8838 | |
| 184 | L | A | 0.0000 | |
| 185 | A | A | 0.0000 | |
| 186 | V | A | 0.6462 | |
| 187 | I | A | 0.0000 | |
| 188 | T | A | -0.5764 | |
| 189 | V | A | 0.0000 | |
| 190 | T | A | -1.9491 | |
| 191 | K | A | -3.1893 | |
| 192 | G | A | -2.6125 | |
| 193 | K | A | -2.4436 | |
| 194 | R | A | -2.0547 | |
| 195 | Y | A | 0.0000 | |
| 196 | R | A | 0.0000 | |
| 197 | F | A | 0.0000 | |
| 198 | R | A | 0.0000 | |
| 199 | L | A | 0.0000 | |
| 200 | V | A | 0.0000 | |
| 201 | S | A | 0.0000 | |
| 202 | L | A | 0.0000 | |
| 203 | S | A | 0.0000 | |
| 204 | C | A | 0.0000 | |
| 205 | D | A | -0.4922 | |
| 206 | P | A | 0.0000 | |
| 207 | N | A | 0.0000 | |
| 208 | Y | A | 0.0000 | |
| 209 | T | A | -0.5490 | |
| 210 | F | A | 0.0000 | |
| 211 | S | A | -0.4881 | |
| 212 | I | A | 0.0000 | |
| 213 | D | A | 0.0000 | |
| 214 | G | A | -1.2250 | |
| 215 | H | A | 0.0000 | |
| 216 | S | A | -0.7835 | |
| 217 | L | A | 0.0000 | |
| 218 | T | A | -0.5581 | |
| 219 | V | A | 0.0000 | |
| 220 | I | A | 0.0000 | |
| 221 | E | A | 0.0000 | |
| 222 | A | A | 0.0000 | |
| 223 | D | A | 0.0000 | |
| 224 | G | A | -0.0880 | |
| 225 | V | A | -0.0587 | |
| 226 | N | A | -0.7613 | |
| 227 | L | A | 0.0000 | |
| 228 | K | A | -1.9682 | |
| 229 | P | A | -1.0258 | |
| 230 | Q | A | -0.8804 | |
| 231 | T | A | -0.8268 | |
| 232 | V | A | 0.0000 | |
| 233 | D | A | -1.0281 | |
| 234 | S | A | 0.0000 | |
| 235 | I | A | 0.0000 | |
| 236 | Q | A | -0.9682 | |
| 237 | I | A | 0.0000 | |
| 238 | F | A | 0.0000 | |
| 239 | P | A | 0.0000 | |
| 240 | A | A | 0.0000 | |
| 241 | Q | A | 0.0000 | |
| 242 | R | A | 0.0000 | |
| 243 | Y | A | 0.0000 | |
| 244 | S | A | 0.0000 | |
| 245 | F | A | 0.0000 | |
| 246 | V | A | 0.0000 | |
| 247 | L | A | 0.0000 | |
| 248 | N | A | -2.3155 | |
| 249 | A | A | 0.0000 | |
| 250 | D | A | -3.3355 | |
| 251 | Q | A | -2.6846 | |
| 252 | D | A | -2.5696 | |
| 253 | V | A | -1.6594 | |
| 254 | D | A | -1.6850 | |
| 255 | N | A | 0.0000 | |
| 256 | Y | A | 0.0000 | |
| 257 | W | A | -0.2725 | |
| 258 | I | A | 0.0000 | |
| 259 | R | A | 0.0000 | |
| 260 | A | A | 0.0000 | |
| 261 | L | A | -0.6773 | |
| 262 | P | A | 0.0000 | |
| 263 | N | A | -1.4003 | |
| 264 | S | A | -1.0966 | |
| 265 | G | A | -1.3221 | |
| 266 | T | A | -1.4058 | |
| 267 | R | A | -2.6594 | |
| 268 | N | A | -2.2568 | |
| 269 | F | A | -1.3887 | |
| 270 | D | A | -1.8292 | |
| 271 | G | A | -0.9508 | |
| 272 | G | A | 0.0000 | |
| 273 | V | A | 0.0000 | |
| 274 | N | A | 0.0000 | |
| 275 | S | A | 0.0000 | |
| 276 | A | A | 0.0000 | |
| 277 | I | A | 0.0000 | |
| 278 | L | A | 0.0000 | |
| 279 | R | A | -0.7907 | |
| 280 | Y | A | 0.0000 | |
| 281 | E | A | -2.3428 | |
| 282 | G | A | -1.5425 | |
| 283 | A | A | -0.9161 | |
| 284 | A | A | -0.2254 | |
| 285 | P | A | 0.2139 | |
| 286 | V | A | 0.7674 | |
| 287 | E | A | -0.6561 | |
| 288 | P | A | 0.0000 | |
| 289 | T | A | -0.4674 | |
| 290 | T | A | -0.7343 | |
| 291 | T | A | -0.7443 | |
| 292 | Q | A | -1.3650 | |
| 293 | T | A | -0.9456 | |
| 294 | P | A | -0.8385 | |
| 295 | S | A | -0.9774 | |
| 296 | T | A | -0.8956 | |
| 297 | Q | A | -1.3145 | |
| 298 | P | A | -0.6494 | |
| 299 | L | A | 0.0000 | |
| 300 | V | A | 1.2088 | |
| 301 | E | A | 0.4161 | |
| 302 | S | A | 0.2610 | |
| 303 | A | A | 0.3246 | |
| 304 | L | A | 0.0000 | |
| 305 | T | A | -0.9974 | |
| 306 | T | A | 0.0000 | |
| 307 | L | A | -1.2015 | |
| 308 | E | A | -2.0311 | |
| 309 | G | A | -1.3874 | |
| 310 | T | A | -0.7948 | |
| 311 | A | A | -0.7231 | |
| 312 | A | A | -0.6955 | |
| 313 | P | A | -0.8501 | |
| 314 | G | A | -1.4723 | |
| 315 | N | A | -1.7518 | |
| 316 | P | A | -0.9540 | |
| 317 | T | A | -0.7558 | |
| 318 | P | A | -0.6885 | |
| 319 | G | A | -1.0333 | |
| 320 | G | A | -1.2359 | |
| 321 | V | A | -1.3481 | |
| 322 | D | A | -2.0772 | |
| 323 | L | A | -0.4437 | |
| 324 | A | A | -0.4679 | |
| 325 | L | A | -0.3539 | |
| 326 | N | A | -1.3089 | |
| 327 | M | A | 0.0000 | |
| 328 | A | A | -0.6817 | |
| 329 | F | A | 0.0000 | |
| 330 | G | A | -0.2399 | |
| 331 | F | A | -0.1335 | |
| 332 | A | A | -0.5961 | |
| 333 | G | A | -1.1349 | |
| 334 | G | A | -1.3903 | |
| 335 | R | A | -2.2025 | |
| 336 | F | A | 0.0000 | |
| 337 | T | A | -0.7349 | |
| 338 | I | A | 0.0000 | |
| 339 | N | A | -1.3371 | |
| 340 | G | A | -0.8639 | |
| 341 | A | A | -0.8420 | |
| 342 | S | A | -0.7441 | |
| 343 | F | A | 0.0000 | |
| 344 | T | A | -0.4830 | |
| 345 | P | A | -0.1729 | |
| 346 | P | A | 0.0000 | |
| 347 | T | A | 0.1383 | |
| 348 | V | A | 0.7956 | |
| 349 | P | A | 0.0000 | |
| 350 | V | A | 0.0000 | |
| 351 | L | A | 0.0000 | |
| 352 | L | A | 0.6128 | |
| 353 | Q | A | 0.0000 | |
| 354 | I | A | 0.0000 | |
| 355 | L | A | 0.2399 | |
| 356 | S | A | -0.1824 | |
| 357 | G | A | -0.6388 | |
| 358 | A | A | -1.0175 | |
| 359 | Q | A | -1.7658 | |
| 360 | S | A | -1.4591 | |
| 361 | A | A | -1.0434 | |
| 362 | Q | A | -1.7456 | |
| 363 | D | A | -1.6268 | |
| 364 | L | A | 0.0000 | |
| 365 | L | A | 0.7587 | |
| 366 | P | A | 0.2961 | |
| 367 | S | A | -0.3714 | |
| 368 | G | A | -0.7370 | |
| 369 | S | A | 0.0000 | |
| 370 | V | A | 0.0000 | |
| 371 | Y | A | -0.0746 | |
| 372 | S | A | -0.3997 | |
| 373 | L | A | 0.0000 | |
| 374 | P | A | -1.1091 | |
| 375 | A | A | -1.6074 | |
| 376 | N | A | -2.4961 | |
| 377 | A | A | 0.0000 | |
| 378 | D | A | 0.0000 | |
| 379 | I | A | 0.0000 | |
| 380 | E | A | 0.0000 | |
| 381 | I | A | 0.0000 | |
| 382 | S | A | -0.5729 | |
| 383 | L | A | 0.0000 | |
| 384 | P | A | -0.6823 | |
| 385 | A | A | -0.6406 | |
| 386 | T | A | -0.5920 | |
| 387 | S | A | -0.4706 | |
| 388 | A | A | -0.0261 | |
| 389 | A | A | 0.0000 | |
| 390 | P | A | -0.4350 | |
| 391 | G | A | -0.8281 | |
| 392 | G | A | -0.8472 | mutated: FA392G |
| 393 | P | A | -0.6579 | |
| 394 | H | A | 0.0000 | |
| 395 | P | A | 0.0000 | |
| 396 | F | A | 0.0000 | |
| 397 | H | A | 0.0000 | |
| 398 | L | A | 0.0000 | |
| 399 | H | A | 0.0000 | |
| 400 | G | A | 0.0000 | |
| 401 | H | A | 0.0000 | |
| 402 | T | A | -0.1073 | |
| 403 | F | A | 0.0000 | |
| 404 | A | A | 0.0000 | |
| 405 | V | A | 0.0000 | |
| 406 | V | A | 0.0000 | |
| 407 | R | A | -0.3835 | |
| 408 | S | A | 0.0000 | |
| 409 | A | A | -0.5234 | |
| 410 | G | A | -0.6456 | |
| 411 | S | A | -0.3527 | |
| 412 | S | A | -0.4827 | |
| 413 | T | A | -0.0885 | |
| 414 | Y | A | 0.2170 | |
| 415 | N | A | -0.3415 | |
| 416 | Y | A | -0.4854 | |
| 417 | A | A | -0.5176 | |
| 418 | N | A | -1.0703 | |
| 419 | P | A | 0.0000 | |
| 420 | V | A | 0.0000 | |
| 421 | Y | A | 0.1028 | |
| 422 | R | A | 0.0000 | |
| 423 | D | A | 0.0000 | |
| 424 | V | A | 0.0000 | |
| 425 | V | A | 0.0000 | |
| 426 | N | A | -0.3987 | |
| 427 | T | A | 0.0000 | |
| 428 | G | A | 0.0000 | |
| 429 | S | A | -0.8899 | |
| 430 | P | A | -0.8957 | |
| 431 | G | A | -0.9992 | |
| 432 | D | A | -1.0418 | |
| 433 | N | A | -0.8639 | |
| 434 | V | A | 0.0000 | |
| 435 | T | A | 0.0000 | |
| 436 | I | A | 0.0000 | |
| 437 | R | A | 0.0000 | |
| 438 | F | A | 0.0000 | |
| 439 | R | A | -2.8635 | |
| 440 | T | A | 0.0000 | |
| 441 | D | A | -2.7805 | |
| 442 | N | A | 0.0000 | |
| 443 | P | A | -1.2974 | |
| 444 | G | A | 0.0000 | |
| 445 | P | A | 0.0000 | |
| 446 | W | A | 0.0000 | |
| 447 | F | A | 0.0000 | |
| 448 | L | A | 0.0000 | |
| 449 | H | A | 0.0000 | |
| 450 | C | A | 0.0000 | |
| 451 | H | A | 0.0000 | |
| 452 | I | A | 0.0000 | |
| 453 | D | A | 0.0000 | |
| 454 | F | A | 0.0000 | |
| 455 | H | A | 0.0000 | |
| 456 | L | A | -0.8359 | |
| 457 | E | A | -1.7873 | |
| 458 | A | A | -1.4525 | |
| 459 | G | A | 0.0000 | |
| 460 | F | A | 0.0000 | |
| 461 | T | A | 0.0000 | |
| 462 | V | A | 0.0000 | |
| 463 | V | A | 0.0000 | |
| 464 | M | A | 0.0000 | |
| 465 | A | A | 0.0000 | |
| 466 | E | A | 0.0000 | |
| 467 | D | A | -1.2208 | |
| 468 | I | A | 0.0000 | |
| 469 | P | A | -1.2611 | |
| 470 | E | A | -1.6184 | |
| 471 | V | A | 0.0000 | |
| 472 | A | A | -0.3284 | |
| 473 | A | A | -0.5042 | |
| 474 | T | A | -0.5457 | |
| 475 | N | A | 0.0000 | |
| 476 | P | A | -0.0079 | |
| 477 | V | A | 0.3161 | |
| 478 | P | A | -0.4701 | |
| 479 | Q | A | -1.3440 | |
| 480 | A | A | -0.6862 | |
| 481 | W | A | 0.0000 | |
| 482 | S | A | -0.7874 | |
| 483 | D | A | -1.2598 | |
| 484 | L | A | 0.0000 | |
| 485 | C | A | -0.6401 | |
| 486 | P | A | -1.0179 | |
| 487 | T | A | -0.8633 | |
| 488 | Y | A | -0.9574 | |
| 489 | D | A | -1.7171 | |
| 490 | A | A | -0.8181 | |
| 491 | L | A | -1.0067 | |
| 492 | S | A | -1.2882 | |
| 493 | P | A | -1.5611 | |
| 494 | D | A | -2.6823 | |
| 495 | D | A | -2.2066 | |
| 496 | Q | A | -1.7516 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine