Project name: Full TAU and CyPA

Status: done

submitted: 2019-02-20 02:39:33, status changed: 2019-02-20 02:58:18
Settings
Chain sequence(s) A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
B: VNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQL
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-3.8149
Maximal score value
1.8649
Average score
-1.1096
Total score value
-670.1926

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.0450
2 A A -1.2986
3 E A -2.3676
4 P A -2.2560
5 R A -2.9978
6 Q A -2.4243
7 E A -1.5931
8 F A 0.0000
9 E A -1.9533
10 V A 0.0000
11 M A -1.4582
12 E A -2.5743
13 D A -2.7825
14 H A -1.9747
15 A A -1.8654
16 G A -1.7913
17 T A -1.4760
18 Y A -1.8083
19 G A 0.0000
20 L A -1.2884
21 G A -1.9671
22 D A -3.0896
23 R A -3.0220
24 K A -2.7764
25 D A -2.1275
26 Q A 0.0000
27 G A 0.0000
28 G A -0.0611
29 Y A 0.8459
30 T A 0.7404
31 M A 0.5678
32 H A -0.9721
33 Q A -2.4996
34 D A -3.6161
35 Q A 0.0000
36 E A -2.8001
37 G A -2.9799
38 D A -3.2984
39 T A -2.4629
40 D A -2.6120
41 A A -1.8635
42 G A -1.1781
43 L A -0.3601
44 K A -2.3666
45 E A -2.8545
46 S A -1.3378
47 P A -0.1587
48 L A 0.5651
49 Q A -0.2625
50 T A 0.0000
51 P A 0.0000
52 T A -2.9654
53 E A -3.5436
54 D A -2.3382
55 G A -1.8387
56 S A -1.5627
57 E A -2.7207
58 E A -2.3203
59 P A -1.6771
60 G A -1.4638
61 S A -1.8671
62 E A -2.4281
63 T A -2.1604
64 S A -1.8894
65 D A -2.1581
66 A A -1.5448
67 K A -2.3992
68 S A -1.1901
69 T A -1.0082
70 P A -1.3243
71 T A 0.0000
72 A A 0.0000
73 E A -1.9876
74 D A -1.3287
75 V A -0.0927
76 T A -0.2961
77 A A 0.4702
78 P A 0.6936
79 L A 1.3804
80 V A 0.4547
81 D A -1.8370
82 E A -2.4090
83 G A -1.8478
84 A A -1.4605
85 P A -1.4287
86 G A -1.8105
87 K A -2.7855
88 Q A -2.1562
89 A A -1.4627
90 A A -1.3292
91 A A -1.2731
92 Q A -1.6227
93 P A -1.7716
94 H A -2.1946
95 T A -2.0394
96 E A -2.7914
97 I A -1.4632
98 P A -1.9669
99 E A -2.7354
100 G A -2.0982
101 T A -1.8970
102 T A -1.7264
103 A A -2.2178
104 E A -2.9097
105 E A -2.6449
106 A A -2.1060
107 G A -1.9413
108 I A -0.9065
109 G A -1.9634
110 D A -2.5738
111 T A -1.8270
112 P A -1.2927
113 S A -1.3164
114 L A -1.5899
115 E A -2.7805
116 D A -2.6928
117 E A -1.9060
118 A A 0.0000
119 A A -0.6044
120 G A -1.0741
121 H A -1.0694
122 V A 0.8311
123 T A -0.5168
124 Q A -0.7620
125 A A -1.0041
126 R A 0.0000
127 M A -0.2971
128 V A -0.3682
129 S A -1.2950
130 K A -2.2494
131 S A -2.1671
132 K A -2.9187
133 D A -3.6528
134 G A -2.0885
135 T A -1.5282
136 G A -1.8171
137 S A -2.7248
138 D A -3.3026
139 D A -3.8149
140 K A -3.3092
141 K A -2.2321
142 A A 0.0000
143 K A -1.4527
144 G A -1.6937
145 A A -1.9226
146 D A -3.1143
147 G A -2.6336
148 K A -2.6030
149 T A -1.9691
150 K A -1.4741
151 I A 0.8230
152 A A 0.1881
153 T A -0.2739
154 P A -1.2408
155 R A -2.5683
156 G A -1.9067
157 A A -1.1327
158 A A -1.0663
159 P A -1.0371
160 P A -1.4526
161 G A -2.1640
162 Q A -2.9182
163 K A -2.8028
164 G A -2.4742
165 Q A -2.7188
166 A A -2.2408
167 N A -2.5096
168 A A -1.2294
169 T A -0.9347
170 R A -1.0872
171 I A 0.6818
172 P A 0.1017
173 A A -0.5798
174 K A -1.3168
175 T A -0.6124
176 P A -1.0404
177 P A -0.9151
178 A A -0.9134
179 P A -1.2951
180 K A -1.9164
181 T A -1.2129
182 P A -0.9425
183 P A -1.0886
184 S A 0.0000
185 S A -0.5814
186 G A -1.2047
187 E A -1.9885
188 P A -2.1953
189 P A -1.9443
190 K A -2.8642
191 S A -2.4549
192 G A -2.1208
193 D A -3.4036
194 R A -3.5005
195 S A 0.0000
196 G A -1.2395
197 Y A 0.0000
198 S A -0.5687
199 S A 0.0000
200 P A -0.4782
201 G A -0.7054
202 S A -0.3927
203 P A -0.3489
204 G A -0.8410
205 T A 0.0000
206 P A 0.0000
207 G A -0.2931
208 S A 0.0000
209 R A 0.0000
210 S A -0.7612
211 R A -1.4667
212 T A -0.8580
213 P A -1.0711
214 S A -1.1306
215 L A -1.2838
216 P A 0.0000
217 T A -2.1004
218 P A -2.1551
219 P A -1.2261
220 T A -1.4762
221 R A -3.2133
222 E A -3.1620
223 P A 0.0000
224 K A -2.9819
225 K A -2.2189
226 V A -0.5448
227 A A 0.3915
228 V A 1.8649
229 V A 1.7551
230 R A -0.8850
231 T A -1.1757
232 P A -1.1464
233 P A -1.4569
234 K A -2.0453
235 S A 0.0000
236 P A 0.0000
237 S A -0.6508
238 S A 0.0000
239 A A -0.9693
240 K A -1.2710
241 S A -1.8531
242 R A -2.3582
243 L A -0.8455
244 Q A -1.1966
245 T A -0.5584
246 A A -0.1449
247 P A -0.2758
248 V A -0.1465
249 P A 0.0000
250 M A -0.6219
251 P A 0.0000
252 D A -1.3103
253 L A -0.5805
254 K A -1.5451
255 N A -2.0331
256 V A -1.0055
257 K A -2.1785
258 S A -1.5060
259 K A -1.2168
260 I A 0.4047
261 G A -1.3180
262 S A -1.1896
263 T A -1.0661
264 E A -2.1452
265 N A -2.2835
266 L A -1.0680
267 K A -2.3971
268 H A -2.2580
269 Q A -2.0608
270 P A -1.7185
271 G A -1.9358
272 G A -1.1206
273 G A -0.6845
274 K A -0.6803
275 V A -0.1529
276 Q A -1.7097
277 I A -1.2054
278 I A 0.0000
279 N A -2.7210
280 K A -3.0272
281 K A -2.3724
282 L A -1.0631
283 D A 0.0000
284 L A -1.7878
285 S A -1.7595
286 N A -2.0532
287 V A -1.2256
288 Q A -1.9885
289 S A -2.0320
290 K A -2.7322
291 C A 0.0000
292 G A 0.0000
293 S A -2.2195
294 K A -2.9838
295 D A -2.7048
296 N A -1.9315
297 I A -1.2797
298 K A -1.9959
299 H A 0.0000
300 V A 0.0000
301 P A 0.0489
302 G A -0.8189
303 G A -0.8859
304 G A -0.3493
305 S A 0.0869
306 V A 1.3828
307 Q A 0.2844
308 I A 0.0000
309 V A 0.8722
310 Y A 0.8074
311 K A -0.8163
312 P A 0.1488
313 V A 1.2534
314 D A -0.4856
315 L A 0.4636
316 S A -0.4966
317 K A -1.6474
318 V A -0.3121
319 T A -0.2712
320 S A -0.8643
321 K A -1.6140
322 C A -0.8520
323 G A -0.3103
324 S A 0.0000
325 L A -0.0179
326 G A -0.4838
327 N A -0.4864
328 I A 0.7647
329 H A -0.7884
330 H A -1.2380
331 K A -0.8795
332 P A -1.0743
333 G A -1.4909
334 G A -1.4098
335 G A -1.8811
336 Q A -2.8539
337 V A -1.9291
338 E A -2.1484
339 V A -0.5048
340 K A -2.0289
341 S A -1.9711
342 E A -2.7624
343 K A -1.5744
344 L A -0.4367
345 D A -1.3281
346 F A -0.1444
347 K A -1.2391
348 D A -1.9319
349 R A -1.8856
350 V A -0.1715
351 Q A -1.6109
352 S A -1.0523
353 K A -1.1502
354 I A 0.6103
355 G A -0.1321
356 S A -0.0221
357 L A 0.0905
358 D A -1.4503
359 N A -0.7531
360 I A 1.0112
361 T A 0.2258
362 H A 0.1428
363 V A 1.4174
364 P A 0.1938
365 G A -0.8656
366 G A -1.4785
367 G A -1.7978
368 N A -2.2927
369 K A -2.3603
370 K A -2.0393
371 I A -0.4380
372 E A -1.9858
373 T A -1.5483
374 H A -1.7389
375 K A -1.4267
376 L A 0.7267
377 T A 0.5434
378 F A 0.5763
379 R A -1.8940
380 E A -3.0240
381 N A -2.6791
382 A A -2.1303
383 K A -2.7883
384 A A -1.7921
385 K A -2.6972
386 T A -1.9054
387 D A -2.1344
388 H A -2.1214
389 G A -1.0151
390 A A -0.5021
391 E A -0.8924
392 I A 0.0753
393 V A 0.1084
394 Y A -0.7363
395 K A -1.6009
396 S A -0.1513
397 P A 0.5914
398 V A 1.3628
399 V A 1.7085
400 S A 0.2377
401 G A -0.0691
402 D A -0.4729
403 T A -0.6363
404 S A -0.6326
405 P A -0.9725
406 R A -2.2360
407 H A -1.3968
408 L A 0.0111
409 S A -0.6256
410 N A -1.3672
411 V A -0.7624
412 S A -0.7631
413 S A -0.5762
414 T A 0.0824
415 G A 0.0000
416 S A 0.5536
417 I A 1.5803
418 D A -0.2967
419 M A 0.7366
420 V A 0.1451
421 D A -1.1256
422 S A -0.7153
423 P A -0.3432
424 Q A -0.8657
425 L A 0.0000
426 A A 0.6067
427 T A 0.3234
428 L A 0.8490
429 A A -0.2822
430 D A -1.8460
431 E A -1.7114
432 V A 0.2858
433 S A -0.3694
434 A A -0.1285
435 S A -0.2239
436 L A -0.5179
437 A A -0.8125
438 K A -1.8991
439 Q A -0.9643
440 G A -0.4531
441 L A 1.0506
2 V B 1.3769
3 N B -0.0049
4 P B -0.0427
5 T B -0.1564
6 V B 0.0000
7 F B -0.7744
8 F B 0.0000
9 D B -1.3784
10 I B 0.0000
11 A B 0.0000
12 V B 0.0000
13 D B -3.3407
14 G B -2.5517
15 E B -2.7604
16 P B -1.5866
17 L B -0.7541
18 G B -1.2053
19 R B -2.2607
20 V B 0.0000
21 S B 0.0000
22 F B 0.0000
23 E B -1.3331
24 L B 0.0000
25 F B -0.9338
26 A B -1.3821
27 D B -2.1173
28 K B -1.6405
29 V B 0.0000
30 P B -1.6787
31 K B -1.8033
32 T B 0.0000
33 A B 0.0000
34 E B -1.2624
35 N B 0.0000
36 F B 0.0000
37 R B -1.1683
38 A B 0.0000
39 L B 0.0000
40 S B 0.0000
41 T B -1.4875
42 G B -2.0268
43 E B -2.8626
44 K B -2.7173
45 G B -1.7284
46 F B -1.0897
47 G B -1.2392
48 Y B 0.0000
49 K B -2.1431
50 G B -1.4032
51 S B 0.0000
52 C B 0.0000
53 F B 0.0000
54 H B 0.0000
55 R B -1.7872
56 I B 0.0000
57 I B -1.4943
58 P B -1.3843
59 G B -1.3793
60 F B -0.4155
61 M B 0.0000
62 C B 0.0000
63 Q B 0.0000
64 G B 0.0000
65 G B 0.0000
66 D B 0.0000
67 F B -1.1017
68 T B -1.3107
69 R B -2.4718
70 H B -2.0766
71 N B -1.9268
72 G B -1.5163
73 T B 0.0000
74 G B -1.7267
75 G B -1.3839
76 K B -1.3045
77 S B 0.0000
78 I B -0.4914
79 Y B -0.0514
80 G B -0.8321
81 E B -1.8246
82 K B -2.0794
83 F B 0.0000
84 E B -2.6781
85 D B -1.9679
86 E B -1.3224
87 N B -0.1367
88 F B 0.7324
89 I B 1.5047
90 L B 0.2718
91 K B -1.7389
92 H B 0.0000
93 T B -1.6435
94 G B -1.6197
95 P B -1.0125
96 G B 0.0000
97 I B 0.0000
98 L B 0.0000
99 S B 0.0000
100 M B 0.0000
101 A B -0.3769
102 N B -0.7176
103 A B -0.7166
104 G B 0.0000
105 P B -1.0547
106 N B -1.9968
107 T B -1.4427
108 N B 0.0000
109 G B -1.2730
110 S B 0.0000
111 Q B -0.3308
112 F B 0.0000
113 F B 0.0000
114 I B 0.0000
115 C B 0.0000
116 T B -0.8130
117 A B -1.1775
118 K B -2.4008
119 T B 0.0000
120 E B -2.4809
121 W B -0.8300
122 L B 0.0000
123 D B -1.2687
124 G B -0.8889
125 K B -1.0820
126 H B 0.0000
127 V B 0.0000
128 V B 0.0000
129 F B 0.0000
130 G B 0.0000
131 K B -1.8371
132 V B 0.0000
133 K B -2.9576
134 E B -3.2498
135 G B -2.3495
136 M B -2.0321
137 N B -2.2731
138 I B -1.5916
139 V B 0.0000
140 E B -2.7265
141 A B 0.0000
142 M B 0.0000
143 E B -2.0205
144 R B -2.4597
145 F B -1.7984
146 G B -1.9753
147 S B -2.2876
148 R B -3.0118
149 N B -2.8197
150 G B 0.0000
151 K B -2.7631
152 T B -2.2769
153 S B -1.7396
154 K B -2.5751
155 K B -2.9674
156 I B 0.0000
157 T B -1.5694
158 I B 0.0000
159 A B -1.4645
160 D B -1.6428
161 C B -1.1567
162 G B -0.7728
163 Q B -0.1787
164 L B 1.0967

 

Laboratory of Theory of Biopolymers 2015