| Chain sequence(s) |
A: GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW C: KLIETYFSK B: AQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRD |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -1.3322 | |
| 2 | S | A | -0.9725 | |
| 3 | H | A | -0.8517 | |
| 4 | S | A | 0.0000 | |
| 5 | M | A | 0.0000 | |
| 6 | R | A | -0.5990 | |
| 7 | Y | A | 0.0000 | |
| 8 | F | A | 0.0077 | |
| 9 | F | A | 0.0000 | |
| 10 | T | A | 0.0000 | |
| 11 | S | A | 0.0000 | |
| 12 | V | A | 0.0000 | |
| 13 | S | A | -1.9642 | |
| 14 | R | A | -2.4725 | |
| 15 | P | A | -2.2356 | |
| 16 | G | A | -2.4236 | |
| 17 | R | A | -2.9006 | |
| 18 | G | A | -2.6369 | |
| 19 | E | A | -3.0638 | |
| 20 | P | A | -2.2488 | |
| 21 | R | A | -1.6921 | |
| 22 | F | A | 0.0000 | |
| 23 | I | A | 0.0000 | |
| 24 | A | A | 0.0000 | |
| 25 | V | A | 0.0000 | |
| 26 | G | A | 0.0000 | |
| 27 | Y | A | -0.5037 | |
| 28 | V | A | 0.0000 | |
| 29 | D | A | -0.8718 | |
| 30 | D | A | -1.1412 | |
| 31 | T | A | -0.7033 | |
| 32 | Q | A | -0.8364 | |
| 33 | F | A | 0.0000 | |
| 34 | V | A | 0.0000 | |
| 35 | R | A | -0.7688 | |
| 36 | F | A | 0.0000 | |
| 37 | D | A | 0.0000 | |
| 38 | S | A | -1.6142 | |
| 39 | D | A | -1.9201 | |
| 40 | A | A | -1.1516 | |
| 41 | A | A | -0.7536 | |
| 42 | S | A | -1.0581 | |
| 43 | Q | A | -1.6182 | |
| 44 | R | A | -2.0745 | |
| 45 | M | A | 0.0000 | |
| 46 | E | A | -1.2773 | |
| 47 | P | A | -1.6224 | |
| 48 | R | A | -1.6746 | |
| 49 | A | A | 0.0000 | |
| 50 | P | A | -1.4392 | |
| 51 | W | A | 0.0000 | |
| 52 | I | A | 0.0000 | |
| 53 | E | A | -2.9015 | |
| 54 | Q | A | -2.6101 | |
| 55 | E | A | -2.1656 | |
| 56 | G | A | -2.0086 | |
| 57 | P | A | -2.2808 | |
| 58 | E | A | -2.8440 | |
| 59 | Y | A | 0.0000 | |
| 60 | W | A | 0.0000 | |
| 61 | D | A | -3.4083 | |
| 62 | Q | A | -2.7501 | |
| 63 | E | A | 0.0000 | |
| 64 | T | A | 0.0000 | |
| 65 | R | A | -3.0452 | |
| 66 | N | A | 0.0000 | |
| 67 | V | A | 0.0000 | |
| 68 | K | A | -1.7314 | |
| 69 | A | A | -1.3287 | |
| 70 | Q | A | 0.0000 | |
| 71 | S | A | 0.0000 | |
| 72 | Q | A | -1.0489 | |
| 73 | T | A | -0.4035 | |
| 74 | D | A | 0.0000 | |
| 75 | R | A | -1.4220 | |
| 76 | V | A | 0.3452 | |
| 77 | D | A | 0.0000 | |
| 78 | L | A | 0.0000 | |
| 79 | G | A | -0.7927 | |
| 80 | T | A | -0.3812 | |
| 81 | L | A | 0.0000 | |
| 82 | R | A | -1.7727 | |
| 83 | G | A | -1.2543 | |
| 84 | Y | A | -0.0311 | |
| 85 | Y | A | -0.5131 | |
| 86 | N | A | -1.7647 | |
| 87 | Q | A | -1.7863 | |
| 88 | S | A | -1.8206 | |
| 89 | E | A | -2.6574 | |
| 90 | A | A | -1.3725 | |
| 91 | G | A | -1.3560 | |
| 92 | S | A | -1.1010 | |
| 93 | H | A | -0.9748 | |
| 94 | T | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | Q | A | 0.0000 | |
| 97 | I | A | 0.0000 | |
| 98 | M | A | -0.3126 | |
| 99 | Y | A | 0.0000 | |
| 100 | G | A | 0.0000 | |
| 101 | C | A | 0.0000 | |
| 102 | D | A | 0.0000 | |
| 103 | V | A | 0.0000 | |
| 104 | G | A | -1.5071 | |
| 105 | S | A | -1.6782 | |
| 106 | D | A | -2.6171 | |
| 107 | G | A | -2.1882 | |
| 108 | R | A | -2.5932 | |
| 109 | F | A | -1.2372 | |
| 110 | L | A | -0.6051 | |
| 111 | R | A | -2.1685 | |
| 112 | G | A | -1.5371 | |
| 113 | Y | A | -0.9539 | |
| 114 | R | A | 0.0000 | |
| 115 | Q | A | -1.0231 | |
| 116 | D | A | 0.0000 | |
| 117 | A | A | 0.0000 | |
| 118 | Y | A | 0.0000 | |
| 119 | D | A | -1.4026 | |
| 120 | G | A | -1.8045 | |
| 121 | K | A | -2.7395 | |
| 122 | D | A | -2.8302 | |
| 123 | Y | A | 0.0000 | |
| 124 | I | A | 0.0000 | |
| 125 | A | A | -0.8563 | |
| 126 | L | A | 0.0000 | |
| 127 | N | A | -1.8945 | |
| 128 | E | A | -2.9774 | |
| 129 | D | A | -2.6442 | |
| 130 | L | A | 0.0000 | |
| 131 | R | A | -3.4474 | |
| 132 | S | A | -2.2056 | |
| 133 | W | A | 0.0000 | |
| 134 | T | A | -0.6861 | |
| 135 | A | A | -0.6896 | |
| 136 | A | A | -0.8187 | |
| 137 | D | A | -0.3200 | |
| 138 | M | A | 0.7745 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | Q | A | -1.0868 | |
| 142 | I | A | -0.1058 | |
| 143 | T | A | 0.0000 | |
| 144 | K | A | -1.9733 | |
| 145 | R | A | -2.9547 | |
| 146 | K | A | -2.2089 | |
| 147 | W | A | 0.0000 | |
| 148 | E | A | -3.4023 | |
| 149 | A | A | -1.8524 | |
| 150 | A | A | -1.6680 | |
| 151 | H | A | -2.7761 | |
| 152 | E | A | -2.1497 | |
| 153 | A | A | 0.0000 | |
| 154 | E | A | -3.1687 | |
| 155 | Q | A | -2.0384 | |
| 156 | L | A | 0.0000 | |
| 157 | R | A | -2.1838 | |
| 158 | A | A | -1.2878 | |
| 159 | Y | A | 0.0000 | |
| 160 | L | A | 0.0000 | |
| 161 | D | A | -1.9265 | |
| 162 | G | A | -1.0964 | |
| 163 | T | A | -0.9582 | |
| 164 | C | A | 0.0000 | |
| 165 | V | A | 0.0000 | |
| 166 | E | A | -1.9828 | |
| 167 | W | A | -1.2262 | |
| 168 | L | A | 0.0000 | |
| 169 | R | A | -2.8138 | |
| 170 | R | A | -2.6543 | |
| 171 | Y | A | 0.0000 | |
| 172 | L | A | 0.0000 | |
| 173 | E | A | -3.9039 | |
| 174 | N | A | -3.4806 | |
| 175 | G | A | 0.0000 | |
| 176 | K | A | -4.5157 | |
| 177 | E | A | -3.9540 | |
| 178 | T | A | -2.8029 | |
| 179 | L | A | 0.0000 | |
| 180 | Q | A | -3.5705 | |
| 181 | R | A | -3.4346 | |
| 182 | T | A | -2.0798 | |
| 183 | D | A | -1.5084 | |
| 184 | P | A | -1.1478 | |
| 185 | P | A | 0.0000 | |
| 186 | K | A | -1.8548 | |
| 187 | T | A | -1.0124 | |
| 188 | H | A | -0.8917 | |
| 189 | M | A | -0.3820 | |
| 190 | T | A | -0.7203 | |
| 191 | H | A | -0.7965 | |
| 192 | H | A | -0.7706 | |
| 193 | P | A | -0.3295 | |
| 194 | I | A | 1.0133 | |
| 195 | S | A | -0.8226 | |
| 196 | D | A | -2.2944 | |
| 197 | H | A | -2.1400 | |
| 198 | E | A | -1.2131 | |
| 199 | A | A | 0.0000 | |
| 200 | T | A | 0.4063 | |
| 201 | L | A | 0.0000 | |
| 202 | R | A | -0.2657 | |
| 203 | C | A | 0.0000 | |
| 204 | W | A | -0.3710 | |
| 205 | A | A | 0.0000 | |
| 206 | L | A | -0.7183 | |
| 207 | G | A | -1.0079 | |
| 208 | F | A | 0.0000 | |
| 209 | Y | A | 0.0000 | |
| 210 | P | A | -1.6608 | |
| 211 | A | A | -1.3238 | |
| 212 | E | A | -2.1858 | |
| 213 | I | A | -1.2317 | |
| 214 | T | A | -0.6479 | |
| 215 | L | A | 0.0000 | |
| 216 | T | A | -0.7417 | |
| 217 | W | A | 0.0000 | |
| 218 | Q | A | -2.7308 | |
| 219 | R | A | -3.2521 | |
| 220 | D | A | -3.2806 | |
| 221 | G | A | -2.9179 | |
| 222 | E | A | -3.6630 | |
| 223 | D | A | -3.7608 | |
| 224 | Q | A | -2.7172 | |
| 225 | T | A | -2.2779 | |
| 226 | Q | A | -2.7148 | |
| 227 | D | A | -2.6706 | |
| 228 | T | A | -1.8779 | |
| 229 | E | A | -1.6580 | |
| 230 | L | A | -0.1486 | |
| 231 | V | A | -0.1343 | |
| 232 | E | A | -0.3466 | |
| 233 | T | A | -0.2719 | |
| 234 | R | A | 0.0000 | |
| 235 | P | A | -0.6196 | |
| 236 | A | A | 0.0000 | |
| 237 | G | A | -1.3175 | |
| 238 | D | A | -2.2478 | |
| 239 | G | A | -1.5735 | |
| 240 | T | A | -0.9507 | |
| 241 | F | A | -0.5907 | |
| 242 | Q | A | 0.0000 | |
| 243 | K | A | 0.1769 | |
| 244 | W | A | -0.0083 | |
| 245 | A | A | 0.0000 | |
| 246 | A | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | V | A | 1.0778 | |
| 249 | V | A | 0.0000 | |
| 250 | P | A | -0.9760 | |
| 251 | S | A | -1.3608 | |
| 252 | G | A | -1.6339 | |
| 253 | E | A | -1.5417 | |
| 254 | E | A | -1.4661 | |
| 255 | Q | A | -2.3320 | |
| 256 | R | A | -2.5393 | |
| 257 | Y | A | 0.0000 | |
| 258 | T | A | 0.0000 | |
| 259 | C | A | 0.0000 | |
| 260 | H | A | -0.7164 | |
| 261 | V | A | 0.0000 | |
| 262 | Q | A | -1.6481 | |
| 263 | H | A | 0.0000 | |
| 264 | E | A | -2.6806 | |
| 265 | G | A | -1.9145 | |
| 266 | L | A | -1.3491 | |
| 267 | P | A | -1.4519 | |
| 268 | K | A | -2.1417 | |
| 269 | P | A | -1.4375 | |
| 270 | L | A | -0.4982 | |
| 271 | T | A | -0.5183 | |
| 272 | L | A | -0.5409 | |
| 273 | R | A | -1.8486 | |
| 274 | W | A | -0.8672 | |
| 1 | A | B | -1.2498 | |
| 2 | Q | B | -1.4141 | |
| 3 | R | B | -1.0735 | |
| 4 | T | B | -0.6268 | |
| 5 | P | B | 0.0000 | |
| 6 | K | B | -1.5897 | |
| 7 | I | B | -0.6382 | |
| 8 | Q | B | 0.0000 | |
| 9 | V | B | -0.3832 | |
| 10 | Y | B | 0.0000 | |
| 11 | S | B | -1.0444 | |
| 12 | R | B | -1.3178 | |
| 13 | H | B | -1.7086 | |
| 14 | P | B | -1.5929 | |
| 15 | A | B | -2.3319 | |
| 16 | E | B | -3.4751 | |
| 17 | N | B | -3.2142 | |
| 18 | G | B | -2.4766 | |
| 19 | K | B | -2.8392 | |
| 20 | S | B | -2.0100 | |
| 21 | N | B | -1.8055 | |
| 22 | F | B | -1.0572 | |
| 23 | L | B | 0.0000 | |
| 24 | N | B | 0.0000 | |
| 25 | C | B | 0.0000 | |
| 26 | Y | B | 0.0000 | |
| 27 | V | B | 0.0000 | |
| 28 | S | B | 0.0000 | |
| 29 | G | B | -0.9397 | |
| 30 | F | B | 0.0000 | |
| 31 | H | B | 0.0000 | |
| 32 | P | B | -0.8086 | |
| 33 | S | B | -1.0012 | |
| 34 | D | B | -1.8385 | |
| 35 | I | B | -1.2896 | |
| 36 | E | B | -2.3065 | |
| 37 | V | B | -1.4974 | |
| 38 | D | B | -2.0006 | |
| 39 | L | B | 0.0000 | |
| 40 | L | B | 0.0000 | |
| 41 | K | B | -2.7365 | |
| 42 | N | B | -3.1276 | |
| 43 | G | B | -2.7881 | |
| 44 | E | B | -3.7311 | |
| 45 | R | B | -3.9126 | |
| 46 | I | B | -2.6968 | |
| 47 | E | B | -3.3150 | |
| 48 | K | B | -3.1403 | |
| 49 | V | B | -2.4351 | |
| 50 | E | B | -2.8380 | |
| 51 | H | B | -1.7027 | |
| 52 | S | B | -0.9571 | |
| 53 | D | B | -0.6717 | |
| 54 | L | B | 0.0000 | |
| 55 | S | B | 0.0000 | |
| 56 | F | B | 0.0000 | |
| 57 | S | B | -1.2066 | |
| 58 | K | B | -2.2579 | |
| 59 | D | B | -2.2701 | |
| 60 | W | B | 0.0000 | |
| 61 | S | B | 0.0000 | |
| 62 | F | B | 0.0000 | |
| 63 | Y | B | -0.0258 | |
| 64 | L | B | 0.0000 | |
| 65 | L | B | 0.0000 | |
| 66 | Y | B | -0.7305 | |
| 67 | Y | B | -1.1065 | |
| 68 | T | B | 0.0000 | |
| 69 | E | B | -2.1536 | |
| 70 | F | B | 0.0000 | |
| 71 | T | B | -1.6322 | |
| 72 | P | B | 0.0000 | |
| 73 | T | B | -2.6727 | |
| 74 | E | B | -3.3691 | |
| 75 | K | B | -3.1237 | |
| 76 | D | B | -2.4825 | |
| 77 | E | B | -2.8540 | |
| 78 | Y | B | 0.0000 | |
| 79 | A | B | 0.0000 | |
| 80 | C | B | 0.0000 | |
| 81 | R | B | -2.3069 | |
| 82 | V | B | 0.0000 | |
| 83 | N | B | -1.6633 | |
| 84 | H | B | 0.0000 | |
| 85 | V | B | 0.8304 | |
| 86 | T | B | 0.3150 | |
| 87 | L | B | -0.1534 | |
| 88 | S | B | -0.5884 | |
| 89 | Q | B | -1.3227 | |
| 90 | P | B | -1.4957 | |
| 91 | K | B | -1.6482 | |
| 92 | I | B | -0.6474 | |
| 93 | V | B | -0.7797 | |
| 94 | K | B | -2.3160 | |
| 95 | W | B | 0.0000 | |
| 96 | D | B | -3.4590 | |
| 97 | R | B | -3.3309 | |
| 98 | D | B | -3.1317 | |
| 1 | K | C | 0.0000 | |
| 2 | L | C | 0.0000 | |
| 3 | I | C | 0.0000 | |
| 4 | E | C | -1.7497 | |
| 5 | T | C | -0.6518 | |
| 6 | Y | C | -0.1119 | |
| 7 | F | C | 0.1998 | |
| 8 | S | C | 0.0191 | |
| 9 | K | C | 0.0000 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine