| Chain sequence(s) |
A: QVQLQESGPGLVKPSETLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEVHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6580 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1233 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8529 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.7712 | |
| 8 | G | A | -0.6200 | |
| 9 | P | A | -0.6446 | |
| 10 | G | A | -0.5350 | |
| 11 | L | A | -0.5078 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -2.1552 | |
| 14 | P | A | -1.4478 | |
| 15 | S | A | -1.2316 | |
| 16 | E | A | -1.5760 | |
| 17 | T | A | -1.2457 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.9556 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.6963 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1449 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3047 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8557 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2070 | |
| 31 | S | A | 0.0149 | |
| 32 | G | A | 0.1264 | |
| 33 | Y | A | 0.1765 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8016 | |
| 40 | P | A | -0.9910 | |
| 41 | P | A | -1.1109 | |
| 42 | G | A | -1.4999 | |
| 43 | K | A | -2.3779 | |
| 44 | G | A | -1.5503 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6570 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0432 | |
| 53 | Y | A | 0.5855 | |
| 54 | S | A | -0.4379 | |
| 55 | G | A | -0.9415 | |
| 56 | D | A | -1.5432 | |
| 57 | T | A | -0.3320 | |
| 58 | Y | A | 0.8098 | |
| 59 | Y | A | 0.5243 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -0.8685 | |
| 62 | S | A | -1.1332 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0189 | |
| 65 | S | A | -1.2796 | |
| 66 | R | A | -1.3890 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.6046 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.6305 | |
| 71 | V | A | -0.2924 | |
| 72 | D | A | -1.1888 | |
| 73 | T | A | -1.1487 | |
| 74 | S | A | -1.3409 | |
| 75 | K | A | -2.1423 | |
| 76 | N | A | -1.4597 | |
| 77 | Q | A | -1.2633 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.5284 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.6854 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -1.0237 | |
| 84 | S | A | -0.9014 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.5506 | |
| 87 | A | A | -0.2069 | |
| 88 | A | A | 0.0288 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0316 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.1147 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6540 | |
| 98 | Y | A | -0.0569 | |
| 99 | G | A | -0.0785 | |
| 100 | S | A | -0.0784 | |
| 101 | Y | A | 0.2730 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4264 | |
| 105 | Y | A | -0.7894 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8498 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.5053 | |
| 111 | T | A | -0.2254 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.3040 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.8333 | |
| 116 | S | A | -0.9407 | |
| 117 | A | A | -0.5492 | |
| 118 | S | A | -0.6645 | |
| 119 | T | A | -0.7614 | |
| 120 | K | A | -1.2040 | |
| 121 | G | A | -1.3221 | |
| 122 | P | A | -0.6133 | |
| 123 | S | A | -0.4657 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3364 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.9000 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4628 | |
| 131 | S | A | -0.5479 | |
| 132 | R | A | -0.8972 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8919 | |
| 135 | S | A | -1.3611 | |
| 136 | E | A | -2.0794 | |
| 137 | S | A | -1.3122 | |
| 138 | T | A | -0.9408 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.2820 | |
| 147 | D | A | -0.3690 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.5942 | |
| 152 | P | A | -0.7037 | |
| 153 | V | A | -0.6269 | |
| 154 | T | A | -0.5315 | |
| 155 | V | A | -0.3204 | |
| 156 | S | A | -0.4534 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0246 | |
| 159 | S | A | -0.7673 | |
| 160 | G | A | -0.5950 | |
| 161 | A | A | -0.2860 | |
| 162 | L | A | -0.1403 | |
| 163 | T | A | -0.2494 | |
| 164 | S | A | -0.2757 | |
| 165 | G | A | -0.3877 | |
| 166 | V | A | 0.0669 | |
| 167 | H | A | -0.2387 | |
| 168 | T | A | -0.0046 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.3253 | |
| 171 | A | A | 0.2744 | |
| 172 | V | A | 0.6499 | |
| 173 | L | A | 1.3583 | |
| 174 | Q | A | 0.3537 | |
| 175 | S | A | -0.0021 | |
| 176 | S | A | -0.1599 | |
| 177 | G | A | 0.1238 | |
| 178 | L | A | 0.2188 | |
| 179 | Y | A | 0.4988 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1894 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6409 | |
| 189 | S | A | -0.6897 | |
| 190 | S | A | -0.5503 | |
| 191 | S | A | -0.6623 | |
| 192 | L | A | -0.8221 | |
| 193 | G | A | -1.1719 | |
| 194 | T | A | -0.8980 | |
| 195 | K | A | -1.6280 | |
| 196 | T | A | -1.4888 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7300 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.8003 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.7006 | |
| 205 | P | A | -1.6602 | |
| 206 | S | A | -1.8341 | |
| 207 | N | A | -2.5178 | |
| 208 | T | A | -2.0484 | |
| 209 | K | A | -2.6455 | |
| 210 | V | A | -2.0005 | |
| 211 | D | A | -2.9376 | |
| 212 | K | A | -2.7203 | |
| 213 | R | A | -3.1227 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6261 | |
| 216 | S | A | -1.1034 | |
| 217 | D | B | -1.2309 | |
| 218 | I | B | -0.2006 | |
| 219 | V | B | 0.7416 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.5056 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3595 | |
| 224 | P | B | -0.2236 | |
| 225 | L | B | 0.0516 | |
| 226 | S | B | -0.4998 | |
| 227 | L | B | -0.6291 | |
| 228 | S | B | -0.9505 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6787 | |
| 231 | P | B | -2.0153 | |
| 232 | G | B | -1.8895 | |
| 233 | Q | B | -2.2977 | |
| 234 | P | B | -2.0890 | |
| 235 | A | B | -1.2556 | |
| 236 | S | B | -0.7693 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8850 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -2.1231 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8590 | |
| 243 | Q | B | -1.3824 | |
| 244 | S | B | -0.7227 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.5209 | |
| 247 | H | B | -0.6043 | |
| 248 | S | B | -0.9348 | |
| 249 | N | B | -1.6460 | |
| 250 | G | B | -1.1394 | |
| 251 | N | B | -0.9772 | |
| 252 | T | B | -0.2756 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1713 | |
| 260 | K | B | -1.7578 | |
| 261 | P | B | -1.4360 | |
| 262 | G | B | -1.6449 | |
| 263 | Q | B | -2.0417 | |
| 264 | S | B | -1.4115 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.3404 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4936 | |
| 271 | K | B | -0.9089 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9366 | |
| 274 | N | B | -1.2348 | |
| 275 | R | B | -1.7422 | |
| 276 | F | B | -0.6662 | |
| 277 | S | B | -0.5855 | |
| 278 | G | B | -0.8189 | |
| 279 | V | B | -0.9034 | |
| 280 | P | B | -1.2926 | |
| 281 | D | B | -2.2301 | |
| 282 | R | B | -2.0143 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3075 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7751 | |
| 287 | G | B | -0.9680 | |
| 288 | S | B | -0.6447 | |
| 289 | G | B | -0.6161 | |
| 290 | T | B | -1.3640 | |
| 291 | D | B | -1.9872 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9884 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5597 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2541 | |
| 298 | R | B | -3.0092 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.4132 | |
| 301 | A | B | -2.3252 | |
| 302 | E | B | -2.3105 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.8037 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.0743 | |
| 315 | V | B | 0.8833 | |
| 316 | P | B | 0.3489 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | 0.1182 | |
| 319 | F | B | 0.1184 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.3061 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.7951 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.6784 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.5879 | |
| 329 | R | B | -1.2060 | |
| 330 | T | B | -0.0831 | |
| 331 | V | B | 0.2939 | |
| 332 | A | B | -0.0848 | |
| 333 | A | B | -0.1568 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1238 | |
| 336 | V | B | -0.1541 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6887 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.5210 | |
| 343 | D | B | -2.9757 | |
| 344 | E | B | -2.7865 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.1522 | |
| 347 | K | B | -2.7274 | |
| 348 | S | B | -1.7544 | |
| 349 | G | B | -1.0917 | |
| 350 | T | B | -1.1008 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.1598 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.8117 | |
| 363 | R | B | -3.1804 | |
| 364 | E | B | -3.3048 | |
| 365 | A | B | -2.4295 | |
| 366 | K | B | -2.6490 | |
| 367 | V | B | -1.3759 | |
| 368 | Q | B | -1.2267 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.9397 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -1.8440 | |
| 373 | N | B | -1.6988 | |
| 374 | A | B | -0.4140 | |
| 375 | L | B | 0.5792 | |
| 376 | Q | B | -0.3163 | |
| 377 | S | B | -0.5595 | |
| 378 | G | B | -0.9001 | |
| 379 | N | B | -0.8061 | |
| 380 | S | B | -1.1390 | |
| 381 | Q | B | -1.2834 | |
| 382 | E | B | -1.5194 | |
| 383 | S | B | -0.6791 | |
| 384 | V | B | -0.7419 | |
| 385 | T | B | -1.2715 | |
| 386 | E | B | -2.3507 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.4750 | |
| 389 | S | B | -2.5540 | |
| 390 | K | B | -3.0566 | |
| 391 | D | B | -2.7750 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.5657 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4552 | |
| 402 | L | B | -0.7652 | |
| 403 | S | B | -0.9887 | |
| 404 | K | B | -1.6289 | |
| 405 | A | B | -1.1865 | |
| 406 | D | B | -1.6505 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -1.8484 | |
| 409 | V | B | -0.3059 | |
| 410 | H | B | -1.7060 | |
| 411 | K | B | -2.7110 | |
| 412 | V | B | -1.8302 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.9439 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -1.1100 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.3510 | |
| 419 | H | B | -1.6201 | |
| 420 | Q | B | -1.8214 | |
| 421 | G | B | -0.5149 | |
| 422 | L | B | -0.3093 | |
| 423 | S | B | -0.4522 | |
| 424 | S | B | -0.4421 | |
| 425 | P | B | -0.5788 | |
| 426 | V | B | 0.0982 | |
| 427 | T | B | -0.4705 | |
| 428 | K | B | -0.7028 | |
| 429 | S | B | -0.9686 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.5124 | |
| 432 | R | B | -2.4495 | |
| 433 | G | B | -2.2254 | |
| 434 | E | B | -2.2147 | |
| 435 | C | B | -0.7049 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine