Project name: ER_monomer

Chain sequence(s)	A: SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.2578
• Maximal score value: 1.9124
• Average score: -0.6006
• Total score value: -141.1483

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
305	S	A	0.5446
306	L	A	1.3361
307	A	A	0.0000
308	L	A	0.1321
309	S	A	0.3052
310	L	A	0.0000
311	T	A	-1.1706
312	A	A	-1.6844
313	D	A	-2.3569
314	Q	A	-1.9067
315	M	A	0.0000
316	V	A	0.0000
317	S	A	-1.2109
318	A	A	-1.5010
319	L	A	0.0000
320	L	A	-0.8344
321	D	A	-2.2297
322	A	A	0.0000
323	E	A	-2.3150
324	P	A	-0.7962
325	P	A	0.3703
326	I	A	1.9124
327	L	A	1.1519
328	Y	A	0.9735
329	S	A	-0.2251
330	E	A	-1.5821
337	F	A	1.7413
338	S	A	0.3288
339	E	A	-0.6483
340	A	A	-0.1352
341	S	A	0.4660
342	M	A	0.0000
343	M	A	0.0000
344	G	A	0.2671
345	L	A	0.1750
346	L	A	0.0882
347	T	A	0.0000
348	N	A	-0.2956
349	L	A	0.0000
350	A	A	-0.0310
351	D	A	-0.3412
352	R	A	-0.2585
353	E	A	-0.0470
354	L	A	0.0000
355	V	A	0.8058
356	H	A	-0.0694
357	M	A	0.0000
358	I	A	0.1174
359	N	A	-1.3321
360	W	A	0.0000
361	A	A	0.0000
362	K	A	-1.7465
363	R	A	-2.5777
364	V	A	0.0000
365	P	A	0.0000
366	G	A	0.0000
367	F	A	0.0000
368	V	A	0.6787
369	D	A	-0.2885
370	L	A	0.0000
371	T	A	0.2267
372	L	A	1.2715
373	H	A	-0.0634
374	D	A	0.0826
375	Q	A	0.0000
376	V	A	0.6416
377	H	A	0.0635
378	L	A	0.0000
379	L	A	0.0000
380	E	A	-0.8078
381	C	A	-0.1093
382	A	A	0.0000
383	W	A	0.0000
384	L	A	-0.1093
385	E	A	0.0000
386	I	A	0.0000
387	L	A	0.1644
388	M	A	0.0000
389	I	A	0.0000
390	G	A	0.0525
391	L	A	0.0000
392	V	A	0.0000
393	W	A	-0.2887
394	R	A	-0.2767
395	S	A	0.0000
396	M	A	-1.3755
397	E	A	-2.2006
398	H	A	-1.6571
399	P	A	-1.4769
400	G	A	-1.6586
401	K	A	-1.8562
402	L	A	0.0000
403	L	A	-0.2961
404	F	A	0.6080
405	A	A	0.0000
406	P	A	0.1392
407	N	A	-0.9775
408	L	A	0.0000
409	L	A	-0.1090
410	L	A	0.0000
411	D	A	-2.1342
412	R	A	-2.7670
413	N	A	-2.6996
414	Q	A	-1.6410
415	G	A	0.0000
416	K	A	-2.9353
417	C	A	-1.0546
418	V	A	0.0000
419	E	A	-2.4850
420	G	A	-1.7809
421	M	A	0.0000
422	V	A	-2.0885
423	E	A	-2.5927
424	I	A	0.0000
425	F	A	0.0000
426	D	A	-1.8876
427	M	A	-0.9432
428	L	A	0.0000
429	L	A	0.0000
430	A	A	-0.6817
431	T	A	0.0000
432	S	A	0.0000
433	S	A	-0.9352
434	R	A	-1.1978
435	F	A	0.0000
436	R	A	-1.1804
437	M	A	0.0599
438	M	A	-0.6757
439	N	A	-1.4501
440	L	A	0.0000
441	Q	A	-1.5525
442	G	A	-0.9054
443	E	A	-0.8217
444	E	A	0.0000
445	F	A	0.0000
446	V	A	0.0000
447	C	A	0.0000
448	L	A	0.0000
449	K	A	-0.1365
450	S	A	0.0000
451	I	A	0.0000
452	I	A	0.0000
453	L	A	0.0000
454	L	A	0.0000
455	N	A	-0.5207
456	S	A	-0.2556
457	G	A	0.0000
458	V	A	0.0000
459	Y	A	1.2401
460	T	A	0.7434
461	F	A	0.5391
465	T	A	0.2320
466	L	A	0.6572
467	K	A	-1.4160
468	S	A	-0.5059
469	L	A	-0.1266
470	E	A	-2.2554
471	E	A	0.0000
472	K	A	-1.7404
473	D	A	-3.2199
474	H	A	-2.6054
475	I	A	0.0000
476	H	A	-2.9419
477	R	A	-3.2578
478	V	A	0.0000
479	L	A	-2.1666
480	D	A	-3.0367
481	K	A	-2.1550
482	I	A	0.0000
483	T	A	-1.6107
484	D	A	-2.2391
485	T	A	0.0000
486	L	A	0.0000
487	I	A	-0.4690
488	H	A	-1.2387
489	L	A	-1.1163
490	M	A	0.0000
491	A	A	-0.6324
492	K	A	-1.6847
493	A	A	-0.8335
494	G	A	-0.7922
495	L	A	-0.5728
496	T	A	-0.3345
497	L	A	0.2385
498	Q	A	-1.6217
499	Q	A	-1.9805
500	Q	A	-1.3092
501	H	A	-1.9553
502	Q	A	-2.3296
503	R	A	-1.3321
504	L	A	-0.6506
505	A	A	-0.3121
506	Q	A	-0.2758
507	L	A	0.0000
508	L	A	1.1648
509	L	A	1.5807
510	I	A	0.0000
511	L	A	0.1623
512	S	A	-0.3854
513	H	A	-1.0363
514	I	A	0.0000
515	R	A	-1.9998
516	H	A	-2.0929
517	M	A	0.0000
518	S	A	0.0000
519	N	A	-2.7495
520	K	A	-2.6115
521	G	A	0.0000
522	M	A	0.0000
523	E	A	-2.7034
524	H	A	-1.5605
525	L	A	0.0000
526	Y	A	-1.1658
527	S	A	-1.0637
528	M	A	0.0000
529	K	A	-0.9511
530	C	A	-0.6083
531	K	A	-1.8569
532	N	A	-1.6205
533	V	A	-0.7736
534	V	A	-0.0677
535	P	A	0.3670
536	L	A	1.0036
537	Y	A	-0.1196
538	D	A	-1.5657
539	L	A	-1.0483
540	L	A	0.0000
541	L	A	-1.4089
542	E	A	-2.8116
543	M	A	0.0000
544	L	A	0.0000
545	D	A	-3.1431
546	A	A	-2.0796
547	H	A	-2.5964
548	R	A	-2.8732