Project name: 1561b1c50e6685d

Chain sequence(s)	A: MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2699
• Maximal score value: 4.1018
• Average score: 0.1192
• Total score value: 41.9652

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.8710
2	D	A	-0.0891
3	Y	A	-0.1470
4	Q	A	0.3032
5	V	A	1.4343
6	S	A	0.0084
7	S	A	0.0000
8	P	A	0.4263
9	I	A	1.2499
10	Y	A	1.3422
11	D	A	0.4649
12	I	A	0.2058
13	N	A	0.2050
14	Y	A	1.2784
15	Y	A	0.9465
16	T	A	-0.1749
17	S	A	-0.6546
18	E	A	-1.5219
19	P	A	-1.1923
20	C	A	-0.8862
21	Q	A	-1.6929
22	K	A	-1.7168
23	I	A	-0.7366
24	N	A	-0.8987
25	V	A	0.0000
26	K	A	-2.2638
27	Q	A	-1.3976
28	I	A	0.2903
29	A	A	-0.1307
30	A	A	-0.8546
31	R	A	-1.0649
32	L	A	0.8619
33	L	A	0.0000
34	P	A	0.1717
35	P	A	0.4057
36	L	A	1.2284
37	Y	A	0.0000
38	S	A	1.4820
39	L	A	2.7829
40	V	A	0.0000
41	F	A	2.8214
42	I	A	3.9461
43	F	A	3.4726
44	G	A	0.0000
45	F	A	3.1218
46	V	A	3.2507
47	G	A	0.0000
48	N	A	0.0000
49	M	A	1.8338
50	L	A	1.6210
51	V	A	0.0000
52	I	A	1.2310
53	L	A	0.8708
54	I	A	0.0000
55	L	A	0.0000
56	I	A	-0.1132
57	N	A	-1.1217
58	C	A	-0.4994
59	K	A	-1.4551
60	R	A	-2.1551
61	L	A	-1.1233
62	K	A	-1.8167
63	S	A	-0.8677
64	M	A	0.0000
65	T	A	-0.1107
66	D	A	0.0000
67	I	A	0.0000
68	Y	A	0.0000
69	L	A	0.0000
70	L	A	0.7166
71	N	A	0.0000
72	L	A	0.0000
73	A	A	0.0000
74	I	A	0.8966
75	S	A	0.0000
76	D	A	0.0000
77	L	A	1.1603
78	F	A	1.1880
79	F	A	0.0000
80	L	A	0.0000
81	L	A	1.3383
82	T	A	0.0000
83	V	A	0.0000
84	P	A	0.5150
85	F	A	0.4316
86	W	A	0.4196
87	A	A	0.2988
88	H	A	-0.2691
89	Y	A	0.0688
90	A	A	-0.2184
91	A	A	-0.5111
92	A	A	-0.5133
93	Q	A	-0.4796
94	W	A	0.0000
95	D	A	-1.6190
96	F	A	-0.4478
97	G	A	-1.2621
98	N	A	-1.8667
99	T	A	-0.5014
100	M	A	-0.0134
101	C	A	0.0000
102	Q	A	0.1618
103	L	A	1.1101
104	L	A	0.0000
105	T	A	0.0000
106	G	A	0.0000
107	L	A	1.1202
108	Y	A	0.0000
109	F	A	0.7009
110	I	A	1.3529
111	G	A	0.0000
112	F	A	0.0000
113	F	A	0.0000
114	S	A	0.0000
115	G	A	0.1938
116	I	A	0.0000
117	F	A	0.0000
118	F	A	0.0000
119	I	A	0.0000
120	I	A	0.0000
121	L	A	0.5097
122	L	A	0.0000
123	T	A	0.0000
124	I	A	1.1510
125	D	A	0.0000
126	R	A	0.0000
127	Y	A	0.9133
128	L	A	1.2366
129	A	A	1.0159
130	V	A	0.6661
131	V	A	0.8188
132	H	A	1.2662
133	A	A	1.8385
134	V	A	2.9049
135	F	A	2.7945
136	A	A	0.0000
137	L	A	1.7133
138	K	A	-0.0540
139	A	A	0.6466
140	R	A	0.4013
141	T	A	0.4356
142	V	A	1.1438
143	T	A	1.7370
144	F	A	2.6019
145	G	A	0.0000
146	V	A	3.1894
147	V	A	3.5300
148	T	A	2.8711
149	S	A	0.0000
150	V	A	4.1018
151	I	A	4.0633
152	T	A	0.0000
153	W	A	2.8016
154	V	A	3.6760
155	V	A	3.5467
156	A	A	0.0000
157	V	A	2.8895
158	F	A	3.1801
159	A	A	0.0000
160	S	A	0.0000
161	L	A	2.0141
162	P	A	1.2641
163	G	A	0.0000
164	I	A	1.3462
165	I	A	1.6245
166	F	A	0.6882
167	T	A	0.0000
168	R	A	-1.7420
169	S	A	-2.2976
170	Q	A	-2.8669
171	K	A	-2.8317
172	E	A	-2.7595
173	G	A	-1.2903
174	L	A	0.2456
175	H	A	-1.1998
176	Y	A	-1.3764
177	T	A	-1.5155
178	C	A	-1.3163
179	S	A	-0.6763
180	S	A	-0.3626
181	H	A	-0.1629
182	F	A	0.4622
183	P	A	0.4235
184	Y	A	1.0601
185	S	A	0.2182
186	Q	A	-0.0382
187	Y	A	0.2960
188	Q	A	-0.0386
189	F	A	1.6224
190	W	A	1.1996
191	K	A	0.1532
192	N	A	0.8183
193	F	A	1.7817
194	Q	A	0.7796
195	T	A	0.0000
196	L	A	1.2346
197	K	A	0.5411
198	I	A	0.0000
199	V	A	0.0000
200	I	A	1.6856
201	L	A	1.1758
202	G	A	0.0000
203	L	A	1.6019
204	V	A	2.1135
205	L	A	2.1291
206	P	A	0.0000
207	L	A	3.0329
208	L	A	3.4201
209	V	A	2.7340
210	M	A	2.8408
211	V	A	3.5704
212	I	A	3.5086
213	C	A	0.0000
214	Y	A	0.0000
215	S	A	0.7802
216	G	A	0.4272
217	I	A	0.0000
218	L	A	0.1133
219	K	A	-1.2003
220	T	A	-0.3931
221	L	A	-0.4853
222	L	A	0.2515
223	R	A	-1.5979
224	C	A	-1.0430
225	R	A	-2.7795
226	N	A	-3.4549
227	E	A	-3.8709
228	K	A	-4.2699
229	K	A	-4.1200
230	R	A	-3.3562
231	H	A	-3.2921
232	R	A	-3.6621
233	A	A	-2.1820
234	V	A	0.0000
235	R	A	-2.3432
236	L	A	-0.7683
237	I	A	0.0000
238	F	A	0.1542
239	T	A	0.2742
240	I	A	0.0000
241	M	A	0.0000
242	I	A	1.8493
243	V	A	1.5028
244	Y	A	0.0000
245	F	A	1.6208
246	L	A	2.2147
247	F	A	1.4553
248	W	A	0.0000
249	A	A	1.1513
250	P	A	1.0107
251	Y	A	0.0000
252	N	A	0.0000
253	I	A	1.5658
254	V	A	0.0000
255	L	A	0.7797
256	L	A	1.0962
257	L	A	1.4069
258	N	A	0.2970
259	T	A	-0.0214
260	F	A	0.5242
261	Q	A	-0.0771
262	E	A	-0.8982
263	F	A	1.8210
264	F	A	2.0512
265	G	A	-0.0527
266	L	A	-0.5441
267	N	A	-1.8845
268	N	A	-2.1335
269	C	A	-1.0373
270	S	A	-0.7645
271	S	A	-1.0875
272	S	A	-1.4187
273	N	A	0.0000
274	R	A	-1.6041
275	L	A	0.0000
276	D	A	-1.0775
277	Q	A	-1.1654
278	A	A	-0.2418
279	M	A	0.0423
280	Q	A	0.0004
281	V	A	1.3921
282	T	A	0.7551
283	E	A	-0.0659
284	T	A	0.0000
285	L	A	1.0351
286	G	A	0.0000
287	M	A	0.0000
288	T	A	0.5045
289	H	A	0.0000
290	C	A	0.0000
291	C	A	0.0000
292	I	A	0.6433
293	N	A	0.0000
294	P	A	0.0000
295	I	A	1.3566
296	I	A	0.0000
297	Y	A	0.0000
298	A	A	0.3818
299	F	A	1.9587
300	V	A	0.3989
301	G	A	-1.0154
302	E	A	-1.7769
303	K	A	-2.7782
304	F	A	0.0000
305	R	A	-1.5865
306	N	A	-1.6164
307	Y	A	-0.1032
308	L	A	0.4749
309	L	A	1.5055
310	V	A	1.3246
311	F	A	1.1910
312	F	A	2.0356
313	Q	A	0.2691
314	K	A	-1.1794
315	H	A	-0.3698
316	I	A	0.9232
317	A	A	-0.5769
318	K	A	-2.5299
319	R	A	-1.8816
320	F	A	0.5471
321	C	A	-0.5848
322	K	A	-1.6744
323	C	A	-0.2186
324	C	A	0.2707
325	S	A	-0.3977
326	I	A	0.1967
327	F	A	-0.4918
328	Q	A	-1.7277
329	Q	A	-1.6628
330	E	A	-1.6463
331	A	A	-1.9678
332	P	A	-1.8029
333	E	A	-2.8661
334	R	A	-2.8027
335	A	A	0.0000
336	S	A	-1.2894
337	S	A	-1.4448
338	V	A	-0.3143
339	Y	A	-0.3803
340	T	A	-1.2886
341	R	A	-1.9679
342	S	A	-1.4081
343	T	A	-1.5000
344	G	A	-1.9215
345	E	A	-2.2164
346	Q	A	-1.7266
347	E	A	-1.6720
348	I	A	0.8201
349	S	A	0.5388
350	V	A	1.2141
351	G	A	1.0156
352	L	A	1.9868