Project name: ATIII

Chain sequence(s)	A: GSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.4261
• Maximal score value: 2.0887
• Average score: -1.0455
• Total score value: -450.5956

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	G	A	-0.7192
3	S	A	-0.5887
4	P	A	-0.3776
5	V	A	-0.4004
6	D	A	-1.5027
7	I	A	-0.9709
8	C	A	-1.1551
9	T	A	-0.7808
10	A	A	-1.8361
11	K	A	-3.0786
12	P	A	-2.4753
13	R	A	-3.3588
14	D	A	-3.0605
15	I	A	-1.6064
16	P	A	-1.2266
17	M	A	-0.7627
18	N	A	-0.7768
19	P	A	0.2723
20	M	A	1.0537
21	C	A	0.9306
22	I	A	1.2665
23	Y	A	-0.3998
24	R	A	-1.8593
25	S	A	-1.9636
26	P	A	-2.4377
27	E	A	-3.3620
28	K	A	-3.2752
29	K	A	-2.6495
30	A	A	-2.0310
31	T	A	-2.1396
32	E	A	-3.0873
33	D	A	-3.3367
34	E	A	-3.5930
35	G	A	-2.8542
36	S	A	-2.9152
37	E	A	-3.4025
38	Q	A	-2.9048
39	K	A	-3.1179
40	I	A	-2.1167
41	P	A	-1.7118
42	E	A	-2.2492
43	A	A	-1.1150
44	T	A	-1.2362
45	N	A	-1.5383
46	R	A	-1.9929
47	R	A	-1.6729
48	V	A	0.0000
49	W	A	-0.9476
50	E	A	-0.9358
51	L	A	0.0000
52	S	A	0.0000
53	K	A	-1.0998
54	A	A	0.0000
55	N	A	0.0000
56	S	A	-0.7777
57	R	A	-0.8473
58	F	A	0.0000
59	A	A	0.0000
60	T	A	0.0000
61	T	A	-0.6057
62	F	A	0.0000
63	Y	A	0.0000
64	Q	A	-1.7915
65	H	A	-1.9946
66	L	A	0.0000
67	A	A	-2.4496
68	D	A	-3.1345
69	S	A	-2.1374
70	K	A	-2.8764
71	N	A	-3.4047
72	D	A	-3.8046
73	N	A	-2.9939
74	D	A	-2.5605
75	N	A	-2.0818
76	I	A	0.0000
77	F	A	0.0000
78	L	A	0.0000
79	S	A	0.0000
80	P	A	0.0000
81	L	A	0.0000
82	S	A	0.0000
83	I	A	0.0000
84	S	A	0.0000
85	T	A	0.0000
86	A	A	0.0000
87	F	A	0.0000
88	A	A	0.0000
89	M	A	0.0000
90	T	A	0.0000
91	K	A	0.0000
92	L	A	0.0000
93	G	A	0.0000
94	A	A	0.0000
95	C	A	-0.9415
96	N	A	-2.4572
97	D	A	-3.0922
98	T	A	0.0000
99	L	A	0.0000
100	Q	A	-2.5338
101	Q	A	-2.0541
102	L	A	0.0000
103	M	A	0.0000
104	E	A	-2.6806
105	V	A	0.0000
106	F	A	0.0000
107	K	A	-1.5505
108	F	A	0.0000
109	D	A	-2.3976
110	T	A	-1.2417
111	I	A	0.0000
112	S	A	0.0000
113	E	A	0.0000
114	K	A	-2.4174
115	T	A	0.0000
116	S	A	0.0000
117	D	A	-1.1258
118	Q	A	-0.6593
119	I	A	0.0000
120	H	A	0.0000
121	F	A	0.0000
122	F	A	0.0000
123	F	A	0.0000
124	A	A	0.0000
125	K	A	-1.2307
126	L	A	0.0000
127	N	A	-1.0454
128	C	A	-1.7975
129	R	A	-2.6739
130	L	A	0.0000
131	Y	A	-1.5387
132	R	A	-3.1091
133	K	A	-3.3942
134	A	A	-2.2566
135	N	A	-2.7375
136	K	A	-2.7162
137	S	A	-1.6043
138	S	A	-2.1450
139	K	A	-1.6844
140	L	A	-0.5321
141	V	A	-0.2210
142	S	A	0.0548
143	A	A	0.0000
144	N	A	-0.3335
145	R	A	-0.4269
146	L	A	0.0000
147	F	A	0.0000
148	G	A	0.0000
149	D	A	0.0000
150	K	A	-1.9888
151	S	A	-1.4992
152	L	A	-1.5328
153	T	A	-1.2355
154	F	A	0.0000
155	N	A	-1.6347
156	E	A	-2.6493
157	T	A	-1.7718
158	Y	A	0.0000
159	Q	A	-2.4567
160	D	A	-2.9942
161	I	A	-1.6799
162	S	A	0.0000
163	E	A	-2.5303
164	L	A	-1.2425
165	V	A	0.0000
166	Y	A	-0.8602
167	G	A	-1.6208
168	A	A	-1.3248
169	K	A	-1.7874
170	L	A	0.0000
171	Q	A	-0.6276
172	P	A	-0.8447
173	L	A	-1.3198
174	D	A	-2.6656
175	F	A	0.0000
176	K	A	-3.4778
177	E	A	-3.7248
178	N	A	-3.4091
179	A	A	0.0000
180	E	A	-3.7375
181	Q	A	-2.6546
182	S	A	0.0000
183	R	A	-2.3970
184	A	A	-1.8560
185	A	A	-1.2716
186	I	A	0.0000
187	N	A	-1.7527
188	K	A	-2.4515
189	W	A	-1.4488
190	V	A	0.0000
191	S	A	-2.7650
192	N	A	-3.1409
193	K	A	-2.3988
194	T	A	0.0000
195	E	A	-3.1710
196	G	A	-2.8701
197	R	A	-2.7136
198	I	A	0.0000
199	T	A	-1.9377
200	D	A	-2.0270
201	V	A	0.0000
202	I	A	0.0000
203	P	A	-1.4024
204	S	A	-1.9027
205	E	A	-2.5666
206	A	A	-1.5757
207	I	A	0.0000
208	N	A	-2.8886
209	E	A	-3.1776
210	L	A	-0.2795
211	T	A	-0.3945
212	V	A	-0.5817
213	L	A	0.0000
214	V	A	0.0000
215	L	A	0.0000
216	V	A	0.0000
217	N	A	0.0000
218	T	A	0.0000
219	I	A	0.0000
220	Y	A	0.0000
221	F	A	0.0000
222	K	A	-0.9177
223	G	A	0.0000
224	L	A	-1.0653
225	W	A	0.0000
226	K	A	-2.0116
227	S	A	-1.7839
228	K	A	-1.7993
229	F	A	0.0000
230	S	A	-1.3065
231	P	A	-1.2612
232	E	A	-1.6612
233	N	A	-1.2790
234	T	A	0.0000
235	R	A	-0.6228
236	K	A	-0.7922
237	E	A	-0.8341
238	L	A	0.1378
239	F	A	0.0000
240	Y	A	-0.2497
241	K	A	-1.6508
242	A	A	-2.2236
243	D	A	-2.9416
244	G	A	-2.1169
245	E	A	-2.5071
246	S	A	-1.0258
247	C	A	0.0043
248	S	A	0.1711
249	A	A	0.0000
250	S	A	-0.2231
251	M	A	0.0000
252	M	A	0.0000
253	Y	A	-1.0836
254	Q	A	-1.4863
255	E	A	-2.0591
256	G	A	-1.7134
257	K	A	-2.3623
258	F	A	0.0000
259	R	A	-2.6449
260	Y	A	0.0000
261	R	A	-2.5699
262	R	A	-2.5315
263	V	A	-1.5963
264	A	A	-1.1512
265	E	A	-2.3458
266	G	A	-2.1052
267	T	A	0.0000
268	Q	A	-1.4487
269	V	A	0.0000
270	L	A	0.0000
271	E	A	0.0000
272	L	A	0.0000
273	P	A	-1.2746
274	F	A	0.0000
275	K	A	-2.4374
276	G	A	-2.2800
277	D	A	-2.1912
278	D	A	-1.9221
279	I	A	0.0000
280	T	A	0.0000
281	M	A	0.0000
282	V	A	0.0000
283	L	A	0.0000
284	I	A	0.0000
285	L	A	0.0000
286	P	A	0.0000
287	K	A	-2.6359
288	P	A	-1.8701
289	E	A	-2.5948
290	K	A	-2.4729
291	S	A	-1.7765
292	L	A	0.0000
293	A	A	-2.1816
294	K	A	-2.7315
295	V	A	0.0000
296	E	A	0.0000
297	K	A	-3.4224
298	E	A	-2.9442
299	L	A	0.0000
300	T	A	-1.3477
301	P	A	-1.5451
302	E	A	-2.3511
303	V	A	-1.4976
304	L	A	0.0000
305	Q	A	-2.5358
306	E	A	-3.3011
307	W	A	-2.4389
308	L	A	-2.4467
309	D	A	-3.5704
310	E	A	-3.9406
311	L	A	0.0000
312	E	A	-3.7402
313	E	A	-3.1559
314	M	A	-1.3540
315	M	A	-0.8037
316	L	A	0.0000
317	V	A	0.0000
318	V	A	0.0000
319	H	A	0.0000
320	M	A	0.0000
321	P	A	0.0000
322	R	A	-0.3642
323	F	A	0.0000
324	R	A	-1.4397
325	I	A	0.0000
326	E	A	-2.3231
327	D	A	-1.8089
328	G	A	-1.3972
329	F	A	-0.8921
330	S	A	-0.9705
331	L	A	0.0000
332	K	A	-1.7074
333	E	A	-2.6338
334	Q	A	-2.0577
335	L	A	0.0000
336	Q	A	-1.6809
337	D	A	-2.5300
338	M	A	-1.3182
339	G	A	-0.9203
340	L	A	0.0000
341	V	A	-0.3771
342	D	A	0.0000
343	L	A	0.0000
344	F	A	0.0000
345	S	A	-1.3498
346	P	A	-2.2810
347	E	A	-3.3867
348	K	A	-3.3397
349	S	A	0.0000
350	K	A	-2.5454
351	L	A	0.0000
352	P	A	-0.7099
353	G	A	0.0000
354	I	A	0.0000
355	V	A	0.0000
356	A	A	-1.7877
357	E	A	-3.5403
358	G	A	-2.8057
359	R	A	-3.6798
360	D	A	-4.4261
361	D	A	-4.2092
362	L	A	0.0000
363	Y	A	-1.1488
364	V	A	0.0000
365	S	A	0.1084
366	D	A	-0.5957
367	A	A	0.0000
368	F	A	0.0000
369	H	A	0.0000
370	K	A	-1.1531
371	A	A	0.0000
372	F	A	-1.2645
373	L	A	0.0000
374	E	A	-1.0050
375	V	A	0.0000
376	N	A	0.0000
377	E	A	0.0000
378	E	A	-0.9337
379	G	A	0.0000
380	S	A	0.0000
381	E	A	0.0000
382	A	A	-0.2287
383	A	A	-0.0207
384	A	A	-0.1409
385	S	A	0.1422
386	T	A	0.4853
387	A	A	0.9364
388	V	A	2.0887
389	V	A	1.2695
390	I	A	1.7013
391	A	A	0.3486
392	G	A	-0.4397
393	R	A	-0.4856
394	S	A	0.1231
395	L	A	0.9549
396	N	A	-0.2324
397	P	A	-0.9258
398	N	A	-1.8491
399	R	A	-1.4775
400	V	A	0.6661
401	T	A	0.1230
402	F	A	0.0000
403	K	A	-0.7120
404	A	A	0.0000
405	N	A	-0.3165
406	R	A	-0.5798
407	P	A	-0.7890
408	F	A	0.0000
409	L	A	0.0000
410	V	A	0.0000
411	F	A	0.0000
412	I	A	0.0000
413	R	A	0.0000
414	E	A	0.0000
415	V	A	-0.4914
416	P	A	-0.9033
417	L	A	0.0000
418	N	A	-0.5985
419	T	A	0.0000
420	I	A	0.0000
421	I	A	0.0000
422	F	A	0.0000
423	M	A	0.0000
424	G	A	0.0000
425	R	A	0.0000
426	V	A	0.0000
427	A	A	0.0000
428	N	A	-0.9917
429	P	A	-0.5286
430	C	A	0.0000
431	V	A	0.8590
432	K	A	-0.9402