Project name: TAU1

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7357
• Maximal score value: 2.7183
• Average score: -0.682
• Total score value: -516.991

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.3162
2	A	A	0.0246
3	E	A	-0.8430
4	P	A	-1.5110
5	R	A	-2.7188
6	Q	A	-2.6998
7	E	A	-2.2039
8	F	A	0.0618
9	E	A	-0.4322
10	V	A	0.8383
11	M	A	0.0791
12	E	A	-1.9734
13	D	A	-2.2538
14	H	A	-1.3976
15	A	A	-0.4897
16	G	A	-0.5835
17	T	A	-0.8197
18	Y	A	-1.3309
19	G	A	-1.1165
20	L	A	-1.3889
21	G	A	-1.7898
22	D	A	-2.5817
23	R	A	-3.2262
24	K	A	-3.7357
25	D	A	-3.4433
26	Q	A	-2.8383
27	G	A	-1.5762
28	G	A	-0.3865
29	Y	A	0.7465
30	T	A	0.0848
31	M	A	-0.6841
32	H	A	-2.2785
33	Q	A	-2.7157
34	D	A	-3.3162
35	Q	A	-3.2623
36	E	A	-2.9521
37	G	A	-3.0299
38	D	A	-3.5436
39	T	A	-2.2038
40	D	A	-2.3287
41	A	A	0.0000
42	G	A	-0.5715
43	L	A	-0.0846
44	K	A	0.0000
45	E	A	-1.7768
46	S	A	-1.1694
47	P	A	-0.2871
48	L	A	0.1275
49	Q	A	-0.4547
50	T	A	0.0000
51	P	A	-1.0711
52	T	A	0.0000
53	E	A	0.0000
54	D	A	-2.5247
55	G	A	-1.5393
56	S	A	0.0000
57	E	A	-1.3224
58	E	A	-1.4779
59	P	A	-1.4302
60	G	A	-1.2217
61	S	A	0.0000
62	E	A	-0.8196
63	T	A	-0.5859
64	S	A	-0.3651
65	D	A	-0.7577
66	A	A	0.0000
67	K	A	-0.8863
68	S	A	0.0000
69	T	A	0.0000
70	P	A	0.0000
71	T	A	-0.7662
72	A	A	-1.0536
73	E	A	-1.8719
74	D	A	-0.8762
75	V	A	0.0000
76	T	A	0.0000
77	A	A	-1.0655
78	P	A	-1.1554
79	L	A	0.0000
80	V	A	-1.6171
81	D	A	-2.5977
82	E	A	-2.8292
83	G	A	-1.7333
84	A	A	-1.0243
85	P	A	0.0000
86	G	A	0.0000
87	K	A	0.0000
88	Q	A	0.0000
89	A	A	-0.3006
90	A	A	-0.5213
91	A	A	-0.3997
92	Q	A	-1.1056
93	P	A	-1.1810
94	H	A	-1.4279
95	T	A	-1.5189
96	E	A	-2.0180
97	I	A	0.0000
98	P	A	-1.4899
99	E	A	-2.4197
100	G	A	-1.6947
101	T	A	0.0000
102	T	A	-1.0024
103	A	A	-0.8699
104	E	A	0.0000
105	E	A	-0.9420
106	A	A	-0.3300
107	G	A	-0.8543
108	I	A	-0.9016
109	G	A	-1.4746
110	D	A	-1.4279
111	T	A	-0.7168
112	P	A	-0.8106
113	S	A	-0.7796
114	L	A	0.0000
115	E	A	-0.6679
116	D	A	-0.6244
117	E	A	-0.7676
118	A	A	0.0000
119	A	A	-0.4261
120	G	A	-0.6299
121	H	A	-0.7334
122	V	A	-0.6007
123	T	A	-1.2420
124	Q	A	-1.7990
125	E	A	0.0000
126	P	A	0.0000
127	E	A	-2.0067
128	S	A	-1.0610
129	G	A	0.0000
130	K	A	-0.2948
131	V	A	0.8532
132	V	A	-0.0872
133	Q	A	-0.2513
134	E	A	-0.6019
135	G	A	-0.8223
136	F	A	-0.7982
137	L	A	0.0000
138	R	A	-2.5118
139	E	A	-2.3722
140	P	A	-0.9522
141	G	A	-0.9235
142	P	A	-0.7941
143	P	A	-0.5275
144	G	A	0.0000
145	L	A	0.0000
146	S	A	-0.3375
147	H	A	0.0000
148	Q	A	-0.1326
149	L	A	0.9586
150	M	A	0.5791
151	S	A	0.2516
152	G	A	0.2632
153	M	A	0.9138
154	P	A	0.9624
155	G	A	0.3368
156	A	A	0.5400
157	P	A	0.0000
158	L	A	1.4422
159	L	A	1.4487
160	P	A	0.0000
161	E	A	0.1402
162	G	A	-0.1118
163	P	A	-0.1653
164	R	A	0.0000
165	E	A	-1.0627
166	A	A	-0.5158
167	T	A	-0.6084
168	R	A	-0.4041
169	Q	A	0.0000
170	P	A	-0.0213
171	S	A	0.0000
172	G	A	0.1971
173	T	A	0.0000
174	G	A	-0.7986
175	P	A	-1.6741
176	E	A	-3.3358
177	D	A	-2.9023
178	T	A	-1.3715
179	E	A	0.0000
180	G	A	-1.6326
181	G	A	-0.7331
182	R	A	0.0000
183	H	A	-0.7596
184	A	A	0.6265
185	P	A	0.0000
186	E	A	0.0000
187	L	A	1.6109
188	L	A	1.1859
189	K	A	0.0368
190	H	A	-0.7380
191	Q	A	-0.8796
192	L	A	-0.1547
193	L	A	0.0000
194	G	A	-0.1565
195	D	A	0.0000
196	L	A	0.0187
197	H	A	0.0000
198	Q	A	-0.6567
199	E	A	0.0000
200	G	A	-1.2798
201	P	A	0.0000
202	P	A	0.0000
203	L	A	0.0000
204	K	A	-0.9549
205	G	A	-0.6788
206	A	A	-0.7001
207	G	A	-1.2392
208	G	A	-1.5137
209	K	A	-1.8146
210	E	A	-2.0164
211	R	A	-2.6591
212	P	A	-2.1563
213	G	A	0.0000
214	S	A	-2.1630
215	K	A	-2.4636
216	E	A	-3.1858
217	E	A	-3.0017
218	V	A	-1.9966
219	D	A	-2.3348
220	E	A	-2.8825
221	D	A	-2.0031
222	R	A	-1.6787
223	D	A	-1.2547
224	V	A	0.6189
225	D	A	0.0529
226	E	A	-0.4057
227	S	A	-0.5217
228	S	A	-0.5280
229	P	A	-0.4325
230	Q	A	-0.4184
231	D	A	0.0000
232	S	A	-0.4457
233	P	A	-0.4317
234	P	A	-0.4774
235	S	A	-0.3716
236	K	A	-0.6551
237	A	A	-1.0606
238	S	A	-0.9961
239	P	A	-1.0315
240	A	A	0.0000
241	Q	A	-1.5244
242	D	A	-2.1141
243	G	A	0.0000
244	R	A	0.0000
245	P	A	-1.3939
246	P	A	-1.3862
247	Q	A	-1.3163
248	T	A	0.0000
249	A	A	-0.4289
250	A	A	-0.7052
251	R	A	-1.5569
252	E	A	-1.6824
253	A	A	-1.4749
254	T	A	-1.4700
255	S	A	-1.2354
256	I	A	0.0000
257	P	A	-1.1449
258	G	A	0.0000
259	F	A	0.0000
260	P	A	0.0000
261	A	A	0.0000
262	E	A	0.0000
263	G	A	0.0000
264	A	A	0.0000
265	I	A	0.0000
266	P	A	0.0000
267	L	A	0.0000
268	P	A	0.0000
269	V	A	1.1253
270	D	A	-0.1414
271	F	A	0.0000
272	L	A	-0.4945
273	S	A	-1.0086
274	K	A	-1.7198
275	V	A	0.0000
276	S	A	0.0000
277	T	A	-1.4994
278	E	A	-1.6140
279	I	A	0.0000
280	P	A	-0.9332
281	A	A	-0.4268
282	S	A	-0.3533
283	E	A	0.0000
284	P	A	-1.2700
285	D	A	-2.1315
286	G	A	-1.9040
287	P	A	-1.5178
288	S	A	-1.2814
289	V	A	0.0000
290	G	A	-1.7350
291	R	A	-2.4349
292	A	A	-1.7121
293	K	A	0.0000
294	G	A	-1.8865
295	Q	A	-2.4937
296	D	A	-2.4198
297	A	A	-1.3106
298	P	A	-0.7400
299	L	A	-0.3088
300	E	A	0.0000
301	F	A	-0.7032
302	T	A	-0.7715
303	F	A	0.0000
304	H	A	-0.0071
305	V	A	-0.1260
306	E	A	-0.9794
307	I	A	1.1370
308	T	A	0.3497
309	P	A	-0.1862
310	N	A	0.0000
311	V	A	0.0000
312	Q	A	0.0000
313	K	A	-0.5454
314	E	A	-1.0655
315	Q	A	-1.6023
316	A	A	-1.4464
317	H	A	0.0000
318	S	A	-0.8404
319	E	A	-1.3611
320	E	A	-0.9370
321	H	A	-0.2974
322	L	A	0.4788
323	G	A	-0.6167
324	R	A	-0.1294
325	A	A	0.0401
326	A	A	-0.0403
327	F	A	0.0000
328	P	A	-0.6616
329	G	A	-0.2092
330	A	A	-1.0720
331	P	A	-1.4789
332	G	A	-1.6569
333	E	A	-2.6592
334	G	A	-2.0479
335	P	A	-1.7434
336	E	A	-2.3201
337	A	A	-1.4066
338	R	A	-1.6228
339	G	A	-1.2582
340	P	A	-0.9844
341	S	A	-0.6683
342	L	A	0.1102
343	G	A	-1.3009
344	E	A	-2.4217
345	D	A	-2.0342
346	T	A	-2.3212
347	K	A	-3.1253
348	E	A	-2.7426
349	A	A	-1.5349
350	D	A	-0.7385
351	L	A	0.0000
352	P	A	-1.2882
353	E	A	-0.8117
354	P	A	-0.8384
355	S	A	-1.9612
356	E	A	-2.9932
357	K	A	-3.1135
358	Q	A	-2.5906
359	P	A	-1.9371
360	A	A	-1.5531
361	A	A	-0.8989
362	A	A	-0.8556
363	P	A	-0.5405
364	R	A	-1.9630
365	G	A	-1.6533
366	K	A	-1.3191
367	P	A	-0.7977
368	V	A	0.0000
369	S	A	-0.7553
370	R	A	-1.0614
371	V	A	0.0000
372	P	A	-0.9481
373	Q	A	-0.9136
374	L	A	-0.3006
375	K	A	0.0000
376	A	A	-0.5342
377	R	A	-0.3950
378	M	A	0.0000
379	V	A	-0.8641
380	S	A	-1.6204
381	K	A	-2.4278
382	S	A	-2.0848
383	K	A	-2.4205
384	D	A	0.0000
385	G	A	-1.3651
386	T	A	-0.8162
387	G	A	-1.1611
388	S	A	-1.0643
389	D	A	0.0000
390	D	A	-1.3998
391	K	A	-1.9737
392	K	A	-1.4423
393	A	A	-1.3979
394	K	A	-2.3632
395	T	A	-1.2848
396	S	A	-0.7249
397	T	A	0.0000
398	R	A	-1.6984
399	S	A	-1.2310
400	S	A	0.0000
401	A	A	0.0000
402	K	A	-2.0867
403	T	A	-0.9548
404	L	A	-0.2307
405	K	A	-1.3180
406	N	A	-2.2745
407	R	A	-2.5055
408	P	A	-1.0290
409	C	A	0.4485
410	L	A	1.4423
411	S	A	0.2310
412	P	A	-0.2892
413	K	A	-0.9031
414	H	A	-1.2599
415	P	A	-1.0630
416	T	A	-1.1267
417	P	A	-0.6667
418	G	A	-1.1412
419	S	A	-0.9184
420	S	A	-1.3606
421	D	A	-2.0908
422	P	A	-1.3385
423	L	A	-0.8059
424	I	A	-1.1177
425	Q	A	-1.6401
426	P	A	-0.7192
427	S	A	0.0000
428	S	A	0.0000
429	P	A	-0.4203
430	A	A	0.1302
431	V	A	0.5148
432	C	A	0.1825
433	P	A	-0.1147
434	E	A	0.0000
435	P	A	-0.6230
436	P	A	-0.5519
437	S	A	-0.8113
438	S	A	-0.9670
439	P	A	0.0000
440	K	A	0.7195
441	Y	A	2.0012
442	V	A	2.7183
443	S	A	1.4597
444	S	A	1.4536
445	V	A	2.1612
446	T	A	0.9279
447	S	A	0.1275
448	R	A	-0.3793
449	T	A	-0.1985
450	G	A	-0.5053
451	S	A	0.0000
452	S	A	-0.8886
453	G	A	-1.0218
454	A	A	-1.0772
455	K	A	-1.8886
456	E	A	-1.4718
457	M	A	-0.4108
458	K	A	-0.6349
459	L	A	-0.3526
460	K	A	-0.5434
461	G	A	0.0000
462	A	A	-0.7209
463	D	A	-0.9526
464	G	A	-0.6562
465	K	A	-0.9678
466	T	A	-0.8299
467	K	A	-0.7420
468	I	A	0.5228
469	A	A	-0.5281
470	T	A	-0.8449
471	P	A	-1.1961
472	R	A	-2.0153
473	G	A	-1.1714
474	A	A	-0.9494
475	A	A	-1.0126
476	P	A	-0.8792
477	P	A	-0.7305
478	G	A	-0.5403
479	Q	A	-0.9231
480	K	A	-1.3084
481	G	A	-1.0802
482	Q	A	0.0000
483	A	A	0.0000
484	N	A	-0.9430
485	A	A	-0.8091
486	T	A	0.0000
487	R	A	-2.1486
488	I	A	-0.7175
489	P	A	-0.6927
490	A	A	-0.9012
491	K	A	-1.7769
492	T	A	-1.3292
493	P	A	0.0000
494	P	A	-1.3419
495	A	A	0.0000
496	P	A	0.0000
497	K	A	0.0000
498	T	A	0.0000
499	P	A	0.0000
500	P	A	0.0000
501	S	A	0.0000
502	S	A	0.0000
503	G	A	0.0000
504	E	A	0.0000
505	P	A	-0.6147
506	P	A	-0.8375
507	K	A	-0.5585
508	S	A	0.0000
509	G	A	-1.1100
510	D	A	-0.9824
511	R	A	-1.6159
512	S	A	-0.6628
513	G	A	0.5120
514	Y	A	0.7709
515	S	A	0.5395
516	S	A	0.0000
517	P	A	-1.1326
518	G	A	-0.4101
519	S	A	0.0000
520	P	A	-0.7437
521	G	A	-1.3758
522	T	A	-0.8506
523	P	A	0.0000
524	G	A	-1.1566
525	S	A	-1.3608
526	R	A	-2.1842
527	S	A	0.0000
528	R	A	-1.3781
529	T	A	-1.3126
530	P	A	-1.1397
531	S	A	-0.9871
532	L	A	-1.0257
533	P	A	-0.6484
534	T	A	-0.4232
535	P	A	-0.8873
536	P	A	-1.2138
537	T	A	-1.6749
538	R	A	-2.9667
539	E	A	-3.0777
540	P	A	-2.1501
541	K	A	-1.9584
542	K	A	-1.4516
543	V	A	0.3877
544	A	A	0.2758
545	V	A	-0.5622
546	V	A	-0.6102
547	R	A	-0.9567
548	T	A	-1.0411
549	P	A	-1.3666
550	P	A	-1.1853
551	K	A	-1.5929
552	S	A	0.0000
553	P	A	-0.7816
554	S	A	-0.5142
555	S	A	-0.5645
556	A	A	-0.8789
557	K	A	-1.4094
558	S	A	-1.6214
559	R	A	-1.9727
560	L	A	-1.1504
561	Q	A	-1.6025
562	T	A	-0.8304
563	A	A	-0.4117
564	P	A	-0.3776
565	V	A	-0.2606
566	P	A	-0.1685
567	M	A	0.2760
568	P	A	-0.5745
569	D	A	-1.3389
570	L	A	0.0000
571	K	A	-0.7316
572	N	A	-0.9069
573	V	A	0.0000
574	K	A	-0.8316
575	S	A	0.0000
576	K	A	-0.1118
577	I	A	0.8303
578	G	A	0.2995
579	S	A	0.0000
580	T	A	0.0000
581	E	A	0.0000
582	N	A	0.0000
583	L	A	0.0432
584	K	A	0.0000
585	H	A	-0.5403
586	Q	A	-0.7698
587	P	A	-0.6183
588	G	A	0.0000
589	G	A	-0.7303
590	G	A	-0.6472
591	K	A	-0.2492
592	V	A	0.0000
593	Q	A	0.0000
594	I	A	1.4700
595	I	A	1.8474
596	N	A	0.0570
597	K	A	-0.5345
598	K	A	-0.1756
599	L	A	0.7576
600	D	A	-0.0196
601	L	A	0.6009
602	S	A	0.1462
603	N	A	-0.2864
604	V	A	0.7455
605	Q	A	-0.5174
606	S	A	-0.3093
607	K	A	0.0000
608	C	A	-0.6888
609	G	A	0.0000
610	S	A	-1.1996
611	K	A	0.0000
612	D	A	-1.9347
613	N	A	-1.3887
614	I	A	0.2778
615	K	A	-1.0094
616	H	A	-0.5844
617	V	A	0.8235
618	P	A	0.0000
619	G	A	-0.3800
620	G	A	0.0000
621	G	A	-0.3502
622	S	A	-0.2963
623	V	A	0.0003
624	Q	A	0.0971
625	I	A	2.0230
626	V	A	1.5015
627	Y	A	1.4380
628	K	A	-0.4030
629	P	A	-0.1525
630	V	A	0.2837
631	D	A	0.0673
632	L	A	0.3053
633	S	A	0.0922
634	K	A	-0.1307
635	V	A	0.4403
636	T	A	-0.3198
637	S	A	-0.7624
638	K	A	-1.5494
639	C	A	-0.3631
640	G	A	-0.8632
641	S	A	-0.9658
642	L	A	0.0000
643	G	A	-0.4711
644	N	A	-0.1958
645	I	A	0.4226
646	H	A	0.2502
647	H	A	-0.4985
648	K	A	-0.5360
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651	G	A	-0.8719
652	G	A	-1.1560
653	Q	A	-1.1445
654	V	A	0.6711
655	E	A	0.1018
656	V	A	1.0851
657	K	A	0.0327
658	S	A	-0.4356
659	E	A	-0.8915
660	K	A	-1.0819
661	L	A	-0.6958
662	D	A	-0.9291
663	F	A	0.0000
664	K	A	-1.4708
665	D	A	-1.8118
666	R	A	-2.1474
667	V	A	-0.9222
668	Q	A	0.0000
669	S	A	-0.7405
670	K	A	0.0000
671	I	A	0.0000
672	G	A	0.3940
673	S	A	0.4144
674	L	A	0.8309
675	D	A	-0.8499
676	N	A	-0.1476
677	I	A	1.3887
678	T	A	0.0938
679	H	A	-0.3740
680	V	A	0.9544
681	P	A	0.3178
682	G	A	0.2987
683	G	A	0.0000
684	G	A	0.1169
685	N	A	0.0000
686	K	A	-0.9344
687	K	A	0.1660
688	I	A	0.9542
689	E	A	-0.1523
690	T	A	-0.8300
691	H	A	-1.1733
692	K	A	-0.7729
693	L	A	0.0973
694	T	A	0.0745
695	F	A	0.3116
696	R	A	-1.7189
697	E	A	-1.6802
698	N	A	-1.9194
699	A	A	-1.5263
700	K	A	-1.9994
701	A	A	-1.0851
702	K	A	-1.0799
703	T	A	-1.0745
704	D	A	-2.2549
705	H	A	-2.0216
706	G	A	-1.5688
707	A	A	-1.1841
708	E	A	-0.9014
709	I	A	1.1766
710	V	A	0.9209
711	Y	A	1.1757
712	K	A	-0.1227
713	S	A	0.4095
714	P	A	-0.0442
715	V	A	0.7706
716	V	A	0.0681
717	S	A	0.0000
718	G	A	-0.9406
719	D	A	-1.5561
720	T	A	-0.8564
721	S	A	-1.1281
722	P	A	-0.8511
723	R	A	-1.0346
724	H	A	-0.9335
725	L	A	0.3936
726	S	A	-0.4730
727	N	A	-1.3614
728	V	A	-0.4776
729	S	A	-0.3791
730	S	A	-0.6289
731	T	A	-0.1319
732	G	A	0.1136
733	S	A	0.0000
734	I	A	1.0076
735	D	A	-0.8521
736	M	A	-0.1916
737	V	A	0.1414
738	D	A	-0.3633
739	S	A	-0.5492
740	P	A	-0.2940
741	Q	A	-0.9508
742	L	A	-0.7627
743	A	A	-0.2155
744	T	A	-0.4435
745	L	A	-0.9557
746	A	A	-0.7425
747	D	A	-1.1650
748	E	A	0.0000
749	V	A	-0.5527
750	S	A	-0.4145
751	A	A	-0.4154
752	S	A	-0.5702
753	L	A	0.0000
754	A	A	-0.5845
755	K	A	-0.4763
756	Q	A	-1.2977
757	G	A	-1.1891
758	L	A	0.6500