| Chain sequence(s) |
A: PRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPP B: CGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHREVIGSVVMLEIDNRLCLDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEP |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1385 | P | A | -1.3138 | |
| 1386 | R | A | -2.1844 | |
| 1387 | C | A | -1.5811 | |
| 1388 | P | A | -1.4980 | |
| 1389 | R | A | -2.1058 | |
| 1390 | A | A | -1.0336 | |
| 1391 | A | A | -1.2146 | |
| 1392 | C | A | 0.0000 | |
| 1393 | Q | A | -2.0423 | |
| 1394 | A | A | -1.5369 | |
| 1395 | K | A | -2.9884 | |
| 1396 | R | A | -3.4494 | |
| 1397 | G | A | -3.2666 | |
| 1398 | D | A | -3.9129 | |
| 1399 | Q | A | -3.7244 | |
| 1400 | R | A | -3.8875 | |
| 1401 | C | A | -2.9017 | |
| 1402 | D | A | -3.4597 | |
| 1403 | R | A | -3.4028 | |
| 1404 | E | A | -3.2142 | |
| 1405 | C | A | 0.0000 | |
| 1406 | N | A | -1.9281 | |
| 1407 | S | A | -1.0566 | |
| 1408 | P | A | -0.6847 | |
| 1409 | G | A | -1.1091 | |
| 1410 | C | A | 0.0000 | |
| 1411 | G | A | -1.0719 | |
| 1412 | W | A | 0.0000 | |
| 1413 | D | A | 0.0000 | |
| 1414 | G | A | -2.2479 | |
| 1415 | G | A | 0.0000 | |
| 1416 | D | A | -2.7266 | |
| 1417 | C | A | 0.0000 | |
| 1418 | S | A | 0.0000 | |
| 1419 | L | A | 0.0000 | |
| 1420 | S | A | -1.1888 | |
| 1421 | V | A | 0.0000 | |
| 1422 | G | A | -1.2728 | |
| 1423 | D | A | -1.8018 | |
| 1424 | P | A | 0.0000 | |
| 1425 | W | A | -1.2344 | |
| 1426 | R | A | -2.5293 | |
| 1427 | Q | A | -2.4194 | |
| 1428 | C | A | -1.5123 | |
| 1429 | E | A | -1.9619 | |
| 1430 | A | A | -0.3618 | |
| 1431 | L | A | 0.6642 | |
| 1432 | Q | A | -0.3997 | |
| 1433 | C | A | 0.0000 | |
| 1434 | W | A | -0.4401 | |
| 1435 | R | A | -1.6520 | |
| 1436 | L | A | -1.2391 | |
| 1437 | F | A | 0.0000 | |
| 1438 | N | A | -1.9386 | |
| 1439 | N | A | -1.6248 | |
| 1440 | S | A | -1.6974 | |
| 1441 | R | A | -2.0988 | |
| 1442 | C | A | -0.7986 | |
| 1443 | D | A | -0.6935 | |
| 1444 | P | A | -0.5034 | |
| 1445 | A | A | -0.4059 | |
| 1446 | C | A | 0.0000 | |
| 1447 | S | A | -0.4550 | |
| 1448 | S | A | -0.8855 | |
| 1449 | P | A | -0.5388 | |
| 1450 | A | A | -1.0992 | |
| 1451 | C | A | 0.0000 | |
| 1452 | L | A | 0.0000 | |
| 1453 | Y | A | 0.0000 | |
| 1454 | D | A | 0.0000 | |
| 1455 | N | A | -0.6281 | |
| 1456 | F | A | 0.0000 | |
| 1457 | D | A | -1.3849 | |
| 1458 | C | A | -0.7845 | |
| 1459 | H | A | -1.3194 | |
| 1460 | A | A | -2.1115 | |
| 1461 | G | A | -2.5626 | |
| 1462 | G | A | -2.7328 | |
| 1463 | R | A | -3.8014 | |
| 1464 | E | A | -4.1258 | |
| 1465 | R | A | -3.8399 | |
| 1466 | T | A | -2.3989 | |
| 1467 | C | A | 0.0000 | |
| 1468 | N | A | -1.3199 | |
| 1469 | P | A | -0.2131 | |
| 1470 | V | A | 0.6860 | |
| 1471 | Y | A | -0.1772 | |
| 1472 | E | A | -1.1095 | |
| 1473 | K | A | -1.3663 | |
| 1474 | Y | A | 0.0000 | |
| 1475 | C | A | 0.0000 | |
| 1476 | A | A | 0.0000 | |
| 1477 | D | A | -1.3942 | |
| 1478 | H | A | -1.6619 | |
| 1479 | F | A | 0.0000 | |
| 1480 | A | A | -1.5127 | |
| 1481 | D | A | -2.3680 | |
| 1482 | G | A | -2.1403 | |
| 1483 | R | A | -2.6536 | |
| 1484 | C | A | -1.6192 | |
| 1485 | D | A | 0.0000 | |
| 1486 | Q | A | -1.5398 | |
| 1487 | G | A | -1.0405 | |
| 1488 | C | A | 0.0000 | |
| 1489 | N | A | -0.4836 | |
| 1490 | T | A | -0.5723 | |
| 1491 | E | A | -0.7185 | |
| 1492 | E | A | -1.5526 | |
| 1493 | C | A | 0.0000 | |
| 1494 | G | A | 0.0000 | |
| 1495 | W | A | -0.0403 | |
| 1496 | D | A | 0.0000 | |
| 1497 | G | A | -0.8302 | |
| 1498 | L | A | -0.5768 | |
| 1499 | D | A | -1.4405 | |
| 1500 | C | A | -0.6780 | |
| 1501 | A | A | 0.0000 | |
| 1502 | S | A | -1.0265 | |
| 1503 | E | A | -1.7181 | |
| 1504 | V | A | -0.3011 | |
| 1505 | P | A | -0.1031 | |
| 1506 | A | A | 0.5802 | |
| 1507 | L | A | 1.3883 | |
| 1508 | L | A | 0.5867 | |
| 1509 | A | A | 0.0000 | |
| 1510 | R | A | -2.0918 | |
| 1511 | G | A | -1.8469 | |
| 1512 | V | A | 0.0000 | |
| 1513 | L | A | 0.0000 | |
| 1514 | V | A | 0.0000 | |
| 1515 | L | A | 0.0000 | |
| 1516 | T | A | 0.0000 | |
| 1517 | V | A | 0.0000 | |
| 1518 | L | A | 0.7919 | |
| 1519 | L | A | 0.2338 | |
| 1520 | P | A | -0.4167 | |
| 1521 | P | A | -0.9089 | |
| 1522 | E | A | -2.8193 | |
| 1523 | E | A | -2.9757 | |
| 1524 | L | A | 0.0000 | |
| 1525 | L | A | -1.5256 | |
| 1526 | R | A | -2.7638 | |
| 1527 | S | A | -1.6358 | |
| 1528 | S | A | -1.2877 | |
| 1529 | A | A | -1.0799 | |
| 1530 | D | A | -1.1523 | |
| 1531 | F | A | 0.0000 | |
| 1532 | L | A | 0.0000 | |
| 1533 | Q | A | 0.0000 | |
| 1534 | R | A | -0.6273 | |
| 1535 | L | A | 0.0000 | |
| 1536 | S | A | 0.0000 | |
| 1537 | A | A | -0.3253 | |
| 1538 | I | A | -0.2461 | |
| 1539 | L | A | 0.0000 | |
| 1540 | R | A | 0.0000 | |
| 1541 | T | A | 0.0000 | |
| 1542 | S | A | 0.0000 | |
| 1543 | L | A | 0.0000 | |
| 1544 | R | A | -2.0402 | |
| 1545 | F | A | 0.0000 | |
| 1546 | R | A | -0.8837 | |
| 1547 | L | A | -0.3061 | |
| 1548 | D | A | -0.9524 | |
| 1549 | A | A | -0.8344 | |
| 1550 | H | A | -1.5407 | |
| 1551 | G | A | -1.3760 | |
| 1552 | Q | A | -1.5335 | |
| 1553 | A | A | -0.4855 | |
| 1554 | M | A | 0.2744 | |
| 1555 | V | A | 0.5835 | |
| 1556 | F | A | 1.0331 | |
| 1557 | P | A | 0.3536 | |
| 1558 | Y | A | 0.0068 | |
| 1559 | H | A | -1.4199 | |
| 1560 | R | A | -2.3318 | |
| 1561 | P | A | -1.4380 | |
| 1562 | S | A | -0.8178 | |
| 1575 | P | A | -1.4811 | |
| 1576 | E | A | -1.9508 | |
| 1577 | V | A | -0.1208 | |
| 1578 | I | A | 0.1199 | |
| 1579 | G | A | 0.0000 | |
| 1580 | S | A | 0.0000 | |
| 1581 | V | A | 0.6825 | |
| 1582 | V | A | 0.0000 | |
| 1583 | M | A | -0.2614 | |
| 1584 | L | A | 0.0000 | |
| 1585 | E | A | -1.2358 | |
| 1586 | I | A | 0.0000 | |
| 1587 | D | A | -0.1186 | |
| 1588 | N | A | 0.5061 | |
| 1589 | R | A | 0.7369 | |
| 1590 | L | A | 0.6457 | |
| 1591 | C | A | 0.0824 | |
| 1592 | L | A | -0.6854 | |
| 1593 | Q | A | -1.6014 | |
| 1594 | S | A | -1.7351 | |
| 1595 | P | A | -1.8940 | |
| 1596 | E | A | -2.7668 | |
| 1597 | N | A | -2.4096 | |
| 1598 | D | A | -1.9291 | |
| 1599 | H | A | 0.0000 | |
| 1600 | C | A | -0.4035 | |
| 1601 | F | A | 0.0000 | |
| 1602 | P | A | -0.7759 | |
| 1603 | D | A | -1.6575 | |
| 1604 | A | A | 0.0000 | |
| 1605 | Q | A | -1.6112 | |
| 1606 | S | A | -0.9212 | |
| 1607 | A | A | 0.0000 | |
| 1608 | A | A | 0.0000 | |
| 1609 | D | A | 0.0000 | |
| 1610 | Y | A | 0.0000 | |
| 1611 | L | A | 0.0000 | |
| 1612 | G | A | 0.0000 | |
| 1613 | A | A | 0.0000 | |
| 1614 | L | A | 0.0000 | |
| 1615 | S | A | -0.9546 | |
| 1616 | A | A | 0.0000 | |
| 1617 | V | A | -1.2483 | |
| 1618 | E | A | -2.3549 | |
| 1619 | R | A | -2.0114 | |
| 1620 | L | A | -1.3084 | |
| 1621 | D | A | -2.0337 | |
| 1622 | F | A | -0.7633 | |
| 1623 | P | A | -0.5559 | |
| 1624 | Y | A | -0.1029 | |
| 1625 | P | A | 0.0830 | |
| 1626 | L | A | 0.0074 | |
| 1627 | R | A | -0.9072 | |
| 1628 | D | A | -0.8552 | |
| 1629 | V | A | 0.0000 | |
| 1630 | R | A | -1.8806 | |
| 1631 | G | A | -2.0073 | |
| 1632 | E | A | -2.3895 | |
| 1633 | P | A | -1.6677 | |
| 1634 | L | A | -1.0167 | |
| 1635 | E | A | -1.6820 | |
| 1636 | P | A | -1.1001 | |
| 1637 | P | A | -0.7027 | |
| 1392 | C | B | -0.1004 | |
| 1397 | G | B | -2.1137 | |
| 1398 | D | B | -3.3068 | |
| 1399 | Q | B | -3.3611 | |
| 1400 | R | B | -3.5294 | |
| 1401 | C | B | -2.4707 | |
| 1402 | D | B | -3.3907 | |
| 1403 | R | B | -3.7093 | |
| 1404 | E | B | -3.0437 | |
| 1405 | C | B | 0.0000 | |
| 1406 | N | B | -1.8152 | |
| 1407 | S | B | -1.1166 | |
| 1408 | P | B | -0.7854 | |
| 1409 | G | B | -0.5034 | |
| 1410 | C | B | -0.0861 | |
| 1411 | G | B | -0.8217 | |
| 1412 | W | B | 0.0000 | |
| 1413 | D | B | 0.0000 | |
| 1414 | G | B | -1.7105 | |
| 1415 | G | B | 0.0000 | |
| 1416 | D | B | -2.2954 | |
| 1417 | C | B | 0.0000 | |
| 1418 | S | B | 0.0000 | |
| 1419 | L | B | 0.0000 | |
| 1420 | S | B | -1.2905 | |
| 1421 | V | B | 0.0000 | |
| 1422 | G | B | -1.5603 | |
| 1423 | D | B | -2.3093 | |
| 1424 | P | B | 0.0000 | |
| 1425 | W | B | -1.3702 | |
| 1426 | R | B | -2.6556 | |
| 1427 | Q | B | -2.4343 | |
| 1428 | C | B | -1.7016 | |
| 1429 | E | B | -2.0441 | |
| 1430 | A | B | -0.6559 | |
| 1431 | L | B | 0.4486 | |
| 1432 | Q | B | -0.9711 | |
| 1433 | C | B | 0.0000 | |
| 1434 | W | B | -0.5015 | |
| 1435 | R | B | -1.9192 | |
| 1436 | L | B | -1.5350 | |
| 1437 | F | B | 0.0000 | |
| 1438 | N | B | -2.0907 | |
| 1439 | N | B | -2.3190 | |
| 1440 | S | B | -1.7694 | |
| 1441 | R | B | -2.2112 | |
| 1442 | C | B | -0.8066 | |
| 1443 | D | B | -0.7781 | |
| 1444 | P | B | -0.4478 | |
| 1445 | A | B | -0.5020 | |
| 1446 | C | B | 0.0000 | |
| 1447 | S | B | -0.4573 | |
| 1448 | S | B | -0.7624 | |
| 1449 | P | B | -0.6664 | |
| 1450 | A | B | -1.0179 | |
| 1451 | C | B | 0.0000 | |
| 1452 | L | B | 0.0000 | |
| 1453 | Y | B | 0.0000 | |
| 1454 | D | B | 0.0000 | |
| 1455 | N | B | 0.0000 | |
| 1456 | F | B | 0.0000 | |
| 1457 | D | B | 0.0000 | |
| 1458 | C | B | -0.5265 | |
| 1459 | H | B | -0.7864 | |
| 1460 | A | B | 0.0000 | |
| 1461 | G | B | -1.5771 | |
| 1462 | G | B | -1.9105 | |
| 1463 | R | B | -2.7689 | |
| 1464 | E | B | -2.3056 | |
| 1465 | R | B | -1.7737 | |
| 1466 | T | B | -1.3385 | |
| 1467 | C | B | 0.0000 | |
| 1468 | N | B | -0.9803 | |
| 1469 | P | B | -0.1292 | |
| 1470 | V | B | 0.7982 | |
| 1471 | Y | B | -0.1136 | |
| 1472 | E | B | -0.8691 | |
| 1473 | K | B | -0.8983 | |
| 1474 | Y | B | 0.0000 | |
| 1475 | C | B | 0.0000 | |
| 1476 | A | B | 0.0000 | |
| 1477 | D | B | -1.2371 | |
| 1478 | H | B | -1.6639 | |
| 1479 | F | B | 0.0000 | |
| 1480 | A | B | -1.5727 | |
| 1481 | D | B | -2.7813 | |
| 1482 | G | B | -2.3278 | |
| 1483 | R | B | -2.7726 | |
| 1484 | C | B | -1.6908 | |
| 1485 | D | B | 0.0000 | |
| 1486 | Q | B | -1.3642 | |
| 1487 | G | B | -1.0324 | |
| 1488 | C | B | 0.0000 | |
| 1489 | N | B | -0.5298 | |
| 1490 | T | B | -0.4428 | |
| 1491 | E | B | -0.4035 | |
| 1492 | E | B | -0.9343 | |
| 1493 | C | B | 0.0000 | |
| 1494 | G | B | 0.0000 | |
| 1495 | W | B | -0.0673 | |
| 1496 | D | B | 0.0000 | |
| 1497 | G | B | -0.7748 | |
| 1498 | L | B | -0.5765 | |
| 1499 | D | B | -1.4996 | |
| 1500 | C | B | -0.6878 | |
| 1501 | A | B | 0.0000 | |
| 1502 | S | B | -1.0399 | |
| 1503 | E | B | -1.7803 | |
| 1504 | V | B | -0.4730 | |
| 1505 | P | B | -0.1557 | |
| 1506 | A | B | 0.6047 | |
| 1507 | L | B | 1.5080 | |
| 1508 | L | B | 0.8594 | |
| 1509 | A | B | 0.0000 | |
| 1510 | R | B | -2.1778 | |
| 1511 | G | B | -1.8871 | |
| 1512 | V | B | 0.0000 | |
| 1513 | L | B | 0.0000 | |
| 1514 | V | B | 0.0000 | |
| 1515 | L | B | 0.0000 | |
| 1516 | T | B | 0.0000 | |
| 1517 | V | B | 0.0000 | |
| 1518 | L | B | 0.7130 | |
| 1519 | L | B | 0.1501 | |
| 1520 | P | B | -0.5414 | |
| 1521 | P | B | -0.9766 | |
| 1522 | E | B | -2.8950 | |
| 1523 | E | B | -3.1658 | |
| 1524 | L | B | 0.0000 | |
| 1525 | L | B | -1.5556 | |
| 1526 | R | B | -2.7792 | |
| 1527 | S | B | -1.6050 | |
| 1528 | S | B | -0.8875 | |
| 1529 | A | B | -0.9723 | |
| 1530 | D | B | -0.9496 | |
| 1531 | F | B | 0.0000 | |
| 1532 | L | B | 0.0000 | |
| 1533 | Q | B | 0.0000 | |
| 1534 | R | B | -0.6774 | |
| 1535 | L | B | 0.0000 | |
| 1536 | S | B | 0.0000 | |
| 1537 | A | B | -0.1736 | |
| 1538 | I | B | -0.0891 | |
| 1539 | L | B | 0.0000 | |
| 1540 | R | B | 0.0000 | |
| 1541 | T | B | 0.0000 | |
| 1542 | S | B | 0.0000 | |
| 1543 | L | B | 0.0000 | |
| 1544 | R | B | -1.0882 | |
| 1545 | F | B | 0.0000 | |
| 1546 | R | B | -1.0647 | |
| 1547 | L | B | -0.8315 | |
| 1548 | D | B | -1.6199 | |
| 1549 | A | B | -1.1010 | |
| 1550 | H | B | -1.6962 | |
| 1551 | G | B | -1.5616 | |
| 1552 | Q | B | -1.7761 | |
| 1553 | A | B | -0.7091 | |
| 1554 | M | B | -0.0380 | |
| 1555 | V | B | 0.5253 | |
| 1556 | F | B | 1.0183 | |
| 1557 | P | B | 0.2774 | |
| 1558 | Y | B | -0.0323 | |
| 1559 | H | B | -1.6130 | |
| 1560 | R | B | -2.4102 | |
| 1576 | E | B | -2.1302 | |
| 1577 | V | B | -0.1929 | |
| 1578 | I | B | -0.1235 | |
| 1579 | G | B | 0.0000 | |
| 1580 | S | B | 0.0000 | |
| 1581 | V | B | 0.7678 | |
| 1582 | V | B | 0.0000 | |
| 1583 | M | B | -0.1028 | |
| 1584 | L | B | 0.0000 | |
| 1585 | E | B | -0.8288 | |
| 1586 | I | B | 0.0000 | |
| 1587 | D | B | 0.0000 | |
| 1588 | N | B | 0.8233 | |
| 1589 | R | B | 0.8951 | |
| 1590 | L | B | 0.9482 | |
| 1591 | C | B | 0.8520 | |
| 1592 | L | B | 1.3635 | |
| 1598 | D | B | -1.5981 | |
| 1599 | H | B | -0.7343 | |
| 1600 | C | B | -0.1601 | |
| 1601 | F | B | 0.0000 | |
| 1602 | P | B | -0.7582 | |
| 1603 | D | B | -1.5988 | |
| 1604 | A | B | 0.0000 | |
| 1605 | Q | B | -1.4645 | |
| 1606 | S | B | -0.8223 | |
| 1607 | A | B | 0.0000 | |
| 1608 | A | B | 0.0000 | |
| 1609 | D | B | 0.0000 | |
| 1610 | Y | B | 0.0000 | |
| 1611 | L | B | 0.0000 | |
| 1612 | G | B | 0.0000 | |
| 1613 | A | B | 0.0000 | |
| 1614 | L | B | 0.0000 | |
| 1615 | S | B | -1.1775 | |
| 1616 | A | B | 0.0000 | |
| 1617 | V | B | -1.6118 | |
| 1618 | E | B | -2.9873 | |
| 1619 | R | B | -2.8664 | |
| 1620 | L | B | -1.8529 | |
| 1621 | D | B | -2.3241 | |
| 1622 | F | B | -0.8741 | |
| 1623 | P | B | -0.5416 | |
| 1624 | Y | B | -0.1371 | |
| 1625 | P | B | 0.0379 | |
| 1626 | L | B | -0.0894 | |
| 1627 | R | B | -1.0161 | |
| 1628 | D | B | 0.0000 | |
| 1629 | V | B | 0.0000 | |
| 1630 | R | B | -1.4373 | |
| 1631 | G | B | -1.8705 | |
| 1632 | E | B | -2.3338 | |
| 1633 | P | B | -1.5986 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine