| Chain sequence(s) |
A: MVLIPNKPAPEFHGCAVIDGDFKEINLKDYSGKYVVLFFYPADFTFVCPTEIIAFSDEVDQFKSRNCQVIACSTDSKYSHLAWTKQDRKSGGLGDMRIPLLADPTKSIARAYGVLDEEEGNAFRGLFIIDPKGILRQITVNDKPVGRSVDETLRLLDAFQFVEKYGE C: MVLIPNKPAPEFHGCAVIDGDFKEINLKDYSGKYVVLFFYPADFTFVCPTEIIAFSDEVDQFKSRNCQVIACSTDSKYSHLAWTKQDRKSGGLGDMRIPLLADPTKSIARAYGVLDEEEGNAFRGLFIIDPKGILRQITVNDKPVGRSVDETLRLLDAFQFVEKYG B: MVLIPNKPAPEFHGCAVIDGDFKEINLKDYSGKYVVLFFYPADFTFVCPTEIIAFSDEVDQFKSRNCQVIACSTDSKYSHLAWTKQDRKSGGLGDMRIPLLADPTKSIARAYGVLDEEEGNAFRGLFIIDPKGILRQITVNDKPVGRSVDETLRLLDAFQFVEKYGE |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 2.0705 | |
| 2 | V | A | 2.9767 | |
| 3 | L | A | 1.3661 | |
| 4 | I | A | 0.2832 | |
| 5 | P | A | 0.0000 | |
| 6 | N | A | -2.0126 | |
| 7 | K | A | -2.1674 | |
| 8 | P | A | -1.7206 | |
| 9 | A | A | 0.0000 | |
| 10 | P | A | -1.1102 | |
| 11 | E | A | -2.4465 | |
| 12 | F | A | 0.0000 | |
| 13 | H | A | -2.3380 | |
| 14 | G | A | -1.3490 | |
| 15 | C | A | -1.3704 | |
| 16 | A | A | 0.0000 | |
| 17 | V | A | 0.0000 | |
| 18 | I | A | -1.8910 | |
| 19 | D | A | -3.0264 | |
| 20 | G | A | -2.4934 | |
| 21 | D | A | -2.5729 | |
| 22 | F | A | -1.3832 | |
| 23 | K | A | -2.5659 | |
| 24 | E | A | -2.9402 | |
| 25 | I | A | 0.0000 | |
| 26 | N | A | -2.6935 | |
| 27 | L | A | 0.0000 | |
| 28 | K | A | -3.5648 | |
| 29 | D | A | -3.2070 | |
| 30 | Y | A | -2.1785 | |
| 31 | S | A | -2.3008 | |
| 32 | G | A | -1.9831 | |
| 33 | K | A | -2.3719 | |
| 34 | Y | A | 0.0000 | |
| 35 | V | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | L | A | 0.0000 | |
| 38 | F | A | 0.0000 | |
| 39 | F | A | 0.0000 | |
| 40 | Y | A | 0.0000 | |
| 41 | P | A | -0.1673 | |
| 42 | A | A | 0.2674 | |
| 43 | D | A | 0.0000 | |
| 44 | F | A | 2.0427 | |
| 45 | T | A | 1.9375 | |
| 46 | F | A | 2.2741 | |
| 47 | V | A | 1.3562 | |
| 48 | C | A | 0.8531 | |
| 49 | P | A | 0.0000 | |
| 50 | T | A | 0.2791 | |
| 51 | E | A | 0.0000 | |
| 52 | I | A | 0.0000 | |
| 53 | I | A | -0.7026 | |
| 54 | A | A | -0.3380 | |
| 55 | F | A | 0.0000 | |
| 56 | S | A | 0.0000 | |
| 57 | D | A | -2.1610 | |
| 58 | E | A | -2.4618 | |
| 59 | V | A | -2.3794 | |
| 60 | D | A | -3.2391 | |
| 61 | Q | A | -2.5580 | |
| 62 | F | A | 0.0000 | |
| 63 | K | A | -3.0922 | |
| 64 | S | A | -2.0487 | |
| 65 | R | A | -2.0383 | |
| 66 | N | A | -2.0002 | |
| 67 | C | A | 0.0000 | |
| 68 | Q | A | -1.0154 | |
| 69 | V | A | 0.0000 | |
| 70 | I | A | 0.0000 | |
| 71 | A | A | 0.0000 | |
| 72 | C | A | 0.0000 | |
| 73 | S | A | 0.0000 | |
| 74 | T | A | -0.5578 | |
| 75 | D | A | -0.4684 | |
| 76 | S | A | -0.1640 | |
| 77 | K | A | 0.0509 | |
| 78 | Y | A | 1.1067 | |
| 79 | S | A | 0.5925 | |
| 80 | H | A | 0.0000 | |
| 81 | L | A | -0.3787 | |
| 82 | A | A | -0.2031 | |
| 83 | W | A | 0.0000 | |
| 84 | T | A | -1.8302 | |
| 85 | K | A | -2.6844 | |
| 86 | Q | A | -2.4743 | |
| 87 | D | A | -3.2308 | |
| 88 | R | A | -2.9495 | |
| 89 | K | A | -2.7126 | |
| 90 | S | A | -1.3900 | |
| 91 | G | A | -0.2867 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | G | A | 0.0000 | |
| 95 | D | A | -3.2928 | |
| 96 | M | A | -2.3600 | |
| 97 | R | A | -2.9367 | |
| 98 | I | A | 0.0000 | |
| 99 | P | A | 0.0000 | |
| 100 | L | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | A | A | 0.0000 | |
| 103 | D | A | 0.0000 | |
| 104 | P | A | -0.7031 | |
| 105 | T | A | -0.7283 | |
| 106 | K | A | -1.4376 | |
| 107 | S | A | -1.0768 | |
| 108 | I | A | -1.1232 | |
| 109 | A | A | 0.0000 | |
| 110 | R | A | -2.1827 | |
| 111 | A | A | -0.8242 | |
| 112 | Y | A | 0.0000 | |
| 113 | G | A | 0.2366 | |
| 114 | V | A | 0.0000 | |
| 115 | L | A | 0.0000 | |
| 116 | D | A | -2.7626 | |
| 117 | E | A | -3.7413 | |
| 118 | E | A | -3.7015 | |
| 119 | E | A | -3.4259 | |
| 120 | G | A | -2.3625 | |
| 121 | N | A | -1.7796 | |
| 122 | A | A | 0.0000 | |
| 123 | F | A | 0.0000 | |
| 124 | R | A | 0.0000 | |
| 125 | G | A | 0.0000 | |
| 126 | L | A | 0.0000 | |
| 127 | F | A | 0.0000 | |
| 128 | I | A | 0.0000 | |
| 129 | I | A | 0.0000 | |
| 130 | D | A | 0.0000 | |
| 131 | P | A | -1.7217 | |
| 132 | K | A | -2.2313 | |
| 133 | G | A | -2.0669 | |
| 134 | I | A | -1.2787 | |
| 135 | L | A | 0.0000 | |
| 136 | R | A | -0.8335 | |
| 137 | Q | A | 0.0000 | |
| 138 | I | A | 0.0000 | |
| 139 | T | A | -0.0110 | |
| 140 | V | A | 0.0000 | |
| 141 | N | A | 0.0000 | |
| 142 | D | A | 0.0000 | |
| 143 | K | A | -0.7421 | |
| 144 | P | A | -0.5016 | |
| 145 | V | A | 0.0000 | |
| 146 | G | A | -0.1309 | |
| 147 | R | A | 0.0000 | |
| 148 | S | A | -0.8959 | |
| 149 | V | A | 0.0000 | |
| 150 | D | A | -2.2347 | |
| 151 | E | A | -1.7495 | |
| 152 | T | A | 0.0000 | |
| 153 | L | A | 0.0000 | |
| 154 | R | A | -1.5901 | |
| 155 | L | A | 0.0000 | |
| 156 | L | A | 0.0000 | |
| 157 | D | A | -1.2423 | |
| 158 | A | A | -0.4511 | |
| 159 | F | A | 0.0000 | |
| 160 | Q | A | -0.7465 | |
| 161 | F | A | 0.3111 | |
| 162 | V | A | -0.5261 | |
| 163 | E | A | -1.7741 | |
| 164 | K | A | -1.5710 | |
| 165 | Y | A | -0.0866 | |
| 166 | G | A | -0.8951 | |
| 167 | E | A | -0.9921 | |
| 1 | M | B | 2.0694 | |
| 2 | V | B | 2.8292 | |
| 3 | L | B | 1.2685 | |
| 4 | I | B | 0.1698 | |
| 5 | P | B | 0.0000 | |
| 6 | N | B | -1.8553 | |
| 7 | K | B | -1.8755 | |
| 8 | P | B | -1.5668 | |
| 9 | A | B | 0.0000 | |
| 10 | P | B | -1.0961 | |
| 11 | E | B | -2.5444 | |
| 12 | F | B | 0.0000 | |
| 13 | H | B | -2.4714 | |
| 14 | G | B | -1.3670 | |
| 15 | C | B | -1.3147 | |
| 16 | A | B | 0.0000 | |
| 17 | V | B | 0.0000 | |
| 18 | I | B | -1.5954 | |
| 19 | D | B | -2.6437 | |
| 20 | G | B | -2.2435 | |
| 21 | D | B | -1.7136 | |
| 22 | F | B | -1.0355 | |
| 23 | K | B | -2.1207 | |
| 24 | E | B | -2.4537 | |
| 25 | I | B | 0.0000 | |
| 26 | N | B | -2.9534 | |
| 27 | L | B | 0.0000 | |
| 28 | K | B | -3.7022 | |
| 29 | D | B | -3.1454 | |
| 30 | Y | B | -2.3071 | |
| 31 | S | B | -2.3992 | |
| 32 | G | B | -2.0928 | |
| 33 | K | B | -2.5574 | |
| 34 | Y | B | 0.0000 | |
| 35 | V | B | 0.0000 | |
| 36 | V | B | 0.0000 | |
| 37 | L | B | 0.0000 | |
| 38 | F | B | 0.0000 | |
| 39 | F | B | 0.0000 | |
| 40 | Y | B | 0.0000 | |
| 41 | P | B | -0.3655 | |
| 42 | A | B | 0.4445 | |
| 43 | D | B | 0.0000 | |
| 44 | F | B | 1.2162 | |
| 45 | T | B | 1.8024 | |
| 46 | F | B | 2.8778 | |
| 47 | V | B | 2.6432 | |
| 48 | C | B | 1.7243 | |
| 49 | P | B | 0.0000 | |
| 50 | T | B | 0.2758 | |
| 51 | E | B | -0.0700 | |
| 52 | I | B | 0.0000 | |
| 53 | I | B | -0.8563 | |
| 54 | A | B | -0.7500 | |
| 55 | F | B | 0.0000 | |
| 56 | S | B | 0.0000 | |
| 57 | D | B | -3.0183 | |
| 58 | E | B | -3.0126 | |
| 59 | V | B | -2.7300 | |
| 60 | D | B | -3.5351 | |
| 61 | Q | B | -2.7226 | |
| 62 | F | B | 0.0000 | |
| 63 | K | B | -3.1346 | |
| 64 | S | B | -2.0416 | |
| 65 | R | B | -2.0609 | |
| 66 | N | B | -2.1248 | |
| 67 | C | B | 0.0000 | |
| 68 | Q | B | -0.9752 | |
| 69 | V | B | 0.0000 | |
| 70 | I | B | 0.0000 | |
| 71 | A | B | 0.0000 | |
| 72 | C | B | 0.0000 | |
| 73 | S | B | 0.0000 | |
| 74 | T | B | 0.0000 | |
| 75 | D | B | 0.0000 | |
| 76 | S | B | -0.3722 | |
| 77 | K | B | -0.2902 | |
| 78 | Y | B | 0.5205 | |
| 79 | S | B | 0.0000 | |
| 80 | H | B | 0.0000 | |
| 81 | L | B | -0.5098 | |
| 82 | A | B | 0.0000 | |
| 83 | W | B | 0.0000 | |
| 84 | T | B | -1.5743 | |
| 85 | K | B | -2.4091 | |
| 86 | Q | B | -2.1881 | |
| 87 | D | B | -2.7654 | |
| 88 | R | B | -2.5861 | |
| 89 | K | B | -2.4931 | |
| 90 | S | B | -1.6223 | |
| 91 | G | B | -0.3996 | |
| 92 | G | B | 0.0000 | |
| 93 | L | B | 0.0000 | |
| 94 | G | B | -2.4963 | |
| 95 | D | B | -3.1909 | |
| 96 | M | B | -2.3113 | |
| 97 | R | B | -3.0428 | |
| 98 | I | B | 0.0000 | |
| 99 | P | B | 0.0000 | |
| 100 | L | B | 0.0000 | |
| 101 | L | B | 0.0000 | |
| 102 | A | B | 0.0000 | |
| 103 | D | B | 0.0000 | |
| 104 | P | B | -1.1709 | |
| 105 | T | B | -1.7351 | |
| 106 | K | B | -1.2174 | |
| 107 | S | B | -0.9732 | |
| 108 | I | B | 0.0000 | |
| 109 | A | B | 0.0000 | |
| 110 | R | B | -2.1527 | |
| 111 | A | B | -0.9096 | |
| 112 | Y | B | 0.0000 | |
| 113 | G | B | 0.1999 | |
| 114 | V | B | 0.0000 | |
| 115 | L | B | -1.6606 | |
| 116 | D | B | -2.5463 | |
| 117 | E | B | -3.5487 | |
| 118 | E | B | -3.5156 | |
| 119 | E | B | -3.0356 | |
| 120 | G | B | 0.0000 | |
| 121 | N | B | -1.5700 | |
| 122 | A | B | 0.0000 | |
| 123 | F | B | 0.0000 | |
| 124 | R | B | -0.3538 | |
| 125 | G | B | 0.0000 | |
| 126 | L | B | 0.0000 | |
| 127 | F | B | 0.0000 | |
| 128 | I | B | 0.0000 | |
| 129 | I | B | 0.0000 | |
| 130 | D | B | 0.0000 | |
| 131 | P | B | -1.8352 | |
| 132 | K | B | -2.2937 | |
| 133 | G | B | -2.0628 | |
| 134 | I | B | -1.1902 | |
| 135 | L | B | 0.0000 | |
| 136 | R | B | -0.8061 | |
| 137 | Q | B | 0.0000 | |
| 138 | I | B | 0.0000 | |
| 139 | T | B | -0.0457 | |
| 140 | V | B | 0.0000 | |
| 141 | N | B | 0.0000 | |
| 142 | D | B | 0.0000 | |
| 143 | K | B | -0.6912 | |
| 144 | P | B | -0.4899 | |
| 145 | V | B | 0.0000 | |
| 146 | G | B | -0.3349 | |
| 147 | R | B | 0.0000 | |
| 148 | S | B | -0.9335 | |
| 149 | V | B | 0.0000 | |
| 150 | D | B | -2.2617 | |
| 151 | E | B | -1.7466 | |
| 152 | T | B | 0.0000 | |
| 153 | L | B | 0.0000 | |
| 154 | R | B | -1.6007 | |
| 155 | L | B | 0.0000 | |
| 156 | L | B | 0.0000 | |
| 157 | D | B | -1.0906 | |
| 158 | A | B | -0.2320 | |
| 159 | F | B | 0.0000 | |
| 160 | Q | B | -0.3526 | |
| 161 | F | B | 0.8491 | |
| 162 | V | B | -0.0695 | |
| 163 | E | B | -1.1818 | |
| 164 | K | B | -1.0580 | |
| 165 | Y | B | 0.3048 | |
| 166 | G | B | -0.4915 | |
| 167 | E | B | -0.9178 | |
| 1 | M | C | 1.7500 | |
| 2 | V | C | 2.8528 | |
| 3 | L | C | 1.9827 | |
| 4 | I | C | 1.9058 | |
| 5 | P | C | -0.3896 | |
| 6 | N | C | -1.8113 | |
| 7 | K | C | -1.9099 | |
| 8 | P | C | -1.5968 | |
| 9 | A | C | 0.0000 | |
| 10 | P | C | -1.0420 | |
| 11 | E | C | -2.5051 | |
| 12 | F | C | 0.0000 | |
| 13 | H | C | -2.4076 | |
| 14 | G | C | -1.4972 | |
| 15 | C | C | -1.5479 | |
| 16 | A | C | 0.0000 | |
| 17 | V | C | 0.0000 | |
| 18 | I | C | -2.0254 | |
| 19 | D | C | -3.0814 | |
| 20 | G | C | -2.7349 | |
| 21 | D | C | -2.7501 | |
| 22 | F | C | -1.6570 | |
| 23 | K | C | -2.9062 | |
| 24 | E | C | -2.8893 | |
| 25 | I | C | 0.0000 | |
| 26 | N | C | -2.7871 | |
| 27 | L | C | 0.0000 | |
| 28 | K | C | -3.6305 | |
| 29 | D | C | -3.0840 | |
| 30 | Y | C | -2.2478 | |
| 31 | S | C | -2.3681 | |
| 32 | G | C | -2.0254 | |
| 33 | K | C | -2.5744 | |
| 34 | Y | C | 0.0000 | |
| 35 | V | C | 0.0000 | |
| 36 | V | C | 0.0000 | |
| 37 | L | C | 0.0000 | |
| 38 | F | C | 0.0000 | |
| 39 | F | C | 0.0000 | |
| 40 | Y | C | 0.0000 | |
| 41 | P | C | 0.0000 | |
| 42 | A | C | 0.0000 | |
| 43 | D | C | 0.0000 | |
| 44 | F | C | 0.9185 | |
| 45 | T | C | 1.6556 | |
| 46 | F | C | 2.8593 | |
| 47 | V | C | 2.7222 | |
| 48 | C | C | 1.5567 | |
| 49 | P | C | 0.7579 | |
| 50 | T | C | 0.3046 | |
| 51 | E | C | 0.0000 | |
| 52 | I | C | 0.0000 | |
| 53 | I | C | -0.8295 | |
| 54 | A | C | -0.7153 | |
| 55 | F | C | 0.0000 | |
| 56 | S | C | 0.0000 | |
| 57 | D | C | -3.1161 | |
| 58 | E | C | -3.2342 | |
| 59 | V | C | 0.0000 | |
| 60 | D | C | -3.7221 | |
| 61 | Q | C | -2.8750 | |
| 62 | F | C | 0.0000 | |
| 63 | K | C | -3.2460 | |
| 64 | S | C | -2.1178 | |
| 65 | R | C | -2.0662 | |
| 66 | N | C | -2.1808 | |
| 67 | C | C | 0.0000 | |
| 68 | Q | C | -0.9699 | |
| 69 | V | C | 0.0000 | |
| 70 | I | C | 0.0000 | |
| 71 | A | C | 0.0000 | |
| 72 | C | C | 0.0000 | |
| 73 | S | C | 0.0000 | |
| 74 | T | C | 0.0000 | |
| 75 | D | C | 0.0000 | |
| 76 | S | C | -0.2439 | |
| 77 | K | C | -0.4037 | |
| 78 | Y | C | 0.7205 | |
| 79 | S | C | 0.0000 | |
| 80 | H | C | 0.0000 | |
| 81 | L | C | -0.3688 | |
| 82 | A | C | 0.0000 | |
| 83 | W | C | 0.0000 | |
| 84 | T | C | -1.5638 | |
| 85 | K | C | -2.4189 | |
| 86 | Q | C | -2.1588 | |
| 87 | D | C | -2.6417 | |
| 88 | R | C | -2.4584 | |
| 89 | K | C | -2.4494 | |
| 90 | S | C | -1.6393 | |
| 91 | G | C | -0.6236 | |
| 92 | G | C | 0.0000 | |
| 93 | L | C | 0.0000 | |
| 94 | G | C | -2.4818 | |
| 95 | D | C | -3.1739 | |
| 96 | M | C | -2.3396 | |
| 97 | R | C | -3.1146 | |
| 98 | I | C | 0.0000 | |
| 99 | P | C | 0.0000 | |
| 100 | L | C | 0.0000 | |
| 101 | L | C | 0.0000 | |
| 102 | A | C | 0.0000 | |
| 103 | D | C | 0.0000 | |
| 104 | P | C | -0.8305 | |
| 105 | T | C | -1.5736 | |
| 106 | K | C | -1.0676 | |
| 107 | S | C | -1.0820 | |
| 108 | I | C | 0.0000 | |
| 109 | A | C | 0.0000 | |
| 110 | R | C | -2.1093 | |
| 111 | A | C | -0.8250 | |
| 112 | Y | C | 0.0000 | |
| 113 | G | C | -0.0165 | |
| 114 | V | C | 0.0000 | |
| 115 | L | C | -1.5854 | |
| 116 | D | C | -2.4815 | |
| 117 | E | C | -3.6554 | |
| 118 | E | C | -3.6648 | |
| 119 | E | C | -3.3564 | |
| 120 | G | C | 0.0000 | |
| 121 | N | C | -1.5262 | |
| 122 | A | C | 0.0000 | |
| 123 | F | C | 0.1196 | |
| 124 | R | C | 0.0000 | |
| 125 | G | C | 0.0000 | |
| 126 | L | C | 0.0000 | |
| 127 | F | C | 0.0000 | |
| 128 | I | C | 0.0000 | |
| 129 | I | C | 0.0000 | |
| 130 | D | C | 0.0000 | |
| 131 | P | C | -1.7852 | |
| 132 | K | C | -2.2577 | |
| 133 | G | C | -2.1579 | |
| 134 | I | C | -1.2785 | |
| 135 | L | C | 0.0000 | |
| 136 | R | C | -0.7365 | |
| 137 | Q | C | 0.0318 | |
| 138 | I | C | 0.9680 | |
| 139 | T | C | 0.7224 | |
| 140 | V | C | 0.8166 | |
| 141 | N | C | -0.1803 | |
| 142 | D | C | -1.2942 | |
| 143 | K | C | -0.5551 | |
| 144 | P | C | 0.1421 | |
| 145 | V | C | 0.9687 | |
| 146 | G | C | 0.2329 | |
| 147 | R | C | -0.2556 | |
| 148 | S | C | -0.9964 | |
| 149 | V | C | -1.5100 | |
| 150 | D | C | -2.6760 | |
| 151 | E | C | -2.2300 | |
| 152 | T | C | 0.0000 | |
| 153 | L | C | -1.8780 | |
| 154 | R | C | -2.6546 | |
| 155 | L | C | -1.1992 | |
| 156 | L | C | 0.0000 | |
| 157 | D | C | -1.1427 | |
| 158 | A | C | -0.0735 | |
| 159 | F | C | 0.0934 | |
| 160 | Q | C | -0.3185 | |
| 161 | F | C | 1.2216 | |
| 162 | V | C | 1.1264 | |
| 163 | E | C | -1.1282 | |
| 164 | K | C | -1.0393 | |
| 165 | Y | C | 0.7653 | |
| 166 | G | C | 0.5047 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine