| Chain sequence(s) |
A: DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC B: EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -2.1852 | |
| 2 | I | A | -1.6944 | |
| 3 | Q | A | -2.0871 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -1.3495 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.8430 | |
| 8 | P | A | -0.5589 | |
| 9 | S | A | -0.7655 | |
| 10 | S | A | -0.6508 | |
| 11 | L | A | -0.5683 | |
| 12 | S | A | -1.0648 | |
| 13 | A | A | -1.0705 | |
| 14 | S | A | -0.8972 | |
| 15 | V | A | 0.2493 | |
| 16 | G | A | -0.5507 | |
| 17 | D | A | -1.5890 | |
| 18 | R | A | -2.3076 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.6413 | |
| 21 | I | A | 0.0000 | |
| 22 | T | A | -0.8624 | |
| 23 | C | A | 0.0000 | |
| 24 | R | A | -2.8731 | |
| 25 | A | A | 0.0000 | |
| 26 | S | A | -2.1784 | |
| 27 | Q | A | -2.8743 | |
| 28 | D | A | -2.8617 | |
| 29 | V | A | 0.0000 | |
| 30 | N | A | -2.0300 | |
| 31 | T | A | -1.0968 | |
| 32 | A | A | 0.0183 | |
| 33 | V | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | 0.0000 | |
| 38 | Q | A | 0.0000 | |
| 39 | K | A | -1.7274 | |
| 40 | P | A | -1.5121 | |
| 41 | G | A | -1.7502 | |
| 42 | K | A | -2.5810 | |
| 43 | A | A | -1.7005 | |
| 44 | P | A | 0.0000 | |
| 45 | K | A | -1.8983 | |
| 46 | L | A | 0.0000 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | 1.2030 | |
| 50 | S | A | 0.3940 | |
| 51 | A | A | 0.0000 | |
| 52 | S | A | 0.5145 | |
| 53 | F | A | 2.1306 | |
| 54 | L | A | 1.4698 | |
| 55 | Y | A | 0.5940 | |
| 56 | S | A | -0.0166 | |
| 57 | G | A | -0.4715 | |
| 58 | V | A | 0.0000 | |
| 59 | P | A | -0.3623 | |
| 60 | S | A | -0.3871 | |
| 61 | R | A | -0.7342 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | 0.1083 | |
| 64 | G | A | -0.1189 | |
| 65 | S | A | -1.1218 | |
| 66 | R | A | -2.6711 | |
| 67 | S | A | -1.6837 | |
| 68 | G | A | -2.0541 | |
| 69 | T | A | -2.3769 | |
| 70 | D | A | -2.0198 | |
| 71 | F | A | 0.0000 | |
| 72 | T | A | -1.0136 | |
| 73 | L | A | 0.0000 | |
| 74 | T | A | -0.6393 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.4440 | |
| 77 | S | A | -1.0934 | |
| 78 | L | A | 0.0000 | |
| 79 | Q | A | -0.9348 | |
| 80 | P | A | -1.5260 | |
| 81 | E | A | -1.5537 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | 0.0000 | |
| 84 | A | A | 0.0000 | |
| 85 | T | A | -0.7049 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 91 | H | A | 0.5681 | |
| 92 | Y | A | 0.6583 | |
| 93 | T | A | 0.0956 | |
| 94 | T | A | -0.2133 | |
| 95 | P | A | -0.5495 | |
| 96 | P | A | 0.0000 | |
| 97 | T | A | -0.5573 | |
| 98 | F | A | -0.4894 | |
| 99 | G | A | 0.0000 | |
| 100 | Q | A | -1.7310 | |
| 101 | G | A | 0.0000 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -1.1647 | |
| 104 | V | A | 0.0000 | |
| 105 | E | A | -1.5434 | |
| 106 | I | A | 0.0000 | |
| 107 | K | A | -1.6612 | |
| 108 | R | A | -1.2403 | |
| 109 | T | A | -0.2636 | |
| 110 | V | A | 0.2800 | |
| 111 | A | A | -0.0342 | |
| 112 | A | A | -0.0228 | |
| 113 | P | A | 0.0000 | |
| 114 | S | A | -0.1251 | |
| 115 | V | A | 0.0000 | |
| 116 | F | A | 0.0000 | |
| 117 | I | A | 0.0000 | |
| 118 | F | A | 0.0000 | |
| 119 | P | A | -0.7082 | |
| 120 | P | A | 0.0000 | |
| 121 | S | A | -1.5696 | |
| 122 | D | A | -2.9500 | |
| 123 | E | A | -2.9428 | |
| 124 | Q | A | 0.0000 | |
| 125 | L | A | -2.2609 | |
| 126 | K | A | -2.7899 | |
| 127 | S | A | -1.7784 | |
| 128 | G | A | -1.4988 | |
| 129 | T | A | -1.1419 | |
| 130 | A | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | V | A | 0.0000 | |
| 133 | V | A | 0.0000 | |
| 134 | C | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | N | A | 0.0000 | |
| 138 | N | A | -0.9197 | |
| 139 | F | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | P | A | -1.8426 | |
| 142 | R | A | -2.9478 | |
| 143 | E | A | -3.2383 | |
| 144 | A | A | -2.4426 | |
| 145 | K | A | -2.6688 | |
| 146 | V | A | -1.6315 | |
| 147 | Q | A | -1.3784 | |
| 148 | W | A | 0.0000 | |
| 149 | K | A | -1.1664 | |
| 150 | V | A | 0.0000 | |
| 151 | D | A | -2.3103 | |
| 152 | N | A | -1.7530 | |
| 153 | A | A | -0.4051 | |
| 154 | L | A | 0.5022 | |
| 155 | Q | A | -0.4211 | |
| 156 | S | A | -0.7112 | |
| 157 | G | A | -1.1108 | |
| 158 | N | A | -1.2214 | |
| 159 | S | A | -1.4566 | |
| 160 | Q | A | -1.6114 | |
| 161 | E | A | -2.1931 | |
| 162 | S | A | -1.0838 | |
| 163 | V | A | -1.0444 | |
| 164 | T | A | -1.1614 | |
| 165 | E | A | -2.3260 | |
| 166 | Q | A | 0.0000 | |
| 167 | D | A | -2.1497 | |
| 168 | S | A | -2.2124 | |
| 169 | K | A | -2.6925 | |
| 170 | D | A | -2.2332 | |
| 171 | S | A | 0.0000 | |
| 172 | T | A | 0.0000 | |
| 173 | Y | A | -1.4289 | |
| 174 | S | A | 0.0000 | |
| 175 | L | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | T | A | -0.7336 | |
| 179 | L | A | 0.0000 | |
| 180 | T | A | -0.6459 | |
| 181 | L | A | -0.9748 | |
| 182 | S | A | -1.3680 | |
| 183 | K | A | -2.4901 | |
| 184 | A | A | -2.3729 | |
| 185 | D | A | -3.2290 | |
| 186 | Y | A | 0.0000 | |
| 187 | E | A | -3.9989 | |
| 188 | K | A | -4.0497 | |
| 189 | H | A | -3.5748 | |
| 190 | K | A | -3.5278 | |
| 191 | V | A | -1.8308 | |
| 192 | Y | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | C | A | 0.0000 | |
| 195 | E | A | -1.3429 | |
| 196 | V | A | 0.0000 | |
| 197 | T | A | -1.3338 | |
| 198 | H | A | 0.0000 | |
| 199 | Q | A | -1.7561 | |
| 200 | G | A | -0.3397 | |
| 201 | L | A | -0.1627 | |
| 202 | S | A | -0.4196 | |
| 203 | S | A | -0.4237 | |
| 204 | P | A | -0.6930 | |
| 205 | V | A | -0.1960 | |
| 206 | T | A | -0.7268 | |
| 207 | K | A | -1.0398 | |
| 208 | S | A | -1.0457 | |
| 209 | F | A | 0.0000 | |
| 210 | N | A | -2.2124 | |
| 211 | R | A | -2.9370 | |
| 212 | G | A | -2.3018 | |
| 213 | E | A | -2.3324 | |
| 214 | C | A | -0.6298 | |
| 1 | E | B | -2.0722 | |
| 2 | V | B | -1.4261 | |
| 3 | Q | B | -1.5161 | |
| 4 | L | B | 0.0000 | |
| 5 | V | B | 0.1440 | |
| 6 | E | B | 0.0000 | |
| 7 | S | B | -0.6227 | |
| 8 | G | B | -0.8871 | |
| 9 | G | B | -0.7265 | |
| 10 | G | B | -0.4163 | |
| 11 | L | B | -0.1973 | |
| 12 | V | B | 0.0000 | |
| 13 | Q | B | -1.6839 | |
| 14 | P | B | -1.5282 | |
| 15 | G | B | -1.4371 | |
| 16 | G | B | -1.2149 | |
| 17 | S | B | -1.4079 | |
| 18 | L | B | -1.2364 | |
| 19 | R | B | -2.1519 | |
| 20 | L | B | 0.0000 | |
| 21 | S | B | -0.5903 | |
| 22 | C | B | 0.0000 | |
| 23 | A | B | -0.4307 | |
| 24 | A | B | 0.0000 | |
| 25 | S | B | -1.1800 | |
| 26 | G | B | -1.3340 | |
| 27 | F | B | -1.5261 | |
| 28 | N | B | -2.4907 | |
| 29 | I | B | 0.0000 | |
| 30 | K | B | -2.7925 | |
| 31 | D | B | -3.0666 | |
| 32 | T | B | 0.0000 | |
| 33 | Y | B | -0.2717 | |
| 34 | I | B | 0.0000 | |
| 35 | H | B | 0.0000 | |
| 36 | W | B | 0.0000 | |
| 37 | V | B | 0.0000 | |
| 38 | R | B | 0.0000 | |
| 39 | Q | B | -0.8128 | |
| 40 | A | B | -1.1662 | |
| 41 | P | B | -0.9646 | |
| 42 | G | B | -1.4759 | |
| 43 | K | B | -2.4061 | |
| 44 | G | B | -1.6752 | |
| 45 | L | B | 0.0000 | |
| 46 | E | B | -1.1037 | |
| 47 | W | B | 0.0000 | |
| 48 | V | B | 0.0000 | |
| 49 | A | B | 0.0000 | |
| 50 | R | B | -0.2580 | |
| 51 | I | B | 0.0000 | |
| 52 | Y | B | -0.2837 | |
| 53 | P | B | 0.0000 | |
| 54 | T | B | -1.2342 | |
| 55 | N | B | -0.9303 | |
| 56 | G | B | -0.4767 | |
| 57 | Y | B | 0.6984 | |
| 58 | T | B | 0.0089 | |
| 59 | R | B | -1.0444 | |
| 60 | Y | B | -1.3978 | |
| 61 | A | B | -1.6604 | |
| 62 | D | B | -2.5283 | |
| 63 | S | B | -1.8159 | |
| 64 | V | B | 0.0000 | |
| 65 | K | B | -2.7247 | |
| 66 | G | B | -1.8076 | |
| 67 | R | B | -1.4953 | |
| 68 | F | B | 0.0000 | |
| 69 | T | B | -1.1607 | |
| 70 | I | B | 0.0000 | |
| 71 | S | B | -0.2615 | |
| 72 | A | B | -0.9104 | |
| 73 | D | B | -1.6356 | |
| 74 | T | B | -1.7089 | |
| 75 | S | B | -1.6290 | |
| 76 | K | B | -2.2909 | |
| 77 | N | B | -1.8857 | |
| 78 | T | B | 0.0000 | |
| 79 | A | B | 0.0000 | |
| 80 | Y | B | 0.0000 | |
| 81 | L | B | 0.0000 | |
| 82 | Q | B | -1.5611 | |
| 83 | M | B | 0.0000 | |
| 84 | N | B | -1.6071 | |
| 85 | S | B | -1.4058 | |
| 86 | L | B | 0.0000 | |
| 87 | R | B | -2.7087 | |
| 88 | A | B | -1.8875 | |
| 89 | E | B | -2.3522 | |
| 90 | D | B | 0.0000 | |
| 91 | T | B | -0.7892 | |
| 92 | A | B | 0.0000 | |
| 93 | V | B | 0.1517 | |
| 94 | Y | B | 0.0000 | |
| 95 | Y | B | 0.0000 | |
| 96 | C | B | 0.0000 | |
| 97 | S | B | 0.0000 | |
| 98 | R | B | -0.1142 | |
| 99 | W | B | 0.0000 | |
| 100 | G | B | 0.0000 | |
| 101 | G | B | -1.3251 | |
| 102 | D | B | -2.1682 | |
| 103 | G | B | -1.0211 | |
| 104 | F | B | -0.1185 | |
| 105 | Y | B | 0.6919 | |
| 106 | A | B | 0.0000 | |
| 107 | M | B | 0.0000 | |
| 108 | D | B | -0.2052 | |
| 109 | Y | B | -0.6277 | |
| 110 | W | B | -0.6908 | |
| 111 | G | B | 0.0000 | |
| 112 | Q | B | -1.5827 | |
| 113 | G | B | -0.7426 | |
| 114 | T | B | -0.1831 | |
| 115 | L | B | 0.0987 | |
| 116 | V | B | 0.0000 | |
| 117 | T | B | -0.5380 | |
| 118 | V | B | 0.0000 | |
| 119 | S | B | -0.8738 | |
| 120 | S | B | -0.7131 | |
| 121 | A | B | -0.4793 | |
| 122 | S | B | -0.6011 | |
| 123 | T | B | -0.6475 | |
| 124 | K | B | -1.0868 | |
| 125 | G | B | -1.3266 | |
| 126 | P | B | -0.5731 | |
| 127 | S | B | -0.4544 | |
| 128 | V | B | 0.0000 | |
| 129 | F | B | 0.0000 | |
| 130 | P | B | -1.0934 | |
| 131 | L | B | 0.0000 | |
| 132 | A | B | -0.8224 | |
| 133 | P | B | 0.0000 | |
| 134 | S | B | -0.7894 | |
| 135 | S | B | -0.9936 | |
| 136 | K | B | -1.6510 | |
| 137 | S | B | 0.0000 | |
| 138 | T | B | -0.8659 | |
| 139 | S | B | -0.7666 | |
| 140 | G | B | -0.8144 | |
| 141 | G | B | -0.8824 | |
| 142 | T | B | -0.6106 | |
| 143 | A | B | 0.0000 | |
| 144 | A | B | 0.0000 | |
| 145 | L | B | 0.0000 | |
| 146 | G | B | 0.0000 | |
| 147 | C | B | 0.0000 | |
| 148 | L | B | 0.0000 | |
| 149 | V | B | 0.0000 | |
| 150 | K | B | 0.0000 | |
| 151 | D | B | -0.3739 | |
| 152 | Y | B | 0.0000 | |
| 153 | F | B | 0.0000 | |
| 154 | P | B | 0.0000 | |
| 155 | E | B | -0.4182 | |
| 156 | P | B | -0.6169 | |
| 157 | V | B | -0.4068 | |
| 158 | T | B | -0.5066 | |
| 159 | V | B | -0.2613 | |
| 160 | S | B | -0.3342 | |
| 161 | W | B | 0.0000 | |
| 162 | N | B | -0.8005 | |
| 163 | S | B | -0.6583 | |
| 164 | G | B | -0.5144 | |
| 165 | A | B | -0.2483 | |
| 166 | L | B | -0.0217 | |
| 167 | T | B | -0.1721 | |
| 168 | S | B | -0.1662 | |
| 169 | G | B | -0.1877 | |
| 170 | V | B | 0.1873 | |
| 171 | H | B | -0.3221 | |
| 172 | T | B | -0.1486 | |
| 173 | F | B | 0.0000 | |
| 174 | P | B | -0.4012 | |
| 175 | A | B | 0.1620 | |
| 176 | V | B | 0.3758 | |
| 177 | L | B | 0.9518 | |
| 178 | Q | B | 0.2122 | |
| 179 | S | B | -0.1036 | |
| 180 | S | B | -0.2149 | |
| 181 | G | B | -0.0045 | |
| 182 | L | B | 0.1096 | |
| 183 | Y | B | 0.4230 | |
| 184 | S | B | 0.2397 | |
| 185 | L | B | 0.0000 | |
| 186 | S | B | 0.0000 | |
| 187 | S | B | 0.0000 | |
| 188 | V | B | 0.0000 | |
| 189 | V | B | 0.0000 | |
| 190 | T | B | -0.1238 | |
| 191 | V | B | 0.0000 | |
| 192 | P | B | -0.6046 | |
| 193 | S | B | -0.6323 | |
| 194 | S | B | -0.5384 | |
| 195 | S | B | -0.5135 | |
| 196 | L | B | -0.6500 | |
| 197 | G | B | -0.9804 | |
| 198 | T | B | -0.6722 | |
| 199 | Q | B | -1.1353 | |
| 200 | T | B | -1.0755 | |
| 201 | Y | B | 0.0000 | |
| 202 | I | B | -1.3456 | |
| 203 | C | B | 0.0000 | |
| 204 | N | B | 0.0000 | |
| 205 | V | B | 0.0000 | |
| 206 | N | B | -1.7275 | |
| 207 | H | B | 0.0000 | |
| 208 | K | B | -2.6791 | |
| 209 | P | B | -1.5507 | |
| 210 | S | B | -1.8140 | |
| 211 | N | B | -2.4056 | |
| 212 | T | B | -2.0203 | |
| 213 | K | B | -2.6716 | |
| 214 | V | B | -1.7828 | |
| 215 | D | B | -2.5786 | |
| 216 | K | B | -2.2942 | |
| 217 | K | B | -2.4855 | |
| 218 | V | B | 0.0000 | |
| 219 | E | B | -1.9915 | |
| 220 | P | B | -0.8849 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine