Project name: 1c0e448132558ce

Chain sequence(s)	A: MKFLLFTLLTFLVSADVVSLNPTNFNTIVDGSKHVFVKFFAPWCGHCKKLAPEYIKLADAYKDKQDIVIAELDCDNKDHKDLCGKFGISGFPTLKFFRKGTTEPIEYEGGRTVEDLSHFIQEKIQPKAPSNVVSVTTATFDSIVMDPTKNVFVKFFAPWCGHCKALAPKYIEVSKMYAGEDDLVVAEVDCTANQETCNKYEVHGYPTLKSFPKGENKKPIAYEGGREVKDFVTYFNTNYGYDRDENGKLGKTAGRIAELDDLAKGFANKENKDEIIKKAEAIEGGAYYVKVMKRIIERGADYVEKEKARINKILENPSMKAKKIDDFTRNLNVLEVF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.764
• Maximal score value: 3.1771
• Average score: -1.0483
• Total score value: -353.2651

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.8317
2	K	A	0.3466
3	F	A	2.5556
4	L	A	3.1771
5	L	A	2.7606
6	F	A	2.1984
7	T	A	2.0151
8	L	A	2.5823
9	L	A	2.5907
10	T	A	2.1174
11	F	A	3.0791
12	L	A	2.8121
13	V	A	2.2481
14	S	A	0.7116
15	A	A	-0.2539
16	D	A	-1.7708
17	V	A	0.0000
18	V	A	1.2018
19	S	A	0.9298
20	L	A	0.0000
21	N	A	0.0000
22	P	A	-0.6244
23	T	A	0.3823
24	N	A	0.0000
25	F	A	0.0000
26	N	A	-1.7874
27	T	A	-0.5324
28	I	A	-0.1509
29	V	A	0.0000
30	D	A	-2.7418
31	G	A	-1.8801
32	S	A	-1.4331
33	K	A	-2.2393
34	H	A	0.0000
35	V	A	0.0000
36	F	A	0.0000
37	V	A	0.0000
38	K	A	0.0000
39	F	A	0.0000
40	F	A	-0.4425
41	A	A	0.0000
42	P	A	-0.3856
43	W	A	0.5475
44	C	A	-0.3529
45	G	A	-1.5987
46	H	A	-2.1175
47	C	A	0.0000
48	K	A	-2.9300
49	K	A	-3.2108
50	L	A	0.0000
51	A	A	-1.7285
52	P	A	-1.4384
53	E	A	-1.6547
54	Y	A	0.0000
55	I	A	-1.4125
56	K	A	-2.4697
57	L	A	0.0000
58	A	A	0.0000
59	D	A	-3.6442
60	A	A	-2.2965
61	Y	A	0.0000
62	K	A	-3.2986
63	D	A	-3.5510
64	K	A	-2.9338
65	Q	A	-2.5437
66	D	A	-2.1328
67	I	A	-0.1099
68	V	A	-0.1462
69	I	A	0.0000
70	A	A	-0.2297
71	E	A	0.0000
72	L	A	0.0000
73	D	A	-0.0302
74	C	A	0.0000
75	D	A	-1.6085
76	N	A	0.0000
77	K	A	-2.8000
78	D	A	-2.3723
79	H	A	0.0000
80	K	A	-3.1431
81	D	A	-2.6148
82	L	A	0.0000
83	C	A	-1.6396
84	G	A	-1.6044
85	K	A	-1.3407
86	F	A	0.0000
87	G	A	-0.9023
88	I	A	0.0000
89	S	A	-0.3770
90	G	A	-0.2123
91	F	A	0.1568
92	P	A	-0.3209
93	T	A	-0.4853
94	L	A	0.0000
95	K	A	0.0000
96	F	A	0.0000
97	F	A	-1.0471
98	R	A	-1.5763
99	K	A	-2.7801
100	G	A	-2.3576
101	T	A	-1.1712
102	T	A	-0.4859
103	E	A	-0.8296
104	P	A	-0.7521
105	I	A	-0.7337
106	E	A	-2.2317
107	Y	A	-1.6131
108	E	A	-2.7302
109	G	A	-1.8833
110	G	A	-1.5514
111	R	A	-1.8021
112	T	A	-1.3427
113	V	A	-1.6585
114	E	A	-2.4540
115	D	A	-2.1435
116	L	A	0.0000
117	S	A	-1.6434
118	H	A	-2.2579
119	F	A	-1.4659
120	I	A	0.0000
121	Q	A	-2.0408
122	E	A	-2.5042
123	K	A	-1.7081
124	I	A	-1.4730
125	Q	A	-1.7990
126	P	A	-1.8849
127	K	A	-2.2251
128	A	A	-1.4020
129	P	A	-1.0391
130	S	A	-0.9534
131	N	A	-1.4190
132	V	A	0.0000
133	V	A	0.1964
134	S	A	-0.2864
135	V	A	0.0000
136	T	A	-0.5259
137	T	A	-0.8433
138	A	A	-0.2384
139	T	A	-0.3311
140	F	A	0.0000
141	D	A	-1.4990
142	S	A	-0.9424
143	I	A	-0.3263
144	V	A	0.0000
145	M	A	-1.7448
146	D	A	-2.5821
147	P	A	-1.7627
148	T	A	-1.9292
149	K	A	-2.7944
150	N	A	0.0000
151	V	A	0.0000
152	F	A	0.0000
153	V	A	0.0000
154	K	A	0.0000
155	F	A	0.0000
156	F	A	0.2339
157	A	A	0.0000
158	P	A	0.2758
159	W	A	0.9387
160	C	A	0.0000
161	G	A	-0.7336
162	H	A	-1.1450
163	C	A	-0.4223
164	K	A	-0.8198
165	A	A	-0.7468
166	L	A	-0.8528
167	A	A	0.0000
168	P	A	-0.5361
169	K	A	-1.5811
170	Y	A	0.0000
171	I	A	-0.5409
172	E	A	-1.4513
173	V	A	0.0000
174	S	A	0.0000
175	K	A	-1.8750
176	M	A	-1.4003
177	Y	A	0.0000
178	A	A	-1.6069
179	G	A	-2.0042
180	E	A	-2.1137
181	D	A	-2.5676
182	D	A	-1.6780
183	L	A	0.0000
184	V	A	-0.6213
185	V	A	0.0000
186	A	A	0.0000
187	E	A	-0.2362
188	V	A	0.0000
189	D	A	-0.6714
190	C	A	0.0000
191	T	A	-0.4960
192	A	A	-0.7664
193	N	A	0.0000
194	Q	A	-2.6657
195	E	A	-3.1745
196	T	A	0.0000
197	C	A	-2.7789
198	N	A	-3.6954
199	K	A	-3.7640
200	Y	A	0.0000
201	E	A	-3.0802
202	V	A	0.0000
203	H	A	-1.7580
204	G	A	-0.9046
205	Y	A	-0.0577
206	P	A	-0.0807
207	T	A	-0.2376
208	L	A	-0.1139
209	K	A	-0.2501
210	S	A	0.0000
211	F	A	0.0000
212	P	A	-1.7171
213	K	A	-3.0210
214	G	A	-2.8399
215	E	A	-3.3515
216	N	A	-3.1216
217	K	A	-3.4797
218	K	A	-2.9213
219	P	A	-1.4602
220	I	A	0.0847
221	A	A	-0.2218
222	Y	A	-0.7377
223	E	A	-1.8355
224	G	A	-1.7941
225	G	A	-2.3392
226	R	A	-2.8949
227	E	A	-3.3282
228	V	A	-2.2534
229	K	A	-2.8795
230	D	A	-2.8849
231	F	A	0.0000
232	V	A	-1.0527
233	T	A	-0.6694
234	Y	A	-0.6823
235	F	A	0.0000
236	N	A	0.0384
237	T	A	0.1521
238	N	A	-0.0231
239	Y	A	0.0885
240	G	A	0.0583
241	Y	A	0.6742
242	D	A	-0.9674
243	R	A	-1.7820
244	D	A	-2.4980
245	E	A	-2.2405
246	N	A	-1.8225
247	G	A	-1.3348
248	K	A	-1.6248
249	L	A	-0.9452
250	G	A	-1.5171
251	K	A	-2.2512
252	T	A	0.0000
253	A	A	-1.3144
254	G	A	-1.4030
255	R	A	-2.2303
256	I	A	0.0000
257	A	A	-1.9591
258	E	A	-2.9482
259	L	A	0.0000
260	D	A	-2.4767
261	D	A	-2.7489
262	L	A	-1.0571
263	A	A	-0.7246
264	K	A	-1.1959
265	G	A	-0.4000
266	F	A	0.5196
267	A	A	-1.0286
268	N	A	-1.8386
269	K	A	-2.7265
270	E	A	-3.2050
271	N	A	-3.3189
272	K	A	-3.7251
273	D	A	-2.8302
274	E	A	-1.9603
275	I	A	1.0807
276	I	A	1.4276
277	K	A	-1.1581
278	K	A	-2.0532
279	A	A	-1.4571
280	E	A	-2.3771
281	A	A	-1.5045
282	I	A	0.0536
283	E	A	-1.5223
284	G	A	0.0000
285	G	A	-1.1868
286	A	A	-0.5617
287	Y	A	-0.3276
288	Y	A	0.0000
289	V	A	-1.0175
290	K	A	-1.2525
291	V	A	0.0000
292	M	A	0.0000
293	K	A	-2.3685
294	R	A	-2.3024
295	I	A	-1.7409
296	I	A	-1.0777
297	E	A	-2.5783
298	R	A	-2.9404
299	G	A	-1.7552
300	A	A	-1.9886
301	D	A	-2.9365
302	Y	A	-2.4295
303	V	A	0.0000
304	E	A	-3.5639
305	K	A	-3.2277
306	E	A	-2.8479
307	K	A	-3.0079
308	A	A	-2.6487
309	R	A	-3.5238
310	I	A	0.0000
311	N	A	-2.9828
312	K	A	-3.5400
313	I	A	-1.8686
314	L	A	-1.9228
315	E	A	-3.1150
316	N	A	-2.2694
317	P	A	-1.6182
318	S	A	-1.0193
319	M	A	-1.2552
320	K	A	-2.4258
321	A	A	-2.0385
322	K	A	-3.0429
323	K	A	-2.3557
324	I	A	-1.4006
325	D	A	-1.5719
326	D	A	-1.4186
327	F	A	-0.4577
328	T	A	-0.4985
329	R	A	-1.2382
330	N	A	-0.7528
331	L	A	-1.0903
332	N	A	-1.4700
333	V	A	0.0000
334	L	A	0.0000
335	E	A	-1.9218
336	V	A	-0.9405
337	F	A	-1.4893