| Chain sequence(s) |
A: GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCCKVSNKGLPSSSIEKTTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNNGQPENNYKTTPPVLDSSDGSFFLYSRLTVDKSRWQEGNVFSCCSVMHEALHNHYTQKSLSLSL B: GGPSVFLFPPKPKDTLMIISRTPEVVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCCKVSNKGLPSSIEKTTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSSCCSSVMHEALHNHYTQKSLSLS |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 236 | G | A | -1.0060 | |
| 237 | G | A | -1.2498 | |
| 238 | P | A | -1.1633 | |
| 239 | S | A | -0.3776 | |
| 240 | V | A | 0.0000 | |
| 241 | F | A | 1.0881 | |
| 242 | L | A | 0.0000 | |
| 243 | F | A | 0.9885 | |
| 244 | P | A | -0.2289 | |
| 245 | P | A | 0.0000 | |
| 246 | K | A | -2.0555 | |
| 247 | P | A | -1.3526 | |
| 248 | K | A | -1.1144 | |
| 249 | D | A | -0.9925 | |
| 250 | T | A | 0.0000 | |
| 251 | L | A | 0.0000 | |
| 252 | M | A | 0.5129 | |
| 253 | I | A | 1.7282 | |
| 254 | S | A | 0.3522 | |
| 255 | R | A | -0.5458 | |
| 256 | T | A | -0.4799 | |
| 257 | P | A | 0.0000 | |
| 258 | E | A | -0.9821 | |
| 259 | V | A | 0.0000 | |
| 260 | T | A | 0.1731 | |
| 261 | C | A | 0.0000 | |
| 262 | V | A | 0.0000 | |
| 263 | V | A | 0.0000 | |
| 264 | V | A | -1.4706 | |
| 265 | D | A | -2.6364 | |
| 266 | V | A | 0.0000 | |
| 267 | S | A | -2.3827 | |
| 268 | Q | A | -3.1956 | |
| 269 | E | A | -3.0203 | |
| 270 | D | A | -2.5744 | |
| 271 | P | A | -2.3167 | |
| 272 | E | A | -3.2832 | |
| 273 | V | A | -2.0733 | |
| 274 | Q | A | -1.8744 | |
| 275 | F | A | -1.2094 | |
| 276 | N | A | -1.0924 | |
| 277 | W | A | 0.0000 | |
| 278 | Y | A | -0.4715 | |
| 279 | V | A | -0.7640 | |
| 280 | D | A | -1.8973 | |
| 281 | G | A | -0.6993 | |
| 282 | V | A | 0.8160 | |
| 283 | E | A | -0.3173 | |
| 284 | V | A | -0.3323 | |
| 285 | H | A | -1.8110 | |
| 286 | N | A | -2.1487 | |
| 287 | A | A | -1.9164 | |
| 288 | K | A | -2.4387 | |
| 289 | T | A | -1.9778 | |
| 290 | K | A | -2.6007 | |
| 291 | P | A | -2.8371 | |
| 292 | R | A | -4.1150 | |
| 293 | E | A | -3.8883 | |
| 294 | E | A | -3.5512 | |
| 295 | Q | A | -1.5956 | |
| 296 | F | A | 0.5644 | |
| 297 | N | A | -0.9736 | |
| 298 | S | A | -1.1129 | |
| 299 | T | A | -2.1227 | |
| 300 | Y | A | -2.9800 | |
| 301 | R | A | -2.9140 | |
| 302 | V | A | 0.0000 | |
| 303 | V | A | -1.0613 | |
| 304 | S | A | 0.0000 | |
| 305 | V | A | 0.0000 | |
| 306 | L | A | 0.0000 | |
| 307 | T | A | -0.6294 | |
| 308 | V | A | 0.0000 | |
| 309 | L | A | 0.7959 | |
| 310 | H | A | 0.0864 | |
| 311 | Q | A | -0.8177 | |
| 312 | D | A | -1.3717 | |
| 313 | W | A | 0.0000 | |
| 314 | L | A | -0.9038 | |
| 315 | N | A | -2.0661 | |
| 316 | G | A | -2.0958 | |
| 317 | K | A | -2.3845 | |
| 318 | E | A | -2.6221 | |
| 319 | Y | A | 0.0000 | |
| 320 | K | A | -1.8873 | |
| 321 | C | A | 0.0000 | |
| 322 | K | A | -1.3238 | |
| 323 | V | A | 0.0000 | |
| 324 | S | A | 0.0000 | |
| 325 | N | A | -1.3885 | |
| 326 | K | A | -1.9888 | |
| 327 | G | A | -0.8209 | |
| 328 | L | A | 0.5789 | |
| 329 | P | A | -0.0054 | |
| 330 | S | A | -0.0230 | |
| 331 | S | A | -0.2090 | |
| 332 | I | A | -0.2426 | |
| 333 | E | A | -1.7241 | |
| 334 | K | A | -1.2000 | |
| 335 | T | A | -1.1944 | |
| 336 | I | A | -0.4967 | |
| 337 | S | A | -1.3604 | |
| 338 | K | A | -1.3808 | |
| 339 | A | A | -1.1759 | |
| 340 | K | A | -2.3384 | |
| 341 | G | A | -2.0900 | |
| 342 | Q | A | -2.1853 | |
| 343 | P | A | -2.2304 | |
| 344 | R | A | -2.9727 | |
| 345 | E | A | -2.9369 | |
| 346 | P | A | 0.0000 | |
| 347 | Q | A | -1.4011 | |
| 348 | V | A | -0.8891 | |
| 349 | Y | A | 0.0000 | |
| 350 | T | A | -0.6986 | |
| 351 | L | A | 0.0000 | |
| 352 | P | A | -0.2684 | |
| 353 | P | A | -0.7201 | |
| 354 | S | A | 0.0000 | |
| 355 | Q | A | -2.0717 | |
| 356 | E | A | -2.5214 | |
| 357 | E | A | 0.0000 | |
| 358 | M | A | -1.7300 | |
| 359 | T | A | -1.5336 | |
| 360 | K | A | -2.2280 | |
| 361 | N | A | -2.4427 | |
| 362 | Q | A | -2.1958 | |
| 363 | V | A | 0.0000 | |
| 364 | S | A | 0.0000 | |
| 365 | L | A | 0.0000 | |
| 366 | T | A | 0.0000 | |
| 367 | C | A | 0.0000 | |
| 368 | L | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | K | A | -0.6058 | |
| 371 | G | A | -1.1889 | |
| 372 | F | A | 0.0000 | |
| 373 | Y | A | -1.4077 | |
| 374 | P | A | 0.0000 | |
| 375 | S | A | -0.3008 | |
| 376 | D | A | -1.2092 | |
| 377 | I | A | -0.6505 | |
| 378 | A | A | 0.0000 | |
| 379 | V | A | 0.0000 | |
| 380 | E | A | -1.1662 | |
| 381 | W | A | 0.0000 | |
| 382 | E | A | -1.5520 | |
| 383 | S | A | -1.1838 | |
| 384 | N | A | -1.8325 | |
| 385 | G | A | -1.8349 | |
| 386 | Q | A | -2.2449 | |
| 387 | P | A | -1.9087 | |
| 388 | E | A | -1.8077 | |
| 389 | N | A | -2.0688 | |
| 390 | N | A | -1.5101 | |
| 391 | Y | A | -0.9433 | |
| 392 | K | A | -0.8803 | |
| 393 | T | A | -0.3111 | |
| 394 | T | A | 0.0000 | |
| 395 | P | A | -0.1011 | |
| 396 | P | A | 0.2009 | |
| 397 | V | A | 0.6748 | |
| 398 | L | A | 1.0454 | |
| 399 | D | A | -0.3737 | |
| 400 | S | A | -1.1569 | |
| 401 | D | A | -1.8892 | |
| 402 | G | A | -0.8587 | |
| 403 | S | A | 0.0000 | |
| 404 | F | A | 0.1035 | |
| 405 | F | A | 0.0000 | |
| 406 | L | A | 0.0000 | |
| 407 | Y | A | 0.0000 | |
| 408 | S | A | 0.0000 | |
| 409 | R | A | 0.0000 | |
| 410 | L | A | 0.0000 | |
| 411 | T | A | -0.8375 | |
| 412 | V | A | 0.0000 | |
| 413 | D | A | -2.3110 | |
| 414 | K | A | -2.6075 | |
| 415 | S | A | -2.3952 | |
| 416 | R | A | -2.2053 | |
| 417 | W | A | 0.0000 | |
| 418 | Q | A | -2.7068 | |
| 419 | E | A | -2.8145 | |
| 420 | G | A | -1.3840 | |
| 421 | N | A | -1.1412 | |
| 422 | V | A | 0.5101 | |
| 423 | F | A | 0.0000 | |
| 424 | S | A | -0.6909 | |
| 425 | C | A | 0.0000 | |
| 426 | S | A | 0.0000 | |
| 427 | V | A | 0.0000 | |
| 428 | M | A | 0.0000 | |
| 429 | H | A | 0.0000 | |
| 430 | E | A | -1.2246 | |
| 431 | A | A | -1.7556 | |
| 432 | L | A | -1.5550 | |
| 433 | H | A | -1.7493 | |
| 434 | N | A | -1.6447 | |
| 435 | H | A | -1.1112 | |
| 436 | Y | A | -0.3018 | |
| 437 | T | A | -0.6666 | |
| 438 | Q | A | -1.1112 | |
| 439 | K | A | -1.1670 | |
| 440 | S | A | -0.4400 | |
| 441 | L | A | 0.0000 | |
| 442 | S | A | 0.1340 | |
| 443 | L | A | 0.1726 | |
| 444 | S | A | 0.6213 | |
| 445 | L | A | 1.5363 | |
| 236 | G | B | -1.0219 | |
| 237 | G | B | -1.2441 | |
| 238 | P | B | -1.2299 | |
| 239 | S | B | -0.4902 | |
| 240 | V | B | 0.0000 | |
| 241 | F | B | 0.9964 | |
| 242 | L | B | 0.8013 | |
| 243 | F | B | 1.0997 | |
| 244 | P | B | -0.1276 | |
| 245 | P | B | 0.0000 | |
| 246 | K | B | -2.0203 | |
| 247 | P | B | -1.3430 | |
| 248 | K | B | -1.0595 | |
| 249 | D | B | -1.1850 | |
| 250 | T | B | 0.0000 | |
| 251 | L | B | 0.0000 | |
| 252 | M | B | 0.3756 | |
| 253 | I | B | 1.5595 | |
| 254 | S | B | 0.1386 | |
| 255 | R | B | -0.9591 | |
| 256 | T | B | -0.6077 | |
| 257 | P | B | 0.0000 | |
| 258 | E | B | -0.8230 | |
| 259 | V | B | 0.0000 | |
| 260 | T | B | 0.2862 | |
| 261 | C | B | 0.0000 | |
| 262 | V | B | 0.0000 | |
| 263 | V | B | 0.0000 | |
| 264 | V | B | -1.3604 | |
| 265 | D | B | -2.6462 | |
| 266 | V | B | 0.0000 | |
| 267 | S | B | -2.4187 | |
| 268 | Q | B | -2.9113 | |
| 269 | E | B | -3.0306 | |
| 270 | D | B | -2.4829 | |
| 271 | P | B | -2.1993 | |
| 272 | E | B | -2.6647 | |
| 273 | V | B | -1.5046 | |
| 274 | Q | B | -1.2909 | |
| 275 | F | B | -0.8613 | |
| 276 | N | B | -0.9833 | |
| 277 | W | B | 0.0000 | |
| 278 | Y | B | -0.5153 | |
| 279 | V | B | -0.8198 | |
| 280 | D | B | -2.0907 | |
| 281 | G | B | -0.8279 | |
| 282 | V | B | 0.6483 | |
| 283 | E | B | -0.5813 | |
| 284 | V | B | -0.4531 | |
| 285 | H | B | -1.8521 | |
| 286 | N | B | -2.1657 | |
| 287 | A | B | -1.8922 | |
| 288 | K | B | -2.3827 | |
| 289 | T | B | -1.6968 | |
| 290 | K | B | -2.2168 | |
| 291 | P | B | -1.7993 | |
| 292 | R | B | -2.7343 | |
| 293 | E | B | -3.1978 | |
| 294 | E | B | -3.2005 | |
| 295 | Q | B | -1.4055 | |
| 296 | F | B | 0.6208 | |
| 297 | N | B | -0.9301 | |
| 298 | S | B | -1.1179 | |
| 299 | T | B | -2.0066 | |
| 300 | Y | B | -2.6414 | |
| 301 | R | B | -2.4402 | |
| 302 | V | B | 0.0000 | |
| 303 | V | B | -0.6860 | |
| 304 | S | B | 0.0000 | |
| 305 | V | B | 0.0000 | |
| 306 | L | B | 0.0000 | |
| 307 | T | B | -0.5020 | |
| 308 | V | B | 0.0000 | |
| 309 | L | B | 1.0812 | |
| 310 | H | B | 0.0000 | |
| 311 | Q | B | -0.9340 | |
| 312 | D | B | -1.1921 | |
| 313 | W | B | 0.0000 | |
| 314 | L | B | -0.9759 | |
| 315 | N | B | -1.9504 | |
| 316 | G | B | -1.9806 | |
| 317 | K | B | -2.0489 | |
| 318 | E | B | -1.9494 | |
| 319 | Y | B | 0.0000 | |
| 320 | K | B | -1.6277 | |
| 321 | C | B | 0.0000 | |
| 322 | K | B | -1.3045 | |
| 323 | V | B | 0.0000 | |
| 324 | S | B | 0.0000 | |
| 325 | N | B | -1.3104 | |
| 326 | K | B | -1.7775 | |
| 327 | G | B | -0.7262 | |
| 328 | L | B | 0.2186 | |
| 329 | P | B | -0.0612 | |
| 330 | S | B | -0.1172 | |
| 331 | S | B | -0.3780 | |
| 332 | I | B | -0.6012 | |
| 333 | E | B | -2.0331 | |
| 334 | K | B | -1.3228 | |
| 335 | T | B | -1.0297 | |
| 336 | I | B | -0.1670 | |
| 337 | S | B | -0.9828 | |
| 338 | K | B | 0.0000 | |
| 339 | A | B | -1.0962 | |
| 340 | K | B | -2.2841 | |
| 341 | G | B | -2.0508 | |
| 342 | Q | B | -2.1345 | |
| 343 | P | B | -2.1216 | |
| 344 | R | B | -2.7799 | |
| 345 | E | B | -2.8231 | |
| 346 | P | B | 0.0000 | |
| 347 | Q | B | -1.0701 | |
| 348 | V | B | 0.0000 | |
| 349 | Y | B | 0.0000 | |
| 350 | T | B | 0.0000 | |
| 351 | L | B | 0.0000 | |
| 352 | P | B | -0.2442 | |
| 353 | P | B | -0.6999 | |
| 354 | S | B | 0.0000 | |
| 355 | Q | B | -2.0660 | |
| 356 | E | B | -2.5181 | |
| 357 | E | B | 0.0000 | |
| 358 | M | B | -1.6725 | |
| 359 | T | B | -1.4389 | |
| 360 | K | B | -2.0172 | |
| 361 | N | B | -2.4382 | |
| 362 | Q | B | -2.2796 | |
| 363 | V | B | 0.0000 | |
| 364 | S | B | 0.0000 | |
| 365 | L | B | 0.0000 | |
| 366 | T | B | 0.0000 | |
| 367 | C | B | 0.0000 | |
| 368 | L | B | 0.0000 | |
| 369 | V | B | 0.0000 | |
| 370 | K | B | -0.5978 | |
| 371 | G | B | -1.2087 | |
| 372 | F | B | 0.0000 | |
| 373 | Y | B | -1.3650 | |
| 374 | P | B | 0.0000 | |
| 375 | S | B | -0.2564 | |
| 376 | D | B | -1.0870 | |
| 377 | I | B | -0.5550 | |
| 378 | A | B | 0.0000 | |
| 379 | V | B | -0.3965 | |
| 380 | E | B | -1.3689 | |
| 381 | W | B | 0.0000 | |
| 382 | E | B | -1.7642 | |
| 383 | S | B | 0.0000 | |
| 384 | N | B | -1.7830 | |
| 385 | G | B | -1.7212 | |
| 386 | Q | B | -2.2264 | |
| 387 | P | B | -1.9668 | |
| 388 | E | B | 0.0000 | |
| 389 | N | B | -2.3222 | |
| 390 | N | B | -1.9509 | |
| 391 | Y | B | -1.2423 | |
| 392 | K | B | -0.8829 | |
| 393 | T | B | -0.3664 | |
| 394 | T | B | 0.0000 | |
| 395 | P | B | -0.0184 | |
| 396 | P | B | 0.1540 | |
| 397 | V | B | 0.5394 | |
| 398 | L | B | 0.8473 | |
| 399 | D | B | -0.5046 | |
| 400 | S | B | -1.1409 | |
| 401 | D | B | -1.9109 | |
| 402 | G | B | -0.9262 | |
| 403 | S | B | 0.0000 | |
| 404 | F | B | 0.0522 | |
| 405 | F | B | 0.0000 | |
| 406 | L | B | 0.0000 | |
| 407 | Y | B | 0.0000 | |
| 408 | S | B | 0.0000 | |
| 409 | R | B | 0.0000 | |
| 410 | L | B | 0.0000 | |
| 411 | T | B | -1.0465 | |
| 412 | V | B | 0.0000 | |
| 413 | D | B | -2.6324 | |
| 414 | K | B | -2.7335 | |
| 415 | S | B | -2.4923 | |
| 416 | R | B | -2.3026 | |
| 417 | W | B | 0.0000 | |
| 418 | Q | B | -2.6853 | |
| 419 | E | B | -2.7447 | |
| 420 | G | B | -1.4484 | |
| 421 | N | B | -0.9767 | |
| 422 | V | B | 0.2647 | |
| 423 | F | B | 0.0000 | |
| 424 | S | B | 0.0000 | |
| 425 | C | B | 0.0000 | |
| 426 | S | B | 0.0000 | |
| 427 | V | B | 0.0000 | |
| 428 | M | B | 0.0000 | |
| 429 | H | B | 0.0000 | |
| 430 | E | B | -1.1536 | |
| 431 | A | B | -1.6708 | |
| 432 | L | B | -1.4630 | |
| 433 | H | B | -1.7398 | |
| 434 | N | B | -1.6321 | |
| 435 | H | B | -1.0937 | |
| 436 | Y | B | -0.3864 | |
| 437 | T | B | -0.8121 | |
| 438 | Q | B | -1.4846 | |
| 439 | K | B | -1.3167 | |
| 440 | S | B | -0.5834 | |
| 441 | L | B | 0.0000 | |
| 442 | S | B | -0.0349 | |
| 443 | L | B | -0.0894 | |
| 444 | S | B | -0.1003 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine